Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis

Infection and Immunity

Volumn 73, Issue 12, 2005, Pages 7853-7859

  Faria, Daniela R ^a   Gollob, Kenneth J ^a   Barbosa Jr , José ^a,b   Schriefer, Albert ^c   Machado, Paulo R L ^c   Lessa, Hélio ^c   Carvalho, Lucas P ^c   Romano Silva, Marco Aurélio ^a   De Jesus, Amélia R ^c   Carvalho, Edgar M ^c   Dutra, Walderez O ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Health Sciences School   (Brazil)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GRANZYME A; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; INFLAMMATION; INFLAMMATORY INFILTRATE; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS; MUCOSAL LEISHMANIASIS; PRIORITY JOURNAL; SKIN BIOPSY; SKIN LEISHMANIASIS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DERMATITIS; DOWN-REGULATION; GRANZYMES; HUMANS; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS, MUCOCUTANEOUS; NITRIC OXIDE SYNTHASE TYPE II; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-10; SERINE ENDOPEPTIDASES;

EID: 28444434128     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.12.7853-7859.2005     Document Type: Article

References (36)

1. Amato, V. S., H. F. Andrade, V. Amato Neto, and M. L. Duarte. 2003. Persistence of tumor necrosis factor-alpha in situ after lesion healing in mucosal leishmaniasis. Am. J. Trop. Med. Hyg. 68:527-528.
2. + T lymphocytes. J. Immunol. 144:574-582.
3. Antonelli, L. R., W. O. Dutra, R. P. Almeida, O. Bacellar, and K, J. Gollob. 2004. Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation. Clin. Exp. Immunol. 136:341-348.
4. Azulay, R. D., and D. R. Azulay, Jr. 1995. Immune-clinical-pathologic spectrum of leishmaniasis. Int. J. Dermatol. 34:303-307.
5. Bacellar, O., H. Lessa, A. Schriefer, P. Machado, A. R. Jesus, W. O. Dutra, K. J. Gollob, and E. M. Carvalho. 2002. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect. Immun. 70:6734-6740.
6. Barral-Netto, M., A. Barral, C. Brodskyn, E. M. Carvalho, and S. G. Reed. 1995. Cytotoxicity in human mucosal and cutaneous leishmaniasis. Parasite Immunol. 17:21-28.
7. + regulatory T cells control Leishmania major persistence and immunity. Nature 420:502-507.
8. Bittencourt, A. L., and A. Barral. 1991. Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. Mem. Inst. Oswaldo Cruz 86:51-56.
9. Bottrel, R. L., W. O. Dutra, F. A. Martins, B. Gontijo, E. M. Carvalho, M. Barral-Netto, A. Barrai, R. P. Almeida, W. Mayrink, R. Locksley, and K. J. Gollob. 2001. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect. Immun. 69:3232-3239.
10. + T cells unresponsive to IL-12. J. Infect. Dis. 183:953-959.
11. Caceres-Dittmar, G., F. J. Tapia, M. A. Sanchez, M. Yamamura, K. Uyemura, R. L. Modlin, B. R. Bloom, and J. Convit. 1993. Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction. Clin. Exp. Immunol. 91:500-505.
12. Carvalho, E. M., W. D. Johnson, E. Barreto, P. D. Marsden, J. L. Costa, S. Reed, and H. Rocha. 1985. Cell mediated immunity in American cutaneous and mucosal leishmaniasis. J. Immunol. 135:4144-4148.
13. Castes, M., A. Agnelli, and A. J. Rondon. 1984. Mechanisms associated with immunoregulation in human American cutaneous leishmaniasis. Clin. Exp. Immunol. 57:279-286.
14. Castes, M., A. Agnelli, O. Verde, and A. J. Rondon. 1983. Characterization of the cellular immune response in American cutaneous leishmaniasis. Clin. Immunol. Immunopathol. 27:176-186.
15. Esterre, P., S. Guerret, P. Ravisse, L. Dimier-David, J. P. Dedet, and J. A. Grimaud. 1994. Immunohistochemical analysis of the mucosal lesion in mucocutaneous leishmaniasis. Parasite 1:305-309.
16. + T cells from susceptible mice. Immunology 82:255-260.
