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Volumn 25, Issue 6, 2013, Pages 676-686

Feedback loops and reciprocal regulation: Recurring motifs in the systems biology of the cell cycle

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CELL CYCLE PROTEIN 20; CELL PROTEIN; CYCLIN B; CYCLIN DEPENDENT KINASE 1; PROTEASOME; UNCLASSIFIED DRUG; WEE1 PROTEIN;

EID: 84887621295     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2013.07.007     Document Type: Review
Times cited : (69)

References (116)
  • 1
    • 0023647143 scopus 로고
    • Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
    • Lee M.G., Nurse P.N. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature 1987, 327:31-35.
    • (1987) Nature , vol.327 , pp. 31-35
    • Lee, M.G.1    Nurse, P.N.2
  • 2
    • 0020383408 scopus 로고
    • Functionally homologous cell cycle control genes in budding and fission yeast
    • Beach D., Durkacz B., Nurse P. Functionally homologous cell cycle control genes in budding and fission yeast. Nature 1982, 300:706-709.
    • (1982) Nature , vol.300 , pp. 706-709
    • Beach, D.1    Durkacz, B.2    Nurse, P.3
  • 3
    • 0020961333 scopus 로고
    • Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division
    • Evans T., Rosenthal E.T., Youngblom J., Distel D., Hunt T. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 1983, 33:389-396.
    • (1983) Cell , vol.33 , pp. 389-396
    • Evans, T.1    Rosenthal, E.T.2    Youngblom, J.3    Distel, D.4    Hunt, T.5
  • 4
    • 0021215746 scopus 로고
    • Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs
    • Gerhart J., Wu M., Kirschner M. Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs. J Cell Biol 1984, 98:1247-1255.
    • (1984) J Cell Biol , vol.98 , pp. 1247-1255
    • Gerhart, J.1    Wu, M.2    Kirschner, M.3
  • 5
    • 0024978338 scopus 로고
    • Cyclin synthesis drives the early embryonic cell cycle
    • Murray A.W., Kirschner M.W. Cyclin synthesis drives the early embryonic cell cycle. Nature 1989, 339:275-280.
    • (1989) Nature , vol.339 , pp. 275-280
    • Murray, A.W.1    Kirschner, M.W.2
  • 6
    • 0024978344 scopus 로고
    • The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
    • Murray A.W., Solomon M.J., Kirschner M.W. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 1989, 339:280-286.
    • (1989) Nature , vol.339 , pp. 280-286
    • Murray, A.W.1    Solomon, M.J.2    Kirschner, M.W.3
  • 7
    • 0023753715 scopus 로고
    • The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis
    • Dunphy W.G., Brizuela L., Beach D., Newport J. The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell 1988, 54:423-431.
    • (1988) Cell , vol.54 , pp. 423-431
    • Dunphy, W.G.1    Brizuela, L.2    Beach, D.3    Newport, J.4
  • 9
    • 0345054420 scopus 로고
    • Purification of maturation-promoting factor, an intracellular regulator of early mitotic events
    • Lohka M.J., Hayes M.K., Maller J.L. Purification of maturation-promoting factor, an intracellular regulator of early mitotic events. Proc Natl Acad Sci U S A 1988, 85:3009-3013.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 3009-3013
    • Lohka, M.J.1    Hayes, M.K.2    Maller, J.L.3
  • 10
    • 0025012866 scopus 로고
    • Cyclin is a component of maturation-promoting factor from Xenopus
    • Gautier J., Minshull J., Lohka M., Glotzer M., Hunt T., Maller J.L. Cyclin is a component of maturation-promoting factor from Xenopus. Cell 1990, 60:487-494.
    • (1990) Cell , vol.60 , pp. 487-494
    • Gautier, J.1    Minshull, J.2    Lohka, M.3    Glotzer, M.4    Hunt, T.5    Maller, J.L.6
  • 11
    • 0024342438 scopus 로고
    • MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B
    • Labbe J.-C., Capony J.-P., Caput D., Cavadore J.-C., Derancourt J., Kaghad M., Lelias J.-M., Picard A., Doree M. MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO J 1989, 8:3053-3058.
    • (1989) EMBO J , vol.8 , pp. 3053-3058
    • Labbe, J.-C.1    Capony, J.-P.2    Caput, D.3    Cavadore, J.-C.4    Derancourt, J.5    Kaghad, M.6    Lelias, J.-M.7    Picard, A.8    Doree, M.9
  • 14
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: theory and experimental approaches
    • Alon U. Network motifs: theory and experimental approaches. Nat Rev Genet 2007, 8:450-461.
