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Volumn 170, Issue 7, 2013, Pages 1293-1307

CGRP in the trigeminovascular system: A role for CGRP, adrenomedullin and amylin receptors?

Author keywords

Amylin; calcitonin gene related peptide; CGRP; G protein coupled receptor; GPCR; migraine; trigeminal ganglia; trigeminovascular system

Indexed keywords

ADENYLATE CYCLASE; ADRENOMEDULLIN; AMYLIN RECEPTOR; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN RECEPTOR LIKE RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CAPSAICIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE SYNTHASE; POTASSIUM CHLORIDE; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; CALCITONIN RECEPTOR; CENTRAL NERVOUS SYSTEM AGENTS;

EID: 84887643807     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12129     Document Type: Review
Times cited : (73)

References (137)
  • 2
    • 72149097863 scopus 로고    scopus 로고
    • Guide to Receptors and Channels (GRAC), 4th edition
    • Alexander SP, Mathie A, Peters JA, (2009). Guide to Receptors and Channels (GRAC), 4th edition. Br J Pharmacol 158 (Suppl. 1): S1-S254.
    • (2009) Br J Pharmacol , vol.158 , Issue.SUPPL. 1
    • Alexander, S.P.1    Mathie, A.2    Peters, J.A.3
  • 3
    • 65349194408 scopus 로고    scopus 로고
    • Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies
    • Ambalavanar R, Dessem D, (2009). Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies. J Dent Res 88: 201-211.
    • (2009) J Dent Res , vol.88 , pp. 201-211
    • Ambalavanar, R.1    Dessem, D.2
  • 4
    • 10644231738 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide regulates gene transcription in primary afferent neurons
    • Anderson LE, Seybold VS, (2004). Calcitonin gene-related peptide regulates gene transcription in primary afferent neurons. J Neurochem 91: 1417-1429.
    • (2004) J Neurochem , vol.91 , pp. 1417-1429
    • Anderson, L.E.1    Seybold, V.S.2
  • 5
    • 0023860342 scopus 로고
    • Brain stem terminations of the trigeminal and upper spinal ganglia innervation of the cerebrovascular system: WGA-HRP transganglionic study
    • Arbab MA, Delgado T, Wiklund L, Svendgaard NA, (1988). Brain stem terminations of the trigeminal and upper spinal ganglia innervation of the cerebrovascular system: WGA-HRP transganglionic study. J Cereb Blood Flow Metab 8: 54-63.
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 54-63
    • Arbab, M.A.1    Delgado, T.2    Wiklund, L.3    Svendgaard, N.A.4
  • 6
    • 0036372264 scopus 로고    scopus 로고
    • Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in pulp tissue from painful and healthy human teeth
    • Awawdeh L, Lundy FT, Shaw C, Lamey PJ, Linden GJ, Kennedy JG, (2002). Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in pulp tissue from painful and healthy human teeth. Int Endod J 35: 30-36.
    • (2002) Int Endod J , vol.35 , pp. 30-36
    • Awawdeh, L.1    Lundy, F.T.2    Shaw, C.3    Lamey, P.J.4    Linden, G.J.5    Kennedy, J.G.6
  • 7
    • 33747276441 scopus 로고    scopus 로고
    • Pharmacology of the human CGRP1 receptor in Cos 7 cells
    • Bailey RJ, Hay DL, (2006). Pharmacology of the human CGRP1 receptor in Cos 7 cells. Peptides 27: 1367-1375.
    • (2006) Peptides , vol.27 , pp. 1367-1375
    • Bailey, R.J.1    Hay, D.L.2
  • 8
    • 9644291506 scopus 로고    scopus 로고
    • Immunohistochemical mapping of calcitonin receptors in the adult rat brain
    • Becskei C, Riediger T, Zund D, Wookey P, Lutz TA, (2004). Immunohistochemical mapping of calcitonin receptors in the adult rat brain. Brain Res 1030: 221-233.
    • (2004) Brain Res , vol.1030 , pp. 221-233
    • Becskei, C.1    Riediger, T.2    Zund, D.3    Wookey, P.4    Lutz, T.A.5
  • 9
    • 84887654536 scopus 로고    scopus 로고
    • Calcitonin Receptor and receptor activity-modifying protein 1 expression in the human medulla
    • London 2011. Available at (accessed 3/11/2013)
    • Bower RL, Valdvogel HJ, Faull RLM, Hay DL, (2011). Calcitonin Receptor and receptor activity-modifying protein 1 expression in the human medulla. British Pharmacological Society Winter Meeting. London 2011. Available at: http://www.pa2online.org/abstracts/vol9issue3abst066p.pdf (accessed 3/11/2013).
    • (2011) British Pharmacological Society Winter Meeting
    • Bower, R.L.1    Valdvogel, H.J.2    Faull, R.L.M.3    Hay, D.L.4
  • 10
    • 3042597423 scopus 로고    scopus 로고
    • Vascular actions of calcitonin gene-related peptide and adrenomedullin
    • Brain SD, Grant AD, (2004). Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 84: 903-934.
    • (2004) Physiol Rev , vol.84 , pp. 903-934
    • Brain, S.D.1    Grant, A.D.2
  • 11
    • 0033279612 scopus 로고    scopus 로고
    • A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1
    • Buhlmann N, Leuthauser K, Muff R, Fischer JA, Born W, (1999). A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1. Endocrinology 140: 2883-2890.
    • (1999) Endocrinology , vol.140 , pp. 2883-2890
    • Buhlmann, N.1    Leuthauser, K.2    Muff, R.3    Fischer, J.A.4    Born, W.5
  • 12
    • 33750910190 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons
    • Buldyrev I, Tanner NM, Hsieh HY, Dodd EG, Nguyen LT, Balkowiec A, (2006). Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons. J Neurochem 99: 1338-1350.
    • (2006) J Neurochem , vol.99 , pp. 1338-1350
    • Buldyrev, I.1    Tanner, N.M.2    Hsieh, H.Y.3    Dodd, E.G.4    Nguyen, L.T.5    Balkowiec, A.6
  • 13
    • 82655162516 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization
    • Cady RJ, Glenn JR, Smith KM, Durham PL, (2011). Calcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization. Mol Pain 7: 94.
    • (2011) Mol Pain , vol.7 , pp. 94
    • Cady, R.J.1    Glenn, J.R.2    Smith, K.M.3    Durham, P.L.4
  • 14
    • 70349899104 scopus 로고    scopus 로고
    • Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan
    • Cady RK, Vause CV, Ho TW, Bigal ME, Durham PL, (2009). Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan. Headache 49: 1258-1266.
    • (2009) Headache , vol.49 , pp. 1258-1266
    • Cady, R.K.1    Vause, C.V.2    Ho, T.W.3    Bigal, M.E.4    Durham, P.L.5
  • 15
    • 34547152636 scopus 로고    scopus 로고
    • Nociceptin (1-13)NH2 inhibits stimulated calcitonin-gene-related-peptide release from primary cultures of rat trigeminal ganglia neurones
    • Capuano A, Curro D, Dello Russo C, Tringali G, Pozzoli G, Di Trapani G, et al. (2007). Nociceptin (1-13)NH2 inhibits stimulated calcitonin-gene-related- peptide release from primary cultures of rat trigeminal ganglia neurones. Cephalalgia 27: 868-876.
