Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeutics

Biochemical Society Transactions

Volumn 41, Issue 1, 2013, Pages 127-133

  Mitchell, Tanecia ^a,b   Chacko, Balu ^a,b   Ballinger, Scott W ^a,b   Bailey, Shannon M ^a,b   Zhang, Jianhua ^a,b   Darley Usmar, Victor ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Alcoholic liver disease; Cellular bioenergetics; Diabetes; Metabolic syndrome; Mitochondria; Mitoquinone (MitoQ); Reserve respiratory capacity; Steatosis

Indexed keywords

ALCOHOL CONSUMPTION; AUTOPHAGOSOME; CONFERENCE PAPER; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HYPERLIPIDEMIA; IMMOBILIZATION; INSULIN RESISTANCE; LIVER TOXICITY; METABOLIC DISORDER; METABOLIC STRESS; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL GENETICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; NITRATIVE STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEDENTARY LIFESTYLE; SIGNAL TRANSDUCTION; XENOBIOTIC STRESS;

HUMANS; INDIVIDUALIZED MEDICINE; METABOLIC DISEASES; MITOCHONDRIA; OXIDATIVE STRESS; QUALITY CONTROL; SIGNAL TRANSDUCTION;

EID: 84873197455     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120231     Document Type: Conference Paper

References (61)