17. Grisham, M. B., K. P. Pavlick, F. S. Laroux, J. Hoffman, S. Bharwani, and R. E. Wolf. 2002. Nitric oxide and chronic gut inflammation: controversies in inflammatory bowel disease. J. Investig. Med. 50:272-283.
18. Joyce, D. A., J. H. Steer, and A. Kloda. 1996. Dexamethasone antagonizes 1L-4 and IL-10-induced release of 1L-1RA by monocytes but augments 1L-4-, 1L-10-, and TGF-β-induced suppression of TNF-α release. J. Interferon Cytokine Res. 16:511-517.
19. Lee, S. A., and R. Hasburn. 2003. Therapy of cutaneous leishmaniasis. Int. J. Infect. Dis. 7:86-93.
20. Lessa, H. A., P. Machado, F. Lima, A. A. Cruz, O. Bacellar, J. Guerreiro, and E. M. Carvalho. 2001. Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony. Am. J. Trop. Med. Hyg. 65:87-89.
21. Liew, F. Y. 1995. Regulation of lymphocyte functions by nitric oxide. Curr. Opin. Immunol. 7:396-399.
22. Liew, F. Y., Y. Li, and S. Millott. 1990. Tumor necrosis factor-alpha synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide. J. Immunol. 145:4306-4310.
23. Machado, P., J. Kanitakis, R. Almeida, A. Chalon, C. Araujo, and E. M. Carvalho. 2002. Evidence of in situ cytotoxicity in American cutaneous leishmaniasis. Eur. J. Dermatol. 12:449-451.
24. Melby, P. C., B. J. Darnell, and V. V. Tryon. 1993. Quantitative measurement of human cytokine gene expression by polymerase chain reaction. J. Immunol. Methods 159:235-244.
25. Melby, P. C., F. J. Andrade-Narvaez, B. J. Darnell, G. Valencia-Pacheco, V. V. Tryon, and A. Palomo-Cetina. 1994. Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis. Infect. Immun. 62:837-842.
26. Michel, G., A. Mirmohammadsadegh, E. Olasz, B. Jarzebska-Deussen, A. Muschen, L. Kemeny, H. F. Abts, and T. Ruzicka. 1997. Demonstration and functional analysis of IL-10 receptors in human epidermal cells: decreased expression in psoriatic skin, down-modulation by IL-8, and up-regulation by an antipsoriatic glucocorticosteroid in normal cultured keratinocytes. J. Immunol. 159:6291-6297.
27. Mosmann, T. R., and K. W. Moore. 1991. The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol. Today 12:49-53.
28. Napoli, C. 2002. Nitric oxide and atherosclerotic lesion progression: an overview. J. Card. Surg. 17:355-362.
29. Netto, E. M, P. D. Marsden, E. A. Llanos-Cuentas, J. M. Costa, C. C. Cuba, A. C. Barreto, R, Badaro, W. D. Johnson, and T. C. Jones. 1990. Long-term follow-up of patients with Leishmania (Viannia) braziliensis infection and treated with Glucantime. Trans. R. Soc. Trop. Med. Hyg. 84:367-370.
30. Pirmez, C., C. Cooper, M. Paes-Oliveira, A. Schubach, V. K. Torigian, and R. L. Modlin. 1990. Immunologic responsiveness in American cutaneous leishmaniasis lesions. J. Immunol. 145:3100-3104.
31. Pirmez, C., M. Yamamura, K. Uyemura, M. Paes-Oliveira, F. Conceiçao-Silva, and R. L. Modlin. 1993. Cytokine patterns in the pathogenesis of human leishmaniasis. J. Clin. Investig. 91:1390-1395.
32. Ribeiro-de-Jesus, A., R. P. Almeida, H. Lessa, O. Bacellar, and E. M. Carvalho. 1998. Cytokine profile and pathology in human leishmaniasis. Braz. J. Med. Biol. Res. 31:143-148.
33. Sacks, D., and N. Noben-Trauth. 2002. The immunology of susceptibility and resistance to Leishmania major in mice. Nat. Rev. Immunol. 2:845-858.
34. Sasiain, M. C., S. de la Barrera, S. Fink, M. Finiasz, M. Aleman, M. H. Farina, G. Pizzariello, and R. Valdez. 1998. Interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobaclerium leprae heat shock protein (hsp) 65 kD. Clin. Exp. Immunol. 114:196-203.
35. Tannenbaum, C. S., J. A. Major, and T. A. Hamilton. 1993. IFN-γ and lipopolysaccharide differentially modulate expression of tumor necrosis factor receptor mRNA in murine peritoneal macrophages. J. Immunol. 152: 6833-6839.
36. Trapani, J. A., and M. J. Smyth. 2002. Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2:735-747.