    • (2007) Nat Rev Genet , vol.8 , pp. 450-461
    • Alon, U.1
  • 15
    • 77951681944 scopus 로고    scopus 로고
    • Functional motifs in biochemical reaction networks
    • Tyson J.J., Novak B. Functional motifs in biochemical reaction networks. Annu Rev Phys Chem 2010, 61:219-240.
    • (2010) Annu Rev Phys Chem , vol.61 , pp. 219-240
    • Tyson, J.J.1    Novak, B.2
  • 16
    • 0036428761 scopus 로고    scopus 로고
    • Negative autoregulation speeds the response times of transcription networks
    • Rosenfeld N., Elowitz M.B., Alon U. Negative autoregulation speeds the response times of transcription networks. J Mol Biol 2002, 323:785-793.
    • (2002) J Mol Biol , vol.323 , pp. 785-793
    • Rosenfeld, N.1    Elowitz, M.B.2    Alon, U.3
  • 17
    • 0034212551 scopus 로고    scopus 로고
    • Engineering stability in gene networks by autoregulation
    • Becskei A., Serrano L. Engineering stability in gene networks by autoregulation. Nature 2000, 405:590-593.
    • (2000) Nature , vol.405 , pp. 590-593
    • Becskei, A.1    Serrano, L.2
  • 19
    • 56749160113 scopus 로고    scopus 로고
    • Design principles of biochemical oscillators
    • Novak B., Tyson J.J. Design principles of biochemical oscillators. Nat Rev Mol Cell Biol 2008, 9:981-991.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 981-991
    • Novak, B.1    Tyson, J.J.2
  • 20
    • 79952637804 scopus 로고    scopus 로고
    • Modeling the cell cycle: why do certain circuits oscillate?
    • Ferrell J.E., Tsai T.Y., Yang Q. Modeling the cell cycle: why do certain circuits oscillate?. Cell 2011, 144:874-885.
    • (2011) Cell , vol.144 , pp. 874-885
    • Ferrell, J.E.1    Tsai, T.Y.2    Yang, Q.3
  • 21
    • 0000915688 scopus 로고
    • On the relation between the logical structure of systems and their ability to generate multiple steady states or sustained oscillations
    • Thomas R. On the relation between the logical structure of systems and their ability to generate multiple steady states or sustained oscillations. Springer Ser Synergetics 1981, 9:180-193.
    • (1981) Springer Ser Synergetics , vol.9 , pp. 180-193
    • Thomas, R.1
  • 22
    • 80051665924 scopus 로고    scopus 로고
    • Stable periodicity and negative circuits in differential systems
    • Richard A., Comet J.P. Stable periodicity and negative circuits in differential systems. J Math Biol 2011, 63:593-600.
    • (2011) J Math Biol , vol.63 , pp. 593-600
    • Richard, A.1    Comet, J.P.2
  • 24
    • 0016659905 scopus 로고
    • Control of mitosis by a continuous biochemical oscillation: synchronization; spatially inhomogeneous oscillations
    • Tyson J., Kauffman S. Control of mitosis by a continuous biochemical oscillation: synchronization; spatially inhomogeneous oscillations. J Math Biol 1975, 1:289-310.
    • (1975) J Math Biol , vol.1 , pp. 289-310
    • Tyson, J.1    Kauffman, S.2
  • 25
    • 0025367233 scopus 로고
    • Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
    • Felix M.A., Labbe J.C., Doree M., Hunt T., Karsenti E. Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase. Nature 1990, 346:379-382.
    • (1990) Nature , vol.346 , pp. 379-382
    • Felix, M.A.1    Labbe, J.C.2    Doree, M.3    Hunt, T.4    Karsenti, E.5
  • 26
    • 0026089183 scopus 로고
    • Cyclin is degraded by the ubiquitin pathway
    • Glotzer M., Murray A.W., Kirschner M.W. Cyclin is degraded by the ubiquitin pathway. Nature 1991, 349:132-138.
    • (1991) Nature , vol.349 , pp. 132-138
    • Glotzer, M.1    Murray, A.W.2    Kirschner, M.W.3
  • 27
    • 79959555511 scopus 로고    scopus 로고
    • Cubism and the cell cycle: the many faces of the APC/C
    • Pines J. Cubism and the cell cycle: the many faces of the APC/C. Nat Rev Mol Cell Biol 2011, 12:427-438.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 427-438
    • Pines, J.1
  • 28
    • 84877578533 scopus 로고    scopus 로고
    • The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch
    • Yang Q., Ferrell J.E. The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat Cell Biol 2013, 15:519-525.