1. Altamirano, J. and Bataller, R. (2011) Alcoholic liver disease: pathogenesis and new targets for therapy. Nat. Rev. Gastroenterol. Hepatol. 8, 491-501
2. Seth, D., Haber, P. S., Syn, W. K., Diehl, A. M. and Day, C. P. (2011) Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. J. Gastroenterol. Hepatol. 26, 1089-1105
3. Corrao, G., Ferrari, P., Zambon, A., Torchio, P., Arico, S. and Decarli, A. (1997) Trends of liver cirrhosis mortality in Europe, 1970-1989: age-period-cohort analysis and changing alcohol consumption. Int. J. Epidemiol. 26, 100-109 (Pubitemid 27129574)
4. Bellentani, S., Saccoccio, G., Costa, G., Tiribelli, C., Manenti, F., Sodde, M., Saveria Croce, L., Sasso, F., Pozzato, G., Cristianini, G. and Brandi, G. (1997) Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut 41, 845-850
5. Day, C. P. (2006) Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int. 26, 1021-1028 (Pubitemid 44541742)
6. Shukla, S. D. and Aroor, A. R. (2006) Epigenetic effects of ethanol on liver and gastrointestinal injury. World J. Gastroenterol. 12, 5265-5271 (Pubitemid 44501767)
7. Marrero, J. A., Fontana, R. J., Fu, S., Conjeevaram, H. S., Su, G. L. and Lok, A. S. (2005) Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma. J. Hepatol. 42, 218-224 (Pubitemid 40143468)
8. Cassetti, T., La Rosa, F., Rossi, L., D'Alo, D. and Stracci, F. (2008) Cancer incidence in men: a cluster analysis of spatial patterns. BMC Cancer 8, 344
9. Butow, R. A. and Avadhani, N. G. (2004) Mitochondrial signaling: the retrograde response. Mol. Cell 14, 1-15 (Pubitemid 38469905)
10. Gutierrez, J., Ballinger, S. W., Darley-Usmar, V. M. and Landar, A. (2006) Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ. Res. 99, 924-932 (Pubitemid 44657795)
11. Murphy, M. P. (2009) How mitochondria produce reactive oxygen species. Biochem. J. 417, 1-13
12. Brookes, P. S., Levonen, A. L., Shiva, S., Sarti, P. and Darley-Usmar, V. M. (2002) Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. Free Radical Biol. Med. 33, 755-764 (Pubitemid 35232311)
13. Ji, C. (2008) Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J. Gastroenterol. Hepatol. 23(Suppl. 1), S16-S24 (Pubitemid 351389024)
14. Osna, N. A. and Donohue, Jr, T. M. (2007) Implication of altered proteasome function in alcoholic liver injury. World J. Gastroenterol. 13, 4931-4937 (Pubitemid 47496824)
15. Pezzotti, A., Kraft, P., Hankinson, S. E., Hunter, D. J., Buring, J. and Cox, D. G. (2009) The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk. PLoS ONE 4, e5356
16. Zelickson, B. R., Benavides, G. A., Johnson, M. S., Chacko, B. K., Venkatraman, A., Landar, A., Betancourt, A. M., Bailey, S. M. and Darley-Usmar, V. M. (2011) Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochim. Biophys. Acta 1807, 1573-1582
17. Venkatraman, A., Shiva, S., Wigley, A., Ulasova, E., Chhieng, D., Bailey, S. M. and Darley-Usmar, V. M. (2004) The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice. Hepatology 40, 565-573 (Pubitemid 39265577)
18. Bailey, S. M. (2003) A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction. Free Radical Res. 37, 585-596 (Pubitemid 36603668)
19. Shiva, S., Oh, J. Y., Landar, A. L., Ulasova, E., Venkatraman, A., Bailey, S. M. and Darley-Usmar, V. M. (2005) Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway. Free Radical Biol. Med. 38, 297-306 (Pubitemid 40075573)
20. Chacko, B. K., Srivastava, A., Johnson, M. S., Benavides, G. A., Chang, M. J., Ye, Y., Jhala, N., Murphy, M. P., Kalyanaraman, B. and Darley-Usmar, V. M. (2011) Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology 54, 153-163
21. Venkatraman, A., Shiva, S., Davis, A. J., Bailey, S. M., Brookes, P. S. and Darley-Usmar, V. M. (2003) Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide. Hepatology 38, 141-147 (Pubitemid 36775805)
22. Kim, I., Rodriguez-Enriquez, S. and Lemasters, J. J. (2007) Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 462, 245-253 (Pubitemid 46876640)
23. Lee, J., Giordano, S. and Zhang, J. (2012) Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem. J. 441, 523-540
24. Novak, I. (2012) Mitophagy: a complex mechanism of mitochondrial removal. Antioxid. Redox Signaling 17, 794-802
25. Twig, G. and Shirihai, O. S. (2011) The interplay between mitochondrial dynamics and mitophagy. Antioxid. Redox Signaling 14, 1939-1951
26. Okamoto, K. and Kondo-Okamoto, N. (2012) Mitochondria and autophagy: critical interplay between the two homeostats. Biochim. Biophys. Acta 1820, 595-600
27. Kim, J. S., Nitta, T., Mohuczy, D., O'Malley, K. A., Moldawer, L. L., Dunn, Jr, W. A. and Behrns, K. E. (2008) Impaired autophagy: a mechanism of mitochondrial dysfunction in anoxic rat hepatocytes. Hepatology 47, 1725-1736 (Pubitemid 351702754)
