Impact of nutrition and obesity on chronic liver disease

Clinics in Liver Disease

Volumn 18, Issue 1, 2014, Pages 205-218

  Manne, Vignan ^a   Saab, Sammy ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chronic liver disease; Malnutrition; Nonalcoholic fatty liver disease; Obesity; Protein calorie malnutrition

Indexed keywords

TRACE ELEMENT;

CHRONIC LIVER DISEASE; DISEASE ASSOCIATION; FATTY LIVER; HAND GRIP; HUMAN; INSULIN SENSITIVITY; LIVER METABOLISM; MALNUTRITION; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; NUTRITION; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; OBESITY; PROTEIN CALORIE MALNUTRITION; REVIEW;

CHRONIC LIVER DISEASE; MALNUTRITION; NONALCOHOLIC FATTY LIVER DISEASE; OBESITY; PROTEIN-CALORIE MALNUTRITION;

CHRONIC DISEASE; FATTY LIVER; HUMANS; LIVER; LIVER DISEASES; MALNUTRITION; NUTRITIONAL STATUS; OBESITY; RISK FACTORS;

EID: 84888030876     PISSN: 10893261     EISSN: 15578224     Source Type: Journal    
DOI: 10.1016/j.cld.2013.09.008     Document Type: Review

References (113)

