Use of libraries to access new chemical space: Applications to CRTH2

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3682-3687

  Masood, M Abid ^a   Gardner, Mark ^a   Dack, Kevin ^a   Winpenny, David ^a   Lunn, Graham ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Antagonist; CRTH2; Libraries; Prostaglandin; Prostanoid

Indexed keywords

CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE 2; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RAMATROBAN; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; MOLECULAR LIBRARY;

CARBOXYLIC ACIDS; HUMANS; LIGANDS; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SMALL MOLECULE LIBRARIES; TH2 CELLS;

EID: 84861194920     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.041     Document Type: Article

References (26)

1. M. Hecker, and V. Ullrich J. Biol. Chem. 264 1989 141
2. H. Hirai, K. Tanaka, O. Yoshie, K. Ogawa, K. Kenmotsu, Y. Takamori, M. Ichimasa, K. Sugamora, M. Nakamura, S. Takano, and K. Nagata J. Exp. Med. 193 2001 255
3. E. Kostenis, and T. Ulven Trends Mol. Med. 12 2006 148
4. Sandig, H.; Andrew, D. Abstracts of Papers, 231st ACS National Meeting, Atlanta GA, 2006.
5. A.A. Barnes, I. Sabroe, and J. Pease FEBS Lett. 580 2006 373
6. N. Peter Expert Opin. Ther. Patent 2005 1817 15
7. T.W. Ly, and K.B. Bacon Expert Opin. Invest. Drugs 14 2005 769
8. R.E. Armer, M.R. Ashton, E.A. Boyd, C.J. Brennan, F.A. Brookfield, L. Gazi, S.L. Gyles, P.A. Hay, M.G. Hunter, D. Middlemiss, M. Whittaker, L. Xue, and R. Pettipher J. Med. Chem. 48 2005 6174
9. F.G. Gervais, J.-P. Morello, C. Beaulieu, N. Sawyer, D. Denis, G. Greig, D.A. Malebranche, and G.P. O'Neill Mol. Pharmacol. 2005 1834 67
10. V.E. Stubbs, P. Schratl, A. Hartnell, T.J. Williams, B.A. Peskar, A. Heinemann, and I. Sabroe J. Biol. Chem. 277 2002 26012
11. H. Hirai, K. Tanaka, S. Takano, M. Ichimasa, M. Nakamura, and K. Nagata J. Immunol. 168 2002 981
12. H. Sugimoto, M. Shichijo, M. Okano, and K.B. Bacon Eur. J. Pharmacol. 524 2005 30
13. H. Sugimoto, M. Shichijo, T. Iino, Y. Manabe, A. Watanabe, M. Shimazaki, F. Gantner, and K.B. Bacon J. Pharmacol. Exp. Ther. 305 2003 347 352
14. T. Ulven, and E. Kostenis J. Med. Chem. 48 2005 897
15. R. Pettipher, T.T. Hansel, and R. Armer Nat. Rev. 6 2007 313
16. T. Ulven, and E. Kostenis Expert Opin. Ther. Patent 20 2010 1505
17. T. Ulven, J.-M. Receveur, M. Grimstrup, O. Rist, T.M. Frimurer, L.-O. Gerlach, J.M. Mathiesen, E. Kostenis, L. Uller, and T. Högberg J. Med. Chem. 49 2006 6638
18. T.M. Frimurer, T. Ulven, C.E. Elling, L.-O. Gerlach, E. Kostenis, and T. Högberg Bioorg. Med. Chem. Lett. 15 2005 3707
19. T. Luker, R. Bonnert, S. Brough, A.R. Cook, M.R. Dickinson, I. Dougall, C. Logan, R.T. Mohammed, S. Paine, H.J. Sanganee, C. Sargent, J.A. Schmidt, S. Teague, and S. Thom Bioorg. Med. Chem. Lett. 21 2011 6288
20. S. Doherty, J.G. Knight, C.H. Smyth, and G.A. Jorgensen Adv. Synth. Catal. 2008 1801 350
21. WO2007144127; Pyrrole derivatives with CRTH2 receptor modulator activity; Sandham, D. A.; Leblanc, C.; Adcock, C.; Bala, K. J.; Pipet, M.N.P.
22. A. Braibanti, F. Dallavalle, E. Leporati, and G. Mori J. Chem. Soc., Dalton Trans. 1 1973 323
23. R. Huisgen A. Padwa, 1,3-Dipolar Cycloaddition Chemistry 1984 Wiley New York
24. H.C. Kolb, M.G. Finn, and K.B. Sharpless Angew. Chem., Int. Ed. 2001 2004 40
25. V. Rostovtsev, L.G. Green, V.V. Fokin, and K.B. Sharpless Angew. Chem. 41 2002 2596
26. H.A. Rajapakse, H. Zhu, M.B. Young, and B.T. Mott Tetrahedron Lett. 47 2006 4827