    • (2013) Nat Cell Biol , vol.15 , pp. 519-525
    • Yang, Q.1    Ferrell, J.E.2
  • 31
    • 0033598334 scopus 로고    scopus 로고
    • Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle
    • Haase S.B., Reed S.I. Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle. Nature 1999, 401:394-397.
    • (1999) Nature , vol.401 , pp. 394-397
    • Haase, S.B.1    Reed, S.I.2
  • 32
    • 78049290987 scopus 로고    scopus 로고
    • Reliability of transcriptional cycles and the yeast cell-cycle oscillator
    • Sevim V., Gong X., Socolar J.E. Reliability of transcriptional cycles and the yeast cell-cycle oscillator. PLoS Comput Biol 2010, 6:e1000842.
    • (2010) PLoS Comput Biol , vol.6
    • Sevim, V.1    Gong, X.2    Socolar, J.E.3
  • 33
    • 0014319313 scopus 로고
    • Mathematics of cellular control processes. I. Negative feedback to one gene
    • Griffith J.S. Mathematics of cellular control processes. I. Negative feedback to one gene. J Theor Biol 1968, 20:202-208.
    • (1968) J Theor Biol , vol.20 , pp. 202-208
    • Griffith, J.S.1
  • 34
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz M.B., Leibler S. A synthetic oscillatory network of transcriptional regulators. Nature 2000, 403:335-338.
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 35
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner T.S., Cantor C.R., Collins J.J. Construction of a genetic toggle switch in Escherichia coli. Nature 2000, 403:339-342.
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 37
    • 0027509501 scopus 로고
    • Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
    • Hoffmann I., Clarke P.R., Marcote M.J., Karsenti E., Draetta G. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J 1993, 12:53-63.
    • (1993) EMBO J , vol.12 , pp. 53-63
    • Hoffmann, I.1    Clarke, P.R.2    Marcote, M.J.3    Karsenti, E.4    Draetta, G.5
  • 38
    • 0026719599 scopus 로고
    • Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
    • Kumagai A., Dunphy W.G. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell 1992, 70:139-151.
    • (1992) Cell , vol.70 , pp. 139-151
    • Kumagai, A.1    Dunphy, W.G.2
  • 39
    • 0028998865 scopus 로고
    • Cell cycle regulation of a Xenopus Wee1-like kinase
    • Mueller P.R., Coleman T.R., Dunphy W.G. Cell cycle regulation of a Xenopus Wee1-like kinase. Mol Biol Cell 1995, 6:119-134.
    • (1995) Mol Biol Cell , vol.6 , pp. 119-134
    • Mueller, P.R.1    Coleman, T.R.2    Dunphy, W.G.3
  • 40
    • 0027510249 scopus 로고
    • Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15
    • McGowan C.H., Russell P. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J 1993, 12:75-85.
    • (1993) EMBO J , vol.12 , pp. 75-85
    • McGowan, C.H.1    Russell, P.2
  • 41
    • 0027716813 scopus 로고
    • Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos
    • Novak B., Tyson J.J. Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos. J Cell Sci 1993, 106:1153-1168.
    • (1993) J Cell Sci , vol.106 , pp. 1153-1168
    • Novak, B.1    Tyson, J.J.2
  • 42
    • 0027451906 scopus 로고
    • Modeling the cell division cycle: M-phase trigger, oscillations, and size control
    • Novak B., Tyson J.J. Modeling the cell division cycle: M-phase trigger, oscillations, and size control. J Theor Biol 1993, 165:101-134.
    • (1993) J Theor Biol , vol.165 , pp. 101-134
    • Novak, B.1    Tyson, J.J.2
  • 44
    • 0345700833 scopus 로고    scopus 로고
    • Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2
    • Pomerening J.R., Sontag E.D., Ferrell J.E. Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol 2003, 5:346-351.
    • (2003) Nat Cell Biol , vol.5 , pp. 346-351
    • Pomerening, J.R.1    Sontag, E.D.2    Ferrell, J.E.3
  • 46
    • 0345359924 scopus 로고    scopus 로고
    • A positive feedback-based bistable 'memory-module' that governs a cell fate decision
    • Xiong W., Ferrell J.E. A positive feedback-based bistable 'memory-module' that governs a cell fate decision. Nature 2003, 426:460-465.
