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Volumn 81, Issue 12, 2013, Pages 4431-4442

Toll-like receptor 7 mediates early innate immune responses to malaria

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

EID: 84888137927     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00923-13     Document Type: Article
Times cited : (64)

References (77)
  • 1
    • 84874499711 scopus 로고    scopus 로고
    • World Health Organization, World Health Organization, Geneva, Switzerland
    • World Health Organization. 2012. World malaria report 2012. World Health Organization, Geneva, Switzerland.
    • (2012) World malaria report 2012
  • 2
    • 0025809384 scopus 로고
    • CD4γT cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi
    • Meding SJ, Langhorne J. 1991. CD4γT cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi. Eur. J. Immunol. 21:1433-1438.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1433-1438
    • Meding, S.J.1    Langhorne, J.2
  • 3
    • 0026071747 scopus 로고
    • CD4+ T celldependent effector mechanisms important in the immune response to the erythrocytic stages of Plasmodium chabaudi chabaudi (AS)
    • Simon-Haarhaus B, Langhorne J, Meding S. 1991. CD4+ T celldependent effector mechanisms important in the immune response to the erythrocytic stages of Plasmodium chabaudi chabaudi (AS). Behring Inst. Mitt. 94-98.
    • (1991) Behring Inst. Mitt , pp. 94-98
    • Simon-Haarhaus, B.1    Langhorne, J.2    Meding, S.3
  • 4
    • 0025045107 scopus 로고
    • The role of CD4+ T cells in the protective immune response to Plasmodium chabaudi in vivo
    • Langhorne J, Simon-Haarhaus B, Meding SJ. 1990. The role of CD4+ T cells in the protective immune response to Plasmodium chabaudi in vivo. Immunol. Lett. 25:101-107.
    • (1990) Immunol. Lett. , vol.25 , pp. 101-107
    • Langhorne, J.1    Simon-Haarhaus, B.2    Meding, S.J.3
  • 5
    • 0028281381 scopus 로고
    • The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse
    • van der Heyde HC, Huszar D, Woodhouse C, Manning DD, Weidanz WP. 1994. The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse. J. Immunol. 152:4557-4562.
    • (1994) J. Immunol. , vol.152 , pp. 4557-4562
    • van der Heyde, H.C.1    Huszar, D.2    Woodhouse, C.3    Manning, D.D.4    Weidanz, W.P.5
  • 6
    • 84856282078 scopus 로고    scopus 로고
    • The contribution of Plasmodium chabaudi to our understanding of malaria
    • Stephens R, Culleton RL, Lamb TJ. 2012. The contribution of Plasmodium chabaudi to our understanding of malaria. Trends Parasitol. 28:73-82.
    • (2012) Trends Parasitol. , vol.28 , pp. 73-82
    • Stephens, R.1    Culleton, R.L.2    Lamb, T.J.3
  • 7
    • 0027304906 scopus 로고
    • Resolution of blood-stage malarial infections in CD8+cell-deficient beta 2-m0/0 mice
    • van der Heyde HC, Manning DD, Roopenian DC, Weidanz WP. 1993. Resolution of blood-stage malarial infections in CD8+cell-deficient beta 2-m0/0 mice. J. Immunol. 151:3187-3191.
    • (1993) J. Immunol. , vol.151 , pp. 3187-3191
    • van der Heyde, H.C.1    Manning, D.D.2    Roopenian, D.C.3    Weidanz, W.P.4
  • 8
    • 0027947420 scopus 로고
    • A dual role for B cells in Plasmodium chabaudi chabaudi (AS) infection?
    • von der Weid T, Kitamura D, Rajewsky K, Langhorne J. 1994. A dual role for B cells in Plasmodium chabaudi chabaudi (AS) infection? Res. Immunol. 145:412-419.
    • (1994) Res. Immunol. , vol.145 , pp. 412-419
    • von der Weid, T.1    Kitamura, D.2    Rajewsky, K.3    Langhorne, J.4
  • 9
    • 0030001823 scopus 로고    scopus 로고
    • Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection
    • von der Weid T, Honarvar N, Langhorne J. 1996. Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. J. Immunol. 156:2510-2516.
    • (1996) J. Immunol. , vol.156 , pp. 2510-2516
    • von der Weid, T.1    Honarvar, N.2    Langhorne, J.3
  • 10
    • 0032539562 scopus 로고    scopus 로고
    • A role for B cells in the development of T cell helper function in a malaria infection in mice
    • Langhorne J, Cross C, Seixas E, Li C, von der Weid T. 1998. A role for B cells in the development of T cell helper function in a malaria infection in mice. Proc. Natl. Acad. Sci. U. S. A. 95:1730-1734.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 1730-1734
    • Langhorne, J.1    Cross, C.2    Seixas, E.3    Li, C.4    von der Weid, T.5
  • 14
    • 0036467349 scopus 로고    scopus 로고
    • IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice
    • Su Z, Stevenson MM. 2002. IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice. J. Immunol. 168:1348-1355.
