메뉴 건너뛰기




Volumn 7, Issue 4, 2013, Pages 385-396

The future of antimicrobial therapy in the era of antibiotic resistance in cystic fibrosis pulmonary infection

Author keywords

anaerobic growth; antibiotic resistance; antibiotics; biofilms; cystic fibrosis; polymicrobial infection; quorum sensing; susceptibility testing

Indexed keywords

AJOENE; AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ARIKACE; AZITHROMYCIN; AZTREONAM LYSINE; BETA LACTAM ANTIBIOTIC; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; FLUCLOXACILLIN; FOSFOMYCIN; FOSFOMYCIN PLUS TOBRAMYCIN; FUSIDATE SODIUM; GARLIC EXTRACT; IBERIN; LEVOFLOXACIN; NICLOSAMIDE; PSEUDOMONIC ACID; RIFAMPICIN; TEICOPLANIN; TOBRAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

EID: 84887728119     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/17476348.2013.814411     Document Type: Review
Times cited : (11)

References (117)
  • 1
    • 33847711906 scopus 로고    scopus 로고
    • Cystic fibrosis mortality and survival in the UK: 1947-2003
    • Dodge JA, Lewis PA, Stanton M, Wilsher J. Cystic fibrosis mortality and survival in the UK: 1947-2003. Eur. Respir. J. 29(3), 522-526 (2007).
    • (2007) Eur. Respir. J. , vol.29 , Issue.3 , pp. 522-526
    • Dodge, J.A.1    Lewis, P.A.2    Stanton, M.3    Wilsher, J.4
  • 2
    • 0142043977 scopus 로고    scopus 로고
    • Pathophysiology and management of pulmonary infections in cystic fibrosis
    • Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am. J. Respir. Crit. Care Med. 168(8), 918-951 (2003).
    • (2003) Am. J. Respir. Crit. Care Med. , vol.168 , Issue.8 , pp. 918-951
    • Gibson, R.L.1    Burns, J.L.2    Ramsey, B.W.3
  • 3
    • 84863476402 scopus 로고    scopus 로고
    • Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
    • Pezzulo AA, Tang XX, Hoegger MJ et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature 487(7405), 109-113 (2012).
    • (2012) Nature , vol.487 , Issue.7405 , pp. 109-113
    • Pezzulo, A.A.1    Tang, X.X.2    Hoegger, M.J.3
  • 4
    • 23644451772 scopus 로고    scopus 로고
    • Infection and inflammation in cystic fibrosis: A short review
    • Heijerman H. Infection and inflammation in cystic fibrosis: a short review. J. Cyst. Fibros. 4(Suppl. 2), 3-5 (2005).
    • (2005) J. Cyst. Fibros. , vol.4 , Issue.SUPPL. 2 , pp. 3-5
    • Heijerman, H.1
  • 5
    • 3343016793 scopus 로고    scopus 로고
    • 'Cepacia syndrome' with Burkholderia multivorans, 9 years after initial colonization
    • Blackburn L, Brownlee K, Conway S, Denton M. 'Cepacia syndrome' with Burkholderia multivorans, 9 years after initial colonization. J. Cyst. Fibros 3(2), 133-134 (2004).
    • (2004) J. Cyst. Fibros , vol.3 , Issue.2 , pp. 133-134
    • Blackburn, L.1    Brownlee, K.2    Conway, S.3    Denton, M.4
  • 6
    • 80051543764 scopus 로고    scopus 로고
    • Achromobacter xylosoxidans respiratory tract infection in cystic fibrosis patients
    • Lambiase A, Catania MR, Del Pezzo M et al. Achromobacter xylosoxidans respiratory tract infection in cystic fibrosis patients. Eur. J. Clin. Microbiol. Infect. Dis. 30(8), 973-980 (2011).
    • (2011) Eur. J. Clin. Microbiol. Infect. Dis. , vol.30 , Issue.8 , pp. 973-980
    • Lambiase, A.1    Catania, M.R.2    Del Pezzo, M.3
  • 7
    • 84855864416 scopus 로고    scopus 로고
    • Chronic Stenotrophomonas maltophilia infection and exacerbation outcomes in cystic fibrosis
    • Waters V, Atenafu EG, Salazar JG et al. Chronic Stenotrophomonas maltophilia infection and exacerbation outcomes in cystic fibrosis. J. Cyst. Fibros. 11(1), 8-13 (2012).
    • (2012) J. Cyst. Fibros. , vol.11 , Issue.1 , pp. 8-13
    • Waters, V.1    Atenafu, E.G.2    Salazar, J.G.3
  • 8
    • 38049129070 scopus 로고    scopus 로고
    • Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis
    • Harris JK, De Groote MA, Sagel SD et al. Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Proc. Natl Acad. Sci. USA 104(51), 20529-20533 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.51 , pp. 20529-20533
    • Harris, J.K.1    De Groote, M.A.2    Sagel, S.D.3
  • 9
    • 42949105490 scopus 로고    scopus 로고
    • Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis
    • Tunney MM, Field TR, Moriarty TF et al. Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 177(9), 995-1001 (2008).
    • (2008) Am. J. Respir. Crit. Care Med. , vol.177 , Issue.9 , pp. 995-1001
    • Tunney, M.M.1    Field, T.R.2    Moriarty, T.F.3
  • 10
    • 79959325084 scopus 로고    scopus 로고
    • Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis
    • Tunney MM, Klem ER, Fodor AA et al. Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis. Thorax 66(7), 579-584 (2011).
    • (2011) Thorax , vol.66 , Issue.7 , pp. 579-584
    • Tunney, M.M.1    Klem, E.R.2    Fodor, A.A.3
  • 11
    • 84866841728 scopus 로고    scopus 로고
    • The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations
    • Fodor AA, Klem ER, Gilpin DF et al. The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations. PLoS ONE 7(9), e45001 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.9
    • Fodor, A.A.1    Klem, E.R.2    Gilpin, D.F.3
  • 12
    • 55449135547 scopus 로고    scopus 로고
    • Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections
    • Sibley CD, Duan K, Fischer C et al. Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections. PLoS Pathog. 4(10), e1000184 (2008).
