Cystic fibrosis upper airways primary colonization with Pseudomonas aeruginosa: Eradicated by sinonasal antibiotic inhalation

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 9, 2011, Pages 1089-1090

  Mainz, J G ^a   Michl, R ^a   Pfister, W ^a   Beck, J F ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTAZIDIME; DORNASE ALFA; SODIUM CHLORIDE; TOBRAMYCIN;

ANTIBIOTIC THERAPY; BACTERIAL COLONIZATION; CASE REPORT; CHILD; CYSTIC FIBROSIS; HUMAN; LETTER; NASAL LAVAGE; NEBULIZER; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RHINOSINUSITIS; SCHOOL CHILD; TREATMENT DURATION; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT; UPPER RESPIRATORY TRACT INFECTION;

EID: 81055139582     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/ajrccm.184.9.1089     Document Type: Letter

References (9)

1. Walter S, Gudowius P, Bosshammer J, Römling U, Weissbrodt H, Schürmann W, von der Hardt H, Tümmler B. Epidemiology of chronic Pseudomonas aeruginosa infections in the airways of lung transplant recipients with cystic fibrosis. Thorax 1997;52:318-321. (Pubitemid 27204891)
2. Mainz JG, Naehrlich L, Schien M, Käding M, Schiller I, Mayr S, Schneider G, Wiehlmann L, Wiedemann B, Cramer N, et al. Concordant genotype of upper and lower airways P. aeruginosa and S. aureus isolates in cystic fibrosis. Thorax 2009;64:535-540.
3. Hansen SK, RauMH, Johansen HK, Ciofu O, Jelsbak L, Yang L, Folkesson A, Jarmer HO, Aanæs K, von Buchwald C, et al. Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection. ISME J (In press)
4. Gysin C, Alothman GA, Papsin BC. Sinonasal disease in cystic fibrosis: clinical characteristics, diagnosis, and management. Pediatr Pulmonol 2000;30:481-489.
5. Doring G, Hoiby N; Consensus Study Group. Early intervention and prevention of lung disease in cystic fibrosis: a European consensus. J Cyst Fibros 2004;3:67-91. (Pubitemid 38987019)
6. Mainz JG, Koitschev A. Management of chronic rhinosinusitis in CF. J Cyst Fibros 2009;8S:10-14.
7. Möller W, Schuschnig U, Meyer G, Mentzel H, Keller M. Ventilation and drug delivery to the paranasal sinuses: studies in a nasal cast using pulsating airflow. Rhinology 2008;46:213-220.
8. Möller W, Schuschnig U, Khadem Saba G, Meyer G, Junge-Hülsing B, Keller M, Häussinger M. Pulsating aerosols for drug delivery to the sinuses in healthy volunteers. Otolaryngol Head Neck Surg 2010;142: 382-388.
9. Mainz JG, Schiller I, Ritschel C, Mentzel H-J, Riethmüller J, Koitschev A, Schneider G, Beck JF, Wiedemann B. Sinonasal inhalation of dornase alfa in CF: a double-blind placebo-controlled cross-over pilot trial. Auris Nasus Larynx 2011;38:220-227.