Two steps in one pot: Enzyme cascade for the synthesis of nor(pseudo)ephedrine from inexpensive starting materials

Angewandte Chemie - International Edition

Volumn 52, Issue 26, 2013, Pages 6772-6775

  Sehl, Torsten ^a   Hailes, Helen C ^b   Ward, John M ^b   Wardenga, Rainer ^c   Von Lieres, Eric ^a   Offermann, Heike ^a   Westphal, Robert ^a   Pohl, Martina ^a   Rother, Dörte ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Enzymicals AG   (Germany)

Author keywords

transaminase; asymmetric synthesis; biocatalysis; enzyme cascades; phenylpropanolamine

Indexed keywords

ASYMMETRIC SYNTHESIS; BIOCATALYSIS; DIASTEREOMERIC PURITY; ENANTIO; ENZYME CASCADES; ONE POT; ONE-POT REACTION; PHENYLPROPANOLAMINE;

ENZYMES;

REACTION INTERMEDIATES;

AMINOTRANSFERASE; ENZYME; PHENYLPROPANOLAMINE; PSEUDOEPHEDRINE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG DESIGN; ENZYME SPECIFICITY; SYNTHESIS; TIME;

CATALYSIS; DRUG DESIGN; ENZYMES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENYLPROPANOLAMINE; PSEUDOEPHEDRINE; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSAMINASES;

EID: 84879336455     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201300718     Document Type: Article

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