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Volumn 31, Issue 11, 2013, Pages 2396-2407

Induction of β-Cell Replication by a Synthetic HNF4α Antagonist

Author keywords

Beta cells; Diabetes mellitus; Islet of Langerhans; Regeneration; Replication

Indexed keywords

BI 6015; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 84887899719     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1496     Document Type: Article
Times cited : (10)

References (61)
  • 3
    • 79960081993 scopus 로고    scopus 로고
    • Beta-cell replication and islet neogenesis following partial pancreatectomy
    • Lee SH, Hao E, Levine F. Beta-cell replication and islet neogenesis following partial pancreatectomy. Islets 2011; 3: 188-195.
    • (2011) Islets , vol.3 , pp. 188-195
    • Lee, S.H.1    Hao, E.2    Levine, F.3
  • 4
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic -cells are formed by self-duplication rather than stem-cell differentiation
    • DOI 10.1038/nature02520
    • Dor Y, Brown J, Martinez OI et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004; 429: 41-46. (Pubitemid 38620543)
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 5
    • 77958099053 scopus 로고    scopus 로고
    • Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells
    • Chung CH, Hao E, Piran R et al. Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells. Stem Cells 2010; 28: 1630-1638.
    • (2010) Stem Cells , vol.28 , pp. 1630-1638
    • Chung, C.H.1    Hao, E.2    Piran, R.3
  • 6
    • 66649128739 scopus 로고    scopus 로고
    • Adaptive beta-cell proliferation is severely restricted with advanced age
    • Rankin MM, Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 2009; 58: 1365-1372.
    • (2009) Diabetes , vol.58 , pp. 1365-1372
    • Rankin, M.M.1    Kushner, J.A.2
  • 7
    • 24144473869 scopus 로고    scopus 로고
    • Very slow turnover of -cells in aged adult mice
    • DOI 10.2337/diabetes.54.9.2557
    • Teta M, Long SY, Wartschow LM et al. Very slow turnover of beta-cells in aged adult mice. Diabetes 2005; 54: 2557-2567. (Pubitemid 41233576)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2557-2567
    • Teta, M.1    Long, S.Y.2    Wartschow, L.M.3    Rankin, M.M.4    Kushner, J.A.5
  • 8
    • 77957787230 scopus 로고    scopus 로고
    • Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating
    • Perl S, Kushner JA, Buchholz BA et al. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab 2010; 95:E234-239.
    • (2010) J Clin Endocrinol Metab , vol.95
    • Perl, S.1    Kushner, J.A.2    Buchholz, B.A.3
  • 9
    • 79952633428 scopus 로고    scopus 로고
    • CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells
    • Lee SH, Itkin-Ansari P, Levine F. CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells. Aging (Albany Ny) 2010; 2: 785-790.
    • (2010) Aging (Albany Ny) , vol.2 , pp. 785-790
    • Lee, S.H.1    Itkin-Ansari, P.2    Levine, F.3
  • 10
    • 77949289481 scopus 로고    scopus 로고
    • The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
    • Cnop M, Hughes SJ, Igoillo-Esteve M et al. The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia 2010; 53: 321-330.
    • (2010) Diabetologia , vol.53 , pp. 321-330
    • Cnop, M.1    Hughes, S.J.2    Igoillo-Esteve, M.3
  • 11
    • 78049320362 scopus 로고    scopus 로고
    • Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin medalist study
    • Keenan HA, Sun JK, Levine J et al. Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes 2010; 59: 2846-2853.
    • (2010) Diabetes , vol.59 , pp. 2846-2853
    • Keenan, H.A.1    Sun, J.K.2    Levine, J.3
  • 12
    • 0037219411 scopus 로고    scopus 로고
    • Cell deficit and increased -cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • Butler AE, Janson J, Bonner-Weir S et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-110. (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 13
    • 0037414812 scopus 로고    scopus 로고
    • Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death
    • DOI 10.1074/jbc.M207848200
    • Garcia-Ocana A., Takane KK, Reddy VT et al. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem 2003; 278: 343-351. (Pubitemid 36043582)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.1 , pp. 343-351
    • Garcia-Ocana, A.1    Takane, K.K.2    Reddy, V.T.3    Lopez-Talavera, J.-C.4    Vasavada, R.C.5    Stewart, A.F.6
  • 15
    • 77954480533 scopus 로고    scopus 로고
    • Serotonin regulates pancreatic beta cell mass during pregnancy
    • Kim H, Toyofuku Y, Lynn FC et al. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 2010; 16: 804-808.
