Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Toxicological Sciences

Volumn 136, Issue 1, 2013, Pages 107-119

  Solaimani, Parrisa ^a   Damoiseaux, Robert ^b   Hankinson, Oliver ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AHR; CYP1A1; EsiRNA.; High throughput screening; RNAi; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ARMC8 PROTEIN; AROMATIC HYDROCARBON RECEPTOR; CRYGD PROTEIN; CYTOCHROME P450 1A1; DCTN4 PROTEIN; PROTEIN; RAB40C PROTEIN; RAD50 PROTEIN; RBM5 PROTEIN; SMALL INTERFERING RNA; TCF20 PROTEIN; UBE2I PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DENSITOMETRY; GENE INDUCTION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; PROTEIN DEGRADATION; WESTERN BLOTTING;

AHR; CYP1A1; ESIRNA.; HIGH-THROUGHPUT SCREENING; RNAI; TCDD;

ANIMALS; ANTIGENS, CD9; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; EYE PROTEINS; GENES, REPORTER; GENOME-WIDE ASSOCIATION STUDY; GTP-BINDING PROTEIN REGULATORS; HEPATOCYTES; HIGH-THROUGHPUT SCREENING ASSAYS; MICE; OXAZINES; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; RECEPTORS, ARYL HYDROCARBON; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS; RNA INTERFERENCE; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84887971327     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft191     Document Type: Article

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