The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats

Neuropharmacology

Volumn 77, Issue , 2014, Pages 358-368

  Li, Jun ^a   Yu, Wei ^a   Li, Xue Ting ^a   Qi, Si Hua ^a   Li, Bing ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Focal cerebral ischemia; Mitochondrial membrane potential; Propofol; Reactive oxygen species; Reperfusion; Swelling

Indexed keywords

CALCIUM; PROPOFOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CELL ISOLATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; ELECTRON MICROSCOPY; FLOW CYTOMETRY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

FOCAL CEREBRAL ISCHEMIA; IB; ISOLATION BUFFER; MCAO; MEMBRANE PERMEABILITY TRANSITION; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MMP; MPT; MPTP; OGD; OXYGEN-GLUCOSE DEPRIVATION; PROPOFOL; REACTIVE OXIDATIVE SPECIES; REACTIVE OXYGEN SPECIES; REPERFUSION; ROS; SWELLING;

ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; PROPOFOL; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY;

EID: 84887605497     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.08.029     Document Type: Article

References (57)

1. C. Adembri, L. Venturi, A. Tani, A. Chiarugi, E. Gramigni, A. Cozzi, T. Pancani, R.A. De Gaudio, and D.E. Pellegrini-Giampietro Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism Anesthesiology 104 2006 80 89 (Pubmed: 16394694)
2. P. Amorim, G. Chambers, J. Cottrell, and I.S. Kass Propofol reduces neuronal transmission damage and attenuates the changes in calcium, potassium, and sodium during hyperthermic anoxia in the rat hippocampal slice Anesthesiology 83 1995 1254 1265 (Pubmed: 8533918)
3. M.F. Anderson, and N.R. Sims Mitochondrial respiratory function and cell death in focal cerebral ischemia J. Neurochem. 73 1999 1189 1199 (Pubmed: 10461911)
4. F.A. Arcadi, A. Rapisarda, R. De Luca, G.R. Trimarchi, and G. Costa Effect of 2,6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil Life Sci. 58 1996 961 970 (Pubmed: 8786708)
5. R. Bains, M.C. Moe, M.L. Vinje, and J. Berg-Johnsen Sevoflurane and propofol depolarize mitochondria in rat and human cerebrocortical synaptosomes by different mechanisms Acta Anaesthesiol. Scand. 53 10 2009 1354 1360 (Pubmed: 19650805)
6. A. Bhardwaj, A.F. Castro III, N.J. Alkayed, P.D. Hurn, and J.R. Kirsch Anesthetic choice of halothane versus propofol: impact on experimental perioperative stroke Stroke 32 8 2001 1920 1925 (Pubmed: 11486126)
7. D.J. Buggy, B. Nicol, D.J. Rowbotham, and D.G. Lambert Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition Anesthesiology 92 4 2000 1067 1073 (Pubmed: 10754627)
8. L. Canevari, S. Kuroda, T.E. Bates, J.B. Clark, and B.K. Siesjö Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat J. Cereb. Blood Flow Metab. 17 11 1997 1166 1169 (Pubmed: 9390648)
9. M. Christophe, and S. Nicolas Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion Curr. Pharm. Des. 12 2006 739 757 (Pubmed: 16472163)
10. R. Daskalopoulos, J. Korcok, P. Farhangkhgoee, M. Karmazyn, A.W. Gelb, and J.X. Wilson Propofol protection of sodium-hydrogen exchange activity sustains glutamate uptake during oxidative stress Anesth. Analg. 93 5 2001 1199 1204 (Pubmed: 11682397)
11. K.P. Doyle, R.P. Simon, and M.P. Stenzel-Poore Mechanisms of ischemic brain damage Neuropharmacology 55 3 2008 310 318 (Pubmed: 18308346)
12. K. Engelhard, C. Werner, E. Eberspächer, M. Pape, U. Stegemann, K. Kellermann, R. Hollweck, P. Hutzler, and E. Kochs nfluence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation Anesthesiology 101 4 2004 912 917 (Pubmed: 15448524)
13. Z.C. Feng, T.J. Sick, and M. Rosenthal Oxygen sensitivity of mitochondrial redox status and evoked potential recovery early during reperfusion in post-ischemic rat brain Resuscitation 37 1998 33 41 (Pubmed: 9667336)
14. J.H. Garcia, A.S. Lossinsky, F.C. Kauffman, and K.A. Conger Neuronal ischemic injury: light microscopy, ultrastructure and biochemistry Acta Neuropathol. 43 1978 85 95 (Pubmed: 97917)
