Endothelin A-endothelin B receptor cross-talk and endothelin receptor binding

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 11, 2011, Pages 1373-1377

  Rapoport, Robert M ^a   Zuccarello, Mario ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

endothelin 1; endothelin A; endothelin B; receptor binding; receptor cross talk

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DARUSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; IODINE 125; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N ACETYLENDOTHELIN 1 [6-21][11,15 ALANINE]; PHOSPHOLIPASE D; SARAFOTOXIN S6C; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE];

COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; INTRACELLULAR SIGNALING; LIGAND BINDING; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; REVIEW;

ANIMALS; ENDOTHELIN-1; HUMANS; RECEPTOR CROSS-TALK; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SIGNAL TRANSDUCTION;

EID: 80054114650     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01334.x     Document Type: Review

References (28)

1. Clozel M, Flores S,. Endothelin receptors as drug targets in chronic cardiovascular diseases: the rationale for dual antagonism. Drug Dev Res 2006; 67: 825-834.
2. Thorin E, Clozel M,. The cardiovascular physiology and pharmacology of endothelin-1. Adv Pharmacol 2010; 60: 1-26.
3. Watts SW,. Endothelin receptors: what's new and what do we need to know? Am J Physiol 2010; 298: R254-R260.
4. Harada N, et al,. Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer. Cell Mol Neurobiol 2002; 22: 207-226.
5. Ishikawa K, et al,. Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci USA 1994; 91: 4892-4896. (Pubitemid 24177756)
6. Mihara S, Fujimoto M,. Non-isopeptide-selective endothelin receptors in human Girardi heart cells. Life Sci 1992; 50: 219-226.
7. Ozaki S, et al,. Coexpression studies with endothelin receptor subtypes indicate the existence of intracellular cross-talk between ET(A) and ET(B) receptors. J Biochem 1997; 121: 440-447. (Pubitemid 27145897)
8. Freedman NJ, et al,. Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. J Biol Chem 1997; 272: 17 734-17 743.
9. Cramer H, et al,. Subtype-specific desensitization of human endothelin ETA and ETB receptors reflects differential receptor phosphorylation. Biochemistry 1997; 36: 13 325-13 332.
10. Hay DWP, et al,. Functional and binding characterization of endothelin receptors in human bronchus: evidence for a novel endothelin B receptor subtype? J Pharmacol Exp Ther 1998; 284: 669-677. (Pubitemid 28086657)
11. 125I-endothelin-1 binding to rat and rabbit renal microvasculature. J Pharmacol Exp Ther 1995; 274: 1084-1089.
12. Karaki H, et al,. Lack of endothelin ETB receptor binding and function in the rat with a mutant ETB receptor gene. Biochem Biophys Res Commun 1996; 222: 139-143.
13. Himeno A, et al,. Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: interaction in the recognition of endothelin-1 between ETA and ETB receptors. Cell Mol Neurobiol 1998; 18: 447-452.
14. Hasselblatt M, et al,. ETA and ETB receptor antagonists synergistically increase extracellular endothelin-1 levels in primary rat astrocyte cultures. Brain Res 1998; 785: 253-261. (Pubitemid 28179388)
15. Jensen N, et al,. ET(A) and ET(B) specific ligands synergistically antagonize endothelin-1 binding to an atypical endothelin receptor in primary rat astrocytes. J Neurochem 1998; 70: 473-482. (Pubitemid 28079335)
16. Ehrenreich H, et al,. Endothelin B receptor-deficient rats as a subtraction model to study the cerebral endothelin system. Neuroscience 1999; 91: 1067-1075. (Pubitemid 29225637)
17. Henry PJ,. Endothelin-1 (ET-1)-induced contraction in rat isolated trachea: involvement of ETA and ETB receptors and multiple signal transduction systems. Br J Pharmacol 1993; 110: 435-441. (Pubitemid 23257816)
18. A receptor-mediated contractions to endothelin-1 attenuated by respiratory tract viral infection in mouse airways. Br J Pharmacol 1994; 112: 1188-1194.
19. Carr MJ, et al,. Time course of changes in ETB receptor density and function in tracheal airway smooth muscle during respiratory tract viral infection in mice. Br J Pharmacol 1996; 117: 1222-1228.
20. 2+ signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ finger. Can J Physiol Pharmacol 2008; 86: 526-535.
21. Evans NJ, Walker JW,. Endothelin receptor dimers evaluated by FRET, ligand binding, and calcium mobilization. Biophys J 2008; 95: 483-492.
22. Gregan B, et al,. Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers. J Biol Chem 2004; 279: 27 679-27 687.
23. Samson WK,. The endothelin-A receptor subtype transduces the effects of the endothelins in the anterior pituitary gland. Biochem Biophys Res Commun 1992; 187: 590-595.
24. Kanyicska B, Freeman ME,. Characterization of endothelin receptors in the anterior pituitary gland. Am J Physiol 1993; 265 (4 Pt 1): E601-E608.
25. Servitja JM, et al,. Involvement of ET(A) and ET(B) receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br J Pharmacol 1998; 124: 1728-1734.
26. Sokolovsky M,. BQ-123 identifies heterogeneity and allosteric interactions at the rat heart endothelin receptor. Biochem Biophys Res Commun 1993; 196: 32-38. (Pubitemid 23309471)
27. Fukuroda T, et al,. Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin-1-induced contraction in human bronchi. Br J Pharmacol 1996; 117: 995-999.
28. Fukuroda T, et al,. Synergistic inhibition by BQ-123 and BQ-788 of endothelin-1-induced contractions of the rabbit pulmonary artery. Br J Pharmacol 1994; 113: 336-338. (Pubitemid 24310722)