Peptide cotransporter 1 in intestine and organic anion transporters in kidney are targets of interaction between JBP485 and lisinopril in rats

Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 2, 2012, Pages 232-241

  Guo, Xinjin ^a   Meng, Qiang ^a   Liu, Qi ^a   Wang, Changyuan ^a   Mao, Qi ^a   Sun, Huijun ^a   Peng, Jinyong ^a   Kaku, Taiichi ^b   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Japan Bioproducts Industry Co Ltd   (Japan)

Author keywords

ACE inhibitor; Dipeptide; Drug interaction; Intestinal absorption; JBP485; Pharmacokinetics; Renal excretion; Transporters

Indexed keywords

ANTIVIRUS AGENT; COTRANSPORTER; CYCLO TRANS 4 HYDROXYPROPYL SERINE; JBP 485; LISINOPRIL; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PEPTIDE COTRANSPORTER 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EXCRETION; DRUG MECHANISM; DRUG STABILITY; DRUG TARGETING; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA; INTESTINE PERFUSION; KIDNEY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT;

EID: 84860283189     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-089     Document Type: Article

References (30)

1. +/peptide symporterPEPT2: structure-affinity relationships. Amino Acids, 31: 137-156 (2006).
2. Terada, T. and Inui, K. I.: Peptide Transporters: Structure, Function, Regulation and Application for Drug Delivery. Curr. Drug Metab., 5: 85-94 (2004).
3. Brandsch, M., Knütter, I. and Bosse-Doenecke, E.: Pharmaceutical and pharmacological importance of peptide transporters. J. Pharm. Pharmacol., 60: 543-585 (2008).
4. +/ peptide symporter (PEPT1), theuptake into Caco-2 cell monolayers and the transepithelial flux. Pharm. Res., 16: 55-61 (1999).
5. Daniel, H. and Kottra, G.: The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch., 447: 610-618 (2004).
6. +/Peptide Transporters. J. Pharmacol. Exp. Ther., 327: 432-441 (2008).
7. Nielsen, C. U. and Brodin, B.: Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions. Curr. Drug Targets, 4: 373-388 (2003).
8. Wright, S. H. and Dantzler, W. H.: Molecular and cellular physiology of renal organic cation and anion transport. Physiol. Rev., 84: 987-1049 (2004).
9. Dresser, M. J., Leabman, M. K. and Giacomini, K. M.: Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J. Pharm. Sci., 90: 397-421 (2001).
10. Cha, S. H., Sekine, T., Fukushima, J. I., Kanai, Y., Kobayashi, Y., Goya, T. and Endou, H.: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol., 59: 1277-1286 (2001).
11. Hasegawa, M., Kusuhara, H., Sugiyama, D., Ito, K., Ueda, S., Endou, H. and Sugiyama, Y.: Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J. Pharmacol. Exp. Ther., 300: 746-753 (2002).
12. Race, J. E., Grassl, S. M., Williams, W. J. and Holtzman, E. J.: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem. Biophys. Res. Commun., 255: 508-514 (1999).
13. Tojo, A., Sekine, T., Nakajima, N., Hosoyamada, M., Kanai, Y., Kimura, K. and Endou, H.: Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J. Am. Soc. Nephrol., 10: 464-471 (1999).
14. Uwai, Y., Saito, H. and Inui, K.: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur. J. Pharmacol., 409: 31-36 (2000).
15. Zhang, J., Wang, C. Y., Liu, Q., Meng, Q., Cang, J., Sun, H. J., Gao, Y., Kaku, T. I. and Liu, K. X.: Pharmacokinetic Interaction between JBP485 and Cephalexin. Drug Metab. Dispos., 38: 930-938 (2010).
16. Liu, K. X., Kato, Y., Kaku, T. I., Santa, T., Imai, K., Yaqi, A., Ishizu, T. and Sugiyama, Y.: Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats. J. Pharmacol. Exp. Ther., 294: 510-515 (2000).
17. Liu, K. X., Kato, Y., Kaku, T. I. and Sugiyama, Y.: Human placental extract stimulates liver regeneration in rat. Biol. Pharm. Bull., 21: 44-49 (1998).
18. Wu, J., Wang, C., Liu, Q., Yang, T., Zhang, Q., Peng, J., Gao, Y., Sun, H., Kaku, T. and Liu, K.: Protective effect of JBP485 on concanavalin A-induced hepatocyte toxicity in primary cultured rat hepatocytes. Eur. J. Pharmacol., 589: 299-305 (2008).
19. Yang, T., Wu, J., Wang, C., Liu, Q., Ma, X., Peng, J., Kaku, T. and Liu, K.: Protective effect of JBP485 on concanavalin A-induced liver injury in mice. J. Pharm. Pharmacol., 61: 767-774 (2009).
20. Wang, W., Liu, Q., Wang, C., Meng, Q., Kaku, T. and Liu, K.: Effect of JBP485 on the Expression and Function of PEPT1 in Indomethacin-induced Intestinal Injury in Rats and Damage in Caco- 2 Cells. Peptides, 32: 946-955 (2011).
21. Cang, J., Zhang, J., Wang, C. Y., Liu, Q., Meng, Q., Wang, D., Sugiyama, Y., Tsuji, A., Kaku, T. and Liu, K.: Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats. Drug Metab. Pharmacokinet., 25: 500-507 (2010).
22. Liu, Z., Wang, C., Liu, Q., Meng, Q., Cang, J., Mei, L., Kaku, T. and Liu, K.: Uptake, Transport and Regulation of JBP485 by PEPT1 in vitro and in vivo. Peptides, 32: 747-754 (2011).
23. Bussien, J. P., Waeber, B., Nussberger, J., Gomez, H. J. and Brunner, H. R.: Once-daily lisinopril in hypertensive patients: Effect on blood pressure and the renin-angiotensin system. Curr. Ther. Res., 37: 342-351 (1985).
24. Bai, J. P. and Amidon, G. L.: Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery. Pharm. Res., 9: 969-978 (1992).
25. Zhang, Q., Liu, Q., Wu, J. J., Wang, C. Y., Peng, J. Y., Ma, X. C. and Liu, K. X.: PEPT1 involved in the uptake and transepithelial transport of cefditoren in vivo and in vitro. Eur. J. Pharmacol., 612: 9-14 (2009).
26. Wilson, T. H. and Wiseman, G.: The use of sacs of everted small intestine for the study of transference of substances from the mucosal to the serosal surface. J. Physiol., 123: 116-125 (1954).
27. Nozaki, Y., Kusuhara, H., Kondo, T., Hasegawa, M., Shiroyanagi, Y., Nakazawa, H., Okano, T. and Sugiyama, Y.: Characterization of the uptake of organic anion transporter OAT1 and OAT3 substrates by human kidney slices. J. Pharmacol. Exp. Ther., 321: 362-369 (2007).
28. Khamdang, S., Teda, M., Babu, E., Marreli, M. and Shafran, S. D.: Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur. J. Pharmacol., 465: 1-7 (2003).
29. Kusuhara, H. and Sugiyama, Y.: Role of transporters in the tissue selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J. Control. Release, 78: 43-54 (2002).
30. Yuan, H., Feng, B., Yu, Y., Chupka, J., Zheng, J. Y., Timothy, G. H. and Bond, B. R.: Renal Organic Anion Transporter-Mediated Drug-Drug Interaction between Gemcabene and Quinapril. J. Pharmacol. Exp. Ther., 330: 191-197 (2009).