15. A.P. Halestrap, S.J. Clarke, and S.A. Javadov Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection Cardiovasc. Res. 61 2004 372 385 (Pubmed: 14962470)
16. M.J. Hansson, T. Persson, H. Friberg, M.F. Keep, A. Rees, T. Wieloch, and E. Elmér Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria Brain Res. 960 2003 99 111 (Pubmed: 12505662)
17. T. Iijima, T. Mishima, M. Tohyama, K. Akagawa, and Y. Iwao Mitochondrial membrane potential and intracellular ATP content after transient experimental ischemia in the cultured hippocampal neuron Neurochem. Int. 43 2003 263 269 (Pubmed: 12689606)
18. T. Iijima, T. Mishima, K. Akagawa, and Y. Iwao Mitochondrial hyperpolarization after transient oxygen-glucose deprivation and subsequent apoptosis in cultured rat hippocampal neurons Brain Res. 993 2003 140 145 (Pubmed: 14642839)
19. T. Iijima Mitochondrial membrane potential and ischemic neuronal death Neurosci. Res. 55 2006 234 243 (Pubmed: 16716421)
20. H. Ito, S. Watanabe, A. Sanchez, M.A. Whitt, and Y. Kawaoka Mutational analysis of the putative fusion domain of Ebola virus glycoprotein J. Virol. 73 1999 8907 8912 (Pubmed: 10482652)
21. S.A. Javadov, K.H. Lim, P.M. Kerr, M.S. Suleiman, G.D. Angelini, and A.P. Halestrap Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition Cardiovasc. Res. 45 2000 360 369 (Pubmed: 10728356)
22. M. Kawaguchi, H. Furuya, and P.M. Patel Neuroprotective effects of anesthetic agents J. Anesth. 19 2005 150 156 (Pubmed: 15875133)
23. I.P. Koerner, and A.M. Brambrink Brain protection by anesthetic agents Curr. Opin. Anaesthesiol. 19 2006 481 486 (Pubmed: 16960478)
24. B.S. Kristal, and J.M. Dubinsky Mitochondrial permeability transition in the central nervous system: induction by calcium cycling-dependent and -independent pathways J. Neurochem. 69 1997 524 538 (Pubmed: 9231710)
25. T. Kristián, and B.K. Siesjö Calcium in ischemic cell death Stroke 29 1998 705 718 (Pubmed: 9506616)
26. S. Kuroda, K. Katsura, L. Hillered, T.E. Bates, and B.K. Siesjö Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat Neurobiol. Dis. 3 1996 149 157 (Pubmed: 9173922)
27. J. Li, B. Han, X. Ma, and S. Qi The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats Brain Res. 1356 2010 11 23 (Pubmed: 20707988)
28. Y. Liu, R.E. Rosenthal, Y. Haywood, M. Miljkovic-Lolic, J.Y. Vanderhoek, and G. Fiskum Normoxic ventilation after cardiac arrest reduces oxidation of brain lipids and improves neurological outcome Stroke 29 1998 1679 1686 (Pubmed: 9707212)
29. E.Z. Longa, P.R. Weinstein, S. Carlson, and R. Cummins Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91 (Pubmed: 2643202)
30. W.D. Lust, C. Taylor, S. Pundik, W.R. Selman, and R.A. Ratcheson Ischemic cell death: dynamics of delayed secondary energy failure during reperfusion following focal ischemia Metab. Brain Dis. 17 2002 113 121 (Pubmed: 12083336)
31. M. Marian, A. Bindoli, F. Callegarin, M.P. Rigobello, E. Vincenti, M. Bragadin, and G. Scutari Effect of 2,6-diisopropylphenol and halogenated anesthetics on tetraphenylphosphonium uptake by rat brain synaptosomes: determination of membrane potential Neurochem. Res. 24 1999 875 881 (Pubmed: 10403628)
32. S.M. McGee-Russell, A.W. Brown, and J.B. Brierley A combined light and electron microscope study of early anoxic-ischaemic cell change in rat brain Brain Res. 20 1970 193 200 (Pubmed: 4101881)
33. K.M. Myers, G. Fiskum, Y. Liu, S.J. Simmens, D.E. Bredesen, and A.N. Murphy Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability J. Neurochem. 65 1995 2432 2440 (Pubmed: 7595537)
34. K. Murakami, T. Kondo, M. Kawase, Y. Li, S. Sato, S.F. Chen, and P.H. Chan Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency J. Neurosci. 18 1998 205 213 (Pubmed: 9412501)
35. A.N. Murphy, G. Fiskum, and M.F. Beal Mitochondria in neurodegeneration: bioenergetic function in cell life and death J. Cereb. Blood Flow Metab. 19 1999 231 245 (Pubmed: 10078875)
