Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo

Journal of Bone and Mineral Research

Volumn 25, Issue 11, 2010, Pages 2419-2426

  Edwards, James R ^a   Nyman, Jeffry S ^a,b   Lwin, Seint T ^a   Moore, Megan M ^a   Esparza, Javier ^a   O'Quinn, Elizabeth C ^a   Hart, Andrew J ^a   Biswas, Swati ^a   Patil, Chetan A ^c   Lonning, Scott ^d   Mahadevan Jansen, Anita ^c   Mundy, Gregory R ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d GENZYME CORPORATION   (United States)

Author keywords

biomechanics; bone histomorphometry; raman microspectroscopy; TGF ; treatments: novel entities

Indexed keywords

1D11; 1D11 ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MARROW; BONE MASS; BONE STRENGTH; CELL COUNT; CELLULAR DISTRIBUTION; CERVICAL SPINE; CONTROLLED STUDY; CORTICAL BONE; DRUG TARGETING; IN VIVO STUDY; LONG BONE; MALE; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; RAMAN SPECTROMETRY; TRABECULAR BONE;

ANIMALS; ANTIBODIES; BIOMECHANICS; BONE AND BONES; MALE; MICE; MICE, INBRED C57BL; ORGAN SIZE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 78349238109     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.139     Document Type: Article

References (29)

1. Bonewald L,. TGF-β and bone. In:, Bilezikian JR, Rodan GA, eds. Principles of Bone Biology 2nd ed. Vol. 1 London: Academic Press, 903 -919. 2002.
2. Centrella M, McCarthy TL, Canalis E,. Transforming growth factor-β and remodeling of bone. J Bone Joint Surg Am. 1991; 73: 1418 -1428.
3. Centrella M, Horowitz MC, Wozney JM, et al. Transforming growth factor-β gene family members and bone. Endocr Rev. 1994; 15: 27 -39.
4. Pfeilschifter J, Wolf O, Naumann A, et al. Chemotactic response of osteoblastlike cells to transforming growth factor β. J Bone Miner Res. 1990; 5: 825 -830.
5. Mundy GR, Bonewald LF,. Role of TGF-β in bone remodeling. Ann NY Acad Sci. 1990; 593: 91 -97.
6. Horwood NJ, et al. Activated T lymphocytes support osteoclast formation in vitro. Biochem Biophys Res Commun. 1999; 265: 144 -150.
7. Sells Galvin RJ, et al. TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF. Biochem Biophys Res Commun. 1999; 265: 233 -239.
8. Itonaga I, et al. Transforming growth factor-beta induces osteoclast formation in the absence of RANKL. Bone. 2004; 34: 57 -64.
9. Erlebacher A, Derynck R,. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996; 132: 195 -210.
10. Filvaroff E, et al. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999; 126: 4267 -4279.
11. Balooch G, et al. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci USA. 2005; 102: 18813 -18818.
12. Mohammad KS, et al. Pharmacologic inhibition of the tgf-Beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS ONE. 2009; 4: e5275.
13. Uhl M, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004; 64: 7954 -7961.
14. Stebbins EM, Niewolna KS, McKenna M, et al. Inhibition of TGF-beta signalling enhances bone mass, by increasing osteoblast and reducing osteoclast number and activity. J Bone Miner Res. 2006; 21 (S1): S63.
15. Schriefer JL, et al. A comparison of mechanical properties derived from multiple skeletal sites in mice. J Biomech. 2005; 38: 467 -475.
16. Lieber CA, Mahadevan-Jansen A,. Automated method for subtraction of fluorescence from biological Raman spectra. Appl Spectrosc. 2003; 57: 1363 -1367.
17. Oliver WP,. G, Measurement of hardness and elastic modulus by instrumented indentation: Advances in understanding and refinements to methodology. J Mater Res. 2004; 19: 3 -20
18. Karst M, et al. Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation. J Cell Physiol. 2004; 200: 99 -106.
19. Quinn JM, et al. Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions. J Bone Miner Res. 2001; 16: 1787 -1794.
20. Thirunavukkarasu K, et al. Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects. J Biol Chem. 2001; 276: 36241 -36250.
21. Dempster DW, et al. Anabolic actions of parathyroid hormone on bone. Endocr Rev. 1993; 14: 690 -709.
22. Raisz LG,. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. 2005; 115: 3318 -3325.
23. Lee SK, Lorenzo JA,. Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology. 1999; 140: 3552 -3561.
24. Itoh K, et al. Importance of membrane- or matrix-associated forms of M-CSF and RANKL/ODF in osteoclastogenesis supported by SaOS-4/3 cells expressing recombinant PTH/PTHrP receptors. J Bone Miner Res. 2000; 15: 1766 -1775.
25. Katagiri T, et al. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun. 1990; 172: 295 -299.
26. Takuwa Y, et al. Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3 T3-E1. Biochem Biophys Res Commun. 1991; 174: 96 -101.
27. Alliston T, et al. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 2001; 20: 2254 -2272.
28. Kang JS, et al. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005; 24: 2543 -2555.
29. Beamer WG, et al. Genetic variability in adult bone density among inbred strains of mice. Bone. 1996; 18: 397 -403.