Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

Cephalalgia

Volumn 30, Issue 10, 2010, Pages 1179-1186

  Hansen, Jakob Møller ^a   Hauge, Anne Werner ^a   Olesen, Jes ^a   Ashina, Messoud ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Calcitonin gene related peptide; Cortical spreading depression; Migraine; Migraine with aura; Neurotransmitters

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEADACHE; HEART RATE; HUMAN; MALE; MEAN ARTERIAL PRESSURE; MIGRAINE LIKE ATTACK; MIGRAINE WITH AURA; PATHOGENESIS; SCORING SYSTEM; SYMPTOM; VOLUNTEER; CHEMICALLY INDUCED DISORDER; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY;

ADULT; AREA UNDER CURVE; CALCITONIN GENE-RELATED PEPTIDE; FEMALE; HUMANS; MALE; MIDDLE AGED; MIGRAINE WITH AURA;

EID: 78650413846     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1177/0333102410368444     Document Type: Article

References (46)

1. Villalon CM, Olesen J. The role of CGRP in the patho-physiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. Pharmacol Ther 2009; 124(3): 309-323.
2. Rosenfeld MG, Mermod JJ, Amara SG, et al. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 1983; 304(5922): 129-135. (Pubitemid 13079138)
3. Mason RT, Peterfreund RA, Sawchenko PE, et al. Release of the predicted calcitonin gene-related peptide from cul-tured rat trigeminal ganglion cells. Nature 1984; 308(5960): 653-655. (Pubitemid 14129579)
4. McCulloch J, Uddman R, Kingman TA, et al. Calcitonin gene-related peptide: functional role in cerebrovascular regulation. Proc Natl Acad Sci USA 1986; 83(15): 5731-5735. (Pubitemid 16001291)
5. Goadsby PJ, Edvinsson L, Ekman R. Release of vasoac-tive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 1988; 23(2): 193-196. (Pubitemid 18081459)
6. Lassen LH, Haderslev PA, Jacobsen VB, et al. CGRP may play a causative role in migraine. Cephalalgia 2002; 22(1): 54-61. (Pubitemid 34626025)
7. Olesen J, Diener HC, Husstedt IW, et al. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl JMed 2004; 350(11): 1104-1110. (Pubitemid 38298990)
8. Ho TW, Mannix LK, Fan X, et al. Randomized con-trolled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology 2008; 70(16): 1304-1312. (Pubitemid 351550355)
9. Ho TW, Ferrari MD, Dodick DW, et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antag-onist of calcitonin gene-related peptide receptor, com-pared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 2008; 372(9656): 2115-2123.
10. Sixt ML, Messlinger K, Fischer MJ. Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus. Brain 2009; 132(11): 3134-3141.
11. Hansen J, Thomsen L, Olesen J, et al. Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype. Neurology 2008; 71(11): 841-847.
12. International Headache Society. The International Clas-sification of Headache Disorders, 2nd ed. Cephalalgia 2004; 24(Suppl 1): 9-160.
13. Friberg L, Olsen TS, Roland PE, et al. Focal ischaemia caused by instability of cerebrovascular tone during attacks of hemiplegic migraine: a regional cerebral blood flow study. Brain 1987; 110(Pt 4): 917-934. (Pubitemid 17135219)
14. Sanchez del Rio M, Bakker D, Wu O, et al. Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia 1999; 19(8): 701-707. (Pubitemid 29519412)
15. Olesen J, Larsen B, Lauritzen M. Focal hyperemia fol-lowed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 1981; 9(4): 344-352. (Pubitemid 11106551)
16. Lauritzen M, Olesen J. Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography. Brain 1984; 107(Pt 2): 447-461. (Pubitemid 14108830)
17. Iversen HK, Olesen J, Tfelt-Hansen P. Intravenous nitro-glycerin as an experimental model of vascular headache: basic characteristics. Pain 1989; 38(1): 17-24. (Pubitemid 19184833)
18. Olesen J, Bousser MG, Diener HC, et al. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 2006; 26(6): 742-746.
19. Petersen KA, Lassen LH, Birk S, et al. BIBN4096BS antagonizes human alpha-calcitonin gene related pep-tide-induced headache and extracerebral artery dilata-tion. Clin Pharmacol Ther 2005; 77(3): 202-213. (Pubitemid 40269135)
20. Gore SM, Altman DG. Statistics in practice. London: British Medical Association, 1982, p.6-8.
21. Matthews JN, Altman DG, Campbell MJ, et al. Analysis of serial measurements in medical research. BMJ 1990; 300(6719): 230-235. (Pubitemid 20045528)
