Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

Journal of Antimicrobial Chemotherapy

Volumn 67, Issue 5, 2012, Pages 1198-1206

  Christensen, Louise D ^a   Van Gennip, Maria ^a   Jakobsen, Tim H ^a   Alhede, Morten ^a   Hougen, Hans Petter ^a   Høiby, Niels ^a,b   Bjarnsholt, Thomas ^a,b   Givskov, Michael ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Antibiotics; Biofilm; Implant model; In vivo

Indexed keywords

AJOENE; CHEMOATTRACTANT; CXCL9 CHEMOKINE; EOTAXIN; FURANONE DERIVATIVE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HORSERADISH JUICE EXTRACT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE DERIVED CHEMOATTRACTANT; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; PLANT EXTRACT; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOBRAMYCIN SULFATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIOLOGY; BIOFILM; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG POTENTIATION; FEMALE; FOREIGN BODY; HISTOPATHOLOGY; IN VIVO STUDY; INFECTION PREVENTION; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PERITONEAL CAVITY; PLASMA CONCENTRATION-TIME CURVE; PSEUDOMONAS AERUGINOSA; SILASTIC TUBE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL LOAD; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; FOREIGN BODIES; HISTOCYTOCHEMISTRY; MICE; MICE, INBRED BALB C; PERITONITIS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUORUM SENSING; TOBRAMYCIN;

EID: 84859595773     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks002     Document Type: Article

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