Macrophage polarization in response to wear particles in vitro

Cellular and Molecular Immunology

Volumn 10, Issue 6, 2013, Pages 471-482

  Antonios, Joseph K ^a   Yao, Zhenyu ^a   Li, Chenguang ^a   Rao, Allison J ^a   Goodman, Stuart B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IL 4; macrophage polarization; osteolysis; PMMA particles; total joint replacement

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; POLY(METHYL METHACRYLATE);

ANIMAL CELL; ARTICLE; CELL POPULATION; CYTOKINE RELEASE; GENE EXPRESSION PROFILING; IN VITRO STUDY; MACROPHAGE; MECHANICAL STRESS; MONOCYTE; MOUSE; NONHUMAN; OSTEOLYSIS; PHENOTYPE; POLARIZATION; PROSTHESIS; PROVOCATION TEST; WEAR PARTICLE;

ANIMALS; CELL POLARITY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; PROSTHESIS FAILURE; RNA, MESSENGER;

EID: 84888310086     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2013.39     Document Type: Article

References (87)

1. Harris WH. Wear and periprosthetic osteolysis: the problem. Clin Orthop Relat Res 2001; 393: 66-70.
2. Amstutz HC, Campbell P, Kossovsky N, Clarke IC. Mechanism and clinical significance of wear debris-induced osteolysis. Clin Orthop Relat Res 1992; 276: 7-18.
3. Schmalzried TP, Jasty M, Harris WH. Periprosthetic bone loss in total hip arthroplasty. Polyethylene wear debris and the concept of the effective joint space. J Bone Joint Surg Am 1992; 74: 849-863.
4. Hirakawa K, Bauer TW, Stulberg BN, Wilde AH. Comparison and quantitation of wear debris of failed total hip and total knee arthroplasty. J Biomed Mater Res 1996; 31: 257-263. (Pubitemid 26170800)
5. Margevicius KJ, Bauer TW, McMahon JT, Brown SA, Merritt K. Isolation and characterization of debris in membranes around total joint prostheses. J Bone Joint Surg Am 1994; 76: 1664-1675. (Pubitemid 24372019)
6. Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN et al. Quantitative small animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis. J Orthop Res 2000; 18: 849-855. (Pubitemid 32055754)
7. Merkel KD, Erdmann JM, McHugh KP, Abu-Amer Y, Ross FP, Teitelbaum SL. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol 1999; 154: 203-210. (Pubitemid 29031627)
8. Shanbhag AS, Hasselman CT, Rubash HE. The John Charnley Award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model. Clin Orthop Relat Res 1997; 344: 33-43. (Pubitemid 27490634)
9. Wooley PH, Morren R, Andary J, Sud S, Yang SY, Mayton L et al. Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials 2002; 23: 517-526. (Pubitemid 33051040)
10. Blaine TA, Rosier RN, Puzas JE, Looney RJ, Reynolds PR, Reynolds SD et al. Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles. J Bone Joint Surg Am 1996; 78: 1181-1192. (Pubitemid 26284892)
11. Nakashima Y, Sun DH, Trindade MC, Maloney WJ, Goodman SB, Schurman DJ et al. Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro. J Bone Joint Surg Am 1999; 81: 603-615. (Pubitemid 29241254)
12. Ingham E, Green TR, Stone MH, Kowalski R, Watkins N, Fisher J. Production of TNF-alpha and bone resorbing activity by macrophages in response to different types of bone cement particles. Biomaterials 2000; 21: 1005-1013. (Pubitemid 30145691)
13. Maloney WJ, James RE, Smith RL. Human macrophage response to retrieved titanium alloy particles in vitro. Clin Orthop Relat Res 1996; 322: 268-278. (Pubitemid 26023414)
14. Goodman SB, Lind M, Song Y, Smith RL. In vitro, in vivo, and tissue retrieval studies on particulate debris. Clin Orthop Relat Res 1998; 352: 25-34. (Pubitemid 28326281)
15. Goodman SB, Huie P, Song Y, Schurman D, Maloney W, Woolson S et al. Cellular profile and cytokine production at prosthetic interfaces. Study of tissues retrieved from revised hip and knee replacements. J Bone Joint Surg Br 1998; 80: 531-539. (Pubitemid 128472140)
16. Chiu R, Ma T, Smith RL, Goodman SB. Ultrahigh molecular weight polyethylene wear debris inhibits osteoprogenitor proliferation and differentiation in vitro. J Biomed Mater Res A 2009; 89: 242-247.