    • (2008) PLoS Pathog. , vol.4 , Issue.10
    • Sibley, C.D.1    Duan, K.2    Fischer, C.3
  • 13
    • 54449089545 scopus 로고    scopus 로고
    • A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients
    • Sibley CD, Parkins MD, Rabin HR, Duan K, Norgaard JC, Surette MG. A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients. Proc. Natl Acad. Sci. USA 105(39), 15070-15075 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.39 , pp. 15070-15075
    • Sibley, C.D.1    Parkins, M.D.2    Rabin, H.R.3    Duan, K.4    Norgaard, J.C.5    Surette, M.G.6
  • 14
    • 79960886859 scopus 로고    scopus 로고
    • Culture enriched molecular profiling of the cystic fibrosis airway microbiome
    • Sibley CD, Grinwis ME, Field TR et al. Culture enriched molecular profiling of the cystic fibrosis airway microbiome. PLoS ONE 6(7), e22702 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.7
    • Sibley, C.D.1    Grinwis, M.E.2    Field, T.R.3
  • 15
    • 43249098872 scopus 로고    scopus 로고
    • The Streptococcus milleri group-an unrecognized cause of disease in cystic fibrosis: A case series and literature review
    • Parkins MD, Sibley CD, Surette MG, Rabin HR. The Streptococcus milleri group-an unrecognized cause of disease in cystic fibrosis: a case series and literature review. Pediatr. Pulmonol. 43(5), 490-497 (2008).
    • (2008) Pediatr. Pulmonol. , vol.43 , Issue.5 , pp. 490-497
    • Parkins, M.D.1    Sibley, C.D.2    Surette, M.G.3    Rabin, H.R.4
  • 16
    • 0029930876 scopus 로고    scopus 로고
    • Incidence of anaerobes in ventilator-associated pneumonia with use of a protected specimen brush
    • Dore P, Robert R, Grollier G et al. Incidence of anaerobes in ventilator-associated pneumonia with use of a protected specimen brush. Am. J. Respir. Crit. Care Med. 153(4 Pt 1), 1292-1298 (1996).
    • (1996) Am. J. Respir. Crit. Care Med. , vol.153 , Issue.4 PART 1 , pp. 1292-1298
    • Dore, P.1    Robert, R.2    Grollier, G.3
  • 17
    • 0034785372 scopus 로고    scopus 로고
    • Genotypic characterization of Pseudomonas aeruginosa strains recovered from patients with cystic fibrosis after initial and subsequent colonization
    • Munck A, Bonacorsi S, Mariani-Kurkdjian P et al. Genotypic characterization of Pseudomonas aeruginosa strains recovered from patients with cystic fibrosis after initial and subsequent colonization. Pediatr. Pulmonol. 32(4), 288-292 (2001).
    • (2001) Pediatr. Pulmonol. , vol.32 , Issue.4 , pp. 288-292
    • Munck, A.1    Bonacorsi, S.2    Mariani-Kurkdjian, P.3
  • 18
    • 84869219279 scopus 로고    scopus 로고
    • Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: An evolutionary perspective
    • Folkesson A, Jelsbak L, Yang L et al. Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective. Nat. Rev. Microbiol. 10(12), 841-851 (2012).
    • (2012) Nat. Rev. Microbiol. , vol.10 , Issue.12 , pp. 841-851
    • Folkesson, A.1    Jelsbak, L.2    Yang, L.3
  • 19
    • 84355161775 scopus 로고    scopus 로고
    • Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
    • Hansen SK, Rau MH, Johansen HK et al. Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection. ISME J. 6(1), 31-45 (2012).
    • (2012) ISME J. , vol.6 , Issue.1 , pp. 31-45
    • Hansen, S.K.1    Rau, M.H.2    Johansen, H.K.3
  • 21
    • 34248547055 scopus 로고    scopus 로고
    • Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia
    • Bahrani-Mougeot FK, Paster BJ, Coleman S et al. Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia. J. Clin. Microbiol. 45(5), 1588-1593 (2007).
    • (2007) J. Clin. Microbiol. , vol.45 , Issue.5 , pp. 1588-1593
    • Bahrani-Mougeot, F.K.1    Paster, B.J.2    Coleman, S.3
  • 22
    • 65849522497 scopus 로고    scopus 로고
    • Cystic fibrosis
    • O'Sullivan BP, Freedman SD. Cystic fibrosis. Lancet 373(9678), 1891-1904 (2009).
    • (2009) Lancet , vol.373 , Issue.9678 , pp. 1891-1904
    • O'Sullivan, B.P.1    Freedman, S.D.2
  • 23
    • 84869120178 scopus 로고    scopus 로고
    • Treatment of lung infection in patients with cystic fibrosis: Current and future strategies
    • Doring G, Flume P, Heijerman H, Elborn JS; Treatment of lung infection in patients with cystic fibrosis: current and future strategies. J. Cyst. Fibros. 11(6), 461-479 (2012).
    • (2012) J. Cyst. Fibros. , vol.11 , Issue.6 , pp. 461-479
    • Doring, G.1    Flume, P.2    Heijerman, H.3    Elborn, J.S.4
  • 25
    • 36248953255 scopus 로고    scopus 로고
    • Cystic fibrosis pulmonary guidelines: Chronic medications for maintenance of lung health
    • Flume PA, O'Sullivan BP, Robinson KA et al.; Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health. Am. J. Respir. Crit. Care Med. 176(10), 957-969 (2007).
    • (2007) Am. J. Respir. Crit. Care Med. , vol.176 , Issue.10 , pp. 957-969
    • Flume, P.A.1    O'Sullivan, B.P.2    Robinson, K.A.3
  • 27
    • 0030995361 scopus 로고    scopus 로고
    • Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis
    • Frederiksen B, Koch C, Hoiby N. Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr. Pulmonol. 23(5), 330-335 (1997).
    • (1997) Pediatr. Pulmonol. , vol.23 , Issue.5 , pp. 330-335
    • Frederiksen, B.1    Koch, C.2    Hoiby, N.3
  • 28
    • 77950914953 scopus 로고    scopus 로고
    • Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: The ELITE trial
    • Ratjen F, Munck A, Kho P, Angyalosi G; Group ES. Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial. Thorax 65(4), 286-291 (2010).
    • (2010) Thorax , vol.65 , Issue.4 , pp. 286-291
    • Ratjen, F.1    Munck, A.2    Kho, P.3    Angyalosi, G.4    Group, E.S.5
  • 29
    • 0041353728 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus in children with cystic fibrosis: An eradication protocol
    • Solis A, Brown D, Hughes J, Van Saene HK, Heaf DP. Methicillin-resistant Staphylococcus aureus in children with cystic fibrosis: an eradication protocol. Pediatr. Pulmonol. 36(3), 189-195 (2003).
    • (2003) Pediatr. Pulmonol. , vol.36 , Issue.3 , pp. 189-195
    • Solis, A.1    Brown, D.2    Hughes, J.3    Van Saene, H.K.4    Heaf, D.P.5
  • 30
    • 33847047400 scopus 로고    scopus 로고
    • Successful decolonization of methicillin-resistant Staphylococcus aureus in paediatric patients with cystic fibrosis (CF) using a three-step protocol
    • Macfarlane M, Leavy A, McCaughan J, Fair R, Reid AJ. Successful decolonization of methicillin-resistant Staphylococcus aureus in paediatric patients with cystic fibrosis (CF) using a three-step protocol. J. Hosp. Infect. 65(3), 231-236 (2007).
