Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group

Journal of the American Chemical Society

Volumn 135, Issue 44, 2013, Pages 16705-16713

  Lee, Won Gil ^a   Gallardo Macias, Ricardo ^a   Frey, Kathleen M ^b   Spasov, Krasimir A ^b   Bollini, Mariela ^a   Anderson, Karen S ^b   Jorgensen, William L ^a  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPOUNDS; AQUEOUS SOLUBILITY; DOUBLE MUTATION; HIV REVERSE TRANSCRIPTASE; HIV-1 REVERSE TRANSCRIPTASE; HUMAN T CELLS; POTENT COMPOUNDS; X RAY CRYSTAL STRUCTURES;

COMPUTER SIMULATION;

DISEASES;

EFAVIRENZ; ETRAVIRINE; NEVIRAPINE; PHENYL GROUP; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SOLUBILITY; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION; WILD TYPE; X RAY;

ANTI-HIV AGENTS; BICYCLO COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV REVERSE TRANSCRIPTASE; HIV-1; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MONTE CARLO METHOD; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887723630     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja408917n     Document Type: Article

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