17. Gallo J, Goodman SB, Konttinen YT, Raska M. Particle disease: biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty. Innate Immunity 2012; 19: 213-224.
18. Ren PG, Irani A, Huang Z, Ma T, Biswal S, Goodman SB. Continuous infusion of UHMWPE particles induces increased bone macrophages and osteolysis. Clin Orthop Relat Res 2011; 469:113-122.
19. Huang Z, Ma T, Ren PG, Smith RL, Goodman SB. Effects of orthopaedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells. J Biomed Mater Res A 2010; 94: 1264-1269.
20. Ren PG, Huang Z, Ma T, Biswal S, Smith RL, Goodman SB. Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by noninvasive imaging. J Biomed Mater Res A 2010; 94: 706-711.
21. Ren PG, Lee SW, Biswal S, Goodman SB. Systemic trafficking of macrophages induced by bone cement particles in nude mice. Biomaterials 2008; 29: 4760-4765.
22. Rao AJ, Gibon E, Ma T, Yao Z, Smith RL, Goodman SB. Revision joint replacement wear particles, and macrophage polarization. Acta Biomat 2012; 8: 2815-2823.
23. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23-35. (Pubitemid 37328697)
24. Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009; 27: 451-483.
25. Fairweather D, Cihakova D. Alternatively activated macrophages in infection and autoimmunity. J Autoimmunity 2009; 33: 222-230.
26. Ho VW, Sly LM. Derivation and characterization of murine alternatively activated (M2) macrophages. Methods Mol Biol 2009; 531: 173-185.
27. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011; 11: 723-737.
28. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-969.
29. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002; 23: 549-555. (Pubitemid 35223554)
30. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004; 25: 677-686. (Pubitemid 39457982)
31. Mantovani A, Garlanda C, Locati M. Macrophage diversity and polarization in atherosclerosis: a question of balance. Arterioscler Thromb Vasc Biol 2009; 29: 1419-1423.
32. Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 2006; 177: 7303-7311. (Pubitemid 44715100)
33. Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci 2008; 13: 453-461. (Pubitemid 351599757)
34. Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 2010; 11: 880-896.
35. Raes G, de Baestselier P, Noel W, Beschin A, Brombacher F, Hassanzadeh GH. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol 2002; 71: 597-602.
36. Raes G, Noel W, Beschin A, Brys L, de Baetselier P, Hassanzadeh GH. FIZZ1 andYmastools to discriminate between differentially activated macrophages. Dev Immunol 2002; 9: 151-159. (Pubitemid 36898373)
37. Maresz K, Ponomarev ED, Barteneva N, Tan Y, Mann MK, Dittel BN. IL-13 induces the expressionofthe alternative activation marker Ym1 in a subset of testicular macrophages. J Reprod Immunol 2008; 78: 140-148.
38. Nair MG, Du Y, Perrigoue JG, Zaph C, Taylor JJ, Goldschmidt M et al. Alternatively activated macrophage-derived RELM-a is a negative regulator of type 2 inflammation in the lung. J Exp Med 2009; 206: 937-952.
39. Brown BN, Ratner BD, Goodman SB, Amar S, Badylak SF. Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials 2012; 33: 3792-3802.
40. Doyle AG, Herbein G, Montaner LJ, Minty AJ, Caput D, Ferrara P et al. Interleukin-13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma. Eur J Immunol 1994; 24: 1441-1445. (Pubitemid 24169531)
41. McBride WH, Economou JS, Nayersina R, Comora S, Essner R. Influences of interleukins 2 and 4 on tumor necrosis factor production by murine mononuclear phagocytes. Cancer Res 1990; 50: 2949-2952. (Pubitemid 20170743)
42. Hart PH, Vitti GF, Burgess DR, Whitty GA, Piccoli DS, Hamilton JA. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor ca, interleukin 1, and prostaglandin E2. Proc Natl Acad Sci USA 1989; 86: 3803-3807. (Pubitemid 19141833)