    • (2007) J. Hosp. Infect. , vol.65 , Issue.3 , pp. 231-236
    • MacFarlane, M.1    Leavy, A.2    McCaughan, J.3    Fair, R.4    Reid, A.J.5
  • 31
    • 70350446684 scopus 로고    scopus 로고
    • Cystic fibrosis pulmonary guidelines: Treatment of pulmonary exacerbations
    • Flume PA, Mogayzel PJ Jr, Robinson KA et al. Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations. Am. J. Respir. Crit. Care Med. 180(9), 802-808 (2009).
    • (2009) Am. J. Respir. Crit. Care Med. , vol.180 , Issue.9 , pp. 802-808
    • Flume, P.A.1    Mogayzel Jr., P.J.2    Robinson, K.A.3
  • 32
    • 84863453860 scopus 로고    scopus 로고
    • Effect of pulmonary exacerbations on long-term lung function decline in cystic fibrosis
    • Waters V, Stanojevic S, Atenafu EG et al. Effect of pulmonary exacerbations on long-term lung function decline in cystic fibrosis. Eur. Resp. J. 40(1), 61-66 (2012).
    • (2012) Eur. Resp. J. , vol.40 , Issue.1 , pp. 61-66
    • Waters, V.1    Stanojevic, S.2    Atenafu, E.G.3
  • 33
    • 34548858449 scopus 로고    scopus 로고
    • Clinical utility of synergy testing for multidrug-resistant Pseudomonas aeruginosa isolated from patients with cystic fibrosis: 'The motion for'
    • Saiman L. Clinical utility of synergy testing for multidrug-resistant Pseudomonas aeruginosa isolated from patients with cystic fibrosis: 'the motion for'. Paediatr. Respir. Rev. 8(3), 249-255 (2007).
    • (2007) Paediatr. Respir. Rev. , vol.8 , Issue.3 , pp. 249-255
    • Saiman, L.1
  • 34
    • 77951887288 scopus 로고    scopus 로고
    • Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: A randomized controlled trial
    • Saiman L, Anstead M, Mayer-Hamblett N et al. Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 303(17), 1707-1715 (2010).
    • (2010) JAMA , vol.303 , Issue.17 , pp. 1707-1715
    • Saiman, L.1    Anstead, M.2    Mayer-Hamblett, N.3
  • 36
    • 33644508050 scopus 로고    scopus 로고
    • Outcomes of adults with cystic fibrosis infected with antibioticresistant Pseudomonas aeruginosa
    • Lechtzin N, John M, Irizarry R, Merlo C, Diette GB, Boyle MP. Outcomes of adults with cystic fibrosis infected with antibioticresistant Pseudomonas aeruginosa. Respiration. 73(1), 27-33 (2006).
    • (2006) Respiration. , vol.73 , Issue.1 , pp. 27-33
    • Lechtzin, N.1    John, M.2    Irizarry, R.3    Merlo, C.4    Diette, G.B.5    Boyle, M.P.6
  • 37
    • 77950574187 scopus 로고    scopus 로고
    • Changes in cystic fibrosis sputum microbiology in the United States between 1995 and 2008
    • Emerson J, McNamara S, Buccat AM, Worrell K, Burns JL. Changes in cystic fibrosis sputum microbiology in the United States between 1995 and 2008. Pediatr. Pulmonol. 45(4), 363-370 (2010).
    • (2010) Pediatr. Pulmonol. , vol.45 , Issue.4 , pp. 363-370
    • Emerson, J.1    McNamara, S.2    Buccat, A.M.3    Worrell, K.4    Burns, J.L.5
  • 38
    • 69049110965 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa-A phenomenon of bacterial resistance
    • Strateva T, Yordanov D. Pseudomonas aeruginosa-a phenomenon of bacterial resistance. J. Med. Microbiol. 58(Pt 9), 1133-1148 (2009).
    • (2009) J. Med. Microbiol. , vol.58 , Issue.PART 9 , pp. 1133-1148
    • Strateva, T.1    Yordanov, D.2
  • 39
    • 33744814106 scopus 로고    scopus 로고
    • Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
    • Smith EE, Buckley DG, Wu Z et al. Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc. Natl Acad. Sci. USA 103(22), 8487-8492 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.22 , pp. 8487-8492
    • Smith, E.E.1    Buckley, D.G.2    Wu, Z.3
  • 40
    • 84858673034 scopus 로고    scopus 로고
    • Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infection
    • Alcala-Franco B, Montanari S, Cigana C, Bertoni G, Oliver A, Bragonzi A. Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infection. J. Antimicrob. Chemother. 67(4), 962-969 (2012).
    • (2012) J. Antimicrob. Chemother. , vol.67 , Issue.4 , pp. 962-969
    • Alcala-Franco, B.1    Montanari, S.2    Cigana, C.3    Bertoni, G.4    Oliver, A.5    Bragonzi, A.6
  • 41
    • 0034685940 scopus 로고    scopus 로고
    • High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
    • Oliver A, Canton R, Campo P, Baquero F, Blázquez J. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 288(5469), 1251-1254 (2000).
    • (2000) Science , vol.288 , Issue.5469 , pp. 1251-1254
    • Oliver, A.1    Canton, R.2    Campo, P.3    Baquero, F.4    Blázquez, J.5
  • 42
    • 19544386997 scopus 로고    scopus 로고
    • Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation
    • Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N. Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob. Agents Chemother. 49(6), 2276-2282 (2005).
    • (2005) Antimicrob. Agents Chemother. , vol.49 , Issue.6 , pp. 2276-2282
    • Ciofu, O.1    Riis, B.2    Pressler, T.3    Poulsen, H.E.4    Hoiby, N.5
  • 43
    • 68049096879 scopus 로고    scopus 로고
    • Effect of mutator P. Aeruginosa on antibiotic resistance acquisition and respiratory function in cystic fibrosis
    • Ferroni A, Guillemot D, Moumile K et al. Effect of mutator P. aeruginosa on antibiotic resistance acquisition and respiratory function in cystic fibrosis. Pediatr. Pulmonol. 44(8), 820-825 (2009).
    • (2009) Pediatr. Pulmonol. , vol.44 , Issue.8 , pp. 820-825
    • Ferroni, A.1    Guillemot, D.2    Moumile, K.3
  • 44
    • 33845929250 scopus 로고    scopus 로고
    • Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa
    • Hoffman LR, Deziel E, D'Argenio DA et al. Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 103(52), 19890-19895 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.52 , pp. 19890-19895
    • Hoffman, L.R.1    Deziel, E.2    D'Argenio, D.A.3
  • 45
    • 77957333809 scopus 로고    scopus 로고
    • Fluoroquinolone efflux by the plasmidmediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus
    • Nakaminami H, Noguchi N, Sasatsu M. Fluoroquinolone efflux by the plasmidmediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. Antimicrob. Agents Chemother. 54(10), 4107-4111 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.10 , pp. 4107-4111
    • Nakaminami, H.1    Noguchi, N.2    Sasatsu, M.3
  • 46
    • 0027193708 scopus 로고
    • BlaI and blaR1 regulate beta-lactamase and PBP 2a production in methicillin-resistant Staphylococcus aureus
    • Hackbarth CJ, Chambers HF. blaI and blaR1 regulate beta-lactamase and PBP 2a production in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 37(5), 1144-1149 (1993).
