Polyunsaturated fatty acid deficiency in liver diseases: Pathophysiological and clinical significance

Nutrition

Volumn 12, Issue 7-8, 1996, Pages 542-548

  Cabré, Eduard ^a   Gassull, Miquel A ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

alcoholism; arachidonic acid; cirrhosis; eicosanoids; essential fatty acids; malnutrition; membrane fluidity; polyunsaturated fatty acids; prostaglandins; thromboxanes

Indexed keywords

ARACHIDONIC ACID; FISH OIL; ICOSANOID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN; THROMBOXANE;

ACUTE HEPATITIS; ALCOHOLISM; CHOLESTASIS; DIET THERAPY; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID SYNTHESIS; FATTY LIVER; HUMAN; LIVER CIRRHOSIS; LIVER FAILURE; MALNUTRITION; NUTRITIONAL SUPPORT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0030198302     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(96)00122-0     Document Type: Review

References (81)

1. 1. Holman RT. Nutritional and metabolic interrelationships between fatty acids. Fed Proc 1964;23:1062
2. 2. Brenner RR, Peluffo RO. Regulation of unsaturated fatty acids biosynthesis. I. Effect of unsaturated fatty acid of 18 carbons on the microsomal desaturation of linoleic acid into gamma-linolenic acid. Biochim Biophys Acta 1969;176:471
3. 3. Brenner RR, Peluffo RO. Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic and linolenic acids. J Biol Chem 1966;241:5213
4. 4. Brenner RR, Peluffo RO. Inhibitory effect of docosa-4,7,10,13, 16,19-hexaenoic acid upon the oxidative desaturation of linoleic into gamma-linolenic acid and of alpha-linolenic acid into octadeca-6,9,12,15-tetraenoic acid. Biochim Biophys Acta 1967;137:184
5. 5. Brenner RR, Peluffo RO, Nervi AM, et al. Competitive effect of alpha and gamma-linolenyl-CoA and arachidonyl-CoA in linoleylCoA desaturation to gamma-linolenyl-CoA. Biochim Biophys Acta 1969;176:420
6. 6. Nervi AM, Brenner RR, Peluffo RO. Effect of arachidonic acid on the microsomal desaturation of linoleic into gamma-linolenic acid and their simultaneous incorporation to phospholipids. Biochim Biophys Acta 1968;152:539
7. 7. Brenner RR. Nutritional and hormonal factors influencing desaturation of essential fatty acids. Prog Lipid Res 1981;20:41
8. 8. Williams JN, Hurlebaus AJ. Fatty acid changes in liver produced by protein deficiency and by methionine or cystine fed to rats in a protein-free ration. J Nutr 1966;89:477
9. 9. Gerson T. Comparison of the effects of dietary protein and lipid deprivation on lipid composition of liver membrane in rats. J Nutr 1974;104:701
10. 10. Mercuri O, De Tomás ME, Itarte H. Prenatal protein depletion and delta-9, delta-6 and delta-5 desaturases in rat liver. Lipids 1979:14:822
11. 11. De Tomas ME, Mercuri O, Rodrigo A. Effects of dietary protein and EFA deficiency on liver delta-5, delta-6 and delta-9 desaturase activities in the early developing rat. J Nutr 1980;110:595
12. 12. Peluffo RO, Brenner RR. Influence of dietary protein on delta-6 and delta-9 desaturation of fatty acids in rats of different ages and in different seasons. J Nutr 1974;104:894
13. 13. Peluffo RO, Nervi AM, González MS, et al. Effect of different amino acid diets on delta-5, delta-6 and delta-9 desaturases. Lipids 1984;19:154
14. 14. Schachter D. Fluidity and function of hepatocyte plasma membranes. Hepatology 1984;4:140
15. 15. Stubbs CD, Smith AD. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta 1984;779:89
16. 16. Mead JF. The non-eicosanoid functions of essential fatty acids. J Lipid Res 1984;25:1517
17. 17. Spector AA, Yorek MA. Membrane lipid composition and cellular function. J Lipid Res 1985;26:1015
18. 18. Kinsella JE. Lipids, membrane receptors, and enzymes: effects of dietary fatty acids. JPEN 1990;14:200S
19. 19. The British Nutrition Foundation's Task Force. Functions of unsaturated fatty acids. In: The British Nutrition Foundation, ed. Unsaturated fatty acids: nutritional and physiological significance, 1st ed. Chapman & Hall: London, 1992:48
20. 20. Haitl WH, Wolfe RR. The phospholipid/arachidonic acid second messenger system: its possible role in physiology and pathophysiology of metabolism. JPEN 1990;14:416
21. 21. Merrill AH, Bracco U, Deckelbaum RJ, eds. Long chain fatty acids and other lipid second messengers. In: Polyunsaturated fatty acids in human nutrition. New York: Raven Press, 1992:41
22. 22. Berridge MJ. Inositol triphosphate and diacylglycerol: two interacting second messengers. Annu Rev Biochem 1987;56:159
