PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cells

Thrombosis Research

Volumn 129, Issue 6, 2012, Pages 750-753

  Yang, Fan ^a   Liu, Shuo ^a   Yu, Chuanhui ^a   Wang, Shur Jen ^a   Paganini Hill, Annlia ^a   Fisher, Mark J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cell culture; endothelium; microcirculation; tPA; vascular biology

Indexed keywords

MESSENGER RNA; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; SMALL INTERFERING RNA; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; ASTROCYTE; BRAIN CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISCHEMIA; MICROVASCULAR ENDOTHELIAL CELL; MONOCULTURE; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

BRAIN; CELL CULTURE TECHNIQUES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ENDOTHELIAL CELLS; HUMANS; MICROCIRCULATION; PHOSPHODIESTERASE 4 INHIBITORS; RNA, MESSENGER; ROLIPRAM; SIGNAL TRANSDUCTION; TISSUE PLASMINOGEN ACTIVATOR; TRANSFECTION;

EID: 84862789135     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.12.008     Document Type: Article

References (19)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group Tissue plasminogen activator for acute ischemic stroke N Engl J Med 333 1995 1581 1587
2. R.F. Macko, S.F. Ameriso, A. Gruber, J.H. Griffin, J.A. Fernandez, and R. Barndt Impairments of the protein C system and fibrinolysis in infection-associated stroke Stroke 27 1996 2005 2011
3. S. Gretarsdottir, G. Thorleifsson, S.T. Reynisdottir, A. Manolescu, S. Jonsdottir, and T. Jonsdottir The gene encoding phosphodiesterase 4D confers risk of ischemic stroke Nat Genet 35 2003 131 138
4. Y.C. Liao, H.F. Lin, Y.C. Guo, M.L. Yu, C.K. Liu, and S.H. Juo Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis BMC Med Genet 11 2010 93
5. J.F. Meschia New information on the genetics of stroke Curr Neurol Neurosci Rep 11 2011 35 41
6. Y. Baumer, V. Spindler, R.C. Werthmann, M. Bunemann, and J. Waschke Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown J Cell Physiol 220 2009 716 726
7. M. Gloerich, and J.L. Bos Epac: defining a new mechanism for cAMP action Annu Rev Pharmacol Toxicol 50 2010 355 375
8. M.J. Lorenowicz, M. Fernandez-Borja, M.R. Kooistra, J.L. Bos, and P.L. Hordijk PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways Eur J Cell Biol 87 2008 779 792
9. D.H. Lee, H.R. Lee, H.K. Shin, S.Y. Park, K.W. Hong, and E.K. Kim Cilostazol enhances integrin-dependent homing of progenitor cells by activation of cAMP-dependent protein kinase in synergy with Epac1 J Neurosci Res 89 2011 650 660
10. N. Sharma, D.I. Lopez, and J.K. Nyborg DNA binding and phosphorylation induce conformational alterations in the kinase-inducible domain of CREB. Implications for the mechanism of transcription function J Biol Chem 282 2007 19872 19883
11. M. Grandoch, S.S. Roscioni, and M. Schmidt The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function Br J Pharmacol 159 2010 265 284
12. S. Sehrawat, X. Cullere, S. Patel, J. Italiano Jr., and T.N. Mayadas Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function Mol Biol Cell 19 2008 1261 1270
13. M.R. Kooistra, M. Corada, E. Dejana, and J.L. Bos Epac1 regulates integrity of endothelial cell junctions through VE-cadherin FEBS Lett 579 2005 4966 4972
14. R.J. Hegeman, Y. van den Eijnden-Schrauwen, and J.J. Emeis Adenosine 3':5'-cyclic monophosphate induces regulated secretion of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells Thromb Haemost 79 1998 853 858
15. R. Susarla, J.C. Watkinson, and M.C. Eggo Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function J Cell Physiol 212 2007 643 654
16. M.D. Houslay Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown Trends Biochem Sci 35 2010 91 100
17. H. Poppe, S.D. Rybalkin, H. Rehmann, T.R. Hinds, X.B. Tang, and A.E. Christensen Cyclic nucleotide analogs as probes of signaling pathways Nat Methods 5 2008 277 278
18. L.L. Rubin, D.E. Hall, S. Porter, K. Barbu, C. Cannon, and H.C. Horner A cell culture model of the blood-brain barrier J Cell Biol 115 1991 1725 1735
19. H. Tsukada, D. Fukumoto, S. Nishiyama, K. Sato, and T. Kakiuchi Transient focal ischemia affects the cAMP second messenger system and coupled dopamine D1 and 5-HT1A receptors in the living monkey brain: a positron emission tomography study using microdialysis J Cereb Blood Flow Metab 24 2004 898 906