Neurofibromin GTPase-activating Protein-related Domains Restore Normal Growth in Nf1-/- Cells

Journal of Biological Chemistry

Volumn 276, Issue 10, 2001, Pages 7240-7245

  Hiatt, Kelly K ^a   Ingram, David A ^a   Zhang, Youyan ^a   Bollag, Gideon ^b   Clapp, D Wade ^a,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ONYX PHARMACEUTICALS   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; NEUROLOGY; TUMORS;

PATHOGENESIS;

PROTEINS;

CYTOKINE; EPIDERMAL GROWTH FACTOR; GENOMIC DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROFIBROMIN; PROTEIN KINASE B; PROTEIN P21; RAS PROTEIN; RECOMBINANT PROTEIN; HRAS PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; NERVE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL LINEAGE; CELL TYPE; CONTROLLED STUDY; EMBRYO; FEMALE; FETUS; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MAST CELL; MOUSE; NEUROFIBROMATOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; ANIMAL; CELL CULTURE; CELL DIVISION; CELL LINE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; FIBROBLAST; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HUMAN; KINETICS; METABOLISM; MOUSE MUTANT; MUTATION; PLASMID; PROTEIN TERTIARY STRUCTURE; RETROVIRUS; SIGNAL TRANSDUCTION;

ANIMALIA;

ANIMALS; CELL DIVISION; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GENOTYPE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; KINETICS; MAST CELLS; MICE; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUTATION; NERVE TISSUE PROTEINS; NEUROFIBROMATOSIS 1; NEUROFIBROMIN 1; P120 GTPASE ACTIVATING PROTEIN; PLASMIDS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS P21(RAS); RECOMBINANT PROTEINS; RETROVIRIDAE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0035831543     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009202200     Document Type: Article

References (33)

1. Brodeur, G. (1994) N. Engl. J. Med. 330, 637-638
2. Side, L., Taylor, B., Cayouette, M., Conner, E., Thompson, P., Luce, M., and Shannon, K. (1997) N. Engl. J. Med. 336, 1713-1720
3. Bollag, G., and McCormick, F. (1992) Nature 356, 663-664
4. Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M., and Collins, F. (1990) Cell 63, 851-859
5. Emanuel, P., Bates, L., Castleberry, R., Gualtieri, R., and Zuckerman, K. (1991) Exp. Hematol. 19, 1017-1024
6. Largaespada, D., Brannan, C., Jenkins, N., and Copeland, N. (1996) Nat. Genet. 12, 137-143
7. Zhang, Y., Vik, T., Ryder, J., Srour, E., Jacks, T., Shannon, K., and Clapp, D. (1998) J. Exp. Med. 187, 1893-1902
8. Birnbaum, R., O'Marcaigh, A., Wardak, Z., Zhang, Y., Dranoff, G., Jacks, T., Clapp, D., and Shannon, K. (2000) Mol. Cell. 5, 189-195
9. Ingram, D., Yang, F., Travers, J., Wenning, M., Hiatt, K., New, S., Hood, A., Shannon, K., Williams, D., and Clapp, D. (2000) J. Exp. Med. 191, 181-188
10. Atit, R., Crowe, M., Greenhalgh, D., Wenstrup, R., and Ratner, N. (1999) J. Invest. Dermatol. 112, 835-842
11. Jacks, T., Shih, T., Schmitt, E., Bronson, R., Bernards, A., and Weinberg, R. (1994) Nat. Genet. 7, 353-361
12. Hawley, R., Lieu, F., Fong, A., and Hawley, T. (1994) Gene Ther. 1, 136-138
13. Martin, G., Viskochil, D., Bollag, G., McCabe, P., Crosier, W., Haubruck, H., Conroy, L., Clark, R., O'Conell, P., Cawthon, R., Innis, M., and McCormick, F. (1990) Cell 63, 843-849
14. Markowitz, D., Goff, S., and Banks, A. (1988) Virology 167, 400-406
15. Bollag, G., and McCormick, F. (1991) Nature 35, 576-579
16. Clapp, D., Freie, B., Srour, E., Yoder, M., Fortney, K., and Gerson, S. (1995) Exp. Hematol. 23, 630-638
17. Nakano, T., Sonoda, T., Hayashi, C., Yamatodani, A., Kanayama, Y., Yamamura, T., Asai, H., Yonezawa, T., Kitamura, Y., and Galli, S. (1985) J. Exp. Med. 162, 1025-1043
18. Brannan, C., Perkins, A., Vogel, K., Ratner, N., Nordlund, M., Reid, S., Buchberg, A., Jenkins, N., Parada, L., and Copeland, N. (1994) Genes Dev. 8, 1019-1029
19. Rosenbaum, T., Boissy, Y., Kombrinck, K., Brannan, C., Jenkins, N., Copeland, N., and Ratner, N. (1995) Development 121, 3583-3592
20. Bollag, G., Clapp, D., Shih, S., Adler, F., Zhang, Y., Thompson, P., Lange, B., Freedman, M., McCormick, F., Jacks, T., and Shannon, K. (1996) Nat. Genet. 12, 144-148
21. Rodewald, H., Dessing, M., Dvorak, A., and Galli, S. (1996) Science 271, 818-823
22. Galli, S., Tsai, M., and Wershil, B. (1993) Am. J. Pathol. 142, 965-974
23. Secor, V., Secor, W., Gutekunst, C., and Brown, M. (2000) J. Exp. Med. 191, 813-818
24. Tsai, M., Wedemeyer, J., Ganiatsas, S., Tam, S., Zon, L., and Galli, S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 9168-9190
25. Klose, A., Ahmadian, M., Schuelke, M., Scheffzek, K., Hoffmeyer, S., Gewles, A., Schmitz, F., Kaufmann, D., Peters, H., Wittinghofer, A., and Nurnberg, P. (1998) Hum. Mol. Genet. 7, 1261-1268
26. Scheffzek, K., Ahmadian, M., Wiesmuller, L., Kabsch, W., Stege, P., Schmitz, F., and Wittinghofer, A. (1998) EMBO J. 17, 4313-4327
27. Li, Y., and White, R. (1996) Cancer Res. 56, 2872-2876
28. Fahsold, R., Hoffmeyer, S., Mischung, C., Gille, C., Ehlers, C., Kucukceylan, N., Abdel-Nour, M., Gewies, A., Peters, H., Kaufmann, D., Buske, A., Tinschert, S., and Nurnberg, P. (2000) Am. J. Hum. Genet. 66, 790-818
29. The, I., Hannigan, E., Cowley, G., Reginald, S., Zhong, Y., Gusella, J., Hariharan, I., and Bernards, A. (1997) Science 276, 791-794
30. Bollag, G., McCormick, F., and Clark, R. (1993) EMBO J. 12, 1923-1927
31. Scheffzek, K., Ahmadian, M., Kabsch, W., Wiesmuller, L., Lautwein, A., Schmitz, F., and Wittinghofer, A. (1997) Science 277, 333-338
32. Ahmadian, M., Wiesmuller, L., Lautwein, A., Bischoff, F., and Wittinghofer, A. (1996) J. Biol. Chem. 271, 16409-16415
33. Martin, G., Yatani, A., Clark, R., Conroy, L., Polakis, P., Brown, A., and McCormick, F. (1992) Science 255, 192-194