    • (2010) Nat Med , vol.16 , pp. 804-808
    • Kim, H.1    Toyofuku, Y.2    Lynn, F.C.3
  • 16
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both -cell replication and neogenesis, resulting in increased -cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF et al. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48: 2270-2276. (Pubitemid 30395416)
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 17
    • 79953734660 scopus 로고    scopus 로고
    • Control of pancreatic beta cell regeneration by glucose metabolism
    • Porat S, Weinberg-Corem N, Tornovsky-Babaey S et al. Control of pancreatic beta cell regeneration by glucose metabolism. Cell Metab 2011; 13: 440-449.
    • (2011) Cell Metab , vol.13 , pp. 440-449
    • Porat, S.1    Weinberg-Corem, N.2    Tornovsky-Babaey, S.3
  • 18
    • 84857972319 scopus 로고    scopus 로고
    • Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication
    • Annes JP, Ryu JH, Lam K et al. Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication. Proc Natl Acad Sci USA 2012; 109: 3915-3920.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 3915-3920
    • Annes, J.P.1    Ryu, J.H.2    Lam, K.3
  • 19
    • 84862001481 scopus 로고    scopus 로고
    • Adenosine signaling promotes regeneration of pancreatic beta cells in vivo
    • Andersson O, Adams BA, Yoo D et al. Adenosine signaling promotes regeneration of pancreatic beta cells in vivo. Cell Metab 2012; 15: 885-894.
    • (2012) Cell Metab , vol.15 , pp. 885-894
    • Andersson, O.1    Adams, B.A.2    Yoo, D.3
  • 20
    • 84877707122 scopus 로고    scopus 로고
    • Betatrophin: A hormone that controls pancreatic beta cell proliferation
    • Yi P, Park JS, Melton DA. Betatrophin: A hormone that controls pancreatic beta cell proliferation. Cell 2013; 153: 747-758.
    • (2013) Cell , vol.153 , pp. 747-758
    • Yi, P.1    Park, J.S.2    Melton, D.A.3
  • 21
    • 80052723784 scopus 로고    scopus 로고
    • Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
    • Esterhazy D, Stutzer I, Wang H et al. Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab 2011; 14: 365-377.
    • (2011) Cell Metab , vol.14 , pp. 365-377
    • Esterhazy, D.1    Stutzer, I.2    Wang, H.3
  • 22
    • 84864396846 scopus 로고    scopus 로고
    • HNF4αlpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter
    • Kiselyuk A, Lee SH, Farber-Katz S et al. HNF4αlpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol 2012; 19: 806-818.
    • (2012) Chem Biol , vol.19 , pp. 806-818
    • Kiselyuk, A.1    Lee, S.H.2    Farber-Katz, S.3
  • 24
    • 0030695445 scopus 로고    scopus 로고
    • The maturity-onset diabetes of the young (MODY1) transcription factor HNF4 regulates expression of genes required for glucose transport and metabolism
    • DOI 10.1073/pnas.94.24.13209
    • Stoffel M, Duncan SA. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4αlpha regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci USA 1997; 94: 13209-13214. (Pubitemid 27518501)
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.24 , pp. 13209-13214
    • Stoffel, M.1    Duncan, S.A.2
  • 26
    • 84865596106 scopus 로고    scopus 로고
    • Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets
    • Rieck S, Zhang J, Li Z et al. Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets. Mol Endocrinol 2012; 26: 1590-1602.
    • (2012) Mol Endocrinol , vol.26 , pp. 1590-1602
    • Rieck, S.1    Zhang, J.2    Li, Z.3
  • 27
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 (Nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • DOI 10.1128/MCB.21.4.1393-1403.2001
    • Hayhurst GP, Lee YH, Lambert G et al. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 2001; 21: 1393-1403. (Pubitemid 32114986)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.4 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.-H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 28
    • 84863279150 scopus 로고    scopus 로고
    • Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice
    • Bonzo JA, Ferry CH, Matsubara T et al. Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice. J Biol Chem 2012; 287: 7345-7356.