    • (2003) Nature , vol.426 , pp. 460-465
    • Xiong, W.1    Ferrell, J.E.2
  • 47
    • 0036532226 scopus 로고    scopus 로고
    • Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability
    • Ferrell J.E. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 2002, 14:140-148.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 140-148
    • Ferrell, J.E.1
  • 49
    • 73049167504 scopus 로고
    • General conclusions: teleonomic mechanisms in cellular metabolism, growth, and differentiation
    • Monod J., Jacob F. General conclusions: teleonomic mechanisms in cellular metabolism, growth, and differentiation. Cold Spring Harbor Symp Quant Biol 1961, 26:389-401.
    • (1961) Cold Spring Harbor Symp Quant Biol , vol.26 , pp. 389-401
    • Monod, J.1    Jacob, F.2
  • 50
    • 18144408736 scopus 로고    scopus 로고
    • Cell fates as high-dimensional attractor states of a complex gene regulatory network
    • Huang S., Eichler G., Bar-Yam Y., Ingber D.E. Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett 2005, 94:128701.
    • (2005) Phys Rev Lett , vol.94 , pp. 128701
    • Huang, S.1    Eichler, G.2    Bar-Yam, Y.3    Ingber, D.E.4
  • 51
    • 84861865440 scopus 로고    scopus 로고
    • Bistability, bifurcations, and Waddington's epigenetic landscape
    • Ferrell J.E. Bistability, bifurcations, and Waddington's epigenetic landscape. Curr Biol 2012, 22:R458-R466.
    • (2012) Curr Biol , vol.22
    • Ferrell, J.E.1
  • 52
    • 0033545694 scopus 로고    scopus 로고
    • Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
    • Jaspersen S.L., Charles J.F., Morgan D.O. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol 1999, 9:227-236.
    • (1999) Curr Biol , vol.9 , pp. 227-236
    • Jaspersen, S.L.1    Charles, J.F.2    Morgan, D.O.3
  • 53
    • 70849105394 scopus 로고    scopus 로고
    • Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis
    • Sigl R., Wandke C., Rauch V., Kirk J., Hunt T., Geley S. Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J Cell Sci 2009, 122:4208-4217.
    • (2009) J Cell Sci , vol.122 , pp. 4208-4217
    • Sigl, R.1    Wandke, C.2    Rauch, V.3    Kirk, J.4    Hunt, T.5    Geley, S.6
  • 54
    • 38949099707 scopus 로고    scopus 로고
    • The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells
    • Engelbert D., Schnerch D., Baumgarten A., Wasch R. The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. Oncogene 2008, 27:907-917.
    • (2008) Oncogene , vol.27 , pp. 907-917
    • Engelbert, D.1    Schnerch, D.2    Baumgarten, A.3    Wasch, R.4
  • 55
    • 34347381069 scopus 로고    scopus 로고
    • Irreversible cell-cycle transitions are due to systems-level feedback
    • Novak B., Tyson J.J., Gyorffy B., Csikasz-Nagy A. Irreversible cell-cycle transitions are due to systems-level feedback. Nat Cell Biol 2007, 9:724-728.
    • (2007) Nat Cell Biol , vol.9 , pp. 724-728
    • Novak, B.1    Tyson, J.J.2    Gyorffy, B.3    Csikasz-Nagy, A.4
  • 56
    • 45449123944 scopus 로고
    • Singular perturbation theory of traveling waves in excitable media (a review)
    • Tyson J.J., Keener J.P. Singular perturbation theory of traveling waves in excitable media (a review). Physica D 1988, 32:327-361.
    • (1988) Physica D , vol.32 , pp. 327-361
    • Tyson, J.J.1    Keener, J.P.2
  • 57
    • 84883135332 scopus 로고    scopus 로고
    • Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle
    • Chang J.B., Ferrell J.E. Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle. Nature 2013, 500:603-607.
    • (2013) Nature , vol.500 , pp. 603-607
    • Chang, J.B.1    Ferrell, J.E.2
  • 58
    • 0024959919 scopus 로고
    • + protein kinase regulates entry into mitosis
    • + protein kinase regulates entry into mitosis. Nature 1989, 342:39-45.
    • (1989) Nature , vol.342 , pp. 39-45
    • Gould, K.L.1    Nurse, P.2
  • 59
    • 0023662312 scopus 로고
    • Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog
    • Russell P., Nurse P. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell 1987, 49:559-567.
    • (1987) Cell , vol.49 , pp. 559-567
    • Russell, P.1    Nurse, P.2
  • 60
    • 78650842310 scopus 로고    scopus 로고
    • Driving the cell cycle with a minimal CDK control network
    • Coudreuse D., Nurse P. Driving the cell cycle with a minimal CDK control network. Nature 2010, 468:1074-1079.
