Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: Evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 77, Issue 2, 2011, Pages 327-331

  Omkvist, Diana Højmark ^a   Trangbæk, Dennis Jespersen ^a,b   Mildon, Jemma ^b   Paine, James S ^b   Brodin, Birger ^a   Begtrup, Mikael ^b   Nielsen, Carsten Uhd ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Affinity; Dipeptide; H Xaa Ser OH; hPEPT1; Prodrug; Translocation

Indexed keywords

BENZOIC ACID; DIPEPTIDE; IBUPROFEN; PEPTIDE TRANSPORTER 1; SERINE;

ARTICLE; CELL STRAIN; DRUG BINDING; DRUG TRANSPORT; PEPTIDE SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOIC ACID; DIPEPTIDES; DOGS; DRUG STABILITY; HUMANS; IBUPROFEN; PRODRUGS; SYMPORTERS; TRANSFECTION;

EID: 79551569156     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.12.009     Document Type: Article

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