    • (1993) Antimicrob. Agents Chemother. , vol.37 , Issue.5 , pp. 1144-1149
    • Hackbarth, C.J.1    Chambers, H.F.2
  • 47
    • 84868017750 scopus 로고    scopus 로고
    • Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate Staphylococcus aureus
    • Hafer C, Lin Y, Kornblum J, Lowy FD, Uhlemann AC. Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate Staphylococcus aureus. Antimicrob. Agents Chemother. 56(11), 5845-5851 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , Issue.11 , pp. 5845-5851
    • Hafer, C.1    Lin, Y.2    Kornblum, J.3    Lowy, F.D.4    Uhlemann, A.C.5
  • 48
    • 13444251656 scopus 로고    scopus 로고
    • The multifarious, multireplicon Burkholderia cepacia complex
    • Mahenthiralingam E, Urban TA, Goldberg JB. The multifarious, multireplicon Burkholderia cepacia complex. Nat. Rev. Microbiol 3(2), 144-156 (2005).
    • (2005) Nat. Rev. Microbiol , vol.3 , Issue.2 , pp. 144-156
    • Mahenthiralingam, E.1    Urban, T.A.2    Goldberg, J.B.3
  • 49
    • 0036668118 scopus 로고    scopus 로고
    • Influence of taxonomic status on the in vitro antimicrobial susceptibility of the Burkholderia cepacia complex
    • Nzula S, Vandamme P, Govan JRW. Influence of taxonomic status on the in vitro antimicrobial susceptibility of the Burkholderia cepacia complex. J. Antimicrob. Chemother. 50(2), 265-269 (2002).
    • (2002) J. Antimicrob. Chemother. , vol.50 , Issue.2 , pp. 265-269
    • Nzula, S.1    Vandamme, P.2    Govan, J.R.W.3
  • 50
    • 80052824530 scopus 로고    scopus 로고
    • First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM
    • Bador J, Amoureux L, Duez J-M et al. First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM. Antimicrob. Agents Chemother. 55(10), 4912-4914 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , Issue.10 , pp. 4912-4914
    • Bador, J.1    Amoureux, L.2    Duez, J.-M.3
  • 51
    • 0035873153 scopus 로고    scopus 로고
    • Emerging importance of multidrug-resistant acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: Geographic patterns epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program 1997-1999)
    • Gales AC, Jones RN, Forward KR, Liñares J, Sader HS, Verhoef J. Emerging importance of multidrug-resistant acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999). Clin. Infect. Dis. 32( Suppl. 2), S104-S113 (2001).
    • (2001) Clin. Infect. Dis. , vol.32 , Issue.SUPPL. 2
    • Gales, A.C.1    Jones, R.N.2    Forward, K.R.3    Liñares, J.4    Sader, H.S.5    Verhoef, J.6
  • 52
    • 84864392129 scopus 로고    scopus 로고
    • Combination antimicrobial susceptibility testing of multidrug-resistant Stenotrophomonas maltophilia from cystic fibrosis patients
    • Milne KEN, Gould IM. Combination antimicrobial susceptibility testing of multidrug-resistant Stenotrophomonas maltophilia from cystic fibrosis patients. Antimicrob. Agents Chemother. 56(8), 4071-4077 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , Issue.8 , pp. 4071-4077
    • Milne, K.E.N.1    Gould, I.M.2
  • 53
  • 54
    • 0036781756 scopus 로고    scopus 로고
    • Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria
    • Brown-Elliott BA, Wallace RJ Jr. Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria. Clin. Microbiol. Rev. 15(4), 716-746 (2002).
    • (2002) Clin. Microbiol. Rev. , vol.15 , Issue.4 , pp. 716-746
    • Brown-Elliott, B.A.1    Wallace Jr., R.J.2
  • 55
    • 0034925138 scopus 로고    scopus 로고
    • Cloning and biochemical characterization of a class A beta-lactamase from Prevotella intermedia
    • Madinier I, Fosse T, Giudicelli J, Labia R. Cloning and biochemical characterization of a class A beta-lactamase from Prevotella intermedia. Antimicrob. Agents Chemother. 45(8), 2386-2389 (2001).
    • (2001) Antimicrob. Agents Chemother. , vol.45 , Issue.8 , pp. 2386-2389
    • Madinier, I.1    Fosse, T.2    Giudicelli, J.3    Labia, R.4
  • 56
    • 0034641962 scopus 로고    scopus 로고
    • Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
    • Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407(6805), 762-764 (2000).
    • (2000) Nature , vol.407 , Issue.6805 , pp. 762-764
    • Singh, P.K.1    Schaefer, A.L.2    Parsek, M.R.3    Moninger, T.O.4    Welsh, M.J.5    Greenberg, E.P.6
  • 57
    • 0032898457 scopus 로고    scopus 로고
    • Introduction to biofilm
    • discussion 237-219
    • Costerton JW. Introduction to biofilm. Int. J. Antimicrob. Agents 11(3-4), 217-221; discussion 237-219 (1999).
    • (1999) Int. J. Antimicrob. Agents , vol.11 , Issue.3-4 , pp. 217-221
    • Costerton, J.W.1
  • 58
    • 2442526705 scopus 로고    scopus 로고
    • Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosis
    • Moskowitz SM, Foster JM, Emerson J, Burns JL. Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosis. J. Clin. Microbiol. 42(5), 1915-1922 (2004).
    • (2004) J. Clin. Microbiol. , vol.42 , Issue.5 , pp. 1915-1922
    • Moskowitz, S.M.1    Foster, J.M.2    Emerson, J.3    Burns, J.L.4
  • 59
    • 0036897745 scopus 로고    scopus 로고
    • Understanding bacterial biofilms in patients with cystic fibrosis: Current and innovative approaches to potential therapies
    • Hoiby N. Understanding bacterial biofilms in patients with cystic fibrosis: current and innovative approaches to potential therapies. J. Cyst. Fibros. 1(4), 249-254 (2002).
    • (2002) J. Cyst. Fibros. , vol.1 , Issue.4 , pp. 249-254
    • Hoiby, N.1
  • 60
    • 20444451726 scopus 로고    scopus 로고
    • Persister cells, the biofilm matrix and tolerance to metal cations in biofilm and planktonic Pseudomonas aeruginosa
    • Harrison JJ, Turner RJ, Ceri H. Persister cells, the biofilm matrix and tolerance to metal cations in biofilm and planktonic Pseudomonas aeruginosa. Environ. Microbiol. 7(7), 981-994 (2005).
