메뉴 건너뛰기




Volumn 117, Issue 26, 2011, Pages 7079-7089

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTEIN ETS RELATED GENE; PROTEIN FLI1; PROTEIN LYL1; PROTREIN LMO2; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG;

EID: 79959825899     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-12-317990     Document Type: Article
Times cited : (83)

References (49)
  • 1
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-676. (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 2
    • 21744462604 scopus 로고    scopus 로고
    • Cancer biology: Summing up cancer stem cells
    • DOI 10.1038/4351169a
    • Huntly BJ, Gilliland DG. Cancer biology: summing up cancer stem cells. Nature. 2005;435(7046):1169-1170. (Pubitemid 40943069)
    • (2005) Nature , vol.435 , Issue.7046 , pp. 1169-1170
    • Huntly, B.J.P.1    Gilliland, D.G.2
  • 4
    • 0028307384 scopus 로고
    • A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG
    • DOI 10.1038/ng0294-146
    • Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet. 1994;6(2):146-151. (Pubitemid 24188594)
    • (1994) Nature Genetics , vol.6 , Issue.2 , pp. 146-151
    • Sorensen, P.H.B.1    Lessnick, S.L.2    Lopez-Terrada, D.3    Liu, X.F.4    Triche, T.J.5    Denny, C.T.6
  • 7
    • 24744468832 scopus 로고    scopus 로고
    • The protooncogene ERG in megakaryoblastic leukemias
    • Rainis L, Toki T, Pimanda JE, et al. The protooncogene ERG in megakaryoblastic leukemias. Cancer Res. 2005;65(17):7596-7602.
    • (2005) Cancer Res , vol.65 , Issue.17 , pp. 7596-7602
    • Rainis, L.1    Toki, T.2    Pimanda, J.E.3
  • 8
    • 79551585898 scopus 로고    scopus 로고
    • ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification
    • Taoudi S, Bee T, Hilton A, et al. ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev. 2011;25(3):251-262.
    • (2011) Genes Dev , vol.25 , Issue.3 , pp. 251-262
    • Taoudi, S.1    Bee, T.2    Hilton, A.3
  • 9
    • 77952978963 scopus 로고    scopus 로고
    • Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome
    • Ng AP, Hyland CD, Metcalf D, et al. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood. 2010;115(19):3966-3969.
    • (2010) Blood , vol.115 , Issue.19 , pp. 3966-3969
    • Ng, A.P.1    Hyland, C.D.2    Metcalf, D.3
  • 10
    • 23944458598 scopus 로고    scopus 로고
    • The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells
    • Codrington R, Pannell R, Forster A, et al. The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. PLoS Biol. 2005;3(8):e242.
    • (2005) PLoS Biol , vol.3 , Issue.8
    • Codrington, R.1    Pannell, R.2    Forster, A.3
  • 12
    • 79953833432 scopus 로고    scopus 로고
    • Promotion and maintenance of leukemia by ERG
    • Tsuzuki S, Taguchi O, Seto M. Promotion and maintenance of leukemia by ERG. Blood. 2011;117(14):3858-3868.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3858-3868
    • Tsuzuki, S.1    Taguchi, O.2    Seto, M.3
  • 13
    • 67049108075 scopus 로고    scopus 로고
    • The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development
    • Wilson NK, Miranda-Saavedra D, Kinston S, et al. The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development. Blood. 2009;113(22):5456-5465.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5456-5465
    • Wilson, N.K.1    Miranda-Saavedra, D.2    Kinston, S.3
  • 14
    • 34548565789 scopus 로고    scopus 로고
    • Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice
    • DOI 10.1158/0008-5472.CAN-06-3749
    • Caudell D, Zhang Z, Chung YJ, Aplan PD. Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice. Cancer Res. 2007;67(17):8022-8031. (Pubitemid 47395136)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 8022-8031
    • Caudell, D.1    Zhang, Z.2    Yang, J.C.3    Aplan, P.D.4
  • 15
    • 0033567901 scopus 로고    scopus 로고
    • Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment
    • Ogilvy S, Metcalf D, Gibson L, Bath ML, Harris AW, Adams JM. Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood. 1999;94(6):1855-1863. (Pubitemid 29430401)
    • (1999) Blood , vol.94 , Issue.6 , pp. 1855-1863
    • Ogilvy, S.1    Metcalf, D.2    Gibson, L.3    Bath, M.L.4    Harris, A.W.5    Adams, J.M.6
  • 16
    • 70349251808 scopus 로고    scopus 로고
    • Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells
    • Awong G, Herer E, Surh CD, Dick JE, La Motte-Mohs RN, Zuniga-Pflucker JC. Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells. Blood. 2009;114(5):972-982.
