Alcohol induces mitochondrial redox imbalance in alveolar macrophages

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1427-1434

  Liang, Yan ^a,b   Harris, Frank L ^a,b   Jones, Dean P ^a   Brown, Lou Ann S ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Center for Developmental Lung Biology   (United States)

Author keywords

Alveolar macrophage; Chronic alcohol ingestion; Free radicals; Mitochondria; Peroxiredoxin hyperoxidation; Thioredoxin

Indexed keywords

ALCOHOL; DISULFIDE; GLUTAREDOXIN; GLUTAREDOXIN 2; GLUTATHIONE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE REDUCTASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PEROXIREDOXIN; PEROXIREDOXIN 3; PEROXIREDOXIN 5; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL GROUP; THIOREDOXIN; THIOREDOXIN 2; THIOREDOXIN 2 REDUCTASE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ALCOHOL ABUSE; ALCOHOL BLOOD LEVEL; ALCOHOL OXIDATION; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POPULATION; CELL VIABILITY; CITRIC ACID CYCLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; GLYCOLYSIS; IN VITRO STUDY; IN VIVO STUDY; LONG TERM EXPOSURE; LUNG ALVEOLUS MACROPHAGE; MALE; MITOCHONDRIAL REDOX IMBALANCE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

MUS;

ALVEOLAR MACROPHAGE; AM; CHRONIC ALCOHOL INGESTION; FREE RADICALS; GLUTAREDOXIN; GLUTATHIONE (OXIDIZED); GLUTATHIONE (REDUCED); GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GPX; GR; GRX; GSH; GSSG; MITOCHONDRIA; NAD; NADP; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE; NNT; PEROXIREDOXIN; PEROXIREDOXIN HYPEROXIDATION; PRDX; REACTIVE OXYGEN SPECIES; RELATIVE FLUORESCENCE UNITS; RFU; ROS; THIOREDOXIN; THIOREDOXIN 2; THIOREDOXIN REDUCTASE 2; TRX2; TRXR2;

ALCOHOL DRINKING; ANIMALS; CELL LINE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; GLUTAREDOXINS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NADP; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXIREDOXINS; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; THIOREDOXIN-DISULFIDE REDUCTASE; THIOREDOXINS;

EID: 84887599656     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.10.010     Document Type: Article

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