1. Merli M., Riggio O., Dally L. PINC. Does malnutrition affect survival in cirrhosis?. Hepatology 1996, 23(5):1041-1046.
2. Prijatmoko D., Strauss B.J., Lambert J.R., et al. Early detection of protein depletion in alcoholic cirrhosis: role of body composition analysis. Gastroenterology 1993, 105(6):1839-1845.
3. McCullough A.J., Bugianesi E. Protein calorie malnutrition and the etiology of cirrhosis. Am J Gastroenterol 1997, 92(5):734-738.
4. Lautz H.U., Selberg O., Korber J., et al. Protein calorie malnutrition in liver cirrhosis. Clin Investig 1992, 70(6):478-486.
5. DiCecco S.R., Wieners E.J., Wiesner R.H., et al. Assessment of nutritional status of patients with end stage liver disease undergoing liver transplantation. Mayo Clin Proc 1989, 64(1):95-102.
6. Henkel A.S., Buchman A.L. Nutritional support in patients with chronic liver disease. Nat Clin Pract Gastroenterol Hepatol 2006, 3(4):202-209.
7. Rossouw J.E., Labadarios D., Davis M., et al. Water-soluble vitamins in severe liver disease. SAfr Med J 1978, 54(5):183-186.
8. Mawer E.B., Klass H.J., Warnes T.W., et al. Metabolism of vitamin D in patients with primary biliary cirrhosis and alcoholic liver disease. Clin Sci (Lond) 1985, 69(5):561-570.
9. Mobarhan S.A., Russell R.M., Recker R.R., et al. Metabolic bone disease in alcoholic cirrhosis: a comparison of the effect of vitamin D2, 25-hydroxyvitamin D, or supportive treatment. Hepatology 1984, 4(2):266-273.
10. Gruengreiff K., Gruengreiff S., Reinhold D. Zinc deficiency and hepatic encephalopathy: results of a long term follow-up on zinc supplementation. JTrace Elem Exp Med 2000, 13(1):21-31.
11. Collier J.D., Ninkovic M., Compston J.E. Guidelines on the management of osteoporosis associated with chronic liver disease. Gut 2002, 50(Suppl 1):i1-i9.
12. Tsouka A., Mclin V.A. Complications of chronic liver disease. Clin Res Hepatol Gastroenterol 2012, 36(3):262-267.
13. Kitson M.T., Roberts S.K. D-livering the message: the importance of vitamin D status in chronic liver disease. JHepatol 2012, 57(4):897-909.
14. Duerksen D.R., Nehra V., Palombo J.D., et al. Essential fatty acid deficiencies in patients with chronic liver disease are not reversed by short-term intravenous lipid supplementation. Dig Dis Sci 1999, 44(7):1342-1348.
15. Vos M.B., Ryan C., Patricia B., the NASH CRN Research Group, et al. Correlation of vitamin E, uric acid and diet composition with histologic features of pediatric nonalcoholic fatty liver disease. JPediatr Gastroenterol Nutr 2012, 54(1):90-96.
16. Dietary guidelines for Americans. 2010. Available at: Accessed July 7, 2013. http://www.dietaryguidelines.gov.
17. Diehl A.M. Hepatic complications of obesity. Gastroenterol Clin North Am 2010, 39(1):57-68.
18. Nobili V., Carter-Kent C., Feldstein A.E. The role of lifestyle changes in the management of chronic liver disease. BMC Med 2011, 9:70.
19. Muller M.J. Hepatic energy and substrate metabolism: a possible metabolic basis for early nutritional support in cirrhotic patients. Nutrition 1998, 14(1):30-38.
20. Jungermann K., Kietzmann T. Zonation of parenchymal and nonparenchymal metabolism in the liver. Annu Rev Nutr 1996, 16:179-203.
21. Sherlock S. Carbohydrates changes in liver disease. Am J Clin Nutr 1970, 22(4):462-466.
22. Tavill A.S. The synthesis and degradation of liver-produced proteins. Gut 1972, 13(3):225-241.
23. Hasse J. Nutrition and liver disease: complex connections. Nutr Clin Pract 2013, 28(1):12-14.
24. Racine-Samson L., Scoazec J.Y., D'Errico A., et al. The metabolic organization of the adult human liver: a comparative study of normal, fibrotic, and cirrhotic liver tissue. Hepatology 1996, 24(1):104-113.
25. Merli M., Riggio O., Romiti A., et al. Basal energy production rate and substrate use in stable cirrhotic patients. Hepatology 1990, 12(1):106-112.
26. Green J.H., Bramley P.N., Losowsky M.S. Are patients with primary biliary cirrhosis hypermetabolic? A comparison between patients before and after liver transplantation and controls. Hepatology 1991, 14(3):464-472.
27. Shanbhogue R.L., Bistrian B.R., Jenkins R.L., et al. Resting energy expenditure in patients with end-stage liver disease and in normal population. JPEN J Parenter Enteral Nutr 1987, 11(3):305-308.
