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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3349-3353

2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists

(13) Andrés, Miriam a Bravo, Mónica a Buil, Maria Antonia a Calbet, Marta a Castro, Jordi a Domènech, Teresa a Eichhorn, Peter a Ferrer, Manel a Gómez, Elena a Lehner, Martin D a Moreno, Imma a Roberts, Richard S a Sevilla, Sara a

a Almirall R and D Centre ^* (Spain)

Author keywords

Antagonist; CRTh2; gvProstaglandin D2; Plasma protein binding; Pyrazole

Indexed keywords

ACETIC ACID DERIVATIVE; CYCLIC AMP; INDOMETACIN; PYRAZOLE DERIVATIVE; RAMATROBAN;

ALKYLATION; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SOLUBILITY; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; IC 50; PH; PLASMA PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ACETATES; ANIMALS; HALF-LIFE; HIGH-THROUGHPUT SCREENING ASSAYS; PROTEIN BINDING; PYRAZOLES; RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877585054 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.03.093 Document Type: Article

Times cited : (13)

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