43. Trindade M, Nakashima Y, Lind M, Sun DH, Goodman SB, Maloney WJ et al. Interleukin-4 inhibits granulocyte-macrophage colony-stimulating factor, interleukin-6, and tumor necrosis factor-alpha expression by human monocytes in response to polymethy-lmethacrylate particle challenge in vitro. J Orthop Res 1999; 17: 797-802. (Pubitemid 30033278)
44. Arora S, Olszewski MA, Tsang TM, McDonald RA, Toews GB, Huffnagle GB. Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans. Infect Immun 2011; 79: 1915-1926.
45. Rao AJ, Nich C, Dhulipala LS, Gibon E, Valladares R, Zwingenberger S et al. Local effect of IL-4 delivery on polyethylene particle induced osteolysisin the murine calvarium. J Biomed Mater Res A 2013; 101: 1926-1934.
46. Davies JQ, Gordon S. Isolation and culture of murine macrophages. Methods Mol Biol 2005; 290: 91-103.
47. Stanley ER, Heard PM. Factors regulating macrophage production and growth. J Biol Chem 1977; 252: 4305-4312.
48. Burgess AW, Metcalf D, Kozka IJ, Simpson RJ, Vairo G, Hamilton JA et al. Purification of two-forms of colony-stimulating factor from mouse L-cell conditioned medium. J Biol Chem 1985; 260: 16004-16011. (Pubitemid 16169384)
49. Moura CC, Soares PB, de Souza MA, Zanetta-Barbosa D. Effect of titanium surface on secretion of IL1b and TGFb1 by mononuclear cells. Braz Oral Res 2011; 25: 500-505.
50. Landis RC, Yagnik DR, Florey O, Philippidis P, Emons V, Mason JC et al. Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages. Arthritis Rhem 2002; 46: 3026-3033. (Pubitemid 35315897)
51. Martin WJ, Shaw O, Liu X, Steiger S, Harper JL. Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout. Arthritis Rhem 2011; 63: 1322-1332.
52. Pello OM, de Pizzol M, Soucek L, Zammataro L, Amabile A, Doni A et al. Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. Blood 2012; 119: 411-421.
53. Weisser SB, McLarren KW, Kuroda E, Sly LM. Generation and characterization of murine alternatively activated macrophages. Methods Mol Biol 2013; 946: 225-239.
54. Allavena P, Chieppa M, Bianchi G, Solinas G, Fabbri M, Laskarin G et al. Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages. Clin Dev Immunol 2010; 2010: 547179.
55. Kigerl K, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG. Identification of distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration of the injured mouse spinal cord. J Neurosci 2009; 29: 13435-13444.
56. Tiju JW, Chen JS, Shun CT, Lin SJ, Liao YH, Chu CY et al. Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction. J Invest Dermatol 2009; 129: 1016-1025.
57. Li CY, Chou TC, Wu CC, Wong CS, Ho ST, Yen MH et al. Dantrolene inhibits nitric oxide synthase in rat alveolar macrophages treated with lipopolysaccharide and interferon-gamma. Can J Anaesth 1998; 45: 246-252.
58. Fuentes-Duculan J, Suarez-Farinas M, Zaba LC, Nograles KE, Pierson KC, Mitsui Het al. Asubpopulation of CD163 positive macrophages is classically activated in psoriasis. J Invest Dermatol 2010; 130: 2412-2422.
59. Lopez-Castejon G, Baroja-Mazo A, Pelegrin P. Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules. Cell Mol Life Sci 2011; 68: 3095-3107.
60. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(2Delta Delta C(T)) Method. Methods 2001; 25: 402-408. (Pubitemid 34164012)
61. Hirsch S, Austyn JM, Gordon S. Expression of the macrophage specific antigen F4/80 during differentiation of mouse bone marrow cells in culture. J Exp Med 1981; 154: 713-725. (Pubitemid 11060783)
62. Khazen W, M'Bika JP, Tomkiewicz C, Benelli C, Chany C, Achour A et al. Expression of macrophage-selective markers in human and rodent adipocytes. FEBS Lett 2005; 579: 5631-5634. (Pubitemid 41455641)
63. Keane TJ, Londono R, Turner N, Badylak SF. Consequences of ineffective decellularization of biologic scaffolds on the host response. Biomaterials 2012; 33: 1771-1781.
64. Brown BN, Londono R, Tottey S, Zhang L, Kukla KA, Wolf MT et al. Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. Acta Biomater 2012; 8: 978-987.