28. Schneeweiss B., Graninger W., Ferenci P., et al. Energy metabolism in patients with acute and chronic liver disease. Hepatology 1990, 11(3):387-393.
29. Muller M.J., Boker K.H., Selberg O. Are patients with liver cirrhosis hypermetabolic?. Clin Nutr 1994, 13(3):131-144.
30. Muller M.J., Bottcher J., Selberg O., et al. Hypermetabolism in clinically stable patients with liver cirrhosis. Am J Clin Nutr 1999, 69(6):1194-1201.
31. Delissio M., Goodyear L.J., Fuller S., et al. Effects of treadmill exercise on fuel metabolism in hepatic cirrhosis. JAppl Physiol 1991, 70(1):210-215.
32. Grover Z., Ee L.C. Protein energy malnutrition. Pediatr Clin North Am 2009, 56(5):1055-1068.
33. O'Brien A., Williams R. Nutrition in end-stage liver disease: principles and practice. Gastroenterology 2008, 134:1729-1740.
34. Thuluvath P.J., Triger D.R. Autonomic neuropathy in chronic liver disease. QJMed 1989, 72(268):737-747.
35. Madden A.M., Bradbury W., Morgan M.Y. Taste perception in cirrhosis: its relationship to circulating micronutrients and food preferences. Hepatology 1997, 26(1):40-48.
36. Quigley E.M. Gastrointestinal dysfunction in liver disease and portal hypertension. Gut-liver interaction revisited. Dig Dis Sci 1996, 41(3):557-561.
37. Truswell A.S., Hansen J.D., Watson C.E., et al. Relation of serum lipids and lipoproteins to fatty liver in Kwashiorkor. Am J Clin Nutr 1969, 22(5):568-576.
38. Flores H., Pak N., Maccioni A., et al. Lipid transport in Kwashiorkor. Br J Nutr 1970, 24(4):1005-1011.
39. Dolz C., Raurich J.M., Ibanez J., et al. Ascites increases the resting energy expenditure in liver cirrhosis. Gastroenterology 1991, 100(3):738-744.
40. Peng S., Plank L.D., McCall J.L., et al. Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: a comprehensive study. Am J Clin Nutr 2007, 85(5):1257-1266.
41. Cabre E., Periago J.L., Abad-Lacruz A., et al. Plasma fatty acid profile in advanced cirrhosis: unsaturation deficit of lipid fractions. Am J Gastroenterol 1990, 85(12):1597-1604.
42. Cabre E., Gassull M.A. Polyunsaturated fatty acid deficiencies in liver diseases: pathophysiological and clinical significance. Nutrition 1996, 12:542-548.
43. Cabre E., Gassull M.A. Feeding long-chain PUFA to advanced cirrhotics: is it worthwhile?. Nutrition 1999, 15:322-324.
44. Johnson T.M., Overgard E.B., Cohen A.E., et al. Nutrition assessment and management in advanced liver disease. Nutr Clin Pract 2013, 28(1):15-29.
45. Arteh J., Narra S., Nair S. Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci 2010, 55(9):2624-2628.
46. Look M.P., Reichel C., Von Falkenhausen M., et al. Vitamin E status in patients with liver cirrhosis: normal or deficient?. Metabolism 1999, 48(1):86-91.
47. Cankutaran M., Kav T., Yavuz B., et al. Serum vitamin E levels and its relation to clinical features in nonalcoholic fatty liver disease with elevated ALT levels. Acta Gastroenterol Belg 2006, 69(1):5-11.
48. Kowdley K.V., Emond M.J., Sadowsky J.A., et al. Plasma vitamin K1 level is decreased in primary biliary cirrhosis. Am J Gastroenterol 1997, 92(11):2059-2061.
49. 12) and holotranscobalamin changes in plasma and liver tissues in alcoholics with liver disease. JAm Coll Nutr 1998, 17(3):235-238.
50. Cheung K., Lee S.S., Raman M. Prevalence and mechanisms of malnutrition in patients with advanced liver disease, and nutrition management strategies. Clin Gastroenterol Hepatol 2012, 10(2):117-125.
51. Lin C.C. Selenium, iron, copper, zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. Biol Trace Elem Res 2006, 109(1):15-24.
52. van der Rijt C.C., Schalm S.W., Schat H., et al. Overt hepatic encephalopathy precipitated by zinc deficiency. Gastroenterology 1991, 100(4):1114-1118.
53. Rahelic D., Kujundzic M., Romic Z., et al. Serum concentrations of zinc, copper, manganese, and magnesium in patients with liver cirrhosis. Coll Antropol 2006, 30(3):523-528.
54. Aargaard N.K., Andersen H., Vilstrup H., et al. Muscle strength, Na,K-pumps, magnesium and potassium in patients with alcoholic liver cirrhosis-relation to spironolactone. JIntern Med 2002, 252(1):56-63.
55. Aargaard N.K., Andersen H., Vilstrup H., et al. Decreased muscle strength and contents of Mg and Na,K-pumps in chronic alcoholics occur independently of cirrhosis. JIntern Med 2003, 253(3):359-366.