    • (2007) Cephalalgia , vol.27 , pp. 868-876
    • Capuano, A.1    Curro, D.2    Dello Russo, C.3    Tringali, G.4    Pozzoli, G.5    Di Trapani, G.6
  • 16
    • 0030983875 scopus 로고    scopus 로고
    • Activation of adenylyl cyclase in human myometrial smooth muscle cells by neuropeptides
    • Casey ML, Smith J, Alsabrook G, MacDonald PC, (1997). Activation of adenylyl cyclase in human myometrial smooth muscle cells by neuropeptides. J Clin Endocrinol Metab 82: 3087-3092.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3087-3092
    • Casey, M.L.1    Smith, J.2    Alsabrook, G.3    Macdonald, P.C.4
  • 17
    • 79952417084 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: Implications for basic mechanisms of migraine pain
    • Ceruti S, Villa G, Fumagalli M, Colombo L, Magni G, Zanardelli M, et al. (2011). Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain. J Neurosci 31: 3638-3649.
    • (2011) J Neurosci , vol.31 , pp. 3638-3649
    • Ceruti, S.1    Villa, G.2    Fumagalli, M.3    Colombo, L.4    Magni, G.5    Zanardelli, M.6
  • 19
    • 0035987789 scopus 로고    scopus 로고
    • Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines
    • Choksi T, Hay DL, Legon S, Poyner DR, Hagner S, Bloom SR, et al. (2002). Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines. Br J Pharmacol 136: 784-792.
    • (2002) Br J Pharmacol , vol.136 , pp. 784-792
    • Choksi, T.1    Hay, D.L.2    Legon, S.3    Poyner, D.R.4    Hagner, S.5    Bloom, S.R.6
  • 20
    • 0028138906 scopus 로고
    • Calcitonin gene-related peptide receptors in human gastrointestinal epithelia
    • Cox HM, Tough IR, (1994). Calcitonin gene-related peptide receptors in human gastrointestinal epithelia. Br J Pharmacol 113: 1243-1248.
    • (1994) Br J Pharmacol , vol.113 , pp. 1243-1248
    • Cox, H.M.1    Tough, I.R.2
  • 21
    • 0018248334 scopus 로고
    • The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system
    • Cuello AC, Del Fiacco M, Paxinos G, (1978). The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system. Brain Res 152: 499-500.
    • (1978) Brain Res , vol.152 , pp. 499-500
    • Cuello, A.C.1    Del Fiacco, M.2    Paxinos, G.3
  • 22
    • 80051470137 scopus 로고    scopus 로고
    • Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1beta pro-inflammatory effects
    • De Corato A, Lisi L, Capuano A, Tringali G, Tramutola A, Navarra P, et al. (2011). Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1beta pro-inflammatory effects. J Neuroimmunol 237: 39-46.
    • (2011) J Neuroimmunol , vol.237 , pp. 39-46
    • De Corato, A.1    Lisi, L.2    Capuano, A.3    Tringali, G.4    Tramutola, A.5    Navarra, P.6
  • 23
    • 50249096199 scopus 로고    scopus 로고
    • Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3- (7-methyl-1H-indazol-5 -yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2- yl)piperidine-1-carboxami de (BMS-694153): A potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure
    • Degnan AP, Chaturvedula PV, Conway CM, Cook DA, Davis CD, Denton R, et al. (2008). Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)- N-(3-(7-methyl-1H-indazol-5 -yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl) propan-2-yl)piperidine-1-carboxami de (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. J Med Chem 51: 4858-4861.
    • (2008) J Med Chem , vol.51 , pp. 4858-4861
    • Degnan, A.P.1    Chaturvedula, P.V.2    Conway, C.M.3    Cook, D.A.4    Davis, C.D.5    Denton, R.6
  • 24
    • 79953220801 scopus 로고    scopus 로고
    • BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study
    • Diener HC, Barbanti P, Dahlof C, Reuter U, Habeck J, Podhorna J, (2011). BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia 31: 573-584.
    • (2011) Cephalalgia , vol.31 , pp. 573-584
    • Diener, H.C.1    Barbanti, P.2    Dahlof, C.3    Reuter, U.4    Habeck, J.5    Podhorna, J.6
  • 25
    • 0033766333 scopus 로고    scopus 로고
    • Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line
    • Disa J, Parameswaran N, Nambi P, Aiyar N, (2000). Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line. Neuropeptides 34: 229-233.
    • (2000) Neuropeptides , vol.34 , pp. 229-233
    • Disa, J.1    Parameswaran, N.2    Nambi, P.3    Aiyar, N.4
  • 26
    • 0033970471 scopus 로고    scopus 로고
    • Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
    • Doods H, Hallermayer G, Wu D, Entzeroth M, Rudolf K, Engel W, et al. (2000). Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br J Pharmacol 129: 420-423.
    • (2000) Br J Pharmacol , vol.129 , pp. 420-423
    • Doods, H.1    Hallermayer, G.2    Wu, D.3    Entzeroth, M.4    Rudolf, K.5    Engel, W.6
  • 28
    • 0022255204 scopus 로고
    • Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat
    • Edvinsson L, Fredholm BB, Hamel E, Jansen I, Verrecchia C, (1985). Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neurosci Lett 58: 213-217.
    • (1985) Neurosci Lett , vol.58 , pp. 213-217
    • Edvinsson, L.1    Fredholm, B.B.2    Hamel, E.3    Jansen, I.4    Verrecchia, C.5
  • 29
    • 0023589412 scopus 로고
    • Calcitonin gene-related peptide and cerebral blood vessels: Distribution and vasomotor effects
    • Edvinsson L, Ekman R, Jansen I, McCulloch J, Uddman R, (1987a). Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects. J Cereb Blood Flow Metab 7: 720-728.
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 720-728
    • Edvinsson, L.1    Ekman, R.2    Jansen, I.3    McCulloch, J.4    Uddman, R.5
  • 30
    • 0023261031 scopus 로고
    • Peptide-containing nerve fibers in human cerebral arteries: Immunocytochemistry, radioimmunoassay, and in vitro pharmacology
    • Edvinsson L, Ekman R, Jansen I, Ottosson A, Uddman R, (1987b). Peptide-containing nerve fibers in human cerebral arteries: immunocytochemistry, radioimmunoassay, and in vitro pharmacology. Ann Neurol 21: 431-437.
    • (1987) Ann Neurol , vol.21 , pp. 431-437
    • Edvinsson, L.1    Ekman, R.2    Jansen, I.3    Ottosson, A.4    Uddman, R.5
  • 31
    • 0001458174 scopus 로고    scopus 로고
    • Amylin: Localization, effects on cerebral arteries and on local cerebral blood flow in the cat
    • Edvinsson L, Goadsby PJ, Uddman R, (2001). Amylin: localization, effects on cerebral arteries and on local cerebral blood flow in the cat. ScientificWorldJournal 1: 168-180.