    • (2010) Nature , vol.468 , pp. 1074-1079
    • Coudreuse, D.1    Nurse, P.2
  • 61
    • 84867846008 scopus 로고    scopus 로고
    • The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions
    • Tischer T., Hormanseder E., Mayer T.U. The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions. Science 2012, 338:520-524.
    • (2012) Science , vol.338 , pp. 520-524
    • Tischer, T.1    Hormanseder, E.2    Mayer, T.U.3
  • 62
    • 84875642243 scopus 로고    scopus 로고
    • The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles
    • Vinod P.K., Zhou X., Zhang T., Mayer T.U., Novak B. The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles. Biophys Chem 2013, 177-178:1-6.
    • (2013) Biophys Chem , pp. 1-6
    • Vinod, P.K.1    Zhou, X.2    Zhang, T.3    Mayer, T.U.4    Novak, B.5
  • 63
    • 80051720034 scopus 로고    scopus 로고
    • Distinct interactions select and maintain a specific cell fate
    • Doncic A., Falleur-Fettig M., Skotheim J.M. Distinct interactions select and maintain a specific cell fate. Mol Cell 2011, 43:528-539.
    • (2011) Mol Cell , vol.43 , pp. 528-539
    • Doncic, A.1    Falleur-Fettig, M.2    Skotheim, J.M.3
  • 64
    • 80051716158 scopus 로고    scopus 로고
    • Commitment to a cellular transition precedes genome-wide transcriptional change
    • Eser U., Falleur-Fettig M., Johnson A., Skotheim J.M. Commitment to a cellular transition precedes genome-wide transcriptional change. Mol Cell 2011, 43:515-527.
    • (2011) Mol Cell , vol.43 , pp. 515-527
    • Eser, U.1    Falleur-Fettig, M.2    Johnson, A.3    Skotheim, J.M.4
  • 65
    • 47549106474 scopus 로고    scopus 로고
    • Positive feedback of G1 cyclins ensures coherent cell cycle entry
    • Skotheim J.M., Di Talia S., Siggia E.D., Cross F.R. Positive feedback of G1 cyclins ensures coherent cell cycle entry. Nature 2008, 454:291-296.
    • (2008) Nature , vol.454 , pp. 291-296
    • Skotheim, J.M.1    Di Talia, S.2    Siggia, E.D.3    Cross, F.R.4
  • 66
    • 43149108161 scopus 로고    scopus 로고
    • A bistable Rb-E2F switch underlies the restriction point
    • Yao G., Lee T.J., Mori S., Nevins J.R., You L. A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol 2008, 10:476-482.
    • (2008) Nat Cell Biol , vol.10 , pp. 476-482
    • Yao, G.1    Lee, T.J.2    Mori, S.3    Nevins, J.R.4    You, L.5
  • 67
    • 23944469094 scopus 로고    scopus 로고
    • Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations
    • Pomerening J.R., Kim S.Y., Ferrell J.E. Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell 2005, 122:565-578.
    • (2005) Cell , vol.122 , pp. 565-578
    • Pomerening, J.R.1    Kim, S.Y.2    Ferrell, J.E.3
  • 68
    • 54249138783 scopus 로고    scopus 로고
    • Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF
    • Pomerening J.R., Ubersax J.A., Ferrell J.E. Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. Mol Biol Cell 2008, 19:3426-3441.
    • (2008) Mol Biol Cell , vol.19 , pp. 3426-3441
    • Pomerening, J.R.1    Ubersax, J.A.2    Ferrell, J.E.3
  • 69
    • 0002275384 scopus 로고
    • The dynamics of feedback control circuits in biochemical pathways
    • Tyson J.J., Othmer H.G. The dynamics of feedback control circuits in biochemical pathways. Prog Theor Biol 1978, 5:1-62.
    • (1978) Prog Theor Biol , vol.5 , pp. 1-62
    • Tyson, J.J.1    Othmer, H.G.2
  • 70
    • 46849090495 scopus 로고    scopus 로고
    • Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    • Tsai T.Y., Choi Y.S., Ma W., Pomerening J.R., Tang C., Ferrell J.E. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science 2008, 321:126-129.
    • (2008) Science , vol.321 , pp. 126-129
    • Tsai, T.Y.1    Choi, Y.S.2    Ma, W.3    Pomerening, J.R.4    Tang, C.5    Ferrell, J.E.6
  • 71
    • 70349210060 scopus 로고    scopus 로고
    • Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts
    • Mochida S., Ikeo S., Gannon J., Hunt T. Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J 2009, 28:2777-2785.