    • (2002) J. Immunol. , vol.168 , pp. 1348-1355
    • Su, Z.1    Stevenson, M.M.2
  • 15
    • 0035162563 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malaria
    • Riopel J, Tam M, Mohan K, Marino MW, Stevenson MM. 2001. Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malaria. Infect. Immun. 69:129-136.
    • (2001) Infect. Immun. , vol.69 , pp. 129-136
    • Riopel, J.1    Tam, M.2    Mohan, K.3    Marino, M.W.4    Stevenson, M.M.5
  • 16
    • 84868116568 scopus 로고    scopus 로고
    • Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control
    • doi:10.1371/journal.pone.0048126
    • Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL. 2012. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS One 7:e48126. doi:10.1371/journal.pone.0048126.
    • (2012) PLoS One , vol.7
    • Kim, C.C.1    Nelson, C.S.2    Wilson, E.B.3    Hou, B.4    DeFranco, A.L.5    DeRisi, J.L.6
  • 18
    • 77952581999 scopus 로고    scopus 로고
    • Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria
    • Belyaev NN, Brown DE, Diaz AI, Rae A, Jarra W, Thompson J, Langhorne J, Potocnik AJ. 2010. Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria. Nat. Immunol. 11:477-485.
    • (2010) Nat. Immunol. , vol.11 , pp. 477-485
    • Belyaev, N.N.1    Brown, D.E.2    Diaz, A.I.3    Rae, A.4    Jarra, W.5    Thompson, J.6    Langhorne, J.7    Potocnik, A.J.8
  • 21
    • 84864125760 scopus 로고    scopus 로고
    • Cutting edge: Clec9A+dendritic cells mediate the development of experimental cerebral malaria
    • Piva L, Tetlak P, Claser C, Karjalainen K, Renia L, Ruedl C. 2012. Cutting edge: Clec9A+dendritic cells mediate the development of experimental cerebral malaria. J. Immunol. 189:1128-1132.
    • (2012) J. Immunol. , vol.189 , pp. 1128-1132
    • Piva, L.1    Tetlak, P.2    Claser, C.3    Karjalainen, K.4    Renia, L.5    Ruedl, C.6
  • 29
    • 84861159419 scopus 로고    scopus 로고
    • TLR9 and MyD88 are crucial for the development of protective immunity to malaria
    • Gowda NM, Wu X, Gowda DC. 2012. TLR9 and MyD88 are crucial for the development of protective immunity to malaria. J. Immunol. 188:5073-5085.
    • (2012) J. Immunol. , vol.188 , pp. 5073-5085
    • Gowda, N.M.1    Wu, X.2    Gowda, D.C.3
  • 34
    • 77952757782 scopus 로고    scopus 로고
    • Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses
    • Wu X, Gowda NM, Kumar S, Gowda DC. 2010. Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses. J. Immunol. 184:4338-4348.
    • (2010) J. Immunol. , vol.184 , pp. 4338-4348
    • Wu, X.1    Gowda, N.M.2    Kumar, S.3    Gowda, D.C.4
  • 35
    • 38449113583 scopus 로고    scopus 로고
    • Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host
    • Griffith JW, O'Connor C, Bernard K, Town T, Goldstein DR, Bucala R. 2007. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J. Infect. Dis. 196:1553-1564.
    • (2007) J. Infect. Dis. , vol.196 , pp. 1553-1564
    • Griffith, J.W.1    O'Connor, C.2    Bernard, K.3    Town, T.4    Goldstein, D.R.5    Bucala, R.6
  • 36
    • 80052341059 scopus 로고    scopus 로고
    • Caspase-1 activation of interleukin-1β (IL-1β) and IL-18 is dispensable for induction of experimental cerebral malaria
    • Kordes M, Matuschewski K, Hafalla JCR. 2011. Caspase-1 activation of interleukin-1β (IL-1β) and IL-18 is dispensable for induction of experimental cerebral malaria. Infect. Immun. 79:3633-3641.
    • (2011) Infect. Immun. , vol.79 , pp. 3633-3641
    • Kordes, M.1    Matuschewski, K.2    Hafalla, J.C.R.3
  • 37
    • 14844337835 scopus 로고    scopus 로고
    • Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity
    • Krishnegowda G, Hajjar AM, Zhu J, Douglass EJ, Uematsu S, Akira S, Woods AS, Gowda DC. 2005. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J. Biol. Chem. 280:8606-8616.
