Signaling pathways that regulate cell division

Cold Spring Harbor Perspectives in Biology

Volumn 4, Issue 10, 2012, Pages

  Rhind, Nicholas ^a   Russell, Paul ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 1;

ARTICLE; BIOLOGICAL MODEL; CELL CYCLE CHECKPOINT; CELL DIVISION; DNA DAMAGE; DNA REPLICATION; FEEDBACK SYSTEM; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CDC2 PROTEIN KINASE; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL DIVISION; DNA DAMAGE; DNA REPLICATION; FEEDBACK, PHYSIOLOGICAL; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 84867616397     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a005942     Document Type: Article

References (100)

1. Almonacid M, Paoletti A. 2010. Mechanisms controlling division-plane positioning. Semin Cell Dev Biol 21: 874-880.
2. Archambault V, Glover DM. 2009. Polo-like kinases: Conservation and divergence in their functions and regulation. Nat Rev Mol Cell Biol 10: 265-275.
3. Bardin AJ, Visintin R, Amon A. 2000. A mechanism for coupling exit from mitosis to partitioning of the nucleus. Cell 102: 21-31.
4. Barr FA, Sillje HH, Nigg EA. 2004. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 5: 429-440.
5. Bartek J, Lukas C, Lukas J. 2004. Checking on DNA damage in S phase. Nat Rev Mol Cell Biol 5: 792-804.
6. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP. 2006. A probabilitybased approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol 24: 1285-1292.
7. Bloom J, Cross FR. 2007. Multiple levels of cyclin specificity in cell-cycle control. Nat Rev Mol Cell Biol 8: 149-160.
8. Bonilla CY, Melo JA, Toczyski DP. 2008. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell 30: 267-276.
9. Bonner WM, Redon CE, Dickey JS, Nakamura AJ, SedelnikovaOA, Solier S, Pommier Y. 2008. gH2AX and cancer. Nat Rev Cancer 8: 957-967.
10. Branzei D, Foiani M. 2010. Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol 11: 208-219.
11. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. 1998. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501.
12. Castilho PV, Williams BC, Mochida S, Zhao Y, Goldberg ML. 2009. The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/ B55d, a phosphatase directed against CDK phosphosites. Mol Biol Cell 20: 4777-4789.
13. Cimprich KA, Cortez D. 2008. ATR: An essential regulator of genome integrity. Nat Rev Mol Cell Biol 9: 616-627.
14. Clifford DM, Chen CT, Roberts RH, Feoktistova A, Wolfe BA, Chen JS, McCollum D, Gould KL. 2008. The role of Cdc14 phosphatases in the control of cell division. Biochem Soc Trans 36: 436-438.
15. Coudreuse D, Nurse P. 2010. Driving the cell cycle with a minimal CDK control network. Nature 468: 1074-1079.
16. Davis R. 2012. p38 MAPK. Cold Spring Harb Perspect Biol (to be published).
17. de Bruin RA, Kalashnikova TI, Aslanian A, Wohlschlegel J, Chahwan C, Yates JR, Russell P, Wittenberg C. 2008. DNA replication checkpoint promotes G1-S transcription by inactivating the MBFrepressor Nrm1. Proc Natl Acad Sci 105: 11230-11235.
18. Domingo-Sananes MR, Kapuy O, Hunt T, Novak B. 2011. Switches and latches: A biochemical tug-of-war between the kinases and phosphatases that control mitosis. Philos Trans R Soc Lond B Biol Sci 366: 3584-3594.
19. Du LL, Nakamura TM, Russell P. 2006. Histone modification-dependent and-independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev 20: 1583-1596.
20. Duronio RJ, Xiong Y. 2012. Signaling to the G1 cell cycle. Cold Spring Harb Perspect Biol doi: 10:1101/cshperspect.a008904.
21. Dutta C, Patel PK, Rosebrock A, Oliva A, Leatherwood J, Rhind N. 2008. The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription. Mol Cell Biol 28: 5977-5985.
22. Fantes P, Nurse P. 1977. Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division. Exp Cell Res 107: 377-386.
23. Featherstone C, Russell P. 1991. Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature 349: 808-811.
24. Garcia-Cortes JC, McCollum D. 2009. Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1. J Cell Biol 186: 739-753.
25. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. 1991. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67: 197-211.
26. Gharbi-Ayachi A, Labbe JC, Burgess A, Vigneron S, Strub JM, Brioudes E, Van-Dorsselaer A, Castro A, Lorca T. 2010. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science 330: 1673-1677.
27. +protein kinase regulates entry into mitosis. Nature 342: 39-45.
