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Volumn 15, Issue 12, 2013, Pages 3318-3331

One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols

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EID: 84888232250     PISSN: 14639262     EISSN: 14639270     Source Type: Journal    
DOI: 10.1039/c3gc41666f     Document Type: Article
Times cited : (72)

References (123)
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    • Due to the effect of the azide group on the Cahn-Ingold-Prelog priorities, enzymes with a stereoselectivity according to Prelog's rule will produce the (R)-enantiomer of 3a. However, in the suppliers' catalogs these enzymes are categorised as (S)-selective, in accordance with the stereopreference observed with 'standard substrates' such as acetophenone or 2-octanone
    • R. J. Lamed J. G. Zeikus Biochem. J. 1981 195 183 190
    • (1981) Biochem. J. , vol.195 , pp. 183-190
    • Lamed, R.J.1    Zeikus, J.G.2
  • 112
    • 84888247465 scopus 로고    scopus 로고
    • (Pharmacia & Upjohn, Co.), WO 2004/106345, Since the ADH preparation is a crude cell-free extract, the exact concentration of the productive enzyme is not known. An approximation assuming 20% target protein content and a molecular weight of 30 kDa yields a concentration of 3.33 μM, corresponding to a TON of 30000 at full conversion (100 mM substrate)
    • M. E. Schnute, M. M. Cudahy, M. Eggen, D. J. Anderson, T. M. Judge, E. J. Kim and S. A. Collier (Pharmacia & Upjohn, Co.), Internat. Pat., WO 2004/106345, 2004
    • (2004) Internat. Pat.
    • Schnute, M.E.1    Cudahy, M.M.2    Eggen, M.3    Anderson, D.J.4    Judge, T.M.5    Kim, E.J.6    Collier, S.A.7
  • 123
    • 84888215959 scopus 로고    scopus 로고
    • EATOS: Environmental Assessment Tool for Organic Syntheses, Accessed 13.06.2013
    • EATOS: Environmental Assessment Tool for Organic Syntheses, http://www.metzger.chemie.uni-oldenburg.de/eatos/english.htm, Accessed 13.06.2013


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.