Splenic Red Pulp Macrophages Produce Type I Interferons as Early Sentinels of Malaria Infection but Are Dispensable for Control

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Kim, Charles C ^a   Nelson, Christopher S ^b   Wilson, Emily B ^b   Hou, Baidong ^a,c   DeFranco, Anthony L ^a   DeRisi, Joseph L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERFERON; INTERFERON REGULATORY FACTOR 7; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 9; TYPE I INTERFERON; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; IMMUNOREGULATION; IN VIVO STUDY; INFECTION CONTROL; INFECTION RESISTANCE; INNATE IMMUNITY; INTERFERON PRODUCTION; MACROPHAGE; MALARIA; MOUSE; NONHUMAN; PARASITEMIA; PLASMACYTOID DENDRITIC CELL; PLASMODIUM CHABAUDI; SIGNAL TRANSDUCTION; SPLENIC RED PULP MACROPHAGE;

ANIMALS; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; MACROPHAGES; MALARIA; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASMODIUM CHABAUDI; RECEPTOR, INTERFERON ALPHA-BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN; TIME FACTORS; TOLL-LIKE RECEPTOR 9; TRANSCRIPTOME;

EID: 84868116568     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048126     Document Type: Article

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