23. 23. Samuelsson B, Goldyne M, Granström E, et al. Prostaglandins and thromboxanes. Annu Rev Biochem 1978;47:997
24. 24. Hammarström S. Leukotrienes. Annu Rev Biochem 1983;52:355
25. 25. Lewis RA, Austen KF. The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology. J Clin Invest 1984;73:889
26. 26. Levenson DL, Simmons CE, Brenner BM. Arachidonic acid metabolism, prostaglandins and the kidney. Am J Med 1982;72:354
27. 27. Dinarello C, Wolff SM. Molecular basis of fever in humans. Am J Med 1982;72:799
28. 28. Raymond KH, Lifschitz MD. Effect of prostaglandins on renal salt and water excretion. Am J Med 1986;80(Suppl 1A):22
29. 29. The British Nutrition Foundation's Task Force. Unsaturated fatty acids and blood pressure. In: The British Nutrition Foundation, ed. Unsaturated fatty acids: nutritional and physiological significance, 1st ed. Chapman & Hall: London 1992:114
30. 30. Moncada S, Vane JR. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med 1979;300:1142
31. 31. Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 1983;220:568
32. 32. Endres S. Messengers and mediators: interactions among lipids, eicosanoids, and cytokines. Am J Clin Nutr 1993;57(Suppl):798S
33. 33. Henderson WR. The role of leukotrienes in inflammation. Ann Intern Med 1994;121:684
34. 34. Needleman P, Raz A, Minkes MS, et al. Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci USA 1979;76:944
35. 35. Terano T, Salmon JA, Moncada S. Biosynthesis and biologic activity of leukotriene B5. Prostaglandins 1984;27:217
36. 36. Katz DP, Schwartz S, Askanazi J. Biochemical and cellular basis for potential therapeutic value of n-3 fatty acids derived from fish oil. Nutrition 1993;9:113
37. 37. Caren R, Corbo L. Plasma fatty acids in pancreatic cystic fibrosis and liver disease. J Clin Endocrinol 1966;26:470
38. 38. Gunnlaugsson O, Berkowitz D. Individual free fatty acids in patients with liver disease. Am J Dig Dis 1977;22:1005
39. 39. Wilcox HG, Dunn GD, Schenker S. Plasma long-chain fatty acids and esterified lipids in cirrhosis and hepatic encephalopathy. Am J Med Sci 1978;276:293
40. 40. Johnson SB, Gordon E, McClain C, et al. Abnormal polyunsaturated fatty acid patterns of serum lipids in alcoholism and cirrhosis: arachidonic acid deficiency in cirrhosis. Proc Natl Acad Sci USA 1985;82:1815
41. 41. Cabré E, Periago JL, Abad Lacruz A, et al. Polyunsaturated fatty acid deficiency in liver cirrhosis: its relation to associated protein-energy malnutrition (preliminary report). Am J Gastroenterol 1988:83:712
42. 42. Wilson JHP, Rietveld T, Swart GR, et al. Abnormal fatty acid composition of serum phospholipids in cirrhosis (Abstract). Gastroenterology 1989;95:A674
43. 43. Cabré E, Periago JL, Abad Lacruz A, et al. Plasma fatty acid profile in advanced cirrhosis: unsaturation deficit of lipid fractions. Am J Gastroenterol 1990;85:1597
44. 44. Owen JS, Bruckdorfer KR, Day RC, et al. Decreased erythrocyte membrane fluidity and altered lipid composition in human liver disease. J Lipid Res 1982;23:124
45. 45. Petit J, Poupon RE, Trugnan G, et al. Les phospholipides plaquettaires des malades atteints de cirrhose ont un taux d'acide arachidonique anormal: Une explication biochimique possible des troubles de la fonction plaquettaire (Abstract). Gastroenterol Clin Biol 1978;2:229
46. 46. Owen JS, Hutton RA, Day RC, et al. Platelet lipid composition and platelet aggregation in human liver disease. J Lipid Res 1981:22:423
47. 47. Merli M, Iapichino S, Bolognese A, et al. Fatty acid composition of adipose tissue in patients with chronic liver disease. J Hepatol 1986;3:104
48. 48. Palombo JD, Lopes SM, Zeisel SH, et al. Effectiveness of orthotopic liver transplantation on the restoration of cholesterol metabolism in patients with end-stage liver disease. Gastroenterology 1987:93:1170
49. 49. Scriven MW, Horrobin DF, Puntis MCA. Study of plasma and red cell phospholipid fatty acids in extrahepatic cholestatic jaundice. Gut 1994;35:987
50. 50. Holman RT, Johnson SB, Mercuri O, et al. Essential fatty acid deficiency in malnourished children. Am J Clin Nutr 1981;34:1534
51. 51. Wolff JA, Margolis S, Bujdoso-Wolff K, et al. Plasma and red blood cell fatty acid composition in children with protein-calorie malnutrition. Pediatr Res 1984;18:162
52. 52. González J, Periago JL, Gil A, et al. Malnutrition-related polyunsaturated fatty acid changes in plasma lipid fractions of cirrhotic patients. Metabolism 1992;41:954