    • (2009) Blood , vol.114 , Issue.5 , pp. 972-982
    • Awong, G.1    Herer, E.2    Surh, C.D.3    Dick, J.E.4    La Motte-Mohs, R.N.5    Zuniga-Pflucker, J.C.6
  • 17
    • 0036624736 scopus 로고    scopus 로고
    • The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse
    • DOI 10.1182/blood.V99.11.4100
    • Lock RB, Liem N, Farnsworth ML, et al. The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse. Blood. 2002;99(11):4100-4108. (Pubitemid 35332053)
    • (2002) Blood , vol.99 , Issue.11 , pp. 4100-4108
    • Lock, R.B.1    Liem, N.2    Farnsworth, M.L.3    Milross, C.G.4    Xue, C.5    Tajbakhsh, M.6    Haber, M.7    Norris, M.D.8    Marshall, G.M.9    Rice, A.M.10
  • 18
    • 33745085292 scopus 로고    scopus 로고
    • Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer
    • Pimanda JE, Chan WY, Donaldson IJ, Bowen M, Green AR, Gottgens B. Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer. Blood. 2006;107(12):4737-4745.
    • (2006) Blood , vol.107 , Issue.12 , pp. 4737-4745
    • Pimanda, J.E.1    Chan, W.Y.2    Donaldson, I.J.3    Bowen, M.4    Green, A.R.5    Gottgens, B.6
  • 19
    • 66349125284 scopus 로고    scopus 로고
    • ERG is a megakaryocytic oncogene
    • Salek-Ardakani S, Smooha G, de Boer J, et al. ERG is a megakaryocytic oncogene. Cancer Res. 2009;69(11):4665-4673.
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4665-4673
    • Salek-Ardakani, S.1    Smooha, G.2    De Boer, J.3
  • 20
    • 33645227683 scopus 로고    scopus 로고
    • Notch activation is an early and critical event during Tcell leukemogenesis in Ikaros-deficient mice
    • Dumortier A, Jeannet R, Kirstetter P, et al. Notch activation is an early and critical event during Tcell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol. 2006;26(1):209-220.
    • (2006) Mol Cell Biol , vol.26 , Issue.1 , pp. 209-220
    • Dumortier, A.1    Jeannet, R.2    Kirstetter, P.3
  • 21
    • 17644382970 scopus 로고    scopus 로고
    • Regulation of lymphoid development, differentiation, and function by the Notch pathway
    • DOI 10.1146/annurev.immunol.23.021704.115747
    • Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol. 2005;23:945-974. (Pubitemid 40563190)
    • (2005) Annual Review of Immunology , vol.23 , pp. 945-974
    • Maillard, I.1    Fang, T.2    Pear, W.S.3
  • 24
    • 33644756556 scopus 로고    scopus 로고
    • Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
    • DOI 10.1182/blood-2005-07-3013
    • Lin YW, Nichols RA, Letterio JJ, Aplan PD. Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood. 2006;107(6):2540-2543. (Pubitemid 43345580)
    • (2006) Blood , vol.107 , Issue.6 , pp. 2540-2543
    • Lin, Y.-W.1    Nichols, R.A.2    Letterio, J.J.3    Aplan, P.D.4
  • 25
    • 0037448612 scopus 로고    scopus 로고
    • Molecular biology of the Ets family of transcription factors
    • DOI 10.1016/S0378-1119(02)01156-3
    • Oikawa T, Yamada T. Molecular biology of the Ets family of transcription factors. Gene. 2003;303:11-34. (Pubitemid 36151767)
    • (2003) Gene , vol.303 , Issue.1-2 , pp. 11-34
    • Oikawa, T.1    Yamada, T.2
  • 26
    • 58149158212 scopus 로고    scopus 로고
    • Genome-wide analysis of the zebrafish ETS family identifies 3 genes required for hemangioblast differentiation or angiogenesis
    • Liu F, Patient R. Genome-wide analysis of the zebrafish ETS family identifies 3 genes required for hemangioblast differentiation or angiogenesis. Circ Res. 2008;103(10):1147-1154.