    • (2009) EMBO J , vol.28 , pp. 2777-2785
    • Mochida, S.1    Ikeo, S.2    Gannon, J.3    Hunt, T.4
  • 72
    • 78650366525 scopus 로고    scopus 로고
    • Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis
    • Mochida S., Maslen S.L., Skehel M., Hunt T. Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science 2010, 330:1670-1673.
    • (2010) Science , vol.330 , pp. 1670-1673
    • Mochida, S.1    Maslen, S.L.2    Skehel, M.3    Hunt, T.4
  • 73
    • 33645968394 scopus 로고    scopus 로고
    • Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts
    • Yu J., Zhao Y., Li Z., Galas S., Goldberg M.L. Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts. Mol Cell 2006, 22:83-91.
    • (2006) Mol Cell , vol.22 , pp. 83-91
    • Yu, J.1    Zhao, Y.2    Li, Z.3    Galas, S.4    Goldberg, M.L.5
  • 74
    • 85027928854 scopus 로고    scopus 로고
    • Protein phosphatases and their regulation in the control of mitosis
    • Mochida S., Hunt T. Protein phosphatases and their regulation in the control of mitosis. EMBO Rep 2012.
    • (2012) EMBO Rep
    • Mochida, S.1    Hunt, T.2
  • 75
    • 73949151141 scopus 로고    scopus 로고
    • The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites
    • Castilho P.V., Williams B.C., Mochida S., Zhao Y., Goldberg M.L. The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites. Mol Biol Cell 2009, 20:4777-4789.
    • (2009) Mol Biol Cell , vol.20 , pp. 4777-4789
    • Castilho, P.V.1    Williams, B.C.2    Mochida, S.3    Zhao, Y.4    Goldberg, M.L.5
  • 76
    • 0037605637 scopus 로고    scopus 로고
    • Bistability in cell signaling: how to make continuous processes discontinuous, and reversible processes irreversible
    • Ferrell J.E., Xiong W. Bistability in cell signaling: how to make continuous processes discontinuous, and reversible processes irreversible. Chaos 2001, 11:227-236.
    • (2001) Chaos , vol.11 , pp. 227-236
    • Ferrell, J.E.1    Xiong, W.2
  • 77
    • 33947304756 scopus 로고    scopus 로고
    • Substrate competition as a source of ultrasensitivity in the inactivation of Wee1
    • Kim S.Y., Ferrell J.E. Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell 2007, 128:1133-1145.
    • (2007) Cell , vol.128 , pp. 1133-1145
    • Kim, S.Y.1    Ferrell, J.E.2
  • 78
    • 79251534050 scopus 로고    scopus 로고
    • Ultrasensitivity in the regulation of Cdc25C by Cdk1
    • Trunnell N.B., Poon A.C., Kim S.Y., Ferrell J.E. Ultrasensitivity in the regulation of Cdc25C by Cdk1. Mol Cell 2011, 41:263-274.
    • (2011) Mol Cell , vol.41 , pp. 263-274
    • Trunnell, N.B.1    Poon, A.C.2    Kim, S.Y.3    Ferrell, J.E.4
  • 79
    • 80053342612 scopus 로고    scopus 로고
    • A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast
    • Harvey S.L., Enciso G., Dephoure N., Gygi S.P., Gunawardena J., Kellogg D.R. A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast. Mol Biol Cell 2011, 22:3595-3608.
    • (2011) Mol Biol Cell , vol.22 , pp. 3595-3608
    • Harvey, S.L.1    Enciso, G.2    Dephoure, N.3    Gygi, S.P.4    Gunawardena, J.5    Kellogg, D.R.6
  • 80
    • 40749085952 scopus 로고    scopus 로고
    • Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses
    • Ferrell J.E. Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr Biol 2008, 18:R244-R245.
    • (2008) Curr Biol , vol.18
    • Ferrell, J.E.1
  • 81
    • 0019996706 scopus 로고
    • Amplification and adaptation in regulatory and sensory systems
    • Koshland D.E., Goldbeter A., Stock J.B. Amplification and adaptation in regulatory and sensory systems. Science 1982, 217:220-225.
    • (1982) Science , vol.217 , pp. 220-225
    • Koshland, D.E.1    Goldbeter, A.2    Stock, J.B.3
  • 83
    • 0033615328 scopus 로고    scopus 로고
    • Control of mitotic transitions by the anaphase-promoting complex
    • Fang G., Yu H., Kirschner M.W. Control of mitotic transitions by the anaphase-promoting complex. Philos Trans R Soc Lond B Biol Sci 1999, 354:1583-1590.
