Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 20, 2012, Pages 6162-6170

  Bhabak, Krishna P ^a   Arenz, Christoph ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Enzyme inhibitors; Sphingolipids; Structure activity relationship

Indexed keywords

ACID CERAMIDASE; ENZYME INHIBITOR; ETHANOLAMINE DERIVATIVE; N OLEOYL ETHANOLAMINE; NEUTRAL CERAMIDASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ACID CERAMIDASE; AMIDES; ETHANOLAMINES; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NEUTRAL CERAMIDASE; PROTEIN BINDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84866903639     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.031     Document Type: Article

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