    • (2001) ScientificWorldJournal , vol.1 , pp. 168-180
    • Edvinsson, L.1    Goadsby, P.J.2    Uddman, R.3
  • 32
    • 33847671313 scopus 로고    scopus 로고
    • Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery
    • Edvinsson L, Nilsson E, Jansen-Olesen I, (2007). Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery. Br J Pharmacol 150: 633-640.
    • (2007) Br J Pharmacol , vol.150 , pp. 633-640
    • Edvinsson, L.1    Nilsson, E.2    Jansen-Olesen, I.3
  • 33
    • 79952113515 scopus 로고    scopus 로고
    • Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries
    • Edvinsson L, Chan KY, Eftekhari S, Vries R, Saveland H, et al. (2010). Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries. Cephalalgia 30: 1233-1240.
    • (2010) Cephalalgia , vol.30 , pp. 1233-1240
    • Edvinsson, L.1    Chan, K.Y.2    Eftekhari, S.3    Vries, R.4    Saveland, H.5
  • 34
    • 78649940547 scopus 로고    scopus 로고
    • Possible sites of action of the new calcitonin gene-related peptide receptor antagonists
    • Eftekhari S, Edvinsson L, (2010). Possible sites of action of the new calcitonin gene-related peptide receptor antagonists. Ther Adv Neurol Disord 3: 369-378.
    • (2010) Ther Adv Neurol Disord , vol.3 , pp. 369-378
    • Eftekhari, S.1    Edvinsson, L.2
  • 35
    • 81055126935 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level
    • Eftekhari S, Edvinsson L, (2011). Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level. BMC Neurosci 12: 112.
    • (2011) BMC Neurosci , vol.12 , pp. 112
    • Eftekhari, S.1    Edvinsson, L.2
  • 36
    • 77954620156 scopus 로고    scopus 로고
    • Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
    • Eftekhari S, Salvatore CA, Calamari A, Kane SA, Tajti J, Edvinsson L, (2010). Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion. Neuroscience 169: 683-696.
    • (2010) Neuroscience , vol.169 , pp. 683-696
    • Eftekhari, S.1    Salvatore, C.A.2    Calamari, A.3    Kane, S.A.4    Tajti, J.5    Edvinsson, L.6
  • 37
    • 77957273260 scopus 로고    scopus 로고
    • Lack of adrenomedullin in the central nervous system results in apparently paradoxical alterations on pain sensitivity
    • Fernandez AP, Serrano J, Martinez-Murillo R, Martinez A, (2010). Lack of adrenomedullin in the central nervous system results in apparently paradoxical alterations on pain sensitivity. Endocrinology 151: 4908-4915.
    • (2010) Endocrinology , vol.151 , pp. 4908-4915
    • Fernandez, A.P.1    Serrano, J.2    Martinez-Murillo, R.3    Martinez, A.4
  • 38
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups and fingerprints
    • Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB, (2003). The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups and fingerprints. Mol Pharmacol 63: 1256-1272.
    • (2003) Mol Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerström, M.C.2    Lundin, L.G.3    Schiöth, H.B.4
  • 40
    • 0036168813 scopus 로고    scopus 로고
    • Migraine management: Contrasting patient preferences with current clinical end points: Introduction
    • Goadsby PJ, (2002). Migraine management: contrasting patient preferences with current clinical end points: introduction. Headache 42 (Suppl. 1): 1-2.
    • (2002) Headache , vol.42 , Issue.SUPPL. 1 , pp. 1-2
    • Goadsby, P.J.1
  • 41
    • 0023874663 scopus 로고
    • Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
    • Goadsby PJ, Edvinsson L, Ekman R, (1988). Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 23: 193-196.
    • (1988) Ann Neurol , vol.23 , pp. 193-196
    • Goadsby, P.J.1    Edvinsson, L.2    Ekman, R.3
  • 42
    • 0025143541 scopus 로고
    • Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
    • Goadsby PJ, Edvinsson L, Ekman R, (1990). Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28: 183-187.
    • (1990) Ann Neurol , vol.28 , pp. 183-187
    • Goadsby, P.J.1    Edvinsson, L.2    Ekman, R.3
  • 43
    • 29844443451 scopus 로고    scopus 로고
    • Characterisation of CGRP receptors in human and porcine isolated coronary arteries: Evidence for CGRP receptor heterogeneity
    • Gupta S, Mehrotra S, Villalon CM, Garrelds IM, de, Vries R, van, Kats JP, et al. (2006). Characterisation of CGRP receptors in human and porcine isolated coronary arteries: evidence for CGRP receptor heterogeneity. Eur J Pharmacol 530: 107-116.
    • (2006) Eur J Pharmacol , vol.530 , pp. 107-116
    • Gupta, S.1    Mehrotra, S.2    Villalon, C.M.3    De Garrelds, I.M.4    Van Vries, R.5    Kats, J.P.6
  • 44
    • 77956336134 scopus 로고    scopus 로고
    • Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism
    • ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, et al. (2010). Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure 18: 1083-1093.
    • (2010) Structure , vol.18 , pp. 1083-1093
    • Ter Haar, E.1    Koth, C.M.2    Abdul-Manan, N.3    Swenson, L.4    Coll, J.T.5    Lippke, J.A.6
  • 45
    • 84863814650 scopus 로고    scopus 로고
    • Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma
    • Hagner S, Welz H, Kicic A, Alrifai M, Marsh LM, Sutanto EN, et al. (2012). Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma. Allergy 67: 998-1006.
    • (2012) Allergy , vol.67 , pp. 998-1006
    • Hagner, S.1    Welz, H.2    Kicic, A.3    Alrifai, M.4    Marsh, L.M.5    Sutanto, E.N.6
  • 46
    • 78650413846 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura
    • Hansen JM, Hauge AW, Olesen J, Ashina M, (2010). Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia 30: 1179-1186.
    • (2010) Cephalalgia , vol.30 , pp. 1179-1186
    • Hansen, J.M.1    Hauge, A.W.2    Olesen, J.3    Ashina, M.4
  • 47
    • 0034858770 scopus 로고    scopus 로고
    • CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with 'Compound 1' (WO98/11128), a non-peptide antagonist
    • Hasbak P, Sams A, Schifter S, Longmore J, Edvinsson L, (2001). CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with 'Compound 1' (WO98/11128), a non-peptide antagonist. Br J Pharmacol 133: 1405-1413.
    • (2001) Br J Pharmacol , vol.133 , pp. 1405-1413
    • Hasbak, P.1    Sams, A.2    Schifter, S.3    Longmore, J.4    Edvinsson, L.5
  • 48
    • 0037216736 scopus 로고    scopus 로고
    • Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist
    • Hasbak P, Saetrum Opgaard O, Eskesen K, Schifter S, Arendrup H, Longmore J, et al. (2003). Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist. J Pharmacol Exp Ther 304: 326-333.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 326-333
    • Hasbak, P.1    Saetrum Opgaard, O.2    Eskesen, K.3    Schifter, S.4    Arendrup, H.5    Longmore, J.6
  • 49
    • 0036729745 scopus 로고    scopus 로고
    • A comparison of the actions of BIBN4096BS and CGRP(8-37) on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells
    • Hay DL, Howitt SG, Conner AC, Doods H, Schindler M, Poyner DR, (2002). A comparison of the actions of BIBN4096BS and CGRP(8-37) on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells. Br J Pharmacol 137: 80-86.
