Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF

Cephalalgia

Volumn 32, Issue 9, 2012, Pages 659-667

  Hoffmann, Jan ^a,b   Wecker, Sascha ^a   Neeb, Lars ^a   Dirnagl, Ulrich ^a   Reuter, Uwe ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcitonin gene related peptide; capsaicin; inflammatory soup; trigeminal activation

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CEREBROSPINAL FLUID; CONTROLLED STUDY; GANGLION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; JUGULAR VEIN; MALE; NERVE CELL; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN SECRETION; RAT; SENSORY NERVE; STIMULUS; TRIGEMINAL NERVE; VENOUS BLOOD;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; DISEASE MODELS, ANIMAL; INFLAMMATION MEDIATORS; JUGULAR VEINS; MALE; MIGRAINE DISORDERS; NEURITIS; NEURONS, AFFERENT; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SENSORY SYSTEM AGENTS; TRIGEMINAL GANGLION; TRIGEMINAL NERVE;

EID: 84863696738     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1177/0333102412447701     Document Type: Article

References (37)

1. Zagami AS, Goadsby PJ, Edvinsson L. Stimulation of the superior sagittal sinus in the cat causes release of vasoactive peptides. Neuropeptides. 1990 ; 16: 69-75 (Pubitemid 20174429)
2. Storer RJ, Akerman S, Goadsby PJ. Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat. Br J Pharmacol. 2004 ; 142: 1171-1181 (Pubitemid 39093014)
3. Olesen J, Diener HC, Husstedt IW, et al. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl J Med. 2004 ; 350: 1104-1110 (Pubitemid 38298990)
4. Ho TW, Ferrari MD, Dodick DW, et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet. 2008 ; 372: 2115-2123
5. Ho TW, Mannix LK, Fan X, et al. Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology. 2008 ; 70: 1304-1312 (Pubitemid 351550355)
6. Diener H-C, Barbanti P, Dahlöf C, et al. BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study. Cephalalgia. 2011 ; 31: 573-584
7. Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol. 2004 ; 55: 19-26 (Pubitemid 38067357)
8. Burstein R, Jakubowski M. Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol. 2004 ; 55: 27-36 (Pubitemid 38067358)
9. Dodick D, Silberstein S. Central sensitization theory of migraine: clinical implications. Headache. 2006 ; 46 (Suppl 4). S182 - S191
10. Cady R, Martin V, Mauskop A, et al. Symptoms of cutaneous sensitivity pre-treatment and post-treatment: results from the rizatriptan TAME studies. Cephalalgia. 2007 ; 27: 1055-1060 (Pubitemid 47296031)
11. Goadsby P, Zanchin G, Geraud G, et al. Early vs. non-early intervention in acute migraine-'Act when Mild (AwM)'. A double-blind, placebo-controlled trial of almotriptan. Cephalalgia. 2008 ; 28: 383-391 (Pubitemid 351341454)
12. Schoenen J, De Klippel N, Giurgea S, et al. Almotriptan and its combination with aceclofenac for migraine attacks: a study of efficacy and the influence of auto-evaluated brush allodynia. Cephalalgia. 2008 ; 28: 1095-1105
13. De Felice M, Ossipov MH, Wang R, et al. Triptan-induced latent sensitization: a possible basis for medication overuse headache. Ann Neurol. 2010 ; 67: 325-337
14. Bartsch T, Knight YE, Goadsby PJ. Activation of 5-HT(1B/1D) receptor in the periaqueductal gray inhibits nociception. Ann Neurol. 2004 ; 56: 371-381 (Pubitemid 39166556)
15. Hoffmann J, Neeb L, Israel H, et al. Intracisternal injection of inflammatory soup activates the trigeminal nerve system. Cephalalgia. 2009 ; 29: 1212-1217
16. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 ; 58: 698-705 (Pubitemid 41552545)
17. Markowitz S, Saito K, Moskowitz MA. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J Neurosci. 1987 ; 7: 4129-4136 (Pubitemid 18012423)
18. Jancso G, Kiraly E. Sensory neurotoxins: chemically induced selective destruction of primary sensory neurons. Brain Res. 1981 ; 210: 83-89 (Pubitemid 11145560)
19. Jancso G, Kiraly E, Jancso-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature. 1977 ; 270: 741-743 (Pubitemid 8239254)
20. Ruscher K, Freyer D, Karsch M, et al. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci. 2002 ; 22: 10291-10301 (Pubitemid 35416867)
21. Reuter U, Bolay H, Jansen-Olesen I, et al. Delayed inflammation in rat meninges: implications for migraine pathophysiology. Brain. 2001 ; 124: 2490-2502 (Pubitemid 33134937)
22. Offenhauser N, Zinck T, Hoffmann J, et al. CGRP release and c-fos expression within trigeminal nucleus caudalis of the rat following glyceryltrinitrate infusion. Cephalalgia. 2005 ; 25: 225-236 (Pubitemid 40321716)
23. Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol. 1993 ; 33: 48-56 (Pubitemid 23009909)
24. Limmroth V, Katsarava Z, Liedert B, et al. An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system. Pain. 2001 ; 92: 101-106 (Pubitemid 32367941)
25. Reuter U, Sanchez del Rio M, Moskowitz MA. Experimental models of migraine. Funct Neurol. 2000 ; 15 (Suppl 3). 9-18 (Pubitemid 32051370)
26. Dux M, Santha P, Jancso G. Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat. J Physiol. 2003 ; 552: 859-867 (Pubitemid 37428426)
27. Juhasz G, Zsombok T, Modos EA, et al. NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release. Pain. 2003 ; 106: 461-470 (Pubitemid 37505895)
28. Aita M, Maeda T, Seo K. The effect of neonatal capsaicin treatment on the CGRP-immunoreaction in the trigeminal subnucleus caudalis of mice. Biomed Res. 2008 ; 29: 33-42 (Pubitemid 351425819)
29. Villalon CM, Olesen J. The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. Pharmacol Ther. 2009 ; 124: 309-323
30. Eftekhari S, Edvinsson L. Possible sites of action of the new calcitonin gene-related peptide receptor antagonists. Ther Adv Neurol Disord. 2010 ; 3: 369-378
31. Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev. 2004 ; 84: 903-934 (Pubitemid 38823770)
32. Ho TW, Edvinsson L, Goadsby PJ. CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol. 2010 ; 6: 573-582
33. Reuss S, Riemann R, Vollrath L. Substance P- and calcitonin gene-related peptide-like immunoreactive neurons in the rat trigeminal ganglion-with special reference to meningeal and pineal innervation. Acta Histochem. 1992 ; 92: 104-109
34. Kawajiri H, Furuse M, Namba R, et al. Effect of internal jugular vein ligation on resorption of cerebrospinal fluid. J Maxillofac Surg. 1983 ; 11: 42-45 (Pubitemid 13124832)
35. Amrutkar DV, Ploug KB, Olesen J, et al. Role for voltage gated calcium channels in calcitonin gene-related peptide release in the rat trigeminovascular system. Neuroscience. 2011 ; 172: 510-517
36. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990 ; 28: 183-187 (Pubitemid 20244522)
37. Ebersberger A, Averbeck B, Messlinger K, et al. Release of substance P, calcitonin gene-related peptide and prostaglandin E2 from rat dura mater encephali following electrical and chemical stimulation in vitro. Neuroscience. 1999 ; 89: 901-907 (Pubitemid 29071014)