    • (2012) J Biol Chem , vol.287 , pp. 7345-7356
    • Bonzo, J.A.1    Ferry, C.H.2    Matsubara, T.3
  • 29
    • 66049149024 scopus 로고    scopus 로고
    • Identification of an endogenous ligand bound to a native orphan nuclear receptor
    • Yuan X, Ta TC, Lin M et al. Identification of an endogenous ligand bound to a native orphan nuclear receptor. PLoS One 2009; 4:e5609.
    • (2009) PLoS One , vol.4
    • Yuan, X.1    Ta, T.C.2    Lin, M.3
  • 30
    • 0037063997 scopus 로고    scopus 로고
    • Crystal structure of the HNF4 ligand binding domain in complex with endogenous fatty acid ligand
    • DOI 10.1074/jbc.C200420200
    • Dhe-Paganon S., Duda K, Iwamoto M et al. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J Biol Chem 2002; 277: 37973-37976. (Pubitemid 35154647)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.41 , pp. 37973-37976
    • Dhe-Paganon, S.1    Duda, K.2    Iwamoto, M.3    Chi, Y.-I.4    Shoelson, S.E.5
  • 31
    • 23944525524 scopus 로고    scopus 로고
    • Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: Evidence for specificity of impaired beta cell adaptation
    • DOI 10.1007/s00125-005-1772-9
    • Hull RL, Kodama K, Utzschneider KM et al. Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: Evidence for specificity of impaired beta cell adaptation. Dia-betologia 2005; 48: 1350-1358. (Pubitemid 41186101)
    • (2005) Diabetologia , vol.48 , Issue.7 , pp. 1350-1358
    • Hull, R.L.1    Kodama, K.2    Utzschneider, K.M.3    Carr, D.B.4    Prigeon, R.L.5    Kahn, S.E.6
  • 32
    • 77955830321 scopus 로고    scopus 로고
    • Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen
    • Kiselyuk A, Farber-Katz S, Cohen T et al. Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen. J Biomol Screen 2010; 15: 663-670.
    • (2010) J Biomol Screen , vol.15 , pp. 663-670
    • Kiselyuk, A.1    Farber-Katz, S.2    Cohen, T.3
  • 33
    • 0035445820 scopus 로고    scopus 로고
    • An enhancer element 6 kb upstream of the mouse HNF41 promoter is activated by glucocorticoids and liver-enriched transcription factors
    • Bailly A, Torres-Padilla ME, Tinel AP et al. An enhancer element 6 kb upstream of the mouse HNF4αlpha1 promoter is activated by glu-cocorticoids and liver-enriched transcription factors. Nucleic Acids Res 2001; 29: 3495-3505. (Pubitemid 32898763)
    • (2001) Nucleic Acids Research , vol.29 , Issue.17 , pp. 3495-3505
    • Bailly, A.1    Torres-Padilla, M.E.2    Tinel, A.P.3    Weiss, M.C.4
  • 34
    • 80455143204 scopus 로고    scopus 로고
    • Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic beta-cells
    • Lee SH, Hao E, Levine F et al. Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic beta-cells. Islets 2011; 3: 358-366.
    • (2011) Islets , vol.3 , pp. 358-366
    • Lee, S.H.1    Hao, E.2    Levine, F.3
  • 35
    • 78751484975 scopus 로고    scopus 로고
    • Aging induces a distinct gene expression program in mouse islets
    • Rankin MM, Kushner JA. Aging induces a distinct gene expression program in mouse islets. Islets 2010; 2: 345-352.
    • (2010) Islets , vol.2 , pp. 345-352
    • Rankin, M.M.1    Kushner, J.A.2
  • 36
    • 64649104150 scopus 로고    scopus 로고
    • Survey of the human pancreatic beta cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta cell replication and function in vivo
    • Fiaschi-Taesch N., Bigatel TA, Sicari B et al. Survey of the human pancreatic beta cell G1/S proteome reveals a potential therapeutic role for Cdk-6 and Cyclin D1 in enhancing human beta cell replication and function in vivo. Diabetes 2009; 58: 882-893.