    • (2005) Environ. Microbiol. , vol.7 , Issue.7 , pp. 981-994
    • Harrison, J.J.1    Turner, R.J.2    Ceri, H.3
  • 61
    • 0035992362 scopus 로고    scopus 로고
    • Mechanisms of antibiotic resistance in bacterial biofilms
    • Stewart PS. Mechanisms of antibiotic resistance in bacterial biofilms. Int. J. Med. Microbiol. 292(2), 107-113 (2002).
    • (2002) Int. J. Med. Microbiol. , vol.292 , Issue.2 , pp. 107-113
    • Stewart, P.S.1
  • 62
    • 78549290620 scopus 로고    scopus 로고
    • Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung
    • Schobert M, Jahn D. Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung. Int. J. Med. Microbiol. 300(8), 549-556 (2010).
    • (2010) Int. J. Med. Microbiol. , vol.300 , Issue.8 , pp. 549-556
    • Schobert, M.1    Jahn, D.2
  • 63
    • 34250328344 scopus 로고    scopus 로고
    • Membrane-bound nitrate reductase is required for anaerobic growth in cystic fibrosis sputum
    • Palmer KL, Brown SA, Whiteley M. Membrane-bound nitrate reductase is required for anaerobic growth in cystic fibrosis sputum. J. Bacteriol. 189(12), 4449-4455 (2007).
    • (2007) J. Bacteriol. , vol.189 , Issue.12 , pp. 4449-4455
    • Palmer, K.L.1    Brown, S.A.2    Whiteley, M.3
  • 64
    • 0347777343 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa anaerobic respiration in biofilms: Relationships to cystic fibrosis pathogenesis
    • Yoon SS, Hennigan RF, Hilliard GM et al. Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev. Cell 3(4), 593-603 (2002).
    • (2002) Dev. Cell , vol.3 , Issue.4 , pp. 593-603
    • Yoon, S.S.1    Hennigan, R.F.2    Hilliard, G.M.3
  • 65
    • 0030474876 scopus 로고    scopus 로고
    • Anaerobic production of alginate by Pseudomonas aeruginosa: Alginate restricts diffusion of oxygen
    • Hassett DJ. Anaerobic production of alginate by Pseudomonas aeruginosa: alginate restricts diffusion of oxygen. J. Bacteriol. 178(24), 7322-7325 (1996).
    • (1996) J. Bacteriol. , vol.178 , Issue.24 , pp. 7322-7325
    • Hassett, D.J.1
  • 66
    • 70349972115 scopus 로고    scopus 로고
    • Review: Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa
    • King JD, Kocincova D, Westman EL, Lam JS. Review: Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa. Innate Immun. 15(5), 261-312 (2009).
    • (2009) Innate Immun. , vol.15 , Issue.5 , pp. 261-312
    • King, J.D.1    Kocincova, D.2    Westman, E.L.3    Lam, J.S.4
  • 67
    • 0034878704 scopus 로고    scopus 로고
    • Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function
    • Hentzer M, Teitzel GM, Balzer GJ et al. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function. J. Bacteriol. 183(18), 5395-5401 (2001).
    • (2001) J. Bacteriol. , vol.183 , Issue.18 , pp. 5395-5401
    • Hentzer, M.1    Teitzel, G.M.2    Balzer, G.J.3
  • 68
    • 0027515951 scopus 로고
    • Interaction of gentamicin with the A band and B band lipopolysaccharides of Pseudomonas aeruginosa and its possible lethal effect
    • Kadurugamuwa JL, Lam JS, Beveridge TJ. Interaction of gentamicin with the A band and B band lipopolysaccharides of Pseudomonas aeruginosa and its possible lethal effect. Antimicrob. Agents Chemother. 37(4), 715-721 (1993).
    • (1993) Antimicrob. Agents Chemother. , vol.37 , Issue.4 , pp. 715-721
    • Kadurugamuwa, J.L.1    Lam, J.S.2    Beveridge, T.J.3
  • 69
    • 27944440475 scopus 로고    scopus 로고
    • Effect of oxygen limitation on the in vitro antimicrobial susceptibility of clinical isolates of Pseudomonas aeruginosa grown planktonically and as biofilms
    • Field TR, White A, Elborn JS, Tunney MM. Effect of oxygen limitation on the in vitro antimicrobial susceptibility of clinical isolates of Pseudomonas aeruginosa grown planktonically and as biofilms. Eur. J. Clin. Microbiol. Infect. Dis. 24(10), 677-687 (2005).
    • (2005) Eur. J. Clin. Microbiol. Infect. Dis. , vol.24 , Issue.10 , pp. 677-687
    • Field, T.R.1    White, A.2    Elborn, J.S.3    Tunney, M.M.4
  • 70
    • 73749084328 scopus 로고    scopus 로고
    • Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients
    • King P, Citron DM, Griffith DC, Lomovskaya O, Dudley MN. Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients. Diagn. Microbiol. Infect. Dis. 66(2), 181-186 (2010).
    • (2010) Diagn. Microbiol. Infect. Dis. , vol.66 , Issue.2 , pp. 181-186
    • King, P.1    Citron, D.M.2    Griffith, D.C.3    Lomovskaya, O.4    Dudley, M.N.5
  • 71
    • 84860626732 scopus 로고    scopus 로고
    • Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions
    • McCaughey G, McKevitt M, Elborn JS, Tunney MM. Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions. J. Cyst. Fibros. 11(3), 163-172 (2012).
    • (2012) J. Cyst. Fibros. , vol.11 , Issue.3 , pp. 163-172
    • McCaughey, G.1    McKevitt, M.2    Elborn, J.S.3    Tunney, M.M.4
  • 72
    • 84858692238 scopus 로고    scopus 로고
    • Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps
    • Schaible B, Taylor CT, Schaffer K. Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps. Antimicrob. Agents Chemother. 56(4), 2114-2118 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , Issue.4 , pp. 2114-2118
    • Schaible, B.1    Taylor, C.T.2    Schaffer, K.3
  • 73
    • 84862501656 scopus 로고    scopus 로고
    • Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis
    • Hurley MN, Ariff AH, Bertenshaw C, Bhatt J, Smyth AR. Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis. J. Cyst. Fibros. 11(4), 288-292 (2012).
    • (2012) J. Cyst. Fibros. , vol.11 , Issue.4 , pp. 288-292
    • Hurley, M.N.1    Ariff, A.H.2    Bertenshaw, C.3    Bhatt, J.4    Smyth, A.R.5
  • 74
    • 0037541096 scopus 로고    scopus 로고
    • Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration: Lack of association in cystic fibrosis
    • Smith AL, Fiel SB, Mayer-Hamblett N, Ramsey B, Burns JL. Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration: lack of association in cystic fibrosis. Chest 123(5), 1495-1502 (2003).