    • (2005) J. Biol. Chem. , vol.280 , pp. 8606-8616
    • Krishnegowda, G.1    Hajjar, A.M.2    Zhu, J.3    Douglass, E.J.4    Uematsu, S.5    Akira, S.6    Woods, A.S.7    Gowda, D.C.8
  • 40
    • 77649221389 scopus 로고    scopus 로고
    • Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation
    • doi:10.1371/journal.ppat.1000744
    • Couper KN, Barnes T, Hafalla JCR, Combes V, Ryffel B, Secher T, Grau GE, Riley EM, de Souza JB. 2010. Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation. PLoS Pathog. 6:e1000744. doi:10.1371/journal.ppat.1000744.
    • (2010) PLoS Pathog. , vol.6
    • Couper, K.N.1    Barnes, T.2    Hafalla, J.C.R.3    Combes, V.4    Ryffel, B.5    Secher, T.6    Grau, G.E.7    Riley, E.M.8    de Souza, J.B.9
  • 41
    • 79957610056 scopus 로고    scopus 로고
    • Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action
    • Barrera V, Skorokhod OA, Baci D, Gremo G, Arese P, Schwarzer E. 2011. Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action. Blood 117:5674-5682.
    • (2011) Blood , vol.117 , pp. 5674-5682
    • Barrera, V.1    Skorokhod, O.A.2    Baci, D.3    Gremo, G.4    Arese, P.5    Schwarzer, E.6
  • 43
    • 0034456693 scopus 로고    scopus 로고
    • Three novel mammalian toll-like receptors: Gene structure, expression, and evolution
    • Du X, Poltorak A, Wei Y, Beutler B. 2000. Three novel mammalian toll-like receptors: Gene structure, expression, and evolution. Eur. Cytokine Netw. 11:362-371.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 362-371
    • Du, X.1    Poltorak, A.2    Wei, Y.3    Beutler, B.4
  • 44
    • 0034457684 scopus 로고    scopus 로고
    • Cloning and characterization of a subfamily of human toll-like receptors: hTLR7, hTLR8 and hTLR9
    • Chuang TH, Ulevitch RJ. 2000. Cloning and characterization of a subfamily of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11:372-378.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 372-378
    • Chuang, T.H.1    Ulevitch, R.J.2
  • 45
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of singlestranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reise Sousa C. 2004. Innate antiviral responses by means of TLR7-mediated recognition of singlestranded RNA. Science 303:1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reise Sousa, C.5
  • 47
    • 0242333835 scopus 로고    scopus 로고
    • Normalization of cDNA microarray data
    • Smyth GK, Speed T. 2003. Normalization of cDNA microarray data. Methods 31:265-273.
    • (2003) Methods , vol.31 , pp. 265-273
    • Smyth, G.K.1    Speed, T.2
  • 48
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U. S. A. 98:5116-5121.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 49
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang DW, Sherman BT, Lempicki RA. 2009. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4:44-57.
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 50
    • 76749088591 scopus 로고    scopus 로고
    • Improved methods for magnetic purification of malaria parasites and haemozoin
    • doi:10.1186/1475-2875-9-17
    • Kim CC, Wilson EB, DeRisi JL. 2010. Improved methods for magnetic purification of malaria parasites and haemozoin. Malar. J. 9:17. doi:10.1186/1475-2875-9-17.
    • (2010) Malar. J. , vol.9 , pp. 17
    • Kim, C.C.1    Wilson, E.B.2    DeRisi, J.L.3
  • 52
    • 9644268181 scopus 로고    scopus 로고
    • The role of type I interferons in non-viral infections
    • Bogdan C, Mattner J, Schleicher U. 2004. The role of type I interferons in non-viral infections. Immunol. Rev. 202:33-48.
    • (2004) Immunol. Rev. , vol.202 , pp. 33-48
    • Bogdan, C.1    Mattner, J.2    Schleicher, U.3
  • 53
    • 77951296065 scopus 로고    scopus 로고
    • Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria
    • Voisine C, Mastelic B, Sponaas AM, Langhorne J. 2010. Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria. Int. J. Parasitol. 40:711-719.