28. Goyal A, Takaine M, Simanis V, Nakano K. 2011. Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis. Cytoskeleton (Hoboken) 68: 69-88.
29. Guertin DA, Chang L, Irshad F, Gould KL, McCollum D. 2000. The role of the Sid1p kinase and Cdc14p in regulating the onset of cytokinesis in fission yeast. EMBO J 19: 1803-1815.
30. Haase SB, Reed SI. 1999. Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle. Nature 401: 394-397.
31. Hachet O, Berthelot-Grosjean M, Kokkoris K, Vincenzetti V, Moosbrugger J, Martin SG. 2011. A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane. Cell 145: 1116-1128.
32. Hariharan lK. 2012. The Hippo pathway. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a011288.
33. Harper JW, Elledge SJ. 2007. The DNA damage response: Ten years after. Mol Cell 28: 739-745.
34. Harrison JC, Haber JE. 2006. Surviving the breakup: The DNA damage checkpoint. Annu Rev Genet 40: 209-235.
35. Hartwell LH, Weinert TA. 1989. Checkpoints: Controls that ensure the order of cell cycle events. Science 246: 629-634.
36. Harvey and Hariharan. 2012. Hippo signaling. Cold Spring Harb Perspect Biol (to be published).
37. Hotamisligil G, Davis RJ. 2012. Cell signaling and stress responses. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a006072.
38. Howell AS, Lew DJ. 2012. Morphogenesis and the cell cycle. Genetics 190: 51-77.
39. Jackson SP, Bartek J. 2009. The DNA-damage response in human biology and disease. Nature 461: 1071-1078.
40. Jorgensen P, Tyers M. 2004. How cells coordinate growth and division. Curr Biol 14: R1014-R1027.
41. Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P. 2009. CyclinA is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138: 352-365.
42. Karlsson-Rosenthal C, Millar JB. 2006. Cdc25: Mechanisms of checkpoint inhibition and recovery. Trends Cell Biol 16: 285-292.
43. Kastan MB, Bartek J. 2004. Cell-cycle checkpoints and cancer. Nature 432: 316-323.
44. Kellogg DR. 2003. Wee1-dependent mechanisms required for coordination of cell growth and cell division. J Cell Sci 116: 4883-4890.
45. Khodjakov A, Pines J. 2010. Centromere tension: Adivisive issue. Nat Cell Biol 12: 919-923.
46. Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM. 2003. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J 22: 6598-6609.
47. Kumagai A, Dunphy WG. 1991. The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 64: 903-914.
48. Kumagai A, Dunphy WG. 1996. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science 273: 1377-1380.
49. Kumagai A, DunphyWG. 2000. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 6: 839-849.
50. Laplante M, Sabatini DM. 2012. mTOR signaling. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a011593.
51. Li X, Nicklas RB. 1995. Mitotic forces control a cell-cycle checkpoint. Nature 373: 630-632.
52. Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. 1991. Mik1 and Wee1 cooperate in the inhibitory tyrosine phosphorylation of Cdc2. Cell 64: 1111-1122.
53. Ma HT, Poon RY. 2011. How protein kinases co-ordinate mitosis in animal cells. Biochem J 435: 17-31.
54. Martin SG, Berthelot-Grosjean M. 2009. Polar gradients of the DYRKfamily kinase Pom1 couple cell length with the cell cycle. Nature 459: 852-856.
55. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER III, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, et al. 2007. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-1166.
56. McCollum D, Gould KL. 2001. Timing is everything: Regulation of mitotic exit and cytokinesis by the MEN and SIN. Trends Cell Biol 11: 89-95.
57. McFarlane RJ, Mian S, Dalgaard JZ. 2010. The many facets of the Tim-Tipin protein families' roles in chromosome biology. Cell Cycle 9: 700-705.
58. Meitinger F, Palani S, Pereira G. 2012. The power of MEN in cytokinesis. Cell Cycle 11: 219-228.
59. Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J. 2008. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol 181: 213-226.
60. Mimitou EP, Symington LS. 2011. DNA end resection-unraveling the tail. DNA Repair (Amst) 10: 344-348.
61. Morgan DO. 1995. Principles of CDK regulation. Nature 374: 131-134.
62. Morgan DO. 2006. The cell cycle: Principles of control. Oxford University Press, Sunderland, MA.
63. Morrison D. 2012. MAP kinase pathways. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a011254.
64. Moseley JB, Mayeux A, Paoletti A, Nurse P. 2009. A spatial gradient coordinates cell size and mitotic entry in fission yeast. Nature 459: 857-860.
65. Mueller PR, Coleman TR, Kumagai A, Dunphy WG. 1995. Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 270: 86-90.