    • (1999) Philos Trans R Soc Lond B Biol Sci , vol.354 , pp. 1583-1590
    • Fang, G.1    Yu, H.2    Kirschner, M.W.3
  • 86
    • 70350111289 scopus 로고    scopus 로고
    • MiR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A
    • Yang X., Feng M., Jiang X., Wu Z., Li Z., Aau M., Yu Q. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 2009, 23:2388-2393.
    • (2009) Genes Dev , vol.23 , pp. 2388-2393
    • Yang, X.1    Feng, M.2    Jiang, X.3    Wu, Z.4    Li, Z.5    Aau, M.6    Yu, Q.7
  • 88
    • 0029000155 scopus 로고
    • Cell cycle regulation of human WEE1
    • McGowan C.H., Russell P. Cell cycle regulation of human WEE1. EMBO J 1995, 14:2166-2175.
    • (1995) EMBO J , vol.14 , pp. 2166-2175
    • McGowan, C.H.1    Russell, P.2
  • 89
    • 0030803797 scopus 로고    scopus 로고
    • Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
    • Booher R.N., Holman P.S., Fattaey A. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J Biol Chem 1997, 272:22300-22306.
    • (1997) J Biol Chem , vol.272 , pp. 22300-22306
    • Booher, R.N.1    Holman, P.S.2    Fattaey, A.3
  • 90
    • 0031297716 scopus 로고    scopus 로고
    • Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14
    • Fattaey A., Booher R.N. Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14. Prog Cell Cycle Res 1997, 3:233-240.
    • (1997) Prog Cell Cycle Res , vol.3 , pp. 233-240
    • Fattaey, A.1    Booher, R.N.2
  • 91
    • 0028783413 scopus 로고
    • Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15
    • Mueller P.R., Coleman T.R., Kumagai A., Dunphy W.G. Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 1995, 270:86-90.
    • (1995) Science , vol.270 , pp. 86-90
    • Mueller, P.R.1    Coleman, T.R.2    Kumagai, A.3    Dunphy, W.G.4
  • 92
    • 0242515843 scopus 로고    scopus 로고
    • Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates
    • Elia A., Cantley L.C., Yaffe M.B. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 2003, 299:1228-1231.
    • (2003) Science , vol.299 , pp. 1228-1231
    • Elia, A.1    Cantley, L.C.2    Yaffe, M.B.3
  • 93
    • 60649091874 scopus 로고    scopus 로고
    • The polo-like kinase 1 regulates CDC25B-dependent mitosis entry
    • Lobjois V., Jullien D., Bouche J.P., Ducommun B. The polo-like kinase 1 regulates CDC25B-dependent mitosis entry. Biochim Biophys Acta 2009, 1793:462-468.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 462-468
    • Lobjois, V.1    Jullien, D.2    Bouche, J.P.3    Ducommun, B.4
  • 94
    • 0029821131 scopus 로고    scopus 로고
    • Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts
    • Kumagai A., Dunphy W.G. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science 1996, 273:1377-1380.
    • (1996) Science , vol.273 , pp. 1377-1380
    • Kumagai, A.1    Dunphy, W.G.2
  • 95
    • 0031850551 scopus 로고    scopus 로고
    • The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs
    • Abrieu A., Brassac T., Galas S., Fisher D., Labb J.C., Doree M. The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. J Cell Sci 1998, 111:1751-1757.
    • (1998) J Cell Sci , vol.111 , pp. 1751-1757
    • Abrieu, A.1    Brassac, T.2    Galas, S.3    Fisher, D.4    Labb, J.C.5    Doree, M.6
  • 96
    • 0032560029 scopus 로고    scopus 로고
    • The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
    • Charles J.F., Jaspersen S.L., Tinker-Kulberg R.L., Hwang L., Szidon A., Morgan D.O. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol 1998, 8:497-507.
    • (1998) Curr Biol , vol.8 , pp. 497-507
    • Charles, J.F.1    Jaspersen, S.L.2    Tinker-Kulberg, R.L.3    Hwang, L.4    Szidon, A.5    Morgan, D.O.6
  • 97
    • 84862682760 scopus 로고    scopus 로고
    • Spatial positive feedback at the onset of mitosis
    • Santos S.D., Wollman R., Meyer T., Ferrell J.E. Spatial positive feedback at the onset of mitosis. Cell 2012, 149:1500-1513.