    • (2009) Diabetes , vol.58 , pp. 882-893
    • Fiaschi-Taesch, N.1    Bigatel, T.A.2    Sicari, B.3
  • 37
    • 0033564697 scopus 로고    scopus 로고
    • 1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501-1512. (Pubitemid 29297917)
    • (1999) Genes and Development , vol.13 , Issue.12 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 40
    • 78650778644 scopus 로고    scopus 로고
    • Cell cycle control of beta-cell replication in the prenatal and postnatal human pancreas
    • Kohler CU, Olewinski M, Tannapfel A et al. Cell cycle control of beta-cell replication in the prenatal and postnatal human pancreas. Am J Physiol Endocrinol Metab 2011; 300:E221-230.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Kohler, C.U.1    Olewinski, M.2    Tannapfel, A.3
  • 41
    • 0025281303 scopus 로고
    • Establishment of a pancreatic cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • Miyazaki J, Araki K, Yamato E et al. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms. Endocrinology 1990; 127: 126-132. (Pubitemid 20228111)
    • (1990) Endocrinology , vol.127 , Issue.1 , pp. 126-132
    • Miyazaki, J.-I.1    Araki, K.2    Yamato, E.3    Ikegami, H.4    Asano, T.5    Shibasaki, Y.6    Oka, Y.7    Yamamura, K.-I.8
  • 42
    • 13944249549 scopus 로고    scopus 로고
    • Destabilization of cyclin D1 message plays a critical role in cell cycle exit upon mitogen withdrawal
    • DOI 10.1038/sj.onc.1208299
    • Guo Y, Harwalkar J, Stacey DW et al. Destabilization of cyclin D1 message plays a critical role in cell cycle exit upon mitogen withdrawal. Oncogene 2005; 24: 1032-1042. (Pubitemid 40313880)
    • (2005) Oncogene , vol.24 , Issue.6 , pp. 1032-1042
    • Guo, Y.1    Harwalkar, J.2    Stacey, D.W.3    Hitomi, M.4
  • 43
    • 33646194560 scopus 로고    scopus 로고
    • A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells
    • Nishimura W, Kondo T, Salameh T et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol 2006; 293: 526-539.
    • (2006) Dev Biol , vol.293 , pp. 526-539
    • Nishimura, W.1    Kondo, T.2    Salameh, T.3
  • 44
    • 34547572645 scopus 로고    scopus 로고
    • Nkx2.2 regulates -cell function in the mature islet
    • DOI 10.2337/db06-1766
    • Doyle MJ, Sussel L. Nkx2.2 regulates beta-cell function in the mature islet. Diabetes 2007; 56: 1999-2007. (Pubitemid 47195826)
    • (2007) Diabetes , vol.56 , Issue.8 , pp. 1999-2007
    • Doyle, M.J.1    Sussel, L.2
  • 45
    • 84864876139 scopus 로고    scopus 로고
    • Reexpression of oncoprotein MafB in proliferative beta-cells and men1 insulinomas in mouse
    • Lu J, Hamze Z, Bonnavion R et al. Reexpression of oncoprotein MafB in proliferative beta-cells and Men1 insulinomas in mouse. Oncogene 2012; 31: 3647-3654.
    • (2012) Oncogene , vol.31 , pp. 3647-3654
    • Lu, J.1    Hamze, Z.2    Bonnavion, R.3
  • 46
    • 79952266114 scopus 로고    scopus 로고
    • Creating a long-term diabetic rabbit model
    • Wang J, Wan R, Mo Y et al. Creating a long-term diabetic rabbit model. Exp Diabetes Res 2010; 2010: 289614.
    • (2010) Exp Diabetes Res , vol.2010 , pp. 289614
    • Wang, J.1    Wan, R.2    Mo, Y.3
  • 47
    • 84864044174 scopus 로고    scopus 로고
    • On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools
    • Duranthon V, Beaujean N, Brunner M et al. On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools. Transgenic Res 2012; 21: 699-713.
