Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 1, 2003, Pages 326-333

  Hasbak, Philip ^a,e   Opgaard, Ole Saetrum ^b   Eskesen, Karen ^a   Schifter, Søren ^a   Arendrup, Henrik ^c   Longmore, Jenny ^d   Edvinsson, Lars ^a  

^a Mental Health Services CPH   (Denmark)

^b KAISER PERMANENTE MEDICAL CENTER   (United States)

^c Rigshospitalet   (Denmark)

^d NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^e GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 (2 OXO 2,3 DIHYDRO BENZOIMIDAZOL 1 YL) PIPERIDINE 1 CARBOXYLIC ACID [1 3,5 DIBROMO 4 HYDROXY BENZYL 2 OXO 2 (4 PHENYL PIPERAZIN 1 YL)ETHYL]AMIDE; ADRENOMEDULLIN; AMYLIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; CYSTEINE DERIVATIVE; DIACETOAMIDOMETHYL CYSTEINE; MESSENGER RNA; PROTEIN; RECEPTOR ACTIVITY MODIFYING PROTEIN; RECEPTOR COMPONENT PROTEIN; UNCLASSIFIED DRUG; WO 98 11128;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENETIC CODE; HUMAN; HUMAN TISSUE; ISOLATED ARTERY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADRENOMEDULLIN; ADULT; AMYLOID; CALCITONIN GENE-RELATED PEPTIDE; CORONARY VESSELS; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; PEPTIDE FRAGMENTS; PEPTIDES; PIPERAZINES; PIPERIDINES; RECEPTORS, CALCITONIN; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RNA, MESSENGER;

EID: 0037216736     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.037754     Document Type: Article

References (37)

1. Aiyar N, Daines RA, Disa J, Chambers PA, Sauermelch CF, Quiniou M, Khandoudi N, Gout B, Douglas SA, and Willette RN (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J Pharmacol Exp Ther 296:768-775.
2. Arunlakshana O and Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol 14:48-58.
3. Buhlmann N, Leuthauser K, Muff R, Fischer JA, and Born W (1999) A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1. Endocrinology 140:2883-2890.
4. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, and Reid KB (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84:8628-8632.
5. Dennis T, Fournier A, St Pierre S, and Quirion R (1989) Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity. J Pharmacol Exp Ther 251:718-725.
6. Doods H, Hallermayer G, Wu D, Entzeroth M, Rudolf K, Engel W, and Eberlein W (2000) Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br J Pharmacol 129:420-423.
7. Edvinsson L, Alm R, Shaw D, Rutledge RZ, Koblan KS, Longmore J, and Kane SA (2002) Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells. Eur J Pharmacol 434:49-53.
8. Edvinsson L, Sams A, Jansen-Olesen I, Tajti J, Kane SA, Rutledge RZ, Koblan KS, Hill RG, and Longmore J (2001) Characterisation of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries. Eur J Pharmacol 415:39-44.
9. Evans BN, Rosenblatt MI, Mnayer LO, Oliver KR, and Dickerson IM (2000) CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. J Biol Chem 275:31438-31443.
10. Feuerstein G, Willette R, and Aiyar N (1995) Clinical perspectives of calcitonin gene related peptide pharmacology. Can J Physiol Pharmacol 73:1070 -1074.
11. Foord SM and Marshall FH (1999) RAMPs: Accessory proteins for seven transmembrane domain receptors. Trends Pharmacol Sci 20:184-187.
12. Giuliani S, Wimalawansa SJ, and Maggi CA (1992) Involvement of multiple receptors in the biological effects of calcitonin gene-related peptide and amylin in rat and guinea-pig preparations. Br J Pharmacol 107:510-514.
13. Gulbenkian S. Saetrum OO, Ekman R, Costa AN, Wharton J, Polak JM, Melo J, and Edvinsson L (1993) Peptidergic innervation of human epicardial coronary arteries. Circ Res 73:579-588.
14. Hasbak P, Sams A, Schifter S, Longmore J, and Edvinsson L (2001) CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with "Compound 1" (W098/11128), a non-peptide antagonist. Br J Pharmacol 133:1405-1413.
15. Hinson JP, Kapas S, and Smith DM (2000) Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 21:138-167.
16. Hojo Y, Ikeda U, Katsuki TA, and Shimada K (2000) Decreased adrenomedullin production in the coronary circulation of patients with coronary artery disease. Heart 84:88.
17. Juaneda C, Dumont Y, and Quirion R (2000) The molecular pharmacology of CGRP and related peptide receptor subtypes. Trends Pharmacol Sci 21:432-438.
18. Kano H, Kohno M, Yasunari K, Yokokawa K, Horio T, Ikeda M, Minami M, Hanehira T, Takeda T, and Yoshikawa J (1996) Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells. J Hypertens 14:209-213.
19. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, and Eto T (1993) Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553-560.
20. Kitamura K, Kangawa K, Matsuo H, and Eto T (1995) Adrenomedullin. Implications for hypertension research. Drugs 49:485-495.
21. Longmore J, Hogg JE, Hutson PH, and Hill RG (1994) Effects of two truncated forms of human calcitonin-gene related peptide: Implications for receptor classification. Eur J Pharmacol 265:53-59.
22. Luebke AE, Dahl GP, Roos BA, and Dickerson IM (1996) Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. Proc Natl Acad Sci USA 93:345-3460.
23. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, and Foord SM (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature (Lond) 393:333-339.
24. Morris HR, Panico M, Etienne T, Tippins J, Girgis SI, and MacIntyre I (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature (Lond) 308:746-748.
25. Mulvany MJ and Halpern W (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41:19-26.
26. Parkes DG (1995) Cardiovascular actions of adrenomedullin in conscious sheep. Am J Physiol 268:H2574-H2578.
27. Rorabaugh BR, Scofield M, Smith D, Jeffries W, and Abel PW (2001) Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther 299:1086-1094.
28. Saetrum OO and Edvinsson L (1996) Effect of parasympathetic and sensory transmitters on human epicardial coronary arteries and veins. Pharmacol Toxicol 78:273-279.
29. Saetrum OO, Hasbak P, de Vries R, Saxena PR, and Edvinsson L (2000) Positive inotropy mediated via CGRP receptors in isolated human myocardial trabeculae. Eur J Pharmacol 397:373-382.
30. Sams A and Jansen-Olesen I (1998) Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries. Neurosci Lett 258:41-44.
31. Sexton PM (1999) Recent advances in our understanding of peptide hormone receptors and RAMPs. Curr Opin Drug Discov Dev 2:440-448.
32. Sheykhzade M and Nyborg NC (1998) Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br J Pharmacol 123:1464-1470.
33. Terata K, Miura H, Liu Y, Loberiza F, and Gutterman DD (2000) Human coronary arteriolar dilation to adrenomedullin: Role of nitric oxide and K(+) channels. Am J Physiol Heart Circ Physiol 279:H2620-H2626.
34. Uren NG, Seydoux C, and Davies GJ (1993) Effect of intravenous calcitonin gene related peptide on ischaemia threshold and coronary stenosis severity in humans. Cardiovasc Res 27:1477-1481.
35. Waugh DJ, Bockman CS, Smith DD, and Abel PW (1999) Limitations in using peptide drugs to characterize calcitonin gene-related peptide receptors. J Pharmacol Exp Ther 289:1419-1426.
36. Winer BJ (1971) Statistical Principles in Experimental Design, McGraw-Hill, New York.
37. World Medical Association Declaration of Helsinki (1997) Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 35: 2-3.