    • (2003) Chest , vol.123 , Issue.5 , pp. 1495-1502
    • Smith, A.L.1    Fiel, S.B.2    Mayer-Hamblett, N.3    Ramsey, B.4    Burns, J.L.5
  • 75
    • 84856731944 scopus 로고    scopus 로고
    • Incidence and risk factors for pulmonary exacerbation treatment failures in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa
    • Parkins MD, Rendall JC, Elborn JS. Incidence and risk factors for pulmonary exacerbation treatment failures in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa. Chest 141(2), 485-493 (2012).
    • (2012) Chest , vol.141 , Issue.2 , pp. 485-493
    • Parkins, M.D.1    Rendall, J.C.2    Elborn, J.S.3
  • 76
    • 23444457294 scopus 로고    scopus 로고
    • Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: A randomised, double-blind, controlled clinical trial
    • Aaron SD, Vandemheen KL, Ferris W et al. Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial. Lancet 366(9484), 463-471 (2005).
    • (2005) Lancet , vol.366 , Issue.9484 , pp. 463-471
    • Aaron, S.D.1    Vandemheen, K.L.2    Ferris, W.3
  • 77
    • 0034518939 scopus 로고    scopus 로고
    • Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with multiresistant strains of Pseudomonas aeruginosa
    • Lang BJ, Aaron SD, Ferris W, Hebert PC, MacDonald NE. Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with multiresistant strains of Pseudomonas aeruginosa. Am. J. Respir. Crit. Care Med. 162(6), 2241-2245 (2000).
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , Issue.6 , pp. 2241-2245
    • Lang, B.J.1    Aaron, S.D.2    Ferris, W.3    Hebert, P.C.4    MacDonald, N.E.5
  • 78
    • 27744591507 scopus 로고    scopus 로고
    • Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection
    • Moskowitz SM, Foster JM, Emerson JC, Gibson RL, Burns JL. Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection. J. Antimicrob. Chemother. 56(5), 879-886 (2005).
    • (2005) J. Antimicrob. Chemother. , vol.56 , Issue.5 , pp. 879-886
    • Moskowitz, S.M.1    Foster, J.M.2    Emerson, J.C.3    Gibson, R.L.4    Burns, J.L.5
  • 79
    • 79251526157 scopus 로고    scopus 로고
    • Randomized trial of biofilm testing to select antibiotics for cystic fibrosis airway infection
    • Moskowitz SM, Emerson JC, McNamara S et al. Randomized trial of biofilm testing to select antibiotics for cystic fibrosis airway infection. Pediatr. Pulmonol. 46(2), 184-192 (2011).
    • (2011) Pediatr. Pulmonol. , vol.46 , Issue.2 , pp. 184-192
    • Moskowitz, S.M.1    Emerson, J.C.2    McNamara, S.3
  • 80
    • 60449106108 scopus 로고    scopus 로고
    • A retrospective analysis of biofilm antibiotic susceptibility testing: A better predictor of clinical response in cystic fibrosis exacerbations
    • Keays T, Ferris W, Vandemheen KL et al. A retrospective analysis of biofilm antibiotic susceptibility testing: a better predictor of clinical response in cystic fibrosis exacerbations. J. Cyst. Fibros. 8(2), 122-127 (2009).
    • (2009) J. Cyst. Fibros. , vol.8 , Issue.2 , pp. 122-127
    • Keays, T.1    Ferris, W.2    Vandemheen, K.L.3
  • 81
    • 21244451543 scopus 로고    scopus 로고
    • Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing
    • Foweraker JE, Laughton CR, Brown DF, Bilton D. Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing. J. Antimicrob. Chemother. 55(6), 921-927 (2005).
    • (2005) J. Antimicrob. Chemother. , vol.55 , Issue.6 , pp. 921-927
    • Foweraker, J.E.1    Laughton, C.R.2    Brown, D.F.3    Bilton, D.4
  • 82
    • 79958115044 scopus 로고    scopus 로고
    • Antibiotic treatment of CF lung disease: From bench to bedside
    • Bals R, Hubert D, Tummler B. Antibiotic treatment of CF lung disease: from bench to bedside. J. Cyst. Fibros. 10(Suppl. 2), S146-S151 (2011).
    • (2011) J. Cyst. Fibros. , vol.10 , Issue.SUPPL. 2
    • Bals, R.1    Hubert, D.2    Tummler, B.3
  • 83
    • 65949124667 scopus 로고    scopus 로고
    • Efficacy and safety of inhaled aztreonam lysine for airway pseudomonas in cystic fibrosis
    • Retsch-Bogart GZ, Quittner AL, Gibson RL et al. Efficacy and safety of inhaled aztreonam lysine for airway pseudomonas in cystic fibrosis. Chest 135(5), 1223-1232 (2009).
    • (2009) Chest , vol.135 , Issue.5 , pp. 1223-1232
    • Retsch-Bogart, G.Z.1    Quittner, A.L.2    Gibson, R.L.3
  • 85
    • 78449294500 scopus 로고    scopus 로고
    • An 18-month study of the safety and efficacy of repeated courses of inhaled aztreonam lysine in cystic fibrosis
    • Oermann CM, Retsch-Bogart GZ, Quittner AL et al. An 18-month study of the safety and efficacy of repeated courses of inhaled aztreonam lysine in cystic fibrosis. Pediatr. Pulmonol. 45(11), 1121-1134 (2010).
    • (2010) Pediatr. Pulmonol. , vol.45 , Issue.11 , pp. 1121-1134
    • Oermann, C.M.1    Retsch-Bogart, G.Z.2    Quittner, A.L.3
  • 86
    • 79958295843 scopus 로고    scopus 로고
    • Aztreonam for inhalation solution (AZLI) in patients with cystic fibrosis, mild lung impairment, and P. Aeruginosa
    • Wainwright CE, Quittner AL, Geller DE et al. Aztreonam for inhalation solution (AZLI) in patients with cystic fibrosis, mild lung impairment, and P. aeruginosa. J. Cyst. Fibros. 10(4), 234-242 (2011).
    • (2011) J. Cyst. Fibros. , vol.10 , Issue.4 , pp. 234-242
    • Wainwright, C.E.1    Quittner, A.L.2    Geller, D.E.3
  • 87
    • 84875842391 scopus 로고    scopus 로고
    • Inhaled aztreonam lysine vs. Inhaled tobramycin in cystic fibrosis: A comparative efficacy trial
    • Assael BM, Pressler T, Bilton D et al. Inhaled aztreonam lysine vs. inhaled tobramycin in cystic fibrosis: A comparative efficacy trial. J. Cyst. Fibros. 12(2), 130-140 (2012).
    • (2012) J. Cyst. Fibros. , vol.12 , Issue.2 , pp. 130-140
    • Assael, B.M.1    Pressler, T.2    Bilton, D.3
  • 88
    • 78651412529 scopus 로고    scopus 로고
    • Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial
    • Konstan MW, Flume PA, Kappler M et al. Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial. J. Cyst. Fibros. 10(1), 54-61 (2011).
