Mechanisms of antibiotic resistance in bacterial biofilms

International Journal of Medical Microbiology

Volumn 292, Issue 2, 2002, Pages 107-113

  Stewart, Philip S ^a  

^a Montana State University   (United States)

Author keywords

Biofilm; Growth rate; Penetration; Persister; Stress response

Indexed keywords

ANTIBIOTIC RESISTANCE; BACTERIUM ADHERENCE; BIOFILM; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; INFECTION; MICROBIOLOGY; PHYSIOLOGY; PSEUDOMONAS AERUGINOSA; REVIEW; STAPHYLOCOCCUS EPIDERMIDIS;

BACTERIAL ADHESION; BIOFILMS; DRUG RESISTANCE, BACTERIAL; HUMANS; PROSTHESIS-RELATED INFECTIONS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 0035992362     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00196     Document Type: Article

References (55)

1. Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin
2. Rapid development in vitro and in vivo of resistance to ceftazidime in biofilm-growing Pseudomonas aeruginosa due to chromosomal beta-lactamase
3. A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms
4. Resistance of bacterial biofilms to antibiotics: A growth-rate related effect?
5. The diffusion characteristics of antibiotics in mucus glycoprotein gels
6. Reduced susceptibility of thin Pseudomonas aeruginosa biofilms to hydrogen peroxide and monochloramine
7. Role of RpoS and AlgT in Pseudomonas aeruginosa biofilm resistance to hydrogen peroxide and monochloramine
8. Bacterial biofilms: A common cause of persistent infections
9. Vancomycin penetration into biofilm covering infected prostheses and effect on bacteria
10. Changes in the biocide susceptibility of Staphylococcus epidermidis and Escherichia coli cells associated with rapid attachment to plastic surfaces
11. Multidrug efflux pumps: Expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms
12. Diffusion of rifampin and vancomycin through a Staphylococcus epidermidis biofilm
13. Pseudomonas aeruginosa biofilm resistance to hydrogen peroxide: Protective role of catalase
14. General stress response master regulator rpoS is expressed in human infection: A possible role in chronicity
15. Mechanisms of the protection of bacterial biofilms from antimicrobial agents
16. Antibiotic interaction and diffusion through alginate and exopolysaccharide of cystic fibrosis-derived Pseudomonas aeruginosa
17. In vitro bactericidal activities of beta-lactamases, amikacin, and fluoroquinolones against Pseudomonas aeruginosa biofilm in artificial urine
18. Flowcell culture of Porphyromonas gingivalis biofilms under anaerobic conditions
19. High rates of conjugation in bacterial biofilms as determined by quantitative in situ analysis
20. Biofilm formation by Candida species on the surface of catheter materials in vitro
21. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function
22. Experimental reproducibility in flow-chamber biofilms
23. Pseudomonas aerugmosa biofilm as a diffusion barrier to piperacillin
24. Agar-entrapped bacteria as an in vitro model of biofilms and their susceptibility to antibiotics
25. A sandwich cup method for the penetration assay of antimicrobial agents through Pseudomonas exopolysaccharides
26. Riddle of biofilm resistance
27. Mechanisms of biofilm resistance to antimicrobial agents
28. Expression of the multiple antibiotic resistance operon (mar) during growth of Escherichia coli as a biofilm
29. An evaluation of the potential of the multiple antibiotic resistance operon (mar) and the multidrug efflux pump acrAB to moderate resistance towards ciprofloxacin in Escherichia coli biofilms
30. The molecular basis of carbon-starvation-induced general resistance in Escherichia coli
31. Molecular ecology of biofilms
32. Inhibition of tobramycin diffusion by binding to alginate
33. Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation
34. Regulation of compatible solute accumulation in bacteria
35. Effects of environmental factors on the in vitro potency of azithromycin
36. Permeation of antimicrobial agents through Pseudomonas aeruginosa biofilms: A simple method
37. Distribution of bacterial growth activity in flow-chamber biofilms
38. Theoretical aspects of antibiotic diffusion into microbial biofilms
39. A review of experimental measurements of effective diffusive permeabilities and effective diffusion coefficients in biofilms
40. Antibiotic resistance of bacteria in biofilms
41. Oxidative stress
42. Investigation of ciprofloxacin penetration into Pseudomonas aeruginosa biofilms
43. Increased minimum inhibitory concentrations with anaerobiasis for tobramycin, gentamicin, and amikacin, compared to latamoxef, piperacillin, chloramphenicol, and clindamycin
44. The rate of killing of Escherichia coli by betalactam antibiotics is strictly proportional to the rate of bacterial growth
45. pH-dependent oxacillin tolerance of Staphylococcus aureus
46. Comparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa biofilms displaying rapid-transport characteristics
47. Spatial variations in growth rate within Klebsiella pneumoniae colonies and biofilm
48. Gene expression in Pseudomonas aeruginosa biofilms
49. Biochemical reactions and the establishment of gradients within biofilms
50. Spatial physiological heterogeneity in Pseudomonas aeruginosa biofilm is determined by oxygen availability
51. Biofilm resistance to antimicrobial agents
52. Gene expression and protein levels of the stationary phase sigma factor, RpoS, in continuously-fed Pseudomonas aeruginosa biofilms
53. Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin
54. Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis
55. Penetration of rifampin through Staphylococcus epidermidis biofilms