56. Aargaard N.K., Andersen H., Vilstrup H., et al. Magnesium supplementation andmuscle function in patients with alcoholic liver disease: a randomized-placebo-controlled trial. Scand J Gastroenterol 2005, 40(8):972-979.
57. Cabre E., Gassull M.A. Nutrition in liver disease. Curr Opin Clin Nutr Metab Care 2005, 8(5):545-551.
58. Thuluvath P.J., Triger D.R. Evaluation of nutritional status by using anthropometry in adults with alcoholic and non-alcoholic liver disease. Am J Clin Nutr 1994, 60:269-273.
59. Caregaro L., Alberino F., Amodio P., et al. Malnutrition in alcoholic and virus-related cirrhosis. Am J Clin Nutr 1996, 63(4):602-609.
60. Caly W.R., Strauss E., Carrilho F.J., et al. Different degrees of malnutrition and immunological alterations according to aetiology of cirrhosis: a prospective and sequential study. Nutr J 2003, 2:10.
61. Calle E.E., Rodriguez C., Walker-Thurmond K., et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. NEngl J Med 2003, 348(17):1625-1638.
62. Frellick M. AMA declares obesity a disease. Medscape Medical News 2013, Available at:, Accessed July 17, 2013. http://www.medscape.com/viewarticle/806566.
63. Willner I.R., Waters B., Patil S.R., et al. Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. Am J Gastroenterol 2001, 96(10):2957-2961.
64. Lyon H.N., Hirschorn J.N. Genetics of common forms of obesity: a brief review. Am J Clin Nutr 2005, 82(1):2155-2175.
65. Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40(6):1387-1395.
66. Donnelly K.L., Smith C.I., Schwarzenberg S.J., et al. Sources of fatty acids stored inliver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. JClin Invest 2005, 115(5):1343-1351.
67. Bjorntorp P. Abdominal obesity and the metabolic syndrome. Ann Med 1992, 24(6):465-468.
68. Sheth S.G., Gordon F.D., Chopra S. Nonalcoholic steatohepatitis. Ann Intern Med 1997, 126(2):137-145.
69. Sanyal A.J., Campbell-Sargent C., Mirshahi F., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120(5):1183-1192.
70. Chitturi S., Abeygunasekara S., Farrell G.C., et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35(2):373-379.
71. Pagano G., Pacini G., Musso G., et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002, 35(2):367-372.
72. Marchesini G., Brizi M., Morselli-Labate A.M., et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999, 107(5):450-455.
73. Hamaguchi M., Kojima T., Takeda N., et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005, 143(10):722-728.
74. Marchesini G., Brizi M., Bianchi G., et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001, 50(8):1844-1850.
75. Gholam P.M., Flancbaum L., Machan J.T., et al. Nonalcoholic fatty liver disease in severely obese subjects. Am J Gastroenterol 2007, 102(2):399-408.
76. Oza N., Eguchi Y., Mizuta T., et al. Apilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff. JGastroenterol 2009, 44(12):1203-1208.
77. Xu A., Wang Y., Keshaw H., et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver disease in mice. JClin Invest 2003, 112(1):91-100.
78. Savvidou S., Hytiroglou P., Orfanau-Koumerkeridou H., et al. Low serum adiponectin levels are predictive of advanced hepatic fibrosis in patients with NAFLD. JClin Gastroenterol 2009, 43(8):765-772.
79. Arita Y., Kihara S., Ouchi N., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999, 257(1):79-83.
80. Viljanen A.P., Iozzo P., Borra R., et al. Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. JClin Endocrinol Metab 2009, 94(1):50-55.
81. Ratziu V., Giral P., Charlotte F., et al. Liver fibrosis in overweight patients. Gastroenterology 2000, 118:1117-1123.
82. Everhart J.E., Lok A.S., Kim H.Y., HALT-C trial group, et al. Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial. Gastroenterology 2009, 137(2):549-557.
83. Powell E.E., Jonsson J.R., Clouston A.D. Steatosis: co-factor in other liver diseases. Hepatology 2005, 42(1):5-13.
84. Persico M., Iolascon A. Steatosis as a co-factor in chronic liver diseases. World J Gastroenterol 2010, 16(10):1171-1176.
85. Welzel T.M., Graubard B.I., Zeuzem S., et al. Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database. Hepatology 2011, 54(2):463-471.
86. Laish I., Braun M., Mor E., et al. Metabolic syndrome in liver transplant recipients: prevalence, risk factors, and association with cardiovascular events. Liver Transpl 2011, 17(1):15-22.
