The effect of 3-(5′-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia

Molecular Vision

Volumn 19, Issue , 2013, Pages 2260-2273

  Tsui, Leo ^a   Fong, Tsorng Harn ^a,b   Wang, I Jong ^c,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT CHLORIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIFICIGUAT; MESSENGER RNA; PROTEIN BAX; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BAX GENE; CELL CYCLE ARREST; CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE INHIBITOR 1A GENE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; P21 GENE; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL DEATH; CELL HYPOXIA; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDAZOLES; MICE; MODELS, BIOLOGICAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84887830244     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Cummins EP, Taylor CT. Hypoxia-responsive transcription factors. Pflugers Arch 2005; 450:363-371. [PMID: 16 0 0 7431].
2. Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 2004; 19:176-182. [PMID: 1530 4 631].
3. Ke Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 2006; 70:1469-1480. [PMID: 16887934].
4. Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92:5510-5514. [PMID: 7539918].
5. Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem 1997; 272:11205-11214. [PMID: 91110 21].
6. Goda N, Dozier SJ, Johnson RS. HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid Redox Signal 2003; 5:467-473. [PMID: 13678535].
7. Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med 2005; 201:105-115. [PMID: 15630139].
8. Taylor CT, Cummins EP. The role of NF-kappaB in hypoxia-induced gene expression. Ann N Y Acad Sci 2009; 1177:178-184. [PMID: 19845620].
9. Chen D, Li M, Luo J, Gu W. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 2003; 278:13595-13598. [PMID: 12606552].
10. Slee EA, O'Connor DJ, Lu X. To die or not to die: how does p53 decide? Oncogene 2004; 23:2809-2818. [PMID: 1507714 4].
11. Jung YS, Qian Y, Chen X. Examination of the expanding path -ways for the regulation of p21 expression and activity. Cell Signal 2010; 22:1003-1012. [PMID: 20100570].
12. Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 2000; 14:34-44. [PMID: 10640274].
13. Garcia-Valenzuela E, Gorczyca W, Darzynkiewicz Z, Sharma SC. Apoptosis in adult retinal ganglion cells after axotomy. J Neurobiol 1994; 25:431-438. [PMID: 8077968].
14. Garcia-Valenzuela E, Shareef S, Walsh J, Sharma SC. Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp Eye Res 1995; 61:33-44. [PMID: 7556468].
15. Kerrigan LA, Zack DJ, Quigley HA, Smith SD, Pease ME. TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch Ophthalmol 1997; 115:1031-1035. [PMID: 9258226].
16. Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest 1998; 102:783-791. [PMID: 9710447].
17. Kern TS, Barber AJ. Retinal ganglion cells in diabetes. J Physiol 2008; 586:4401-4408. [PMID: 185659 95].
18. Kaur C, Foulds WS, Ling EA. Hypoxia-ischemia and retinal ganglion cell damage. Clin Ophthalmol. 2008; 2:879-889. [PMID: 19668442].
19. Kergoat H, Herard ME, Lemay M. RGC sensitivity to mild systemic hypoxia. Invest Ophthalmol Vis Sci 2006; 47: 5423-5427. [PMID: 171 2 213 2].
20. Luo X, Lambrou GN, Sahel JA, Hicks D. Hypoglycemia induces general neuronal death, whereas hypoxia and gluta-mate transport blockade lead to selective retinal ganglion cell death in vitro. Invest Ophthalmol Vis Sci 2001; 42:2695-2705. [PMID: 11581218].
21. Yeo EJ, Chun YS, Park JW. New anticancer strategies targeting HIF-1. Biochem Pharmacol 2004; 68:1061-1069. [PMID: 15313402].
22. Maxwell P, Salnikow K. HIF-1: an oxygen and metal respon-sive transcription factor. Cancer Biol Ther 2004; 3:29-35. [PMID: 14726713].
23. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182:311-322. [PMID: 10653597].