    • (2012) Cell , vol.149 , pp. 1500-1513
    • Santos, S.D.1    Wollman, R.2    Meyer, T.3    Ferrell, J.E.4
  • 99
    • 47549083849 scopus 로고    scopus 로고
    • Positive feedback sharpens the anaphase switch
    • Holt L.J., Krutchinsky A.N., Morgan D.O. Positive feedback sharpens the anaphase switch. Nature 2008, 454:353-357.
    • (2008) Nature , vol.454 , pp. 353-357
    • Holt, L.J.1    Krutchinsky, A.N.2    Morgan, D.O.3
  • 101
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • Vlach J., Hennecke S., Amati B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 1997, 16:5334-5344.
    • (1997) EMBO J , vol.16 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 102
    • 0028114987 scopus 로고
    • The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae
    • Schwob E., Bohm T., Mendenhall M.D., Nasmyth K. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 1994, 79:233-244.
    • (1994) Cell , vol.79 , pp. 233-244
    • Schwob, E.1    Bohm, T.2    Mendenhall, M.D.3    Nasmyth, K.4
  • 105
    • 0027204608 scopus 로고
    • Negative regulation of FAR1 at the Start of the yeast cell cycle
    • McKinney J.D., Chang F., Heintz N., Cross F.R. Negative regulation of FAR1 at the Start of the yeast cell cycle. Genes Dev 1993, 7:833-843.
    • (1993) Genes Dev , vol.7 , pp. 833-843
    • McKinney, J.D.1    Chang, F.2    Heintz, N.3    Cross, F.R.4
  • 106
    • 0027191189 scopus 로고
    • FAR1 links the signal transduction pathway to the cell cycle machinery in yeast
    • Peter M., Gartner A., Horecka J., Ammerer G., Herskowitz I. FAR1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell 1993, 73:747-760.
    • (1993) Cell , vol.73 , pp. 747-760
    • Peter, M.1    Gartner, A.2    Horecka, J.3    Ammerer, G.4    Herskowitz, I.5
  • 107
    • 0036261578 scopus 로고    scopus 로고
    • The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6
    • Wijnen H., Landman A., Futcher B. The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6. Mol Cell Biol 2002, 22:4402-4418.
    • (2002) Mol Cell Biol , vol.22 , pp. 4402-4418
    • Wijnen, H.1    Landman, A.2    Futcher, B.3
  • 110
    • 2942755857 scopus 로고    scopus 로고
    • Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5
    • de Bruin R.A., McDonald W.H., Kalashnikova T.I., Yates J., Wittenberg C. Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. Cell 2004, 117:887-898.
    • (2004) Cell , vol.117 , pp. 887-898
    • de Bruin, R.A.1    McDonald, W.H.2    Kalashnikova, T.I.3    Yates, J.4    Wittenberg, C.5
  • 111
    • 0035513783 scopus 로고    scopus 로고
    • Men and sin: what's the difference?
    • Bardin A.J., Amon A. Men and sin: what's the difference?. Nat Rev Mol Cell Biol 2001, 2:815-826.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 815-826
    • Bardin, A.J.1    Amon, A.2
  • 113
    • 0032941746 scopus 로고    scopus 로고
    • Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
    • Furnari B., Blasina A., Boddy M.N., McGowan C.H., Russell P. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1. Mol Biol Cell 1999, 10:833-845.
    • (1999) Mol Biol Cell , vol.10 , pp. 833-845
    • Furnari, B.1    Blasina, A.2    Boddy, M.N.3    McGowan, C.H.4    Russell, P.5
  • 114
    • 0032555924 scopus 로고    scopus 로고
    • The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
    • Kumagai A., Guo Z., Emami K.H., Wang S.X., Dunphy W.G. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J Cell Biol 1998, 142:1559-1569.
    • (1998) J Cell Biol , vol.142 , pp. 1559-1569
    • Kumagai, A.1    Guo, Z.2    Emami, K.H.3    Wang, S.X.4    Dunphy, W.G.5
  • 115
    • 0031906844 scopus 로고    scopus 로고
    • 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts
    • Kumagai A., Yakowec P.S., Dunphy W.G. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Mol Biol Cell 1998, 9:345-354.
    • (1998) Mol Biol Cell , vol.9 , pp. 345-354
    • Kumagai, A.1    Yakowec, P.S.2    Dunphy, W.G.3
  • 116
    • 0035158899 scopus 로고    scopus 로고
    • Positive regulation of Wee1 by Chk1 and 14-3-3 proteins
    • Lee J., Kumagai A., Dunphy W.G. Positive regulation of Wee1 by Chk1 and 14-3-3 proteins. Mol Biol Cell 2001, 12:551-563.
    • (2001) Mol Biol Cell , vol.12 , pp. 551-563
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3


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