Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2376-2379

  Sun, Lian Qi ^a   Qin, Bingjie ^a   Huang, Li ^b   Qian, Keduo ^c   Chen, Chin Ho ^b   Lee, Kuo Hsiung ^c,d   Xie, Lan ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNC Hamner Institute for Drug Safety Sciences   (United States)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Anti HIV agents; Diarylaniline; Lead optimization; NNRTIs

Indexed keywords

2,4 DIARYLANILINE; ANILINE DERIVATIVE; DELAVIRDINE; EFAVIRENZ; ETRAVIRINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RILPIVIRINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; REACTION OPTIMIZATION; VIRUS STRAIN; WILD TYPE;

ANILINE COMPOUNDS; ANIMALS; ANTI-HIV AGENTS; CELL LINE, TUMOR; DRUG RESISTANCE, VIRAL; DRUG STABILITY; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NITRILES; PYRIMIDINES; RATS; REVERSE TRANSCRIPTASE INHIBITORS; SOLUBILITY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84862820228     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.055     Document Type: Article

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