    • (2002) Br J Pharmacol , vol.137 , pp. 80-86
    • Hay, D.L.1    Howitt, S.G.2    Conner, A.C.3    Doods, H.4    Schindler, M.5    Poyner, D.R.6
  • 50
    • 0142153874 scopus 로고    scopus 로고
    • CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: A comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS
    • Hay DL, Howitt SG, Conner AC, Schindler M, Smith DM, Poyner DR, (2003). CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS. Br J Pharmacol 140: 477-486.
    • (2003) Br J Pharmacol , vol.140 , pp. 477-486
    • Hay, D.L.1    Howitt, S.G.2    Conner, A.C.3    Schindler, M.4    Smith, D.M.5    Poyner, D.R.6
  • 51
    • 17844365264 scopus 로고    scopus 로고
    • Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes
    • Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM, (2005). Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Mol Pharmacol 67: 1655-1665.
    • (2005) Mol Pharmacol , vol.67 , pp. 1655-1665
    • Hay, D.L.1    Christopoulos, G.2    Christopoulos, A.3    Poyner, D.R.4    Sexton, P.M.5
  • 52
    • 33751073196 scopus 로고    scopus 로고
    • Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4- pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1- [(3,5-dibromo-4- hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2 H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors-The role of receptor activity modifying protein 1
    • Hay DL, Christopoulos G, Christopoulos A, Sexton PM, (2006). Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl] carbonyl]pentyl]amino]-1- [(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4- (1,4-dihydro-2-oxo-3(2 H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors-the role of receptor activity modifying protein 1. Mol Pharmacol 70: 1984-1991.
    • (2006) Mol Pharmacol , vol.70 , pp. 1984-1991
    • Hay, D.L.1    Christopoulos, G.2    Christopoulos, A.3    Sexton, P.M.4
  • 53
    • 79251472138 scopus 로고    scopus 로고
    • Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: Opportunities and challenges
    • Hay DL, Walker CS, Poyner DR, (2011). Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges. Endocr Relat Cancer 18: C1-C14.
    • (2011) Endocr Relat Cancer , vol.18
    • Hay, D.L.1    Walker, C.S.2    Poyner, D.R.3
  • 54
    • 0019859031 scopus 로고
    • Capsaicin and potassium evoked substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus in vitro
    • Helke CJ, Jacobowitz DM, Thoa NB, (1981). Capsaicin and potassium evoked substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus in vitro. Life Sci 29: 1779-1785.
    • (1981) Life Sci , vol.29 , pp. 1779-1785
    • Helke, C.J.1    Jacobowitz, D.M.2    Thoa, N.B.3
  • 55
    • 79954607744 scopus 로고    scopus 로고
    • Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine
    • Hewitt DJ, Aurora SK, Dodick DW, Goadsby PJ, Ge YJ, Bachman R, et al. (2011). Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine. Cephalalgia 31: 712-722.
    • (2011) Cephalalgia , vol.31 , pp. 712-722
    • Hewitt, D.J.1    Aurora, S.K.2    Dodick, D.W.3    Goadsby, P.J.4    Ge, Y.J.5    Bachman, R.6
  • 56
    • 0035834719 scopus 로고    scopus 로고
    • Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin
    • Hilairet S, Belanger C, Bertrand J, Laperriere A, Foord SM, Bouvier M, (2001). Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. J Biol Chem 276: 42182-42190.
    • (2001) J Biol Chem , vol.276 , pp. 42182-42190
    • Hilairet, S.1    Belanger, C.2    Bertrand, J.3    Laperriere, A.4    Foord, S.M.5    Bouvier, M.6
  • 57
    • 57649233374 scopus 로고    scopus 로고
    • Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: A randomised, placebo-controlled, parallel-treatment trial
    • Ho TW, Ferrari MD, Dodick DW, Galet V, Kost J, Fan X, et al. (2008). Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 372: 2115-2123.
    • (2008) Lancet , vol.372 , pp. 2115-2123
    • Ho, T.W.1    Ferrari, M.D.2    Dodick, D.W.3    Galet, V.4    Kost, J.5    Fan, X.6
  • 58
    • 84863696738 scopus 로고    scopus 로고
    • Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF
    • Hoffmann J, Wecker S, Neeb L, Dirnagl U, Reuter U, (2012). Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF. Cephalalgia 32: 659-667.
    • (2012) Cephalalgia , vol.32 , pp. 659-667
    • Hoffmann, J.1    Wecker, S.2    Neeb, L.3    Dirnagl, U.4    Reuter, U.5
  • 59
    • 1242288635 scopus 로고    scopus 로고
    • Pharmacological coupling and functional role for CGRP receptors in the vasodilation of rat pial arterioles
    • Hong KW, Yoo SE, Yu SS, Lee JY, Rhim BY, (1996). Pharmacological coupling and functional role for CGRP receptors in the vasodilation of rat pial arterioles. Am J Physiol 270 (1 Pt 2): H317-H323.
    • (1996) Am J Physiol , vol.270 , Issue.1 PART 2
    • Hong, K.W.1    Yoo, S.E.2    Yu, S.S.3    Lee, J.Y.4    Rhim, B.Y.5
  • 60
    • 65549123026 scopus 로고    scopus 로고
    • ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity
    • Huang L, Li B, Li W, Guo H, Zou F, (2009). ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity. Carcinogenesis 30: 737-744.
    • (2009) Carcinogenesis , vol.30 , pp. 737-744
    • Huang, L.1    Li, B.2    Li, W.3    Guo, H.4    Zou, F.5
  • 64
    • 0031787886 scopus 로고    scopus 로고
    • Adrenomedullin as a novel growth-promoting factor for cultured vascular smooth muscle cells: Role of tyrosine kinase-mediated mitogen-activated protein kinase activation
    • Iwasaki H, Eguchi S, Shichiri M, Marumo F, Hirata Y, (1998). Adrenomedullin as a novel growth-promoting factor for cultured vascular smooth muscle cells: role of tyrosine kinase-mediated mitogen-activated protein kinase activation. Endocrinology 139: 3432-3441.
    • (1998) Endocrinology , vol.139 , pp. 3432-3441
    • Iwasaki, H.1    Eguchi, S.2    Shichiri, M.3    Marumo, F.4    Hirata, Y.5
  • 65
    • 0035794027 scopus 로고    scopus 로고
    • Characterization of CGRP(1) receptors in the guinea pig basilar artery
    • Jansen-Olesen I, Kaarill L, Edvinsson L, (2001). Characterization of CGRP(1) receptors in the guinea pig basilar artery. Eur J Pharmacol 414: 249-258.
    • (2001) Eur J Pharmacol , vol.414 , pp. 249-258
    • Jansen-Olesen, I.1    Kaarill, L.2    Edvinsson, L.3
  • 66
    • 0344827157 scopus 로고    scopus 로고
    • In-depth characterization of CGRP receptors in human intracranial arteries
    • Jansen-Olesen I, Jorgensen L, Engel U, Edvinsson L, (2003). In-depth characterization of CGRP receptors in human intracranial arteries. Eur J Pharmacol 481: 207-216.