    • (2011) J. Cyst. Fibros. , vol.10 , Issue.1 , pp. 54-61
    • Konstan, M.W.1    Flume, P.A.2    Kappler, M.3
  • 89
    • 79951840468 scopus 로고    scopus 로고
    • Tobramycin inhalation powder for P. Aeruginosa infection in cystic fibrosis: The EVOLVE trial
    • Konstan MW, Geller DE, Minić P, Brockhaus F, Zhang J, Angyalosi G. Tobramycin inhalation powder for P. aeruginosa infection in cystic fibrosis: The EVOLVE trial. Pediatr. Pulmonol. 46(3), 230-238 (2011).
    • (2011) Pediatr. Pulmonol. , vol.46 , Issue.3 , pp. 230-238
    • Konstan, M.W.1    Geller, D.E.2    Minić, P.3    Brockhaus, F.4    Zhang, J.5    Angyalosi, G.6
  • 90
    • 79960112178 scopus 로고    scopus 로고
    • A multi-cycle open-label study of nebulized liposomal amikacin (Arikace™) in the treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
    • Minic P, Fustik S, Solyom E et al. A multi-cycle open-label study of nebulized liposomal amikacin (Arikace™) in the treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. Pediatr. Pulmonol. (Suppl 33), 243 (2010).
    • (2010) Pediatr. Pulmonol. , Issue.SUPPL. 33 , pp. 243
    • Minic, P.1    Fustik, S.2    Solyom, E.3
  • 91
    • 84870503266 scopus 로고    scopus 로고
    • Full analyses of data from two Phase II blinded and placebo-controlled studies of nebulized liposomal amikacin for inhalation (Arikace™) in the treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
    • Clancy J, Minic P, Dupont L et al. Full analyses of data from two Phase II blinded and placebo-controlled studies of nebulized liposomal amikacin for inhalation (Arikace™) in the treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. Pediatr. Pulmonol. (Suppl. 33), 227(2010).
    • (2010) Pediatr. Pulmonol. , Issue.SUPPL. 33 , pp. 227
    • Clancy, J.1    Minic, P.2    Dupont, L.3
  • 92
    • 79957942626 scopus 로고    scopus 로고
    • Levofloxacin inhalation solution (MP-376) in patients with cystic fibrosis with Pseudomonas aeruginosa
    • Geller DE, Flume PA, Staab D, et al. Levofloxacin inhalation solution (MP-376) in patients with cystic fibrosis with Pseudomonas aeruginosa. Am. J. Respir. Crit. Care Med. 183(11), 1510-1516 (2011).
    • (2011) Am. J. Respir. Crit. Care Med. , vol.183 , Issue.11 , pp. 1510-1516
    • Geller, D.E.1    Flume, P.A.2    Staab, D.3
  • 93
    • 84877093743 scopus 로고    scopus 로고
    • Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis: A Phase II randomised study
    • doi:10.1183/09031936.00071312
    • Wilson R, Welte T, Polverino E et al. Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis: a Phase II randomised study. Eur. Respir. J. doi:10.1183/09031936.00071312 (2013).
    • (2013) Eur. Respir. J.
    • Wilson, R.1    Welte, T.2    Polverino, E.3
  • 94
    • 70349444999 scopus 로고    scopus 로고
    • Antibacterial activities of a fosfomycin/tobramycin combination: A novel inhaled antibiotic for bronchiectasis
    • MacLeod DL, Barker LM, Sutherland JL et al. Antibacterial activities of a fosfomycin/tobramycin combination: a novel inhaled antibiotic for bronchiectasis. J. Antimicrob. Chemother. 64(4), 829-836 (2009).
    • (2009) J. Antimicrob. Chemother. , vol.64 , Issue.4 , pp. 829-836
    • MacLeod, D.L.1    Barker, L.M.2    Sutherland, J.L.3
  • 95
    • 84856010859 scopus 로고    scopus 로고
    • Fosfomycin/tobramycin for inhalation in cystic fibrosis patients with pseudomonas airway infection
    • Trapnell BC, McColley SA, Kissner DG et al. Fosfomycin/tobramycin for inhalation in cystic fibrosis patients with pseudomonas airway infection. Am. J. Respir. Crit. Care Med. 185(2), 171-178 (2012).
    • (2012) Am. J. Respir. Crit. Care Med. , vol.185 , Issue.2 , pp. 171-178
    • Trapnell, B.C.1    McColley, S.A.2    Kissner, D.G.3
  • 96
    • 79956336460 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of MP-376 (levofloxacin inhalation solution) in cystic fibrosis subjects
    • Geller DE, Flume PA, Griffith DC et al. Pharmacokinetics and safety of MP-376 (levofloxacin inhalation solution) in cystic fibrosis subjects. Antimicrob. Agents Chemother. 55(6), 2636-2640 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , Issue.6 , pp. 2636-2640
    • Geller, D.E.1    Flume, P.A.2    Griffith, D.C.3
  • 97
    • 79955886933 scopus 로고    scopus 로고
    • Metabolite-enabled eradication of bacterial persisters by aminoglycosides
    • Allison KR, Brynildsen MP, Collins JJ. Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature 473(7346), 216-220 (2011).
    • (2011) Nature , vol.473 , Issue.7346 , pp. 216-220
    • Allison, K.R.1    Brynildsen, M.P.2    Collins, J.J.3
  • 98
    • 84887790948 scopus 로고    scopus 로고
    • Nitric oxide-mediated dispersal and enhanced antibiotic sensitivity in Pseudomonas aeruginosa biofilms from the cystic fibrosis lung
    • Howlin R, Cathie K, Hall-Stoodley L et al. Nitric oxide-mediated dispersal and enhanced antibiotic sensitivity in Pseudomonas aeruginosa biofilms from the cystic fibrosis lung. Arch. Dis. Child 96(Suppl. 1), A45 (2011).
    • (2011) Arch. Dis. Child , vol.96 , Issue.SUPPL. 1
    • Howlin, R.1    Cathie, K.2    Hall-Stoodley, L.3
  • 99
    • 84864287123 scopus 로고    scopus 로고
    • Nutrient dispersion enhances conventional antibiotic activity against Pseudomonas aeruginosa biofilms
    • Sommerfeld Ross S, Fiegel J. Nutrient dispersion enhances conventional antibiotic activity against Pseudomonas aeruginosa biofilms. Int. J. Antimicrob. Agents 40(2), 177-181 (2012).
