Elevated cell proliferation and VEGF production by high-glucose conditions in Müller cells involve XIAP

Eye (Basingstoke)

Volumn 27, Issue 11, 2013, Pages 1299-1307

  Sun, Y ^a   Wang, D ^a   Ye, F ^b   Hu, D N ^c,d   Liu, X ^a   Zhang, L ^a   Gao, L ^a   Song, E ^a   Zhang, D Y ^b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d NEW YORK EYE AND EAR INFIRMARY   (United States)

Author keywords

embelin; high glucose; protein pathway array; retinal M ller cells; XIAP

Indexed keywords

EMBELIN; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STAT3 PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; MUELLER CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; BENZOQUINONES; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; EPENDYMOGLIAL CELLS; GLUCOSE; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84887638539     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.2013.158     Document Type: Article

References (31)

1. Shah CP, Chen C. Review of therapeutic advances in diabetic retinopathy. Ther Adv Endocrinol Metab 2011; 2(1): 39-53.
2. Miller JW, Le Couter J, Strauss EC, Ferrara N. Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology 2013; 120(1): 106-114.
3. Gupta N, Mansoor S, Sharma A, Sapkal A, Sheth J, Falatoonzadeh P et al. Diabetic retinopathy and VEGF. Open Ophthalmol J 2013; 7: 4-10.
4. KieranMW, Kalluri R, Cho YJ. The VEGF pathway in cancer and disease: Responses, resistance, and the path forward. Cold Spring Harb Perspect Med 2012; 2(12): A006593.
5. Andreoli CM, Miller JW. Anti-vascular endothelial growth factor therapy for ocular neovascular disease. Curr Opin Ophthalmol 2007; 18(6): 502-508.
6. Reichenbach A, Bringmann A. New functions of Müller cells. Glia 2013; 61(5): 651-678.
7. Bringmann A, Wiedemann P. Müller glial cells in retinal disease. Ophthalmologica 2012; 227(1): 1-19.
8. Nelson CM, Hyde DR Müller glia as a source of neuronal progenitor cells to regenerate the damaged zebrafish retina. Adv Exp Med Biol 2012; 723: 425-430.
9. Hu LM, Luo Y, Zhang J, Lei X, Shen J, Wu Y et al. EPO reduces reactive gliosis and stimulates neurotrophin expression in Muller cells. Front Biosci (Elite Ed) 2011; 3: 1541-1555.
10. Ulbricht E, Pannicke T, Uhlmann S, Wiedemann P, Reichenbach A, Francke M. Activation of retinal microglial cells is not associated with Müller cell reactivity in vitrectomized rabbit eyes. Acta Ophthalmol 2013; 91(1): E48-e55.
11. Brooks SE, Gu X, Kaufmann PM, Marcus DM, Caldwell RB. Modulation of VEGF production by pH and glucose in retinal müller cells. Curr Eye Res 1998; 17(9): 875-882.
12. Bai Y, Ma JX, Guo J, Wang J, Zhu M, Chen Y et al. Müller cell-derived VEGF is a significant contributor to retinal neovascularization. J Pathol 2009; 219(4): 446-454.
13. Hicks D, Courtois Y. The growth and behaviour of rat retinal müller cells in vitro. 1. An improved method for isolation and culture. Exp Eye Res 1990; 51(2): 119-129.
14. Ye F, Che Y, McMillen E, Gorski J, Brodman D, Saw D et al. The effect of scutellaria baicalensis on the signaling network in hepatocellular carcinoma cells. Nutr Cancer 2009; 61(4): 530-537.
15. Zhang DY, Ye F, Gao L, Liu X, Zhao X, Che Y et al. Proteomics, pathway array and signaling network-based medicine in cancer. Cell Div 2009; 4: 20.
16. Rungger-Brandle E, Dosso AA, Leuenberger PM. Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci 2000; 41(7): 1971-1980.
17. Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP et al. Discovery of embelin as a cell-permeable, smallmolecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 2004; 47(10): 2430-2440.
18. Bhisitkul RB. Vascular endothelial growth factor biology: Clinical implications for ocular treatments. Br J Ophthalmol 2006; 90(12): 1542-1547.
19. Young TA, Wang H, Munk S, Hammoudi DS, Young DS, Mandelcorn MS et al. Vascular endothelial growth factor expression and secretion by retinal pigment epithelial cells in high glucose and hypoxia is protein kinase C-dependent. Exp Eye Res 2005; 80(5): 651-662.
20. Wu Y, Zuo Y, Chakrabarti R, Feng B, Chen S, Chakrabarti S. ERK5 contributes to VEGF alteration in diabetic retinopathy. J Ophthalmol 2010; 2010: 465824.
21. Gyrd-Hansen M, Meier P. IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 2010; 10(8): 561-574.
22. Wang W, Abbruzzese JL, Evans DB, Chiao PJ. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene 1999; 18(32): 4554-4563.
23. Wang J, Wang X, Hussain S, Zheng Y, Sanjabi S, Ouaaz F et al. Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. J Immunol 2007; 178(11): 6777-6788.
24. Baldari CT, Tonello F, Paccani SR, Montecucco C. Anthrax toxins: A paradigm of bacterial immune suppression. Trends Immunol 2006; 27(9): 434-440.
25. Gaither A, Porter D, Yao Y, Borawski J, Yang G, Donovan J et al. A smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factoralpha signaling. Cancer Res 2007; 67(24): 11493-11498.
26. Ameglio F, D'Auria L, Cordiali-Fei P, Mussi A, Valenzano L, D'Agosto G et al. Bullous pemphigoid and pemphigus vulgaris: Correlated behaviour of serum VEGF, sE-selectin and TNF-alpha levels. J Biol Regul Homeost Agents 1997; 11(4): 148-153.
27. Lemberger T, Parkitna JR, Chai M, Schütz G, Engblom D. CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis. FASEB J 2008; 22(8): 2872-2879.
28. Plouët J, Moro F, Bertagnolli S, Coldeboeuf N, Mazarguil H, Clamens S et al. Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect. J Biol Chem 1997; 272(20): 13390-13396.
29. Tran J, Rak J, Sheehan C, Saibil SD, LaCasse E, Korneluk RG et al. Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells. Biochem Biophys Res Commun 1999; 264(3): 781-788.
30. Chitra M, Sukumar E, Suja V, Devi CS. Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy 1994; 40(2): 109-113.
31. Mahendran S, Badami S, Maithili V. Evaluation of antidiabetic effect of embelin from embelia ribes in alloxan induced diabetes in rats. Biomed Pharmacother 2011; 1(1): 25-31.