65. Sicari BM, Johnson SA, Siu BF, Crapo PM, Daly KA, Jiang H et al. The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold. Biomaterials 2012; 33: 5524-5533.
66. Benoit M, Barbarat B, Bernard A, Olive D, Mege JL. Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages. Eur J Immunol 2008; 38: 1065-1070.
67. Murphy BS, Sundareshan V, Cory TJ, Hayes D Jr, Anstead MI, Feola DJ. Azithromycin alters macrophage phenotype. J Antimicrob Chemother 2008; 61: 554-560. (Pubitemid 351321127)
68. Fiijsaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 2009; 58: 2574-2582.
69. Roca H, Varsos ZS, Sud S, Craig MJ, Ying C, Pienta KJ. CCL2 and interleukin-6 promote survival of human CD11b peripheral blood mononuclear cells and induce M2-type macrophage polarization. J Biol Chem 2009; 49: 34342-34354.
70. Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T et al. CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology 2010; 138: 2399-2409.
71. Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D, Basdevant A et al. Human adipose tissue macrophages: M1 and M2 cell surface markers in subcutaneous and omental depots and after weight loss. J Clin Endocrinol Metab 2009; 94: 4619-4623.
72. Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992; 176: 287-292.
73. Lolmede K, Campana L, Vezzoli M, Bosurgi L, Tonlorenzi R, Clementi E et al. Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1-and MMP-9-dependent pathways. J Leukoc Biol 2009; 85: 779-787.
74. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117: 175-184. (Pubitemid 46048464)
75. Beutler BA, Milsark IW, Cerami A. Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J Immunol 1985; 135: 3972-3977. (Pubitemid 16250378)
76. Yamshchikov VF, Mishina M, Cominelli F. A possible role of IL-1ra 39-untranslated region in modulation of protein production. Cytokine 2002; 10: 897-903.
77. van Deuren M, Twickler TB, de Waal Malefyt MC, van Beem H, van der Ven-Jongekrijg J, Verschueren CM et al. Elective orthopedic surgery, a model for the study of cytokine activation and regulation. Cytokine 1998; 17: 98-107.
78. Duvel A, Frank C, Schnapper A, Schuberth HJ, Sipka A. Classically or alternatively activated bovine monocyte-derived macrophages in vitro do not resemble CD163/Calprotectin biased macrophage populations in the teat. Innate Immunity 2012; 18: 886-896.
79. Daigneault M, Preston JA, Marriott HM, Whyte MK, Dockrell DH. The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS ONE 2010; 5: e8668.
80. Xia W, Hilenbrink AR, Matteson EL, Lockwood MB, Cheng JX, Low PS. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood 2009; 113: 438-446.
81. Zhang L, Tizard IR. Activation of amouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharm 1996; 35: 119-128. (Pubitemid 26387596)
82. Kolodziejska KE, Burns AR, Moore RH, Stenoien DL, Eissa NT. Regulation of inducible nitric oxide synthase by aggresome formation. Proc Natl Acad Sci USA 2005; 102: 4854-4859. (Pubitemid 40471543)
83. Jones RJ, Jourd'heuil D, Salerno JC, Smith SM, Singer HA. iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle. Am J Physiol Heart Circ Physiol 2007; 292: H2634-H2642. (Pubitemid 47084512)
84. Pandil L, Kolodziejska KE, Zeng S, Eissa NT. The physiologic aggresome mediates cellular inactivation of iNOS. Proc Natl Acad Sci USA 2009; 106: 1211-1215.
85. Zhou J, Tsai YT, Weng H, Baker DW, Tang L. Real time monitoring of biomaterial-mediated inflammatory responses via macrophage-targeting NIR nanoprobes. Biomaterials 2011; 32: 9383-9390.
86. Zhou J, Tsai YT, Weng H, Tang L. Noninvasive assessmentof localized inflammatory responses. Free Radic Biol Med 2012; 52: 218-226.
87. Zhou J, Tsai YT, Weng H, Tang EN, Nair A, Dave DP et al. Real-time detection of implant-associated neutrophil responses using a formyl peptide receptor-targeting NIR nanoprobe. Int J Nanomed 2012; 7: 2057-2068.