    • (2003) Eur J Pharmacol , vol.481 , pp. 207-216
    • Jansen-Olesen, I.1    Jorgensen, L.2    Engel, U.3    Edvinsson, L.4
  • 67
    • 0027198997 scopus 로고
    • Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo
    • Kitazono T, Heistad DD, Faraci FM, (1993). Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol 265 (2 Pt 2): H581-H585.
    • (1993) Am J Physiol , vol.265 , Issue.2 PART 2
    • Kitazono, T.1    Heistad, D.D.2    Faraci, F.M.3
  • 68
    • 61849148972 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide receptor inhibition reduces neuronal activity induced by prolonged increase in nitric oxide in the rat spinal trigeminal nucleus
    • Koulchitsky S, Fischer MJ, Messlinger K, (2009). Calcitonin gene-related peptide receptor inhibition reduces neuronal activity induced by prolonged increase in nitric oxide in the rat spinal trigeminal nucleus. Cephalalgia 29: 408-417.
    • (2009) Cephalalgia , vol.29 , pp. 408-417
    • Koulchitsky, S.1    Fischer, M.J.2    Messlinger, K.3
  • 70
    • 40949083906 scopus 로고    scopus 로고
    • Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
    • Lennerz JK, Ruhle V, Ceppa EP, Neuhuber WL, Bunnett NW, Grady EF, et al. (2008). Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distribution. J Comp Neurol 507: 1277-1299.
    • (2008) J Comp Neurol , vol.507 , pp. 1277-1299
    • Lennerz, J.K.1    Ruhle, V.2    Ceppa, E.P.3    Neuhuber, W.L.4    Bunnett, N.W.5    Grady, E.F.6
  • 71
    • 39149112474 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells
    • Li J, Vause CV, Durham PL, (2008). Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells. Brain Res 1196: 22-32.
    • (2008) Brain Res , vol.1196 , pp. 22-32
    • Li, J.1    Vause, C.V.2    Durham, P.L.3
  • 72
    • 84870996301 scopus 로고    scopus 로고
    • Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9- tetrahydro-5H-cyclohepta[b]pyri din-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An oral Calcitonin Gene-Related Peptide (CGRP) antagonist in clinical trials for treating migraine
    • Luo G, Chen L, Conway CM, Denton R, Keavy D, Signor L, et al. (2012). Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H- cyclohepta[b]pyri din-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl) piperidine-1-carboxylate (BMS-927711): an oral Calcitonin Gene-Related Peptide (CGRP) antagonist in clinical trials for treating migraine. J Med Chem 55: 10644-10651.
    • (2012) J Med Chem , vol.55 , pp. 10644-10651
    • Luo, G.1    Chen, L.2    Conway, C.M.3    Denton, R.4    Keavy, D.5    Signor, L.6
  • 73
    • 33750492937 scopus 로고    scopus 로고
    • A role for adrenomedullin as a pain-related peptide in the rat
    • Ma W, Chabot JG, Quirion R, (2006). A role for adrenomedullin as a pain-related peptide in the rat. Proc Natl Acad Sci U S A 103: 16027-16032.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16027-16032
    • Ma, W.1    Chabot, J.G.2    Quirion, R.3
  • 74
    • 0032574982 scopus 로고    scopus 로고
    • RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    • McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, et al. (1998). RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393: 333-339.
    • (1998) Nature , vol.393 , pp. 333-339
    • McLatchie, L.M.1    Fraser, N.J.2    Main, M.J.3    Wise, A.4    Brown, J.5    Thompson, N.6
  • 75
    • 0037134498 scopus 로고    scopus 로고
    • Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists
    • Mallee JJ, Salvatore CA, LeBourdelles B, Oliver KR, Longmore J, Koblan KS, et al. (2002). Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. J Biol Chem 277: 14294-14298.
    • (2002) J Biol Chem , vol.277 , pp. 14294-14298
    • Mallee, J.J.1    Salvatore, C.A.2    Lebourdelles, B.3    Oliver, K.R.4    Longmore, J.5    Koblan, K.S.6
  • 76
    • 77951872871 scopus 로고    scopus 로고
    • Beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation
    • Mangmool S, Shukla AK, Rockman HA, (2010). beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. J Cell Biol 189: 573-587.
    • (2010) J Cell Biol , vol.189 , pp. 573-587
    • Mangmool, S.1    Shukla, A.K.2    Rockman, H.A.3
  • 77
    • 0001985729 scopus 로고    scopus 로고
    • CGRP receptor heterogeneity; Use of CGRP8-37
    • Poyner D. Dickerson I. Brain S.D. (eds). Landes Bioscience: Texax
    • Marshal I, Wisskirchen FM, (2000). CGRP receptor heterogeneity; use of CGRP8-37. In:, Poyner D, Dickerson I, Brain SD, (eds). The CGRP Family. Landes Bioscience: Texax, pp. 13-23.
    • (2000) The CGRP Family , pp. 13-23
    • Marshal, I.1    Wisskirchen, F.M.2
  • 78
    • 84859712236 scopus 로고    scopus 로고
    • G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide
    • Meens MJ, Mattheij NJ, van, Loenen PB, Spijkers LJ, Lemkens P, Nelissen J, et al. (2012). G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. Br J Pharmacol 166: 297-308.
    • (2012) Br J Pharmacol , vol.166 , pp. 297-308
    • Meens, M.J.1    Van, M.N.J.2    Loenen, P.B.3    Spijkers, L.J.4    Lemkens, P.5    Nelissen, J.6
  • 79
    • 84856072587 scopus 로고    scopus 로고
    • Neuropeptide effects in the trigeminal system: Pathophysiology and clinical relevance in migraine
    • Messlinger K, Fischer MJ, Lennerz JK, (2011). Neuropeptide effects in the trigeminal system: pathophysiology and clinical relevance in migraine. Keio J Med 60: 82-89.
    • (2011) Keio J Med , vol.60 , pp. 82-89
    • Messlinger, K.1    Fischer, M.J.2    Lennerz, J.K.3
  • 80
    • 72949116357 scopus 로고    scopus 로고
    • Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74
    • Miller PS, Barwell J, Poyner DR, Wigglesworth MJ, Garland SL, Donnelly D, (2010). Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. Biochem Biophys Res Commun 391: 437-442.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 437-442
    • Miller, P.S.1    Barwell, J.2    Poyner, D.R.3    Wigglesworth, M.J.4    Garland, S.L.5    Donnelly, D.6
  • 81
    • 84859726761 scopus 로고    scopus 로고
    • Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine
    • Moore EL, Salvatore CA, (2012). Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine. Br J Pharmacol 166: 66-78.