    • (2008) Circ Res , vol.103 , Issue.10 , pp. 1147-1154
    • Liu, F.1    Patient, R.2
  • 27
    • 65349165222 scopus 로고    scopus 로고
    • ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
    • Stankiewicz MJ, Crispino JD. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood. 2009;113(14):3337-3347.
    • (2009) Blood , vol.113 , Issue.14 , pp. 3337-3347
    • Stankiewicz, M.J.1    Crispino, J.D.2
  • 28
    • 33646203680 scopus 로고    scopus 로고
    • Development of human lymphoid cells
    • Blom B, Spits H. Development of human lymphoid cells. Annu Rev Immunol. 2006;24:287-320.
    • (2006) Annu Rev Immunol , vol.24 , pp. 287-320
    • Blom, B.1    Spits, H.2
  • 29
    • 63349106061 scopus 로고    scopus 로고
    • Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia
    • Bohne A, Schlee C, Mossner M, et al. Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia. Leuk Res. 2009;33(6):817-822.
    • (2009) Leuk Res , vol.33 , Issue.6 , pp. 817-822
    • Bohne, A.1    Schlee, C.2    Mossner, M.3
  • 30
    • 33644830601 scopus 로고    scopus 로고
    • Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
    • Marcucci G, Baldus CD, Ruppert AS, et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J Clin Oncol. 2005;23(36):9234-9242.
    • (2005) J Clin Oncol , vol.23 , Issue.36 , pp. 9234-9242
    • Marcucci, G.1    Baldus, C.D.2    Ruppert, A.S.3
  • 31
    • 57249098433 scopus 로고    scopus 로고
    • Development of T cells
    • Paul WE, ed. 6th ed. Philadelphia: Lippincott Williams & Wilkins
    • Rothenberg EV, Yui MA. Development of T cells. In: Paul WE, ed. Fundamental Immunology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2008.
    • (2008) Fundamental Immunology
    • Rothenberg, E.V.1    Yui, M.A.2
  • 32
    • 77954324819 scopus 로고    scopus 로고
    • Fine-scale staging of T cell lineage commitment in adult mouse thymus
    • Yui MA, Feng N, Rothenberg EV. Fine-scale staging of T cell lineage commitment in adult mouse thymus. J Immunol. 2010;185(1):284-293.
    • (2010) J Immunol , vol.185 , Issue.1 , pp. 284-293
    • Yui, M.A.1    Feng, N.2    Rothenberg, E.V.3
  • 33
    • 77954321988 scopus 로고    scopus 로고
    • An essential developmental checkpoint for production of the T cell lineage
    • Ikawa T, Hirose S, Masuda K, et al. An essential developmental checkpoint for production of the T cell lineage. Science. 2010;329(5987):93-96.
    • (2010) Science , vol.329 , Issue.5987 , pp. 93-96
    • Ikawa, T.1    Hirose, S.2    Masuda, K.3
  • 34
    • 0032784934 scopus 로고    scopus 로고
    • Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage
    • Anderson MK, Hernandez-Hoyos G, Diamond RA, Rothenberg EV. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development. 1999;126(14):3131-3148. (Pubitemid 29378177)
    • (1999) Development , vol.126 , Issue.14 , pp. 3131-3148
    • Anderson, M.K.1    Hernandez-Hoyos, G.2    Diamond, R.A.3    Rothenberg, E.V.4
  • 35
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • DOI 10.1126/science.278.5340.1059
    • Look AT. Oncogenic transcription factors in the human acute leukemias. Science. 1997;278(5340):1059-1064. (Pubitemid 27517875)
    • (1997) Science , vol.278 , Issue.5340 , pp. 1059-1064
    • Look, A.T.1
  • 37
    • 0030999645 scopus 로고    scopus 로고
    • The LIMonly protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
    • Wadman IA, Osada H, Grutz GG, et al. The LIMonly protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 1997;16(11):3145-3157.