24. Zanella F, Lorens JB, Link W. High content screening: seeing is believing. Trends Biotechnol 2010; 28:237-245. [PMID: 20346526].
25. Tsui L, Fong TH, Wang IJ. YC-1 targeting of hypoxia-inducible factor-1alpha reduces RGC-5 cell viability and inhibits cell proliferation. Mol Vis 2012; 18:1594-1603. [PMID: 22736948].
26. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through tran-scriptional regulation of HIF-1alpha. Nature 2008; 453:807-811. [PMID: 18 43219 2].
27. Chen CJ, Hsu MH, Huang LJ, Yamori T, Chung JG, Lee FY, Teng CM, Kuo SC. Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226. Biochem Pharmacol 2008; 75:360-368. [PMID: 17880926].
28. Chung JG, Yang JS, Huang LJ, Lee FY, Teng CM, Tsai SC, Lin KL, Wang SF, Kuo SC. Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and anti-leukemia activity in orthotopic model of leukemia mice. Proteomics 2007; 7:3305-3317. [PMID: 17849408].
29. Lee CS, Kwak SW, Kim YJ, Lee SA, Park ES, Myung SC, Kim W, Lee MS, Lee JJ. Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways. Eur J Pharmacol 2012; 683:54-62. [PMID: 22 4 65181].
30. Kim HL, Yeo EJ, Chun YS, Park JW. A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent. Int J Oncol 2006; 29:255-260. [PMID: 16773207].
31. Li SH, Shin DH, Chun YS, Lee MK, Kim MS, Park JW. A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}. Mol Cancer Ther 2008; 7:3729-3738. [PMID: 19074848].
32. Yeo EJ, Chun YS, Cho YS, Kim J, Lee JC, Kim MS, Park JW. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 2003; 95:516-525. [PMID: 12671019].
33. Ak P, Levine AJ. p53 and NF-kappaB: different strategies for responding to stress lead to a functional antagonism. FASEB J 2010; 24:3643-3652. [PMID: 20530750].
34. An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV, Neckers LM. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 1998; 392:405-408. [PMID: 9537326].
35. Feng Y, Zhu H, Ling T, Hao B, Zhang G, Shi R. Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesopha-geal squamous carcinoma cell line Eca109 cells. Cell Biol Int 2011; 35:491-497. [PMID: 20977428].
36. Zhu H, Feng Y, Zhang J, Zhou X, Hao B, Zhang G, Shi R. Inhibition of hypoxia inducible factor 1alpha expression suppresses the progression of esophageal squamous cell carcinoma. Cancer Biol Ther 2011; 11:981-987. [PMID: 21519196].
37. Cheng Y, Li W, Liu Y, Cheng HC, Ma J, Qiu L. YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition. Chin J Cancer. 2012; 31:248-256. [PMID: 22507221].
38. DeNiro M, Alsmadi O, Al-Mohanna F. Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis. Exp Eye Res 2009; 89:700-717. [PMID: 19580810].
39. Huh JW, Kim SY, Lee JH, Lee YS. YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice. Pulm Pharmacol Ther 2011; 24:638-646. [PMID: 21963997].
40. Yeo EJ, Ryu JH, Chun YS, Cho YS, Jang IJ, Cho H, Kim J, Kim MS, Park JW. YC-1 induces S cell cycle arrest and apop-tosis by activating checkpoint kinases. Cancer Res 2006; 66:6345-6352. [PMID: 16778212].
41. Li Y, Zhao X, Tang H, Zhong Z, Zhang L, Xu R, Li S, Wang Y. Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells. Urol Int 2012; 88:95-101. [PMID: 22 0 41818].
42. Zhao Q, Du J, Gu H, Teng X, Zhang Q, Qin H, Liu N. Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells. Pancreas 2007; 34:242-247. [PMID: 17312 4 6 4].
43. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 1998; 95:11715-11720. [PMID: 9751731].
44. Guo M, Song LP, Jiang Y, Liu W, Yu Y, Chen GQ. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms. Apoptosis 2006; 11:67-77. [PMID: 16 3 74 551].
45. Yuan Y, Hilliard G, Ferguson T, Millhorn DE. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J Biol Chem 2003; 278:15911-15916. [PMID: 12606543].
46. Whitlock NA, Agarwal N, Ma JX, Crosson CE. Hsp27 upregu-lation by HIF-1 signaling offers protection against retinal ischemia in rats. Invest Ophthalmol Vis Sci 2005; 46:1092-1098. [PMID: 15728570].