Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design

Journal of the American Chemical Society

Volumn 134, Issue 48, 2012, Pages 19501-19503

  Frey, Kathleen M ^b   Bollini, Mariela ^a   Mislak, Andrea C ^b   Cisneros, José A ^a   Gallardo Macias, Ricardo ^a   Jorgensen, William L ^a   Anderson, Karen S ^b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL ACTIVITIES; CONSERVED RESIDUES; DIETHERS; DRUG DESIGN; HALOGEN BONDING; HIGH POTENCY; HIV-1 REVERSE TRANSCRIPTASE; RESISTANCE PROFILES; STRUCTURAL ORIGIN; X RAY CRYSTAL STRUCTURES;

CHEMISTRY; SYNTHESIS (CHEMICAL);

PHENOLS;

CATECHOL DIETHER; ETHER DERIVATIVE; HALOGEN; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL BINDING; CHEMICAL INTERACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; REVERSE TRANSCRIPTION; X RAY CRYSTALLOGRAPHY;

ANTIVIRAL AGENTS; BROMINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HALOGENS; HIV REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 84870654424     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3092642     Document Type: Article

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