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Volumn 71, Issue , 2014, Pages 168-184
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2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists
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Almirall RandD Centre
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(Spain)
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Author keywords
CRTh2 antagonists; Pyrazole; Structure activity relationship (SAR)
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Indexed keywords
1 (BROMOMETHYL) 2 (PHENYLSULFONYL)BENZENE;
1 PHENYL 2 [2 (PHENYLSULFONYL)BENZYL]BUTANE 1,3 DIONE;
1 [3 (TRIFLUOROMETHYL)PHENYL]BUTANE 1,3 DIONE;
2 (1H PYRAZOL 1 YL)ACETIC ACID DERIVATIVE;
2 (5 METHYL 3 PHENYL 4 (QUINOLIN 2 YLMETHYL) 1H PYRAZOL 1 YL)ACETIC ACID;
2 (PHENYLSULFONYL)BENZALDEHYDE;
2 (PHENYLTHIO)BENZALDEHYDE;
2 [2 (PHENYLSULFONYL)BENZYLIDENE] 1 [3 (TRIFLUOROMETHYL)PHENYL]BUTANE 1,3 DIONE;
2 [2 (PHENYLSULFONYL)BENZYL] 1 [3 (TRIFLUOROMETHYL)PHENYL]BUTANE 1,3 DIONE;
2 [4 (3,4 DICHLOROPHENYLSULFONYL) 5 METHYL 3 PHENYL 1H PYRAZOL 1 YL]ACETIC ACID;
2 [4 (3,4 DICHLOROPHENYLTHIO) 5 METHYL 3 PHENYL 1H PYRAZOL 1 YL]ACETIC ACID;
2 [5 (4 FLUOROBENZOYL) 3 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[4,3 C]PYRIDIN 1 YL]ACETIC ACID;
5 METHYL 3 PHENYL 4 [2 (PHENYLSULFONYL)BENZYL]1H PYRAZOLE;
5 METHYL 4 [2 (PHENYLSULFONYL)BENZYL] 3 [3 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE;
ACETIC ACID DERIVATIVE;
CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON TH2 LYMPHOCYTE ANTAGONIST;
ETHYL 2 (3 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[4,3 C]PYRIDIN 1 YL)ACETIC ACID;
ETHYL 2 [4 (3,4 DICHLOROPHENYLSULFONYL) 5METHYL 3 PHENYL 1H PYRAZOL 1 YL]ACETIC ACID;
ETHYL 2 [4 (3,4 DICHLOROPHENYLTHIO) 5 METHYL 3 PHENYL 1H PYRAZOL 1 YL]ACETIC ACID;
ETHYL 2 [5 (4 FLUOROBENZOYL) 3 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[4,3 C]PYRIDIN 1 YL]ACETIC ACID;
ETHYL [5 METHYL 3 PHENYL 4 [2 (PHENYLSULFONYL)BENZYL]1H PYRAZOL 1 YL]ACETIC ACID;
ETHYL[(3 METHYL 5 PHENYL) 1H PYRAZOL 1 YL]ACETIC ACID;
ETHYL[(5 METHYL 3 PHENYL) 1H PYRAZOL 1 YL]ACETIC ACID;
PYRAZOLE DERIVATIVE;
RECEPTOR BLOCKING AGENT;
TERT BUTYL 1 (2 ETHOXY 2 OXOETHYL) 3 PHENYL 6,7 DIHYDRO 1H PYRAZOLO[4,3 C]PYRIDINE 5(4H) CARBOXYLIC ACID;
TERT BUTYL 3 PHENYL 6,7 DIHYDRO 1H PYRAZOLO[4,3 C]PYRIDINE 5(4H) CARBOXYLIC ACID;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
[2 (PHENYLSULFONYL)PHENYL]METHANOL;
[5 METHYL 3 PHENYL 4 [2 (PHENYLSULFONYL)BENZYL] 1H PYRAZOL 1 YL]ACETIC ACID;
2 [2 (PHENYLSULFONYL)BENZYLIDENE] 1 [3 (TRI FL UOROMETHYL) PHENYL]BUTANE 1,3 DIONE;
2 [2 (PHENYLSULFONYL)BENZYL] 1 [3 (TRIFLUOROMETHYL)PHENYL] BUTANE 1,3 DIONE;
2 [5 (4 FLUOROBENZOYL) 3 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[4,3 C]PYRIDIN 1 YL ] ACETIC ACID;
2 [5 METHYL 3 PHENYL 4 (QUINOLIN 2 YLMETHYL) 1H PYRAZOL 1 YL]ACETIC ACID;
4 [[1 (CARBOXYMETHYL) 5 METHYL 3 PHENYL 1H PYRAZOL 4 YL] METHYL] 3 (PHENYLSULFONYL)BENZOIC ACID;
5 METHYL 3 PHENYL 4 [2 (PHENYLSULFONYL)BENZYL] 1H PYRAZOLE;
ETHYL[(3 METHYL 5 PHENYL) 1H PYRAZOL 1 YL]ACETATE;
ETHYL[(5 METHYL 3 PHENYL) 1H PYRAZOL 1 YL]ACETATE;
ETHYL[5 METHYL 3 PHENYL 4 [2 (PHENYLSULFONYL)BENZYL] 1H PYRAZOL 1YL]ACETATE;
GUANOSINE 5' O (3 THIOTRIPHOSPHATE);
TERT BUTYL [5 METHYL 4 [2 (PHENYLSULFONYL)BENZYL] 3 [3 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOL 1 YL] ACETATE;
[4 [2 [(2 FLUOROPHENYL)SULFONYL]BENZYL] 5 METHYL 3 PHENYL 1H PYRAZOL 1 YL]ACETIC ACID;
[4 [2 [(2 FLUOROPHENYL)THIO]BENZYL] 5 METHYL 3 PHENYL 1H PYRAZOL 1 YL]ACETIC ACID;
[4 [2 [(4 FLUOROPHENYL)SULFONYL]BENZYL] 5 METHYL 3 PHENYL 1H PYRAZOL 1YL]ACETIC ACID;
[4 [4 METHOXY 2 (PHENYLSULFONYL)BENZYL] 5 METHYL 3 PHENYL 1H PYRAZOL 1 YL]ACETIC ACID;
[5 METHYL 3 PHENYL 4 [2 (PHENYLSULFONYL) 4 TRIFLUOROMETHYL)BENZYL] 1H PYRAZOL 1 YL]ACETIC ACID;
[5 METHYL 4 [2 (PHENYLSULFONYL)BENZYL] 3 [3 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOL 1 YL]ACETIC ACID;
ARTICLE;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
IN VITRO STUDY;
IN VIVO STUDY;
STRUCTURE ACTIVITY RELATION;
ANIMAL EXPERIMENT;
BINDING ASSAY;
BIOLOGICAL ACTIVITY;
KNOEVENAGEL CONDENSATION;
MEMBRANE PERMEABILITY;
MICROWAVE IRRADIATION;
NONHUMAN;
PH;
PLASMA PROTEIN BINDING;
RAT;
TH2 CELL;
CRTH2 ANTAGONISTS;
PYRAZOLE;
STRUCTURE-ACTIVITY RELATIONSHIP (SAR);
ACETATES;
HUMANS;
PYRAZOLES;
RECEPTORS, IMMUNOLOGIC;
RECEPTORS, PROSTAGLANDIN;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84888343289
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2013.10.072 Document Type: Article |
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Times cited : (13)
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References (35)
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