Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD

Stem Cells

Volumn 29, Issue 9, 2011, Pages 1349-1361

  Hirai, Hiroyuki ^a   Tani, Tetsuya ^a,c   Katoku Kikyo, Nobuko ^a,b   Kellner, Steven ^a   Karian, Peter ^a   Firpo, Meri ^a,b   Kikyo, Nobuaki ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c KINKI UNIVERSITY   (Japan)

Author keywords

Embryonic stem cells; Induced pluripotent stem cells; MyoD; Oct4

Indexed keywords

DNA; HISTONE; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; MYOD PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ARTICLE; CHROMATIN; CHROMATIN ACCESSIBILITY; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; FIBROBLAST; FUSION GENE; HISTONE MODIFICATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PROTEIN BINDING; TRANSACTIVATION;

ANIMALS; CHROMATIN ASSEMBLY AND DISASSEMBLY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MYOD PROTEIN; NUCLEAR REPROGRAMMING; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTIONAL ACTIVATION;

EID: 80052001018     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.684     Document Type: Article

References (45)

1. Yamanaka S., Blau H.M. Nuclear reprogramming to a pluripotent state by three approaches. Nature 2010;465:704-712.
2. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676. (Pubitemid 44233629)
3. Huangfu D., Maehr R., Guo W. et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008;26:795-797. (Pubitemid 351961456)
4. Huangfu D., Osafune K., Maehr R. et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008;26:1269-1275.
5. Jaenisch R., Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008;132:567-582. (Pubitemid 351253686)
6. Niwa H. How is pluripotency determined and maintained? Development 2007;134:635-646. (Pubitemid 46437906)
7. Tapscott S.J. The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription. Development 2005;132:2685-2695. (Pubitemid 40932860)
8. Berkes C.A., Tapscott S.J. MyoD and the transcriptional control of myogenesis. Semin Cell Dev Biol 2005;16:585-595. (Pubitemid 41247882)
9. Weintraub H., Tapscott S.J., Davis R.L. et al. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci USA 1989;86:5434-5438. (Pubitemid 19185563)
10. Hirai H., Tani T., Kikyo N. Structure and functions of powerful transactivators: VP16, MyoD and FoxA. Int J Dev Biol 2010;54:1589-1596.
11. Choi J., Costa M.L., Mermelstein C.S. et al. MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes. Proc Natl Acad Sci USA 1990;87:7988-7992.
12. Kitamura T., Koshino Y., Shibata F. et al. Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics. Exp Hematol 2003;31:1007-1014. (Pubitemid 37329742)
13. Carey B.W., Markoulaki S., Hanna J. et al. Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci USA 2009;106:157-162.
14. Morita S., Kojima T., Kitamura T. Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther 2000;7:1063-1066. (Pubitemid 30398356)
15. Lengner C.J., Camargo F.D., Hochedlinger K. et al. Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 2007;1:403-415. (Pubitemid 47506536)
16. Gerber A.N., Klesert T.R., Bergstrom D.A. et al. Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: A mechanism for lineage determination in myogenesis. Genes Dev 1997;11:436-450. (Pubitemid 27097643)
17. Weintraub H., Dwarki V.J., Verma I. et al. Muscle-specific transcriptional activation by MyoD. Genes Dev 1991;5:1377-1386. (Pubitemid 21906046)
18. Nakagawa M., Koyanagi M., Tanabe K. et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 2008;26:101-106.
19. Wernig M., Meissner A., Cassady J.P. et al. c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell 2008;2:10-12.
20. Niwa H., Toyooka Y., Shimosato D. et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 2005;123:917-929. (Pubitemid 41721036)
21. Boxus M., Twizere J.C., Legros S. et al. The HTLV-1 Tax interactome. Retrovirology 2008;5:76.
22. Romani B., Engelbrecht S., Glashoff R.H. Functions of Tat: The versatile protein of human immunodeficiency virus type 1. J Gen Virol 2010;91:1-12.
23. Pumfery A., Deng L., Maddukuri A. et al. Chromatin remodeling and modification during HIV-1 Tat-activated transcription. Curr HIV Res 2003;1:343-362.
24. Cirillo L.A., Lin F.R., Cuesta I. et al. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell 2002;9:279-289. (Pubitemid 34195554)
25. Ieda M., Fu J-D, Delgado-Olguin P. et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010;142:375-386.
26. Hanna J., Saha K., Pando B. et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009;462:595-601.
27. Stadtfeld M., Maherali N., Breault D.T. et al. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008;2:230-240.
28. Gonzalez F., Barragan Monasterio M., Tiscornia G. et al. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci USA 2009;106:8918-8922.
29. Maherali N., Sridharan R., Xie W. et al. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 2007;1:55-70.
30. Okita K., Ichisaka T., Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448:313-317. (Pubitemid 47080336)
31. Chew J.L., Loh Y.H., Zhang W. et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 2005;25:6031-6046. (Pubitemid 40946556)
32. Carey M.F., Peterson C.L., Smale S.T. In vivo analysis of an endogenous control region. In: Carey MF, Peterson CL, Smale ST, eds. Transcriptional Regulation in Eukaryotes. New York: Cold Spring Harbor Laboratory Press, 2009:261-322.
33. Ding L., Paszkowski-Rogacz M., Nitzsche A. et al. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell 2009;4:403-415.
34. Ponnusamy M.P., Deb S., Dey P. et al. RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells. Stem Cells 2009;27:3001-3011.
35. Gerber M., Shilatifard A. Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem 2003;278:26303-26306. (Pubitemid 36876764)
36. Kouzarides T. Chromatin modifications and their function. Cell 2007;128:693-705. (Pubitemid 46273577)
37. Knoepfler P.S. Why myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell 2008;2:18-21.
38. Kaneto H., Nakatani Y., Miyatsuka T. et al. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005;54:1009-1022. (Pubitemid 40446314)
39. Knoepfler P.S., Zhang X.Y., Cheng P.F. et al. Myc influences global chromatin structure. EMBO J 2006;25:2723-2734. (Pubitemid 43980380)
40. Kidder B.L., Yang J., Palmer S. Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLoS One 2008;3:e3932.
41. Wang Y., Chen J., Hu J.L. et al. Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep 2011;12:373-378.
42. Sartorelli V., Huang J., Hamamori Y. et al. Molecular mechanisms of myogenic coactivation by p300: Direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol 1997;17:1010-1026. (Pubitemid 27044399)
43. Zhou Q., Brown J., Kanarek A. et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455:627-632.
44. Vierbuchen T., Ostermeier A., Pang Z.P. et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010;463:1035-1041.
45. Horb M.E., Shen C.N., Tosh D. et al. Experimental conversion of liver to pancreas. Curr Biol 2003;13:105-115. (Pubitemid 36154337)