Integrity of extracellular loop 1 of the human cannabinoid receptor 1 is critical for high-affinity binding of the ligand CP 55,940 but not SR 141716A

Biochemical Pharmacology

Volumn 65, Issue 10, 2003, Pages 1623-1631

  Murphy, James W ^a   Kendall, Debra A ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Cannabinoid; Cannabinoid receptor; CB1; Extracellular loop; G protein coupled receptor; Ligand binding

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ALANINE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; RIMONABANT;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0037716778     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00155-2     Document Type: Article

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