Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Journal of Bone and Mineral Research

Volumn 28, Issue 12, 2013, Pages 2476-2489

  Rhodes, Steven D ^a,b   Wu, Xiaohua ^b   He, Yongzheng ^b   Chen, Shi ^b   Yang, Hao ^b   Staser, Karl W ^b   Wang, Jiapeng ^b   Zhang, Ping ^b   Jiang, Chang ^c   Yokota, Hiroki ^c   Dong, Ruizhi ^b   Peng, Xianghong ^b   Yang, Xianlin ^b   Murthy, Sreemala ^b   Azhar, Mohamad ^b   Mohammad, Khalid S ^b   Xu, Mingjiang ^b   Guise, Theresa A ^b   Yang, Feng Chun ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Indiana University Purdue University Indianapolis   (United States)

Author keywords

fracture nonunion; neurofibromatosis type 1; osteoporosis; smad; tgf ; Transforming growth factor beta

Indexed keywords

2 (5 CHLORO 2 FLUOROPHENYL) 4 (4 PYRIDINYLAMINO)PTERIDINE; ALKALINE PHOSPHATASE; BETA1 INTEGRIN; ENDOGLIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MESSENGER RNA; NEUROFIBROMIN; PROTEIN P21; RAS PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEFECT; BONE MASS; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; GENE DOSAGE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MORPHOMETRICS; MOUSE; NEUROFIBROMATOSIS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PHENOTYPE; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; SKELETON MALFORMATION;

FRACTURE NONUNION; NEUROFIBROMATOSIS TYPE 1; OSTEOPOROSIS; SMAD; TGF-Β; TRANSFORMING GROWTH FACTOR-BETA;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; GENE DOSAGE; HAPLOINSUFFICIENCY; HUMANS; INTEGRASES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MESENCHYMAL STROMAL CELLS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEUROFIBROMATOSIS 1; NEUROFIBROMIN 1; OSTEOBLASTS; PROTEIN-SERINE-THREONINE KINASES; RAS PROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84888040564     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1992     Document Type: Article

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