53. 53. Cabré E, Núñez MC, González-Huix F, et al. Clinical and nutritional factors predictive of plasma lipid unsaturation deficiency in advanced liver cirrhosis - a logistic regression analysis. Am J Gastroenterol 1993;88:1738
54. 54. Cabré E, Periago JL, González J, et al. Plasma polyunsaturated fatty acids in liver cirrhosis with or without chronic hepatic encephalopathy. A preliminary study. JPEN 1992;16:359
55. 55. Goerig M, Wernze H, Kommerell B, et al. Increased bioavailability of enzymes of eicosanoid synthesis in hepatic and extrahepatic tissues after portacaval shunting. Hepatology 1989;10:154
56. 56. Ailing C, Aspenström G, Decker SJ, et al. Essential fatty acids in chronic alcoholism. Acta Med Scand 1979;(Suppl 631):4
57. 57. Cairns SR, Peters TJ. Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects. Clin Sci 1983;65:645
58. 58. Szebeni J, Eskelson C, Sampliner R, et al. Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. Alcoholism Clin Exp Res 1986;10:647
59. 59. Horrobin DF. Essential fatty acids, prostaglandins, and alcoholism: An overview. Alcoholism Clin Exp Res 1987;11:2
60. 60. Cabré E. Acidos grasos poliinsaturados plasmáticos en la cirrosis hepática. Su relación con el estado clinico-biológico-nutricional y con la evolución de la enfermedad. MD Thesis, University of Barcelona, 1990
61. 61. Epstein M, Lifschitz MD. Renal eicosanoids as determinants of renal function in liver disease. Hepatology 1987;7:1359
62. 62. Gentilini P. Cirrhosis, renal function and NSAIDs. J Hepatol 1993;19:200
63. 63. Govindarajan S, Nast CC, Smith WL, Koyle MA, Daskalopoulos G, Zipser RD. Immunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndrome. Hepatology 1987;7:654
64. 64. Parelon G, Mirouze D, Michel F, et al. Prostaglandines urinaires dans le syndrome hépatorénal du cirrotique: Rôle du thromboxane A2 et d'un déséquilibre des acides gras polyinsaturés précurseurs. Gastroenterol Clin Biol 1985;9:290
65. 65. Rimola A, Ginés P, Cusó E, et al. Prostaglandin precursor fatty acids in cirrhosis with ascites: effect of linoleic acid infusion in functional renal failure. Clin Sci 1988;74:613
66. 66. Morillas R, Cabré E, Navarro E, et al. Does renal function relate to plama arachidonate levels in cirrhosis? (Abstract) Gastroenterology 1994;106:A945
67. 67. Laffi G, La Villa G, Pinzani M, et al. Altered renal and platelet arachidonic acid metabolism in cirrhosis. Gastroenterology 1986; 90:274
68. 68. Laffi G, Cominelli F, Ruggiero M, et al. Altered platelet function in cirrhosis of the liver: impairment of inositol lipid and arachidonic acid metabolism in response to agonists. Hepatology 1988;8:1620
69. 69. Jones DP, LCAT: its significance in liver disease. In: Davidson CS, ed. Problems in liver diseases. Stuttgart: Georg Thieme Publishers, 1979:255
70. 70. Martin Duce A, Ortiz P, et al. S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 1988;8:65
71. 71. Schuller A, Solis-Herruzo JA, Moscat J, et al. The fluidity of liver plasma membranes from patients with different types of liver injury. Hepatology 1986;6:714
72. 72. Peterson SW, Angelico M, Masella R, et al. Altered insulin receptor processing and membrane lipid composition in erythrocyte of cirrhotic patients. Ital J Gastroenterol 1992;24:65
73. 73. Cantafora A, Masella R, Angelico M, et al. Effect of intravenous polyunsaturated phosphatidyicholine infusion on insulin receptor processing and lipid composition of erythrocytes in patients with liver cirrhosis. Eur J Clin Invest 1992;22:777
74. 74. Cabré E, Abad Lacruz A, Núñez MC, et al. The relationship of plasma polyunsaturated fatty acid deficiency with survival in advanced liver cirrhosis - multivariate analysis. Am J Gastroenterol 1993;88:718
75. 75. Knapp HR, Melly MA. Bactericidal effects of polyunsaturated fatty acids. J Infect Dis 1986;154:84
76. 76. Utermohlen V, Tucker MAM. Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. Proc Nutr Soc 1986;45:327
77. 77. Moscarella S, Duchini A, Buzzelli G. Lipoperoxidation, trace elements and vitamin E in patients with liver cirrhosis. Eur J Gastroenterol Hepatol 1994;6:633
78. 78. Clot P, Tabone M, Arico S, et al. Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut 1994;35:1637
79. 79. McClain CJ, Marsano L, Burk RF, Bacon B. Trace metals in liver disease. Semin Liver Dis 1991;11:321
80. 80. Jenkins DJA, Gassull MA, Leeds AR, et al. Prothrombin time and fat malabsorption in alcoholic liver disease. Clin Sci Mol Med 1976;51:9
81. 81. Avgerinos A, Chu P, Greenfield C, et al. Plasma lipid and lipoprotein response to fat feeding in alcoholic liver disease. Hepatology 1983;3:349