87. Laryea M., Watt K.D., Molinari M., et al. Metabolic syndrome in liver transplant recipients: prevalence and association with major vascular events. Liver Transpl 2007, 13(8):1109-1114.
88. Francioso S., Angelico F., Baiocchi L., et al. High prevalence of metabolic syndrome and long-term survival after liver transplantation. JHepatol 2008, 14:S82.
89. Bianchi G., Marchesini G., Marzocchi R., et al. Metabolic syndrome in liver transplantation: relation to etiology and immunosuppression. Liver Transpl 2008, 14:1648-1654.
90. Mueller C.M. The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N) adult nutrition support core curriculum 2012, American Society for Parenteral and Enteral Nutrition, Silver Spring (MD). 2nd edition.
91. Schatzkin A., Kipnis V., Carroll R.J., et al. Comparison of a food frequency questionnaire with a 24-hour recall for use in an epidemiological cohort study: results from the biomarker-based Observing Protein and Energy Nutrition (OPEN) study. Int J Epidemiol 2003, 32(6):1054-1062.
92. Brunner E., Stallone D., Juneja M., et al. Dietary Assessment in Whitehall II: comparison of 7 d diet diary and food-frequency questionnaire and validity against biomarkers. Br J Nutr 2001, 86(3):405-414.
93. Krall E.A., Dwyer J.T. Validity of a food frequency questionnaire and a food diary in a short-term recall situation. JAm Diet Assoc 1987, 87(10):1374-1377.
94. McCullough A.J., Mullen K.D., Smanik E.J., et al. Nutrition therapy and liver disease. Gastroenterol Clin North Am 1989, 18:619-641.
95. Carvalha L., Parise E.R. Evaluation of nutritional status of non hospitalized patients with liver cirrhosis. Arq Gastroenterol 2006, 43:269-274.
96. Alvares-Da-Silva M.R., Reverbel da Silveira T. Comparison between handgrip strength, subjective global assessment, and prognostic nutritional index in assessing malnutrition and predicting clinical outcome in cirrhotic outpatients. Nutrition 2005, 21(2):113-117.
97. Detsky A.S., McLaughlin J.R., Baker J.P., et al. What is subjective global assessment of nutritional status?. JPEN J Parenter Enteral Nutr 1987, 11(1):8-13.
98. Chadalavada R., Sappati Biyyani R.S., Maxwell J., et al. Nutrition in hepatic encephalopathy. Nutr Clin Pract 2010, 25(3):257-264.
99. Baker J.P., Detsky A.S., Wesson D.E., et al. Nutritional assessment: a comparison of clinical judgment and objective measurements. NEngl J Med 1982, 306(16):969-972.
100. Hickman I.J., Jonsson J.R., Prins J.B., et al. Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut 2004, 53(3):413-419.
101. Dixon J.B., Bathal P.S., Hughes N.R., et al. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology 2004, 39(6):1647-1654.
102. Peterson K.F., Dufour S., Befroy D., et al. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 2005, 54(3):603-608.
103. Promrat K., Kleiner D.E., Niemeier H.M., et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010, 51(1):121-129.
104. Keating S.E., Hackett D.A., George J., et al. Exercise and nonalcoholic fatty liver disease: a systematic review and meta-analysis. JHepatol 2012, 57(1):157-166.
105. Larson-Meyer D.E., Heilbronn L.K., Redman L.M., et al. Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat-cell size, and ectopic lipid in overweight subjects. Diabetes Care 2006, 29:1337-1344.
106. Solga S., Alkhuraishe A.R., Clark J.M., et al. Dietary composition and nonalcoholic fatty liver disease. Dig Dis Sci 2004, 49(10):1578-1583.
107. Ueno T., Sugawara H., Sujaku K., et al. Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. JHepatol 1997, 27(1):103-107.
108. Chavez-Tapia N.C., Tellez-Avila F.I., Barrientos-Gutierrez T., et al. Bariatric surgery for nonalcoholic steatohepatitis in obese patients. Cochrane Database Syst Rev 2010, (1). CD007340.
109. Stephen S., Baranova A., Younossi Z.M. Nonalcoholic fatty liver disease and bariatric surgery. Expert Rev Gastroenterol Hepatol 2012, 6(2):163-171.
110. Koretz R.L., Avenell A., Lipman T.O. Nutritional support for liver disease. Cochrane Database Syst Rev 2012, (5). CD008344.
111. Sanyal A.J., Mofrad P.S., Contos M.J., et al. Apilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2004, 2(12):1107-1115.
112. Harrison S.A., Torgerson S., Hayashi P., et al. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2004, 2(12):1107-1115.
113. Lavine J.E. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. JPediatr 2000, 136(6):734-738.