    • (2012) Int. J. Antimicrob. Agents , vol.40 , Issue.2 , pp. 177-181
    • Sommerfeld Ross, S.1    Fiegel, J.2
  • 100
    • 77951226720 scopus 로고    scopus 로고
    • Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents
    • Rogers SA, Huigens RW 3rd, Cavanagh J, Melander C. Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrob. Agents Chemother. 54(5), 2112-2118 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.5 , pp. 2112-2118
    • Rogers, S.A.1    Huigens Iii., R.W.2    Cavanagh, J.3    Melander, C.4
  • 103
    • 3042597309 scopus 로고    scopus 로고
    • Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice
    • Wu H, Song Z, Hentzer M et al. Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. J. Antimicrob. Chemother. 53(6), 1054-1061 (2004).
    • (2004) J. Antimicrob. Chemother. , vol.53 , Issue.6 , pp. 1054-1061
    • Wu, H.1    Song, Z.2    Hentzer, M.3
  • 104
    • 84865703750 scopus 로고    scopus 로고
    • Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
    • Galloway WR, Hodgkinson JT, Bowden S, Welch M, Spring DR. Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria. Trends Microbiol. 20(9), 449-458 (2012).
    • (2012) Trends Microbiol. , vol.20 , Issue.9 , pp. 449-458
    • Galloway, W.R.1    Hodgkinson, J.T.2    Bowden, S.3    Welch, M.4    Spring, D.R.5
  • 105
    • 29244461453 scopus 로고    scopus 로고
    • Garlic blocks quorum sensing and promotes rapid clearing of pulmonary pseudomonas aeruginosa infections
    • Bjarnsholt T, Jensen PO, Rasmussen TB et al. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology 151(Pt 12), 3873-3880 (2005).
    • (2005) Microbiology , vol.151 , Issue.PART 12 , pp. 3873-3880
    • Bjarnsholt, T.1    Jensen, P.O.2    Rasmussen, T.B.3
  • 106
    • 77950573969 scopus 로고    scopus 로고
    • Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis-A pilot randomized controlled trial
    • Smyth AR, Cifelli PM, Ortori CA et al. Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis-a pilot randomized controlled trial. Pediatr. Pulmonol. 45(4), 356-362 (2010).
    • (2010) Pediatr. Pulmonol. , vol.45 , Issue.4 , pp. 356-362
    • Smyth, A.R.1    Cifelli, P.M.2    Ortori, C.A.3
  • 107
    • 84860202961 scopus 로고    scopus 로고
    • Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing
    • Jakobsen TH, van Gennip M, Phipps RK et al. Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob. Agents Chemother. 56(5), 2314-2325 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , Issue.5 , pp. 2314-2325
    • Jakobsen, T.H.1    Van Gennip, M.2    Phipps, R.K.3
  • 108
    • 84861140602 scopus 로고    scopus 로고
    • Food as a source for quorum sensing inhibitors: Iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
    • Jakobsen TH, Bragason SK, Phipps RK et al. Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl. Environ. Microbiol. 78(7), 2410-2421 (2012).
    • (2012) Appl. Environ. Microbiol. , vol.78 , Issue.7 , pp. 2410-2421
    • Jakobsen, T.H.1    Bragason, S.K.2    Phipps, R.K.3
  • 109
    • 84859595773 scopus 로고    scopus 로고
    • Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
    • Christensen LD, van Gennip M, Jakobsen TH et al. Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. J. Antimicrob. Chemother. 67(5), 1198-1206 (2012).
    • (2012) J. Antimicrob. Chemother. , vol.67 , Issue.5 , pp. 1198-1206
    • Christensen, L.D.1    Van Gennip, M.2    Jakobsen, T.H.3
  • 110
    • 54049083045 scopus 로고    scopus 로고
    • Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa
    • Skindersoe ME, Alhede M, Phipps R et al. Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52(10), 3648-3663 (2008).
    • (2008) Antimicrob. Agents Chemother. , vol.52 , Issue.10 , pp. 3648-3663
    • Skindersoe, M.E.1    Alhede, M.2    Phipps, R.3
  • 111
    • 84872874295 scopus 로고    scopus 로고
    • New life for an old drug: The anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing
    • Imperi F, Massai F, Ramachandran Pillai C et al. New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing. Antimicrob. Agents Chemother. 57(2), 996-1005 (2013).
    • (2013) Antimicrob. Agents Chemother. , vol.57 , Issue.2 , pp. 996-1005
    • Imperi, F.1    Massai, F.2    Ramachandran Pillai, C.3
  • 112
    • 77954053982 scopus 로고    scopus 로고
    • Quorum sensing inhibition selects for virulence and cooperation in Pseudomonas aeruginosa
    • Kohler T, Perron GG, Buckling A, van Delden C. Quorum sensing inhibition selects for virulence and cooperation in Pseudomonas aeruginosa. PLoS Pathog. 6(5), e1000883 (2010).
    • (2010) PLoS Pathog. , vol.6 , Issue.5
    • Kohler, T.1    Perron, G.G.2    Buckling, A.3    Van Delden, C.4
  • 113
    • 0034890932 scopus 로고    scopus 로고
    • Antibiotic resistance in Burkholderia cepacia at two regional cystic fibrosis centres in Northern Ireland: Is there a need for synergy testing?
    • Moore JE, Crowe M, Shaw A, McCaughan J, Redmond AO, Elborn JS. Antibiotic resistance in Burkholderia cepacia at two regional cystic fibrosis centres in Northern Ireland: is there a need for synergy testing? J. Antimicrob. Chemother. 48(2), 319-321 (2001).
    • (2001) J. Antimicrob. Chemother. , vol.48 , Issue.2 , pp. 319-321
    • Moore, J.E.1    Crowe, M.2    Shaw, A.3    McCaughan, J.4    Redmond, A.O.5    Elborn, J.S.6
  • 114
    • 84862199752 scopus 로고    scopus 로고
    • Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak
    • Koser CU, Holden MT, Ellington MJ et al. Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak. N. Engl. J. Med. 366(24), 2267-2275 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.24 , pp. 2267-2275
    • Koser, C.U.1    Holden, M.T.2    Ellington, M.J.3
  • 116
    • 81055139582 scopus 로고    scopus 로고
    • Cystic fibrosis upper airways primary colonization with Pseudomonas aeruginosa: Eradicated by sinonasal antibiotic inhalation
    • Mainz JG, Michl R, Pfister W, Beck JF. Cystic fibrosis upper airways primary colonization with Pseudomonas aeruginosa: eradicated by sinonasal antibiotic inhalation. Am. J. Respir. Crit. Care Med. 184(9), 1089-1090 (2011).
    • (2011) Am. J. Respir. Crit. Care Med. , vol.184 , Issue.9 , pp. 1089-1090
    • Mainz, J.G.1    Michl, R.2    Pfister, W.3    Beck, J.F.4
  • 117
    • 84862303965 scopus 로고    scopus 로고
    • Europe to boost development of new antimicrobial drugs
    • Kirby T. Europe to boost development of new antimicrobial drugs. Lancet 379(9833), 2229-2230 (2012).
    • (2012) Lancet , vol.379 , Issue.9833 , pp. 2229-2230
    • Kirby, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.