Studies on the lipase-induced degradation of lipid-based drug delivery systems. Part II - Investigations on the mechanisms leading to collapse of the lipid structure

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 84, Issue 3, 2013, Pages 456-463

  Schwab, Martin ^a   McGoverin, Cushla M ^b   Gordon, Keith C ^b   Winter, Gerhard ^a   Rades, Thomas ^b   Myschik, Julia ^a   Strachan, Clare J ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Biodegradation; Erosion; Extrudates; Implants; Lipase; Lipid based depot systems

Indexed keywords

FATTY ACID; GLYCEROL; GLYCERYLTRILAURATE; GLYCERYLTRIMYRISTATE; GLYCERYLTRIPALMITATE; GLYCERYLTRISTEARATE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIPID DEGRADATION; MICROSCOPY; PHYSICOCHEMICAL MODEL; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY;

BODY TEMPERATURE; CALIBRATION; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; FATTY ACIDS, NONESTERIFIED; HOT TEMPERATURE; LAURIC ACIDS; LIPASE; LIPIDS; MICROSCOPY, ELECTRON, SCANNING; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; TRIGLYCERIDES;

EID: 84879107006     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.12.023     Document Type: Article

References (19)

1. S. Mohl, and G. Winter Continuous release of rh-interferon α-2a from triglyceride implants: storage stability of the dosage forms Pharm. Dev. Technol. 11 2006 103 110
2. S. Mohl, and G. Winter Continuous release of rh-interferon α-2a from triglyceride matrices J. Control. Release 97 2004 67 78
3. C. Guse, S. Koennings, A. Maschke, M. Hacker, C. Becker, S. Schreiner, T. Blunk, T. Spruss, and A. Goepferich Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids Int. J. Pharm. 314 2006 153 160
4. M. Schwab, B. Kessler, E. Wolf, G. Jordan, S. Mohl, and G. Winter Correlation of in vivo and in vitro release data for rh-INFα lipid implants Eur. J. Pharm. Biopharm. 70 2008 690 694
5. S. Reynisdottir, M. Dauzats, A. Thörne, and D. Langin Comparison of hormone-sensitive lipase activity in visceral and subcutaneous human adipose tissue J. Clin. Endocrinol. Metab. 82 1997 4162 4166
6. T. Ruge, V. Sukonina, T. Myrnäs, M. Lundgren, J.W. Eriksson, and G. Olivecrona Lipoprotein lipase activity/mass ratio is higher in omental than in subcutaneous adipose tissue Eur. J. Clin. Investig. 36 2006 16 21
7. S.W. Coppack, M.D. Jensen, and J.M. Miles In vivo regulation of lipolysis in humans J. Lipid Res. 35 1994 177 193
8. M. Schwab, G. Sax, S. Schulze, and G. Winter Studies on the lipase induced degradation of lipid based drug delivery systems J. Control. Release 140 2009 27 33
9. V.P. Dole, and H. Meinertz Microdetermination of long-chain fatty acids in plasma and tissues J. Biol. Chem. 235 1960 2595 2599
10. R. Wood, and T. Lee High-performance liquid chromatography of fatty acids: quantitative analysis of saturated, monoenoic, polyenoic and geometrical isomers J. Chromatogr. A 254 1983 237 246
11. M. Windbergs, C. Strachan, and P. Kleinebudde Investigating the principles of recrystallization from glyceride melts AAPS PharmSciTech 10 2009 1224 1233
12. P. Smith, D. Cebula, and M.W. Povey The effect of lauric-based molecules on trilaurin crystallization J. Am. Oil Chem. Soc. 71 1994 1367 1372
13. The Unscrambler Technical References. < http://camo.com/ DatabaseTheUnscrambler/Appendices > (10.04.10).
14. C. Olbrich, O. Kayser, and R.H. Müller Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN) - effect of surfactants, storage time and crystallinity Int. J. Pharm. 237 2002 119 128
15. P. Reis, K. Holmberg, R. Miller, J. Kraegel, D.O. Grigoriev, M.E. Leser, and H.J. Watzke Competition between lipases and monoglycerides at interfaces Langmuir 24 2008 7400 7407
16. P. Reis, R. Miller, J. Kraegel, M. Leser, V.B. Fainerman, H. Watzke, and K. Holmberg Lipases at interfaces: unique interfacial properties as globular proteins Langmuir 24 2008 6812 6819
17. M.J. Birnbaum Lipolysis J. Cell Biol. 161 2003 1011 1012
18. A.M. Brzozowski, U. Derewenda, Z.S. Derewenda, G.G. Dodson, D.M. Lawson, J.P. Turkenburg, F. Bjorkling, B. Huge-Jensen, S.A. Patkar, and L. Thim A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex Nature 351 1991 491 494
19. T. Maruyama, M. Nakajima, S. Uchikawa, H. Nabetani, S. Furusaki, and M. Seki Oil-water interfacial activation of lipase for interesterification of triglyceride and fatty acid J. Am. Oil Chem. Soc. 77 2000 1121 1127