    • (2010) Int. J. Parasitol. , vol.40 , pp. 711-719
    • Voisine, C.1    Mastelic, B.2    Sponaas, A.M.3    Langhorne, J.4
  • 56
    • 58149522035 scopus 로고    scopus 로고
    • Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo
    • Scheu S, Dresing P, Locksley RM. 2008. Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc. Natl. Acad. Sci. U. S. A. 105:20416-20421.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 20416-20421
    • Scheu, S.1    Dresing, P.2    Locksley, R.M.3
  • 57
    • 79953061608 scopus 로고    scopus 로고
    • Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics
    • Casanova JL, Abel L, Quintana-Murci L. 2011. Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu. Rev. Immunol. 29:447-491.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 447-491
    • Casanova, J.L.1    Abel, L.2    Quintana-Murci, L.3
  • 58
    • 80053590435 scopus 로고    scopus 로고
    • Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter
    • Belgnaoui SM, Paz S, Hiscott J. 2011. Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. Curr. Opin. Immunol. 23:564-572.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 564-572
    • Belgnaoui, S.M.1    Paz, S.2    Hiscott, J.3
  • 63
    • 43849111523 scopus 로고    scopus 로고
    • Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection
    • Long GH, Chan BHK, Allen JE, Read AF, Graham AL. 2008. Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection. Int. J. Parasitol. 38:1073-1081.
    • (2008) Int. J. Parasitol. , vol.38 , pp. 1073-1081
    • Long, G.H.1    Chan, B.H.K.2    Allen, J.E.3    Read, A.F.4    Graham, A.L.5
  • 64
    • 84856567798 scopus 로고    scopus 로고
    • IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
    • Freitas do Rosário AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, O'Garra A, Langhorne J. 2012. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J. Immunol. 188:1178-1190.
    • (2012) J. Immunol. , vol.188 , pp. 1178-1190
    • Freitas do Rosário, A.P.1    Lamb, T.2    Spence, P.3    Stephens, R.4    Lang, A.5    Roers, A.6    Muller, W.7    O'Garra, A.8    Langhorne, J.9
  • 65
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt RL, Liang HE, Locksley RM. 2009. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 10:385-393.
    • (2009) Nat. Immunol. , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 66
    • 33748477504 scopus 로고    scopus 로고
    • Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    • Bafica A, Santiago HC, Goldszmid R, Ropert C, Gazzinelli RT, Sher A. 2006. Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. J. Immunol. 177:3515-3519.
    • (2006) J. Immunol. , vol.177 , pp. 3515-3519
    • Bafica, A.1    Santiago, H.C.2    Goldszmid, R.3    Ropert, C.4    Gazzinelli, R.T.5    Sher, A.6
  • 67
    • 33845204804 scopus 로고    scopus 로고
    • Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism
    • Gazzinelli RT, Denkers EY. 2006. Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism. Nat. Rev. Immunol. 6:895-906.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 895-906
    • Gazzinelli, R.T.1    Denkers, E.Y.2
  • 68
    • 76649108583 scopus 로고    scopus 로고
    • Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells
    • Petzke MM, Brooks A, Krupna MA, Mordue D, Schwartz I. 2009. Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells. J. Immunol. 183:5279-5292.
    • (2009) J. Immunol. , vol.183 , pp. 5279-5292
    • Petzke, M.M.1    Brooks, A.2    Krupna, M.A.3    Mordue, D.4    Schwartz, I.5
  • 70
    • 0017347317 scopus 로고
    • Spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation
    • Wyler DJ, Gallin JI. 1977. Spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation. J. Immunol. 118:478-484.
    • (1977) J. Immunol. , vol.118 , pp. 478-484
    • Wyler, D.J.1    Gallin, J.I.2
  • 71
    • 0033914763 scopus 로고    scopus 로고
    • Central role of endogenous gamma interferon in protective immunity against blood-stage Plasmodium chabaudi AS infection
    • Su Z, Stevenson MM. 2000. Central role of endogenous gamma interferon in protective immunity against blood-stage Plasmodium chabaudi AS infection. Infect. Immun. 68:4399-4406.
    • (2000) Infect. Immun. , vol.68 , pp. 4399-4406
    • Su, Z.1    Stevenson, M.M.2
  • 72
    • 22544441601 scopus 로고    scopus 로고
    • How malaria has affected the human genome and what human genetics can teach us about malaria
    • Kwiatkowski DP. 2005. How malaria has affected the human genome and what human genetics can teach us about malaria. Am. J. Hum. Genet. 77:171-192.
    • (2005) Am. J. Hum. Genet. , vol.77 , pp. 171-192
    • Kwiatkowski, D.P.1
  • 77
    • 39049172286 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: genes versus environment in high risk populations
    • Molokhia M, McKeigue P. 2006. Systemic lupus erythematosus: genes versus environment in high risk populations. Lupus 15:827-832.
    • (2006) Lupus , vol.15 , pp. 827-832
    • Molokhia, M.1    McKeigue, P.2


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