Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis

Human Immunology

Volumn 74, Issue 12, 2013, Pages 1491-1500

  Costa, Diego L ^a   Guimarães, Luiz H ^b   Cardoso, Thiago M ^b   Queiroz, Adriano ^b   Lago, Ednaldo ^b   Roselino, Ana M ^a   Bacellar, Olívia ^b   Carvalho, Edgar M ^b   Silva, João S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 17; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; LEISHMANIA BRAZILIENSIS; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; SKIN LEISHMANIASIS; TH1 CELL;

CL; CUTANEOUS LEISHMANIASIS; IL-10 RECEPTOR; IL-10RΑ; ML; MUCOSAL LEISHMANIASIS; REGULATORY T CELL; SC; SLA; SOLUBLE LEISHMANIA ANTIGEN; SUB-CLINICAL; T REGULATORY TYPE 1; TR-1; TREG; UC; UNINFECTED CONTROLS;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD4; CASE-CONTROL STUDIES; CHILD; CYTOKINES; FEMALE; HUMANS; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS, CUTANEOUS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84888202119     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.08.269     Document Type: Article

References (49)

1. Reithinger R., Dujardin J.C., Louzir H., Pirmez C., Alexander B., Brooker S. Cutaneous leishmaniasis. Lancet Infect Dis 2007, 7:581.
2. Nylen S., Sacks D. Interleukin-10 and the pathogenesis of human visceral leishmaniasis. Trends Immunol 2007, 28:378.
3. Kaye P., Scott P. Leishmaniasis: complexity at the host-pathogen interface. Nat Rev Microbiol 2011, 9:604.
4. Pirmez C., Yamamura M., Uyemura K., Paes-Oliveira M., Conceicao-Silva F., Modlin R.L. Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 1993, 91:1390.
5. Carvalho E.M., Barral A., Costa J.M., Bittencourt A., Marsden P. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Trop 1994, 56:315.
6. Ribeiro-de-Jesus A., Almeida R.P., Lessa H., Bacellar O., Carvalho E.M. Cytokine profile and pathology in human leishmaniasis. Braz J Med Biol Res 1998, 31:143.
7. Follador I., Araujo C., Bacellar O., Araujo C.B., Carvalho L.P., Almeida R.P., et al. Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection. Clin Infect Dis 2002, 34:E54.
8. Lessa H.A., Machado P., Lima F., Cruz A.A., Bacellar O., Guerreiro J., et al. Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony. Am J Trop Med Hyg 2001, 65:87.
9. + T regulatory cell-mediated suppression. Immunity 2009, 30:636.
10. + regulatory T cells control Leishmania major persistence and immunity. Nature 2002, 420:502.
11. Peters N., Sacks D. Immune privilege in sites of chronic infection: Leishmania and regulatory T cells. Immunol Rev 2006, 213:159.
12. + T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. J Infect Dis 2006, 193:1313.
13. de Araujo F.F., Vitelli-Avelar D.M., Teixeira-Carvalho A., Antas P.R., Assis Silva Gomes J., Sathler-Avelar R., et al. Regulatory T cells phenotype in different clinical forms of Chagas' disease. PLoS Negl Trop Dis 2011, 5:e992.
14. Morampudi V., De Craeye S., Le Moine A., Detienne S., Braun M.Y., D'Souza S. Partial depletion of CD4(+)CD25(+)Foxp3(+) T regulatory cells significantly increases morbidity during acute phase Toxoplasma gondii infection in resistant BALB/c mice. Microb Infect 2011, 13:394.
15. Feuerer M., Shen Y., Littman D.R., Benoist C., Mathis D. How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity 2009, 31:654.
16. +CD25(high)CD127(low/-) Treg cell frequency from peripheral blood correlates with disease activity in patients with rheumatoid arthritis. J Rheumatol 2011, 38:2517.
17. Gultner S., Kuhlmann T., Hesse A., Weber J.P., Riemer C., Baier M., et al. Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE. Eur J Immunol 2010, 40:3403.
18. Neidhart M., Jungel A., Ospelt C., Michel B.A., Gay R.E., Gay S. Deficient expression of interleukin-10 receptor alpha chain in rheumatoid arthritis synovium: limitation of animal models of inflammation. Arthritis Rheum 2005, 52:3315.
19. Faria D.R., Gollob K.J., Barbosa J., Schriefer A., Machado P.R., Lessa H., et al. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infect Immun 2005, 73:7853.
20. Brelaz-de-Castro M.C., de Almeida A.F., de Oliveira A.P., de Assis-Souza M., da Rocha L.F., Pereira V.R. Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure. Cell Immunol 2012, 279:180.
21. Vargas-Inchaustegui D.A., Tai W., Xin L., Hogg A.E., Corry D.B., Soong L. Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice. Infect Immun 2009, 77:2948.