36. A. Nakai, S. Kuroda, T. Kristián, and B.K. Siesjö The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat Neurobiol. Dis. 4 1997 288 300 (Pubmed: 9361306)
37. D.G. Nicholls, and S.L. Budd Mitochondria and neuronal survival Physiol. Rev. 80 2000 315 360 (Pubmed: 10617771)
38. M.A. Peinado, A. Quesada, J.A. Pedrosa, M. Martinez, F.J. Esteban, M.L. Del Moral, and J.M. Peinado Light microscopic quantification of morphological changes during aging in neurons and glia of the rat parietal cortex Anat. Rec. 247 1997 420 425 (Pubmed: 9066920)
39. C.A. Piantadosi, and J. Zhang Mitochondrial generation of reactive oxygen species after brain ischemia in the rat Stroke 27 1996 327 331 discussion 332. (Pubmed: 8571432)
40. A. Popp, N. Jaenisch, O.W. Witte, and C. Frahm Identification of ischemic regions in a rat model of stroke PLoS One 4 2009 e4764 (Pubmed: 19274095)
41. S. Qi, R.Z. Zhan, C. Wu, H. Fujihara, K. Taga, and K. Shimoji The effects of thiopental and propofol on cell swelling induced by oxygen/glucose deprivation in the CA1 pyramidal cell layer of rat hippocampal slices Anesth. Analg. 94 2002 655 660 (Pubmed: 11867392)
42. Y. Sagara, S. Hendler, S. Khoh-Reiter, G. Gillenwater, D. Carlo, D. Schubert, and J. Chang Propofol hemisuccinate protects neuronal cells from oxidative injury J. Neurochem. 73 1999 2524 2530 (Pubmed: 10582614)
43. R.D. Sanders, D. Ma, and M. Maze Anaesthesia induced neuroprotection Best Pract. Res. Clin. Anaesthesiol. 19 2005 461 474 (Pubmed: 16013694)
44. B. Schaller, and R. Graf Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy J. Cereb. Blood Flow Metab. 24 2004 351 371 (Pubmed: 15087705)
45. 2+ FEBS J. 272 2005 3593 3601 (Pubmed: 16008559)
46. N.R. Sims Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation J. Neurochem. 55 1990 698 707 (Pubmed: 2164576)
47. N.R. Sims, and M.F. Anderson Mitochondrial contributions to tissue damage in stroke Neurochem. Int. 40 2002 511 526 (Pubmed: 11850108)
48. N.R. Sims, and M.F. Anderson solation of mitochondria from rat brain using Percoll density gradient centrifugation Nat. Protoc. 3 2008 1228 1239 (Pubmed: 18600228)
49. N.R. Sims, and H. Muyderman Mitochondria, oxidative metabolism and cell death in stroke Biochim. Biophys. Acta 1802 2010 80 91 (Pubmed: 19751827)
50. Y. Tsujimoto, T. Nakagawa, and S. Shimizu Mitochondrial membrane permeability transition and cell death Biochim. Biophys. Acta 1757 2006 1297 1300 (Pubmed: 16716247)
51. L.J. Velly, B.A. Guillet, F.M. Masmejean, A.L. Nieoullon, N.J. Bruder, F.M. Gouin, and P.M. Pisano Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters Anesthesiology 99 2003 368 375 (Pubmed: 12883409)
52. B.C. White, J.M. Sullivan, D.J. DeGracia, B.J. O'Neil, R.W. Neumar, L.I. Grossman, J.A. Rafols, and G.S. Krause Brain ischemia and reperfusion: molecular mechanisms of neuronal injury J. Neurol. Sci. 179 2000 1 33 (Pubmed: 11054482)
53. J.X. Wilson, and A.W. Gelb Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics J. Neurosurg. Anesthesiol. 14 2002 66 79 (Pubmed: 11773828)
54. G.J. Wu, Y.T. Tai, T.L. Chen, L.L. Lin, Y.F. Ueng, and R.M. Chen Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophages Ann. N. Y. Acad. Sci. 1042 2005 168 176 (Pubmed: 15965060)
55. Y. Young, D.K. Menon, N. Tisavipat, B.F. Matta, and J.G. Jones Propofol neuroprotection in a rat model of ischaemia reperfusion injury Eur. J. Anaesthesiol. 14 1997 320 326 (Pubmed: 9202922)
56. E. Zaidan, and N.R. Sims Reduced activity of the pyruvate dehydrogenase complex but not cytochrome c oxidase is associated with neuronal loss in the striatum following short-term forebrain ischemia Brain Res. 772 1997 23 28 (Pubmed: 9406951)
57. R.Z. Zhan, S. Qi, C. Wu, H. Fujihara, K. Taga, and K. Shimoji Intravenous anesthetics differentially reduce neurotransmission damage caused by oxygen-glucose deprivation in rat hippocampal slices in correlation with N-methyl-D-aspartate receptor inhibition Crit. Care Med. 29 2001 808 813 (Pubmed: 11333363)