22. Russell MB, Rasmussen BK, Fenger F, et al. Migraine without aura and migraine with aura are distinct clinical entities: a study of four hundred and eighty-four male and female migraineurs from the general population. Cephalalgia 1996; 16(4): 239-245. (Pubitemid 26189249)
23. Nyholt DR, Gillespie NG, Heath AC, et al. Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities. Genet Epidemiol 2004; 26(3): 231-244. (Pubitemid 38420336)
24. Ligthart L, Boomsma DI, Martin NG, et al. Migraine with aura and migraine without aura are not distinct enti-ties: further evidence from a large Dutch population study. Twin Res Hum Genet 2006; 9(1): 54-63. (Pubitemid 43384793)
25. Russell MB, Ulrich V, Gervil M, et al. Migraine without aura and migraine with aura are distinct disorders: a population-based twin survey. Headache 2002; 42(5): 332-336. (Pubitemid 34596147)
26. Woods P, Iacoboni M, Mazziotta JC. Brief report: bilat-eral spreading cerebral hypoperfusion during spontane-ous migraine headache. N Engl J Med 1994; 331(25): 1689-1692. (Pubitemid 24373622)
27. Denuelle M, Fabre N, Payoux P, et al. Posterior cerebral hypoperfusion in migraine without aura. Cephalalgia 2008; 28(8): 856-862.
28. Ferrari MD, Roon KI, Lipton RB, et al. Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 2001; 358(9294): 1668-1675. (Pubitemid 33124324)
29. Reuter U, Del Rio MS, Diener HC, et al. Migraines with and without aura and their response to preventive ther-apy with topiramate. Cephalalgia 2010; 00: 1-9 (accessed March 2010).
30. Afridi SK, Kaube H, Goadsby PJ. Glyceryl trinitrate triggers premonitory symptoms in migraineurs. Pain 2004; 110(3): 675-680. (Pubitemid 39036799)
31. Thomsen LL, Kruuse C, Iversen HK, et al. A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks. Eur J Neurol 1994; 1: 73-80. (Pubitemid 2141297)
32. Christiansen I, Thomsen LL, Daugaard D, et al. Glyceryl trinitrate induces attacks ofmigraine without aura in suf-ferers of migraine with aura. Cephalalgia 1999; 19(7): 660-667. (Pubitemid 29465917)
33. Hansen J, Thomsen L, Olesen J, et al. Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide. Cephalalgia 2008; 28(5): 496-505. (Pubitemid 351502557)
34. Hansen J, Thomsen L, Marconi R, et al. Familial hemi-plegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine. Cephalalgia 2008; 28(4): 367-375. (Pubitemid 351341452)
35. Hadjikhani N, Sanchez Del Rio M, Wu O, et al. Mechan-isms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA 2001; 98(8): 4687-4692. (Pubitemid 32295037)
36. Dreier JP, Kleeberg J, Petzold G, et al. Endothelin-1 potently induces Leao's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain 2002; 125(Pt 1): 102-112. (Pubitemid 34084040)
37. Kleeberg J, Petzold GC, Major S, et al. ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo. Am J Physiol Heart Circ Physiol 2004; 286(4): H1339-1346. (Pubitemid 38381141)
38. Drissi H, Lasmoles F, Le Mellay V, et al. Activation of phospholipase C-beta1 via Galphaq/11 during calcium mobilization by calcitonin gene-related peptide. J Biol Chem 1998; 273(32): 20168-20174. (Pubitemid 28377575)
39. Marquez de Prado B, Hammond DL, Russo AF. Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice. J Pain 2009; 10(9): 992-1000.
40. Christiansen I, Daugaard D, Lykke Thomsen L, et al. Glyceryl trinitrate induced headache in migraineurs-relation to attack frequency. Eur J Neurol 2000; 7(4): 405-411. (Pubitemid 32280902)
41. Brain SD, Williams TJ, Tippins JR, et al. Calcitonin gene-related peptide is a potent vasodilator. Nature 1985; 313(5997): 54-56. (Pubitemid 15192304)
42. Cumberbatch MJ, Williamson DJ, Mason GS, et al. Dural vasodilation causes a sensitization of rat caudal trigeminal neurones in vivo that is blocked by a 5-HT1B/1D agonist. Br J Pharmacol 1999; 126(6): 1478-1486. (Pubitemid 29142080)
43. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol 2005; 58(5): 698-705. (Pubitemid 41552545)
44. Lassen LH, Jacobsen VB, Haderslev PA, et al. Involve-ment of calcitonin gene-related peptide in migraine: regio-nal cerebral blood flow and blood flow velocity in migraine patients. J Headache Pain 2008; 9(3): 151-157.
45. Jansen-Olesen I, Mortensen A, Edvinsson L. Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibres and induces vasodilatation of human cerebral arteries concomitant with activation of adenylyl cyclase. Cephalalgia 1996; 16(5): 310-316. (Pubitemid 26271251)
46. Birk S, Kruuse C, Petersen KA, et al. The headache-indu-cing effect ofcilostazol in human volunteers. Cephalalgia 2006; 26(11): 1304-1309. (Pubitemid 44625681)