    • (2012) Br J Pharmacol , vol.166 , pp. 66-78
    • Moore, E.L.1    Salvatore, C.A.2
  • 82
    • 0033496863 scopus 로고    scopus 로고
    • Functional calcitonin gene-related peptide type 1 and adrenomedullin receptors in human trigeminal ganglia, brain vessels, and cerebromicrovascular or astroglial cells in culture
    • Moreno MJ, Cohen Z, Stanimirovic DB, Hamel E, (1999). Functional calcitonin gene-related peptide type 1 and adrenomedullin receptors in human trigeminal ganglia, brain vessels, and cerebromicrovascular or astroglial cells in culture. J Cereb Blood Flow Metab 19: 1270-1278.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1270-1278
    • Moreno, M.J.1    Cohen, Z.2    Stanimirovic, D.B.3    Hamel, E.4
  • 84
    • 0031055439 scopus 로고    scopus 로고
    • Differential effect of insulin treatment on islet amyloid polypeptide (amylin) and insulin gene expression in streptozotocin-induced diabetes in rats
    • Mulder H, Ahren B, Sundler F, (1997). Differential effect of insulin treatment on islet amyloid polypeptide (amylin) and insulin gene expression in streptozotocin-induced diabetes in rats. J Endocrinol 152: 495-501.
    • (1997) J Endocrinol , vol.152 , pp. 495-501
    • Mulder, H.1    Ahren, B.2    Sundler, F.3
  • 85
    • 0034629226 scopus 로고    scopus 로고
    • Localization of calcitonin receptor mRNA in the mouse brain: Coexistence with serotonin transporter mRNA
    • Nakamoto H, Soeda Y, Takami S, Minami M, Satoh M, (2000). Localization of calcitonin receptor mRNA in the mouse brain: coexistence with serotonin transporter mRNA. Brain Res Mol Brain Res 76: 93-102.
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 93-102
    • Nakamoto, H.1    Soeda, Y.2    Takami, S.3    Minami, M.4    Satoh, M.5
  • 86
    • 84872393606 scopus 로고    scopus 로고
    • Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells
    • Ng KY, Yeung BH, Wong YH, Wise H, (2012). Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells. Br J Pharmacol 168: 746-760.
    • (2012) Br J Pharmacol , vol.168 , pp. 746-760
    • Ng, K.Y.1    Yeung, B.H.2    Wong, Y.H.3    Wise, H.4
  • 87
    • 0030965779 scopus 로고    scopus 로고
    • Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock
    • Nishio K, Akai Y, Murao Y, Doi N, Ueda S, Tabuse H, et al. (1997). Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock. Crit Care Med 25: 953-957.
    • (1997) Crit Care Med , vol.25 , pp. 953-957
    • Nishio, K.1    Akai, Y.2    Murao, Y.3    Doi, N.4    Ueda, S.5    Tabuse, H.6
  • 88
    • 79957762234 scopus 로고    scopus 로고
    • Emerging migraine treatments and drug targets
    • Olesen J, Ashina M, (2011). Emerging migraine treatments and drug targets. Trends Pharmacol Sci 32: 352-359.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 352-359
    • Olesen, J.1    Ashina, M.2
  • 89
    • 1542346238 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine
    • Olesen J, Diener HC, Husstedt IW, Goadsby PJ, Hall D, Meier U, et al. (2004). Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl J Med 350: 1104-1110.
    • (2004) N Engl J Med , vol.350 , pp. 1104-1110
    • Olesen, J.1    Diener, H.C.2    Husstedt, I.W.3    Goadsby, P.J.4    Hall, D.5    Meier, U.6
  • 90
    • 0036253810 scopus 로고    scopus 로고
    • Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature
    • Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG, (2002). Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab 22: 620-629.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 620-629
    • Oliver, K.R.1    Wainwright, A.2    Edvinsson, L.3    Pickard, J.D.4    Hill, R.G.5
  • 91
    • 16344395981 scopus 로고    scopus 로고
    • Alteration of cancer pain-related signals by radiation: Proteomic analysis in an animal model with cancer bone invasion
    • Park HC, Seong J, An JH, Kim J, Kim UJ, Lee BW, (2005). Alteration of cancer pain-related signals by radiation: proteomic analysis in an animal model with cancer bone invasion. Int J Radiat Oncol Biol Phys 61: 1523-1534.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 1523-1534
    • Park, H.C.1    Seong, J.2    An, J.H.3    Kim, J.4    Kim, U.J.5    Lee, B.W.6
  • 92
    • 3142624611 scopus 로고    scopus 로고
    • In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain
    • Paxinos G, Chai SY, Christopoulos G, Huang XF, Toga AW, Wang HQ, et al. (2004). In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain. J Chem Neuroanat 27: 217-236.
    • (2004) J Chem Neuroanat , vol.27 , pp. 217-236
    • Paxinos, G.1    Chai, S.Y.2    Christopoulos, G.3    Huang, X.F.4    Toga, A.W.5    Wang, H.Q.6
  • 93
    • 20044394766 scopus 로고    scopus 로고
    • Presence and function of the calcitonin gene-related peptide receptor on rat pial arteries investigated in vitro and in vivo
    • Petersen KA, Nilsson E, Olesen J, Edvinsson L, (2005). Presence and function of the calcitonin gene-related peptide receptor on rat pial arteries investigated in vitro and in vivo. Cephalalgia 25: 424-432.
    • (2005) Cephalalgia , vol.25 , pp. 424-432
    • Petersen, K.A.1    Nilsson, E.2    Olesen, J.3    Edvinsson, L.4
  • 94
    • 0031818614 scopus 로고    scopus 로고
    • Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: Studies with chimeric and other peptides
    • Poyner DR, Soomets U, Howitt SG, Langel U, (1998). Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br J Pharmacol 124: 1659-1666.
    • (1998) Br J Pharmacol , vol.124 , pp. 1659-1666
    • Poyner, D.R.1    Soomets, U.2    Howitt, S.G.3    Langel, U.4
  • 95
    • 0036266044 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
    • Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, et al. (2002). International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54: 233-246.
    • (2002) Pharmacol Rev , vol.54 , pp. 233-246
    • Poyner, D.R.1    Sexton, P.M.2    Marshall, I.3    Smith, D.M.4    Quirion, R.5    Born, W.6
  • 96
    • 84872381155 scopus 로고    scopus 로고
    • Receptor activity-modifying protein dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function
    • Qi T, Dong M, Watkins HA, Wootten D, Miller LJ, Hay DL, (2012). Receptor activity-modifying protein dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function. Br J Pharmacol 168: 644-657.
    • (2012) Br J Pharmacol , vol.168 , pp. 644-657
    • Qi, T.1    Dong, M.2    Watkins, H.A.3    Wootten, D.4    Miller, L.J.5    Hay, D.L.6
  • 97
    • 84857084559 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide in migraine: Intersection of peripheral inflammation and central modulation
    • Raddant AC, Russo AF, (2011). Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation. Expert Rev Mol Med 13: e36.
    • (2011) Expert Rev Mol Med , vol.13
    • Raddant, A.C.1    Russo, A.F.2
  • 98
    • 77955868216 scopus 로고    scopus 로고
    • New acute treatments for headache
    • Rapoport AM, (2010). New acute treatments for headache. Neurol Sci 31 (Suppl. 1): S129-S132.
    • (2010) Neurol Sci , vol.31 , Issue.SUPPL. 1
    • Rapoport, A.M.1
  • 99
    • 0030665019 scopus 로고    scopus 로고
    • Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors
    • van Rossum D, Hanisch UK, Quirion R, (1997). Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors. Neurosci Biobehav Rev 21: 649-678.