22. Weinkopff T., Mariotto A., Simon G., Hauyon-La Torre Y., Auderset F., Schuster S., et al. Role of Toll-like receptor 9 signaling in experimental Leishmania braziliensis infection. Infect Immun 2013, 81:1575.
23. Bottrel R.L., Dutra W.O., Martins F.A., Gontijo B., Carvalho E., Barral-Netto M., et al. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect Immun 2001, 69:3232.
24. Carvalho L.P., Pearce E.J., Scott P. Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses. J Immunol 2008, 181:6473.
25. + immunoregulatory cells. J Immunol 2001, 167:1137.
26. Davies C.R., Llanos-Cuentas E.A., Pyke S.D., Dye C. Cutaneous leishmaniasis in the Peruvian Andes: an epidemiological study of infection and immunity. Epidemiol Infect 1995, 114:297.
27. Novoa R., Bacellar O., Nascimento M., Cardoso T.M., Ramasawmy R., Oliveira W.N., et al. IL-17 and regulatory cytokines (IL-10 and IL-27) in L. braziliensis infection. Parasite Immunol 2011, 33:132.
28. Di Caro V., D'Anneo A., Phillips B., Engman C., Harnaha J., Lakomy R., et al. Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells. Clin Exp Immunol 2011, 165:60.
29. Rodriguez-Pinto D., Navas A., Blanco V.M., Ramirez L., Garcerant D., Cruz A., et al. Regulatory T cells in the pathogenesis and healing of chronic human dermal leishmaniasis caused by Leishmania (Viannia) species. PLoS Negl Trop Dis 2012, 6:e1627.
30. Schriefer A., Guimaraes L.H., Machado P.R., Lessa M., Lessa H.A., Lago E., et al. Geographic clustering of leishmaniasis in northeastern Brazil. Emerg Infect Dis 2009, 15:871.
31. Leopoldo P.T., Machado P.R., Almeida R.P., Schriefer A., Giudice A., de Jesus A.R., et al. Differential effects of antigens from L. braziliensis isolates from disseminated and cutaneous leishmaniasis on in vitro cytokine production. BMC Infect Dis 2006, 6:75.
32. Rocha P.N., Almeida R.P., Bacellar O., de Jesus A.R., Filho D.C., Filho A.C., et al. Down-regulation of Th1 type of response in early human American cutaneous leishmaniasis. J Infect Dis 1999, 180:1731.
33. Bacellar O., Lessa H., Schriefer A., Machado P., Ribeiro de Jesus A., Dutra W.O., et al. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun 2002, 70:6734.
34. Carvalho L.P., Passos S., Bacellar O., Lessa M., Almeida R.P., Magalhaes A., et al. Differential immune regulation of activated T cells between cutaneous and mucosal leishmaniasis as a model for pathogenesis. Parasite Immunol 2007, 29:251.
35. Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol 2007, 7:875.
36. Mendez S., Reckling S.K., Piccirillo C.A., Sacks D., Belkaid Y. Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med 2004, 200:201.
37. Rai A.K., Thakur C.P., Singh A., Seth T., Srivastava S.K., Singh P., et al. Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis. PLoS One 2012, 7:e31551.
38. + Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 2009, 31:772.
39. Warburg A., Schlein Y. The effect of post-bloodmeal nutrition of Phlebotomus papatasi on the transmission of Leishmania major. Am J Trop Med Hyg 1986, 35:926.
40. Salhi A., Rodrigues V., Santoro F., Dessein H., Romano A., Castellano L.R., et al. Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis. J Immunol 2008, 180:6139.
41. Haringer B., Lozza L., Steckel B., Geginat J. Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood. J Exp Med 2009, 206:1009.
42. + T cells. J Immunol 2009, 183:2435.
43. Shevach E.M. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006, 25:195.
44. Wu K., Bi Y., Sun K., Wang C. IL-10-producing type 1 regulatory T cells and allergy. Cell Mol Immunol 2007, 4:269.
45. Anderson C.F., Oukka M., Kuchroo V.J., Sacks D. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 2007, 204:285.
46. + cells in nonhealing Leishmania major infection. J Immunol 2009, 183:4619.
47. Rodrigues O.R., Marques C., Soares-Clemente M., Ferronha M.H., Santos-Gomes G.M. Identification of regulatory T cells during experimental Leishmania infantum infection. Immunobiology 2009, 214:101.
48. Ansari N.A., Kumar R., Gautam S., Nylen S., Singh O.P., Sundar S., et al. IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. J Immunol 2011, 186:3977.
49. + (Foxp3) regulatory T cells in human visceral leishmaniasis. J Exp Med 2007, 204:805.