    • (1997) EMBO J , vol.16 , Issue.11 , pp. 3145-3157
    • Wadman, I.A.1    Osada, H.2    Grutz, G.G.3
  • 38
    • 78049346302 scopus 로고    scopus 로고
    • A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients
    • Oram SH, Thoms JA, Pridans C, et al. A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients. Oncogene. 2010;29(43):5796-5808.
    • (2010) Oncogene , vol.29 , Issue.43 , pp. 5796-5808
    • Oram, S.H.1    Thoms, J.A.2    Pridans, C.3
  • 39
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • Yu J, Mani RS, Cao Q, et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell. 2010;17(5):443-454.
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 443-454
    • Yu, J.1    Mani, R.S.2    Cao, Q.3
  • 40
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • Carver BS, Tran J, Gopalan A, et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet. 2009;41(5):619-624.
    • (2009) Nat Genet , vol.41 , Issue.5 , pp. 619-624
    • Carver, B.S.1    Tran, J.2    Gopalan, A.3
  • 41
    • 27244440324 scopus 로고    scopus 로고
    • Molecular genetics of acute lymphoblastic leukemia
    • DOI 10.1200/JCO.2005.05.047
    • Armstrong SA, Look AT. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol. 2005;23(26):6306-6315. (Pubitemid 46218840)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.26 , pp. 6306-6315
    • Armstrong, S.A.1    Look, A.T.2
  • 42
    • 76749097260 scopus 로고    scopus 로고
    • The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal
    • McCormack MP, Young LF, Vasudevan S, et al. The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science. 2010;327(5967):879-883.
    • (2010) Science , vol.327 , Issue.5967 , pp. 879-883
    • McCormack, M.P.1    Young, L.F.2    Vasudevan, S.3
  • 43
    • 77957943127 scopus 로고    scopus 로고
    • ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours
    • Chi P, Chen Y, Zhang L, et al. ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature. 2010;467(7317):849-853.
    • (2010) Nature , vol.467 , Issue.7317 , pp. 849-853
    • Chi, P.1    Chen, Y.2    Zhang, L.3
  • 44
    • 0035515347 scopus 로고    scopus 로고
    • The ET. S-domain transcription factor family
    • Sharrocks ADThe ET. S-domain transcription factor family. Nat Rev Mol Cell Biol. 2001;2(11):827-837.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.11 , pp. 827-837
    • Sharrocks, A.D.1
  • 45
    • 77957348625 scopus 로고    scopus 로고
    • Combinatorial transcriptional control in blood stem/progenitor cells: Genome-wide analysis of 10 major transcriptional regulators
    • Wilson NK, Foster SD, Wang X, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of 10 major transcriptional regulators. Cell Stem Cell. 2010;7(4):532-544.
    • (2010) Cell Stem Cell , vol.7 , Issue.4 , pp. 532-544
    • Wilson, N.K.1    Foster, S.D.2    Wang, X.3
  • 46
    • 58749095816 scopus 로고    scopus 로고
    • Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia
    • Coustan-Smith E, Mullighan CG, Onciu M, et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 2009;10(2):147-156.
    • (2009) Lancet Oncol , vol.10 , Issue.2 , pp. 147-156
    • Coustan-Smith, E.1    Mullighan, C.G.2    Onciu, M.3
  • 47
    • 37549010335 scopus 로고    scopus 로고
    • Launching the T-cell-lineage developmental programme
    • Rothenberg EV, Moore JE, Yui MA. Launching the T-cell-lineage developmental programme. Nat Rev Immunol. 2008;8(1):9-21.
    • (2008) Nat Rev Immunol , vol.8 , Issue.1 , pp. 9-21
    • Rothenberg, E.V.1    Moore, J.E.2    Yui, M.A.3
  • 49
    • 42049087865 scopus 로고    scopus 로고
    • The earliest thymic progenitors for T cells possess myeloid lineage potential
    • DOI 10.1038/nature06840, PII NATURE06840
    • Bell JJ, Bhandoola A. The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature. 2008;452(7188):764-767. (Pubitemid 351521083)
    • (2008) Nature , vol.452 , Issue.7188 , pp. 764-767
    • Bell, J.J.1    Bhandoola, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.