Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2458-2468

  Khomane, Kailas S ^a   Nandekar, Prajwal P ^a   Wahlang, Banrida ^a   Bagul, Pravin ^a   Shaikh, Naeem ^a   Pawar, Yogesh B ^a   Meena, Chhuttan Lal ^a   Sangamwar, Abhay T ^a   Jain, Rahul ^a   Tikoo, K ^a   Bansal, Arvind K ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Caco 2 cells; docking studies; homology modeling; intestinal oligopeptide transporter; molecular dynamics simulation; PEPT1 (SLC15A1); peptide transporters; TRH analogues

Indexed keywords

AMOXICILLIN; ANTICONVULSIVE AGENT; GLYCYLSARCOSINE; NP 647; PEPTIDE TRANSPORTER 1; PROTON; SODIUM AZIDE; SODIUM ION; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; DRUG METABOLISM; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; HYDROPHOBICITY; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MONOLAYER CULTURE; PH; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY;

AMOXICILLIN; ANTICONVULSANTS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL LINE, TUMOR; DIPEPTIDES; DRUG STABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTESTINAL ABSORPTION; INTESTINES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; SODIUM; SODIUM AZIDE; SYMPORTERS; THYROTROPIN-RELEASING HORMONE;

EID: 84865980048     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200672d     Document Type: Article

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