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 649-678
    • Van Rossum, D.1    Hanisch, U.K.2    Quirion, R.3
  • 100
    • 84858145008 scopus 로고    scopus 로고
    • Peripheral mechanisms of dental pain: The role of substance P
    • doi: 10.155/2012/951920.
    • Sacerdote P, Levrini L, (2012). Peripheral mechanisms of dental pain: the role of substance P. Mediators Inflamm doi: 10.155/2012/951920.
    • (2012) Mediators Inflamm
    • Sacerdote, P.1    Levrini, L.2
  • 101
    • 38749114993 scopus 로고    scopus 로고
    • Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3- difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2, 3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine
    • Salvatore CA, Hershey JC, Corcoran HA, Fay JF, Johnston VK, Moore EL, et al. (2008). Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3- difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2, 3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine. J Pharmacol Exp Ther 324: 416-421.
    • (2008) J Pharmacol Exp Ther , vol.324 , pp. 416-421
    • Salvatore, C.A.1    Hershey, J.C.2    Corcoran, H.A.3    Fay, J.F.4    Johnston, V.K.5    Moore, E.L.6
  • 102
    • 77949687406 scopus 로고    scopus 로고
    • Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist
    • Salvatore CA, Moore EL, Calamari A, Cook JJ, Michener MS, O'Malley S, et al. (2010). Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther 333: 152-160.
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 152-160
    • Salvatore, C.A.1    Moore, E.L.2    Calamari, A.3    Cook, J.J.4    Michener, M.S.5    O'Malley, S.6
  • 103
    • 0032509186 scopus 로고    scopus 로고
    • Expression of calcitonin receptor-like receptor and receptor-activity- modifying proteins in human cranial arteries
    • Sams A, Jansen-Olesen I, (1998). Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries. Neurosci Lett 258: 41-44.
    • (1998) Neurosci Lett , vol.258 , pp. 41-44
    • Sams, A.1    Jansen-Olesen, I.2
  • 104
    • 0033989163 scopus 로고    scopus 로고
    • Distribution of adrenomedullin-like immunoreactivity in the rat central nervous system by light and electron microscopy
    • Serrano J, Uttenthal LO, Martinez A, Fernandez AP, Martinez de Velasco J, Alonso D, et al. (2000). Distribution of adrenomedullin-like immunoreactivity in the rat central nervous system by light and electron microscopy. Brain Res 853: 245-268.
    • (2000) Brain Res , vol.853 , pp. 245-268
    • Serrano, J.1    Uttenthal, L.O.2    Martinez, A.3    Fernandez, A.P.4    Martinez De Velasco, J.5    Alonso, D.6
  • 105
    • 6844250774 scopus 로고    scopus 로고
    • Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats
    • Sheykhzade M, Nyborg NC, (1998). Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br J Pharmacol 123: 1464-1470.
    • (1998) Br J Pharmacol , vol.123 , pp. 1464-1470
    • Sheykhzade, M.1    Nyborg, N.C.2
  • 106
    • 0033967288 scopus 로고    scopus 로고
    • Amylin compared with calcitonin: Competitive binding studies in rat brain and antinociceptive activity
    • Sibilia V, Pagani F, Lattuada N, Rapetti D, Guidobono F, Netti C, (2000). Amylin compared with calcitonin: competitive binding studies in rat brain and antinociceptive activity. Brain Res 854: 79-84.
    • (2000) Brain Res , vol.854 , pp. 79-84
    • Sibilia, V.1    Pagani, F.2    Lattuada, N.3    Rapetti, D.4    Guidobono, F.5    Netti, C.6
  • 107
    • 10344242416 scopus 로고    scopus 로고
    • Migraine pathophysiology and its clinical implications
    • Silberstein SD, (2004). Migraine pathophysiology and its clinical implications. Cephalalgia 24 (Suppl. 2): 2-7.
    • (2004) Cephalalgia , vol.24 , Issue.SUPPL. 2 , pp. 2-7
    • Silberstein, S.D.1
  • 108
    • 49649113201 scopus 로고    scopus 로고
    • Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons
    • Simonetti M, Giniatullin R, Fabbretti E, (2008). Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons. J Biol Chem 283: 18743-18752.
    • (2008) J Biol Chem , vol.283 , pp. 18743-18752
    • Simonetti, M.1    Giniatullin, R.2    Fabbretti, E.3
  • 109
    • 70350689543 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus
    • Sixt ML, Messlinger K, Fischer MJ, (2009). Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus. Brain 132 (Pt 11): 3134-3141.
    • (2009) Brain , vol.132 , Issue.PART 11 , pp. 3134-3141
    • Sixt, M.L.1    Messlinger, K.2    Fischer, M.J.3
  • 110
    • 0036632586 scopus 로고    scopus 로고
    • An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres
    • Smith D, Hill RG, Edvinsson L, Longmore J, (2002). An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres. Cephalalgia 22: 424-431.
    • (2002) Cephalalgia , vol.22 , pp. 424-431
    • Smith, D.1    Hill, R.G.2    Edvinsson, L.3    Longmore, J.4
  • 112
    • 0022459241 scopus 로고
    • Substance P-containing trigeminal sensory neurons project to the nucleus of the solitary tract
    • South EH, Ritter RC, (1986). Substance P-containing trigeminal sensory neurons project to the nucleus of the solitary tract. Brain Res 372: 283-289.
    • (1986) Brain Res , vol.372 , pp. 283-289
    • South, E.H.1    Ritter, R.C.2
  • 113
    • 0041419861 scopus 로고    scopus 로고
    • Receptor activity modifying protein 2 distribution in the rat central nervous system and regulation by changes in blood pressure
    • Stachniak TJ, Krukoff TL, (2003). Receptor activity modifying protein 2 distribution in the rat central nervous system and regulation by changes in blood pressure. J Neuroendocrinol 15: 840-850.
    • (2003) J Neuroendocrinol , vol.15 , pp. 840-850
    • Stachniak, T.J.1    Krukoff, T.L.2
  • 114
    • 0027393882 scopus 로고
    • Photoaffinity labeling of rat calcitonin gene-related peptide receptors and adenylate cyclase activation: Identification of receptor subtypes
    • Stangl D, Muff R, Schmolck C, Fischer JA, (1993). Photoaffinity labeling of rat calcitonin gene-related peptide receptors and adenylate cyclase activation: identification of receptor subtypes. Endocrinology 132: 744-750.
    • (1993) Endocrinology , vol.132 , pp. 744-750
    • Stangl, D.1    Muff, R.2    Schmolck, C.3    Fischer, J.A.4
  • 115
    • 80051530340 scopus 로고    scopus 로고
    • Increased limbic and brainstem activity during migraine attacks following olfactory stimulation
    • Stankewitz A, May A, (2011). Increased limbic and brainstem activity during migraine attacks following olfactory stimulation. Neurology 77: 476-482.
    • (2011) Neurology , vol.77 , pp. 476-482
    • Stankewitz, A.1    May, A.2
  • 116
    • 33847633583 scopus 로고    scopus 로고
    • The global burden of headache: A documentation of headache prevalence and disability worldwide
    • Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. (2007). The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27: 193-210.
