Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 66, Issue 2-3, 2002, Pages 93-99

  Mechoulam, R ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 AMINOBUTYRIC ACID; ANANDAMIDE; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CANNABIS; DEXANABINOL; DOPAMINE; DRONABINOL; GLUTAMIC ACID; NEUROPROTECTIVE AGENT; NOLADIN ETHER; NORADRENALIN; OUABAIN; RIMONABANT; SEROTONIN; UNCLASSIFIED DRUG; AMIDE; ARACHIDONIC ACID DERIVATIVE; DRUG RECEPTOR; ENDOCANNABINOID; ICOSANOID;

AGGRESSION; DRUG MECHANISM; DRUG RESEARCH; EMOTION; HUMAN; NEUROPHARMACOLOGY; NEUROPROTECTION; PHYTOCHEMISTRY; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; STRESS; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY;

CANNABIS;

AGGRESSION; ANIMALS; ARACHIDONIC ACIDS; CANNABINOIDS; EICOSANOIDS; ENDOCANNABINOIDS; NEUROPROTECTIVE AGENTS; POLYUNSATURATED ALKAMIDES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0036019381     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1054/plef.2001.0340     Document Type: Article

References (63)

1. Isolation, structure and partial synthesis of an active constituent of hashish
2. Marihuana, an annotated bibliography
3. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
4. The pharmacology of Cannabis in animals
5. A historical overview of chemical research on cannabinoids
6. The structure of cannabidiol
7. 1-tetrahydrocannabinol, the major active constituent of hashish
8. Structural requirements for cannabinoid activity
9. The chemical basis of hashish activity
10. 9-THC in normal subjects
11. Constituents of Cannabis sativa L, XVII. A review of the natural constituents
12. Cannabinoid inhibition of adenylate-cyclase - Pharmacology of the response in neuroblastoma cell membranes
13. Determination and characterization of a cannabinoid receptor in rat brain
14. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
15. Molecular characterization of a peripheral receptor for cannabinoids
16. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
17. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
18. Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor
19. 1 receptor
20. Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons
21. Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain
22. Formation of N-acyl-phosphatidylethanolamine and N-acyl- etholamine (including anandamide) during glutamate-induced neurotoxicity
23. Anandamide, but not 2-arachidonylglycerol, accumulates during in vivo neurodegeneration
24. 2-Arachidonoyl glycerol, an endogenous cannabinoid, is neuroprotective after brain injury
25. 1 cannabinoid receptor induction in experimental stroke
26. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures
27. Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity
28. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission
29. Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats
30. 1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity
31. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
32. 9-tetrahydro-cannabinol, the main active compound in marijuana, against ouabain- induced in vivo excitotoxicity
33. Biochemical, cellular and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside
34. Reactive oxygen radicals in signaling and damage in the ischemic brain
35. A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice
36. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
37. Neuroprotection by delta(9)-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity
38. Dexanabinol (HU-211): A nonpsychotropic cannabinoid with neuroprotective properties
39. Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
40. 9-tetrahydrocannabinol are neuroprotective antioxidants
41. A non-psychotropic cannabinoid acts as a functional N-methyl-D-asparate (NMDA) receptor blocker
42. Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: Effect of R-apomorphine
43. Biphasic effects of anandamide
44. Low doses of anandamides inhibit pharmacological effects of delta-9-tetrahydrocannabinol
45. Cannabinoid pharmacology
46. Discovery and characterization of endogenous cannabinoids
47. The role of cannabinoids in neurodegenerative diseases
48. Factors influencing the aggressiveness elicited by marihuana in food-deprived rats
49. Leptin regulated endocannabinoids are involved in maintaining food intake
50. Tetrahydrocannabinol and endocannabinoids in feeding and appetite
51. Aggressive behavior induced by marihuana compounds and by amphetamine in rats previously made dependent on morphine
52. Marihuana aggessiveness in REM-sleep-deprived rats: Neurochemical and neurophysiological correlates
53. Marihuana and shock induced aggression in rats
54. 9-tetrahydrocannabinol and its pharmacological characteristics
55. 9-tetrahydrocannabinol in the rat
56. 9-tetrahydrocannabinol in rats pretreated with 6-hydroxydopamine
57. 9-tetrahydrocannabinol treatment in laboratory rats
58. Dysfunction in the neural circuitry of emotion regulation - A possible prelude to violence
59. Relationship of psychobiological variables to recidivism in voilent offenders and impulsive fire setters. A follow-up study
60. Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice
61. 9-tetrahydrocannabinol: Neurochemical and behavioral effects in the mouse
62. Cannabinoids of diverse structure inhibit two DOI- induced 5-HT (2A) receptor-mediated behaviors in mice