A biomathematical modeling approach to central nervous system radioligand discovery and development

Journal of Nuclear Medicine

Volumn 50, Issue 10, 2009, Pages 1715-1723

  Guo, Qi ^a   Brady, Michael ^a   Gunn, Roger N ^a,b,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Biomathematical modeling; Imaging; Positron emission tomography; Radiochemistry; Radioligand

Indexed keywords

FLB 457 C 11; FLUMAZENIL C 11; GLYCINE TRANSPORTER 1; GR 205171 C 11; GSK 00000E C 11; GSK 215083; GSK 215083 C 11; GSK 224558; GSK 224558 C 11; GSK 931145; GSK 931145 C 11; ISOREMOXIPRIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; NEUROKININ 1 RECEPTOR; RACLOPRIDE C 11; RADIOLIGAND; SEROTONIN 6 RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOFOPITANT;

ARTICLE; CAPILLARY; CENTRAL NERVOUS SYSTEM; CEREBELLUM; COMPARTMENT MODEL; CORPUS STRIATUM; DENSITY; DRUG RECEPTOR BINDING; DRUG TARGETING; FRONTAL CORTEX; GLOBUS PALLIDUS; IN VIVO STUDY; LIPOPHILICITY; MATHEMATICAL MODEL; MOLECULAR IMAGING; MOLECULAR PROBE; MONTE CARLO METHOD; PERFUSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SURFACE PROPERTY; SWINE; TARGET ORGAN; VALIDATION PROCESS;

ANIMALS; CENTRAL NERVOUS SYSTEM; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RADIOLIGAND ASSAY; REPRODUCIBILITY OF RESULTS; SWINE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 70349645989     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.063800     Document Type: Article

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