66. Murray AW, Hunt T. 1993. The cell cycle: An introduction.W.H. Freeman, New York.
67. Musacchio A, Salmon ED. 2007. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8: 379-393.
68. Navadgi-Patil VM, Burgers PM. 2009. A tale of two tails: Activation of DNAdamage checkpoint kinaseMec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) 8: 996-1003.
69. Nurse P. 1975. Genetic control of cell size at cell division in yeast. Nature 256: 547-551.
70. Nurse P. 1990. Universal control mechanism regulating onset of Mphase. Nature 344: 503-508.
71. Nurse P. 2000. A long twentieth century of the cell cycle and beyond. Cell 100: 71-78.
72. Parker LL, Piwnica-Worms H. 1992. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257: 1955-1957.
73. Pesin JA, Orr-Weaver TL. 2008. Regulation of APC/C activators in mitosis and meiosis. Annu Rev Cell Dev Biol 24: 475-499.
74. Petersen J, Nurse P. 2007. TOR signalling regulates mitotic commitment through the stressMAPkinase pathway and the Polo and Cdc2 kinases. Nat Cell Biol 9: 1263-1272.
75. Polymenis M, Schmidt EV. 1997. Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev 11: 2522-2531.
76. Pomerening JR, Sontag ED, Ferrell JE Jr. 2003. Building a cell cycle oscillator: Hysteresis and bistability in the activation of Cdc2. Nat Cell Biol 5: 346-351.
77. Porter LA, Donoghue DJ. 2003. Cyclin B1 and CDK1: Nuclear localization and upstream regulators. Prog Cell Cycle Res 5: 335-347.
78. Rhind N, Russell P. 2000. Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci 113: 3889-3896.
79. Rieder CL. 2011. Mitosis in vertebrates: The G2/M and M/A transitions and their associated checkpoints. Chromosome Res 19: 291-306.
80. Rieder CL, Cole RW, Khodjakov A, Sluder G. 1995. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J Cell Biol 130: 941-948.
81. +functions as an inducer in the mitotic control of fission yeast. Cell 45: 145-153.
82. +, a gene encoding a protein kinase homolog. Cell 49: 559-567.
83. Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJ. 1999. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science 286: 1166-1171.
84. Shiloh Y. 2003. ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 3: 155-168.
85. Shiozaki K, Russell P. 1995. Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 378: 739-743.
86. Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M. 2008. Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol 181: 227-240.
87. Stern B, Nurse P. 1996. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet 12: 345-350.
88. Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ. 2003. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421: 961-966.
89. Stracker TH, Petrini JH. 2011. The MRE11 complex: Starting from the ends. Nat Rev Mol Cell Biol 12: 90-103.
90. Strausfeld U, Labbe JC, Fesquet D, Cavadore JC, Picard A, Sadhu K, Russell P, Doree M. 1991. Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature 351: 242-245.
91. Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackso SP. 2005. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123: 1213-1226.
92. Tanaka TU, Rachidi N, Janke C, Pereira G, Galova M, Schiebel E, Star MJ, Nasmyth K. 2002. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108: 317-329.
93. Tyson JJ. 1983. Unstable activator models for size control of the cell cycle. J Theor Biol 104: 617-631.
94. Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. 2009. Cell growth and size homeostasis in proliferating animal cells. Science 325: 167-171.
95. Uhlmann F, Bouchoux C, Lopez-Aviles S. 2011. A quantitative model for cyclin-dependent kinase control of the cell cycle: Revisited. Philos Trans R Soc Lond B Biol Sci 366: 3572-3583
96. Ward PS, Thompson CB. 2012. Signaling in control of cell growth and metabolism. Cold Spring Harb Perspect Biol doi: 10.1101/ cshperspect.a006783.
97. WelburnJP, Tucker JA, JohnsonT, Lindert L, MorganM, WillisA, NobleME, Endicott JA. 2007. Howtyrosine 15phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A. J BiolChem282: 3173-3181.
98. Wurzenberger C, Gerlich DW. 2011. Phosphatases: Providing safe passage through mitotic exit. Nat Rev Mol Cell Biol 12: 469-482.
99. Yang X, Yu K, Hao Y, Li DM, Stewart R, Insogna KL, Xu T. 2004. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol 6: 609-617.
100. You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T. 2009. CtIP links DNA double-strand break sensing to resection. Mol Cell 36: 954-969.