    • (2007) Cephalalgia , vol.27 , pp. 193-210
    • Stovner, L.1    Hagen, K.2    Jensen, R.3    Katsarava, Z.4    Lipton, R.5    Scher, A.6
  • 118
  • 119
    • 78650510937 scopus 로고    scopus 로고
    • Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2
    • Tajti J, Kuris A, Vecsei L, Xu CB, Edvinsson L, (2011). Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2. Cephalalgia 31: 95-105.
    • (2011) Cephalalgia , vol.31 , pp. 95-105
    • Tajti, J.1    Kuris, A.2    Vecsei, L.3    Xu, C.B.4    Edvinsson, L.5
  • 120
    • 78650963413 scopus 로고    scopus 로고
    • Excellent tolerability but relatively low initial clinical efficacy of telcagepant in migraine
    • Tfelt-Hansen P, (2011). Excellent tolerability but relatively low initial clinical efficacy of telcagepant in migraine. Headache 51: 118-123.
    • (2011) Headache , vol.51 , pp. 118-123
    • Tfelt-Hansen, P.1
  • 121
    • 84857136634 scopus 로고    scopus 로고
    • Clinical pharmacology of current and future drugs for the acute treatment of migraine: A review and an update
    • Tfelt-Hansen P, (2012). Clinical pharmacology of current and future drugs for the acute treatment of migraine: a review and an update. Curr Clin Pharmacol 7: 66-72.
    • (2012) Curr Clin Pharmacol , vol.7 , pp. 66-72
    • Tfelt-Hansen, P.1
  • 122
    • 79954606149 scopus 로고    scopus 로고
    • Possible site of action of CGRP antagonists in migraine
    • Tfelt-Hansen P, Olesen J, (2011). Possible site of action of CGRP antagonists in migraine. Cephalalgia 31: 748-750.
    • (2011) Cephalalgia , vol.31 , pp. 748-750
    • Tfelt-Hansen, P.1    Olesen, J.2
  • 124
    • 47849101639 scopus 로고    scopus 로고
    • Location, location, location. Site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
    • Tobin AB, Butcher AJ, Kong KC, (2008). Location, location, location. site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol Sci 29: 413-420.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 413-420
    • Tobin, A.B.1    Butcher, A.J.2    Kong, K.C.3
  • 125
  • 127
    • 37349055186 scopus 로고    scopus 로고
    • The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors
    • Udawela M, Christopoulos G, Morfis M, Tilakaratne N, Christopoulos A, Sexton PM, (2008). The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors. Regul Pept 145: 65-71.
    • (2008) Regul Pept , vol.145 , pp. 65-71
    • Udawela, M.1    Christopoulos, G.2    Morfis, M.3    Tilakaratne, N.4    Christopoulos, A.5    Sexton, P.M.6
  • 128
    • 0022356240 scopus 로고
    • Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and co-existence with substance P
    • Uddman R, Edvinsson L, Ekman R, Kingman T, McCulloch J, (1985). Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P. Neurosci Lett 62: 131-136.
    • (1985) Neurosci Lett , vol.62 , pp. 131-136
    • Uddman, R.1    Edvinsson, L.2    Ekman, R.3    Kingman, T.4    McCulloch, J.5
  • 129
    • 67650432453 scopus 로고    scopus 로고
    • CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways
    • Vause CV, Durham PL, (2009). CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways. J Neurochem 110: 811-821.
    • (2009) J Neurochem , vol.110 , pp. 811-821
    • Vause, C.V.1    Durham, P.L.2
  • 130
    • 17044372751 scopus 로고    scopus 로고
    • Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors
    • Wacnik PW, Baker CM, Herron MJ, Kren BT, Blazar BR, Wilcox GL, et al. (2005). Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors. Pain 115: 95-106.
    • (2005) Pain , vol.115 , pp. 95-106
    • Wacnik, P.W.1    Baker, C.M.2    Herron, M.J.3    Kren, B.T.4    Blazar, B.R.5    Wilcox, G.L.6
  • 131
    • 84887755145 scopus 로고    scopus 로고
    • Pharmacological characterisation of calcitonin gene-related peptide receptors in primary cultured rat trigeminal ganglia derived neurons
    • Available at (accessed 3/11/2013)
    • Walker CS, Hay DL, (2011). Pharmacological characterisation of calcitonin gene-related peptide receptors in primary cultured rat trigeminal ganglia derived neurons. British Pharmacological Society Winter Meeting. London 2011. Available at: http://www.pa2online.org/abstracts/vol9issue3abst067p.pdf (accessed 3/11/2013).
    • (2011) British Pharmacological Society Winter Meeting. London 2011
    • Walker, C.S.1    Hay, D.L.2
  • 132
    • 77956898559 scopus 로고    scopus 로고
    • Regulation of signal transduction by calcitonin gene-related peptide receptors
    • Walker CS, Conner AC, Poyner DR, Hay DL, (2010). Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends Pharmacol Sci 31: 476-483.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 476-483
    • Walker, C.S.1    Conner, A.C.2    Poyner, D.R.3    Hay, D.L.4
  • 133
    • 0032519856 scopus 로고    scopus 로고
    • ATP-sensitive K+ channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle
    • Wellman GC, Quayle JM, Standen NB, (1998). ATP-sensitive K+ channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle. J Physiol 507 (Pt 1): 117-129.
    • (1998) J Physiol , vol.507 , Issue.PART 1 , pp. 117-129
    • Wellman, G.C.1    Quayle, J.M.2    Standen, N.B.3
  • 134
    • 0032836814 scopus 로고    scopus 로고
    • Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37)
    • Wisskirchen FM, Gray DW, Marshall I, (1999). Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37). Br J Pharmacol 128: 283-292.
    • (1999) Br J Pharmacol , vol.128 , pp. 283-292
    • Wisskirchen, F.M.1    Gray, D.W.2    Marshall, I.3
  • 135
    • 84860282972 scopus 로고    scopus 로고
    • The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172
    • Wookey PJ, McLean CA, Hwang P, Furness SG, Nguyen S, Kourakis A, et al. (2012). The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology 60: 895-910.
    • (2012) Histopathology , vol.60 , pp. 895-910
    • Wookey, P.J.1    McLean, C.A.2    Hwang, P.3    Furness, S.G.4    Nguyen, S.5    Kourakis, A.6
  • 136
    • 0031944896 scopus 로고    scopus 로고
    • Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery
    • Yoshimoto R, Mitsui-Saito M, Ozaki H, Karaki H, (1998). Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery. Br J Pharmacol 123: 1645-1654.
    • (1998) Br J Pharmacol , vol.123 , pp. 1645-1654
    • Yoshimoto, R.1    Mitsui-Saito, M.2    Ozaki, H.3    Karaki, H.4
  • 137
    • 33847790338 scopus 로고    scopus 로고
    • Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion
    • Zhang Z, Winborn CS, Marquez de Prado B, Russo AF, (2007). Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion. J Neurosci 27: 2693-2703.
    • (2007) J Neurosci , vol.27 , pp. 2693-2703
    • Zhang, Z.1    Winborn, C.S.2    Marquez De Prado, B.3    Russo, A.F.4


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