    • (2012) Transgenic Res , vol.21 , pp. 699-713
    • Duranthon, V.1    Beaujean, N.2    Brunner, M.3
  • 48
    • 77955357730 scopus 로고    scopus 로고
    • Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6
    • Fiaschi-Taesch N.M., Salim F, Kleinberger J et al. Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 2010; 59: 1926-1936.
    • (2010) Diabetes , vol.59 , pp. 1926-1936
    • Fiaschi-Taesch, N.M.1    Salim, F.2    Kleinberger, J.3
  • 50
    • 84871876340 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of hepatocyte nuclear factor-4alpha in adult mice results in increased hepatocyte proliferation
    • Walesky C, Gunewardena S, Terwilliger EF et al. Hepatocyte-specific deletion of hepatocyte nuclear factor-4alpha in adult mice results in increased hepatocyte proliferation. Am J Physiol Gastrointest Liver Physiol 2013; 304:G26-37.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304
    • Walesky, C.1    Gunewardena, S.2    Terwilliger, E.F.3
  • 51
    • 70449411394 scopus 로고    scopus 로고
    • Mapping of HNF4αlpha target genes in intestinal epithelial cells
    • Boyd M, Bressendorff S, Moller J et al. Mapping of HNF4αlpha target genes in intestinal epithelial cells. BMC Gastroenterol 2009; 9: 68.
    • (2009) BMC Gastroenterol , vol.9 , pp. 68
    • Boyd, M.1    Bressendorff, S.2    Moller, J.3
  • 54
    • 79959412690 scopus 로고    scopus 로고
    • Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer
    • Li J, Poi MJ, Tsai MD. Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer. Biochemistry 2011; 50: 5566-5582.
    • (2011) Biochemistry , vol.50 , pp. 5566-5582
    • Li, J.1    Poi, M.J.2    Tsai, M.D.3
  • 57
    • 44949197549 scopus 로고    scopus 로고
    • Regulation of p57(KIP2) during muscle differentiation: Role of egr1, sp1 and DNA hypomethylation
    • Figliola R, Busanello A, Vaccarello G et al. Regulation of p57(KIP2) during muscle differentiation: Role of Egr1, Sp1 and DNA hypomethylation. J Mol Biol 2008; 380: 265-277.
    • (2008) J Mol Biol , vol.380 , pp. 265-277
    • Figliola, R.1    Busanello, A.2    Vaccarello, G.3
  • 58
    • 38049077461 scopus 로고    scopus 로고
    • Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-myc for control of the p21/WAF1 promoter
    • Hwang-Verslues W.W., Sladek FM. Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter. Mol Endocrinol 2008; 22: 78-90.
    • (2008) Mol Endocrinol , vol.22 , pp. 78-90
    • Hwang-Verslues, W.W.1    Sladek, F.M.2
  • 59
    • 0037621983 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor (HNF)-4 triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells
    • DOI 10.1016/S0014-4827(03)00116-2
    • Chiba H, Gotoh T, Kojima T et al. Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells. Exp Cell Res 2003; 286: 288-297. (Pubitemid 36566441)
    • (2003) Experimental Cell Research , vol.286 , Issue.2 , pp. 288-297
    • Chiba, H.1    Gotoh, T.2    Kojima, T.3    Satohisa, S.4    Kikuchi, K.5    Osanai, M.6    Sawada, N.7
  • 60
    • 33748742725 scopus 로고    scopus 로고
    • Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor B pathway
    • DOI 10.1042/BJ20060169
    • Nikolaidou-Neokosmidou V., Zannis VI, Kardassis D. Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor kappaB pathway. Biochem J 2006; 398: 439-450. (Pubitemid 44453388)
    • (2006) Biochemical Journal , vol.398 , Issue.3 , pp. 439-450
    • Nikolaidou-Neokosmidou, V.1    Zannis, V.I.2    Kardassis, D.3
  • 61
    • 84867578003 scopus 로고    scopus 로고
    • Beta cell nuclear muscu-loaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes
    • Butler AE, Robertson RP, Hernandez R et al. Beta cell nuclear muscu-loaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes. Diabetologia 2012; 55: 2985-2988.
    • (2012) Diabetologia , vol.55 , pp. 2985-2988
    • Butler, A.E.1    Robertson, R.P.2    Hernandez, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.