Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen

Journal of Biomolecular Screening

Volumn 15, Issue 6, 2010, Pages 663-670

  Kiselyuk, Alice ^a,b   Farber Katz, Suzette ^c   Cohen, Tom ^c   Lee, Seung Hee ^d   Geron, Ifat ^e   Azimi, Behrad ^a   Heynen Genel, Susanne ^d   Singer, Oded ^f   Price, Jeffrey ^d   Mercola, Mark ^d   Itkin Ansari, Pamela ^d,g   Levine, Fred ^d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BURNHAM INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

chlorpromazine; diabetes; ethopropazine

Indexed keywords

BERBAMINE; CHLORPROMAZINE; GREEN FLUORESCENT PROTEIN; INSULIN; PHENOTHIAZINE; PROFENAMINE; TAMOXIFEN; CDKN1C PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1C; NEUROLEPTIC AGENT; PHENOTHIAZINE DERIVATIVE; T CELL FACTOR PROTEIN; TCF7L1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR 7 LIKE 1;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; CELL LINE; CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROCEDURES; PROMOTER REGION; SIGNAL TRANSDUCTION;

ANTIPSYCHOTIC AGENTS; CELL LINE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P57; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; PHENOTHIAZINES; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR 7-LIKE 1 PROTEIN;

EID: 77955830321     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110372257     Document Type: Article

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