The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity

Biochemistry

Volumn 52, Issue 46, 2013, Pages 8286-8294

  Fay, Jonathan F ^a   Farrens, David L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODEL; ALLOSTERIC MODULATORS; CANNABINOID RECEPTORS; CYSTEINE RESIDUES; EXTRACELLULAR LOOP 2; G-PROTEIN COUPLED RECEPTORS; HUMAN CANNABINOID RECEPTORS; LIGAND-BINDING SITES;

AMINO ACIDS; SULFUR COMPOUNDS;

LIGANDS;

CANNABINOID 1 RECEPTOR; CYSTEINE; CYSTEINE 107; CYSTEINE 98; DISULFIDE; DITHIOTHREITOL; G PROTEIN COUPLED RECEPTOR; REDUCING AGENT; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CELL STRAIN COS1; DISSOCIATION CONSTANT; EXTRACELLULAR LOOP 2; LIGAND BINDING; MEMBRANE; MEMBRANE PROXIMAL REGION; MUTAGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLOHEXANOLS; CYSTEINE; DISULFIDES; DITHIOTHREITOL; HUMANS; INDOLES; LIGANDS; PHENYLUREA COMPOUNDS; PIPERIDINES; PYRIDINES; RATS; RECEPTOR, CANNABINOID, CB1;

EID: 84888214257     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400842k     Document Type: Article

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