Efficient siRNA delivery and tumor accumulation mediated by ionically cross-linked folic acid-poly(ethylene glycol)-chitosan oligosaccharide lactate nanoparticles: For the potential targeted ovarian cancer gene therapy

European Journal of Pharmaceutical Sciences

Volumn 52, Issue 1, 2014, Pages 48-61

  Li, Tony Shing Chau ^a   Yawata, Toshio ^a   Honke, Koichi ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Chitosan; Folic acid; Nanoparticles; Ovarian cancer; siRNA; Targeting

Indexed keywords

CHITOSAN; FOLIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; LIPOFECTAMINE; MACROGOL; MESSENGER RNA; NANOPARTICLE; OLIGOSACCHARIDE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD COMPATIBILITY; CANCER GENE THERAPY; CELL PROLIFERATION; CELL VIABILITY; CONJUGATE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG SYNTHESIS; DRUG UPTAKE; ENDOCYTOSIS; ERYTHROCYTE; FLOW CYTOMETRY; GENE DELIVERY SYSTEM; GENE SILENCING; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MACROPHAGE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NANOENCAPSULATION; NONHUMAN; OVARY CANCER; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SURFACE CHARGE; TUMOR XENOGRAFT; WESTERN BLOTTING; ZETA POTENTIAL;

ANALYSIS OF VARIANCE; ANOVA; ARGININE-GLYCINE-ASPARTIC ACID PEPTIDE; BCA; BICINCHONINIC ACID; CENTIPOISE; CHITOSAN; CHITOSAN OLIGOSACCHARIDE LACTATE; COEFFICIENT OF VARIATION; COL; CPS; CV; DCC; DCL; DEPC; DEUTERIUM CHLORIDE; DICYCLOHEXYLCARBODIIMIDE; DIETHYL PYROCARBONATE; DLS; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; DYNAMIC LIGHT SCATTERING; ECL; EDC; ENHANCED CHEMILUMINESCENCE; ENHANCED PERMEABILITY AND RETENTION EFFECT; EPR; ETBR; ETHIDIUM BROMIDE; FA; FA-PEG-COL; FBS; FETAL BOVINE SERUM; FOLIC ACID; FOLIC ACID-POLY(ETHYLENE GLYCOL)-CHITOSAN OLIGOSACCHARIDE LACTATE; FOURIER TRANSFORMED INFRARED SPECTROSCOPY; FT-IR; HIF-1Α; HORSERADISH PEROXIDISE; HRP; HYPOXIC INDUCIBLE FACTOR-1 ALPHA; MALDI-TOF-MS; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT CUT OFF; MWCO; N-(3-DIMETHYLAMINOPROPYL)-N-ETHYLCARBODIIMIDE; N-HYDROXYSUCCINIMIDE; NANOPARTICLES; NEAR-INFRARED FLUORESCENCE; NH(2)-PEG-COOH; NHS; NIRF; NO TEMPLATE CONTROL; NPS; NTC; OVARIAN CANCER; PDI; POLYDISPERSITY INDEX; POLYVINYLIDENE FLUORIDE; PVDF; RBCS; REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION; RED BLOOD CELLS; RGD PEPTIDE; RT-QPCR; SIRNA; TARGETING; TBE; TBS-T; TPP; TRIPOLYPHOSPHATE; TRIS-BUFFERED SALINE WITH TWEEN; TRIS/BORATE/EDTA; Α-AMINOPROPYL-Ω-CARBOXYPENTYLOXY-POLYXYETHYLENE{DOT OPERATOR}HYDROCHLORIDE;

ANIMALS; CARBOCYANINES; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHITOSAN; FEMALE; FLUORESCENT DYES; FOLIC ACID; GENE KNOCKDOWN TECHNIQUES; GENETIC THERAPY; HEMOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, NUDE; NANOPARTICLES; OVARIAN NEOPLASMS; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING;

EID: 84887757893     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.10.011     Document Type: Article

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