28. Donohue, Jr, T. M. (2009) Autophagy and ethanol-induced liver injury. World J. Gastroenterol. 15, 1178-1185
29. Lemasters, J. J., Nieminen, A. L., Qian, T., Trost, L. C., Elmore, S. P., Nishimura, Y., Crowe, R. A., Cascio, W. E., Bradham, C. A., Brenner, D. A. and Herman, B. (1998) The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim. Biophys. Acta 1366, 177-196 (Pubitemid 28467031)
30. Albano, E. (2008) Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol. Aspects Med. 29, 9-16 (Pubitemid 351312214)
31. Gomaa, A. I., Khan, S. A., Toledano, M. B., Waked, I. and Taylor-Robinson, S. D. (2008) Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J. Gastroenterol. 14, 4300-4308
32. Venkatraman, A., Landar, A., Davis, A. J., Ulasova, E., Page, G., Murphy, M. P., Darley-Usmar, V. and Bailey, S. M. (2004) Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G521-G527 (Pubitemid 38374970)
33. Venkatraman, A., Landar, A., Davis, A. J., Chamlee, L., Sanderson, T., Kim, H., Page, G., Pompilius, M., Ballinger, S., Darley-Usmar, V. and Bailey, S. M. (2004) Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity. J. Biol. Chem. 279, 22092-22101 (Pubitemid 38679401)
34. Das, S., Hajnoczky, N., Antony, A. N., Csordas, G., Gaspers, L. D., Clemens, D. L., Hoek, J. B. and Hajnoczky, G. (2012) Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats. Pflügers Arch. 464, 101-109
35. Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R., Hunter, G. C. et al. (2002) Mitochondrial integrity and function in atherogenesis. Circulation 106, 544-549 (Pubitemid 34827702)
36. Andringa, K. K., King, A. L., Eccleston, H. B., Mantena, S. K., Landar, A., Jhala, N. C., Dickinson, D. A., Squadrito, G. L. and Bailey, S. M. (2010) Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection. Am. J. Physiol. Gastrointest. Liver Physiol. 298, G732-G745
37. Poso, A. R. and Hirsimaki, P. (1991) Inhibition of proteolysis in the liver by chronic ethanol feeding. Biochem. J. 273, 149-152
38. Donohue, Jr, T. M., Zetterman, R. K. and Tuma, D. J. (1989) Effect of chronic ethanol administration on protein catabolism in rat liver. Alcohol.: Clin. Exp. Res. 13, 49-57 (Pubitemid 19075573)
39. Rautou, P. E., Mansouri, A., Lebrec, D., Durand, F., Valla, D. and Moreau, R. (2010) Autophagy in liver diseases. J. Hepatol. 53, 1123-1134
40. Wu, D., Wang, X., Zhou, R. and Cederbaum, A. (2010) CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochem. Biophys. Res. Commun. 402, 116-122
41. Petta, S., Muratore, C. and Craxi, A. (2009) Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig. Liver Dis. 41, 615-625
42. Zafrani, E. S. (2004) Non-alcoholic fatty liver disease: an emerging pathological spectrum. Virchows Arch. 444, 3-12 (Pubitemid 38200084)
43. Eccleston, H. B., Andringa, K. K., Betancourt, A. M., King, A. L., Mantena, S. K., Swain, T. M., Tinsley, H. N., Nolte, R. N., Nagy, T. R., Abrams, G. A. and Bailey, S. M. (2011) Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice. Antioxid. Redox Signaling 15, 447-459
44. Mantena, S. K., King, A. L., Andringa, K. K., Landar, A., Darley-Usmar, V. and Bailey, S. M. (2007) Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver diseases. World J. Gastroenterol. 13, 4967-4973 (Pubitemid 47496829)
45. Bailey, S. M., Robinson, G., Pinner, A., Chamlee, L., Ulasova, E., Pompilius, M., Page, G. P., Chhieng, D., Jhala, N., Landar, A. et al. (2006) S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G857-G867 (Pubitemid 44772012)
46. Kharbanda, K. K., Todero, S. L., King, A. L., Osna, N. A., McVicker, B. L., Tuma, D. J., Wisecarver, J. L. and Bailey, S. M. (2012) Betaine treatment attenuates chronic ethanol-induced hepatic steatosis and alterations to the mitochondrial respiratory chain proteome. Int. J. Hepatol. 2012, 962183
47. Smith, R. A., Porteous, C. M., Gane, A. M. and Murphy, M. P. (2003) Delivery of bioactive molecules to mitochondria in vivo. Proc. Natl. Acad. Sci. U. S. A. 100, 5407-5412 (Pubitemid 36542718)
48. Graham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A., Cocheme, H. M., Murphy, M. P. and Dominiczak, A. F. (2009) Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension 54, 322-328
49. Lowes, D. A., Thottakam, B. M., Webster, N. R., Murphy, M. P. and Galley, H. F. (2008) The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radical Biol. Med. 45, 1559-1565
50. Lowes, D. A., Wallace, C., Murphy, M. P., Webster, N. R. and Galley, H. F. (2009) The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells. Free Radical Res. 43, 323-328
51. Smith, R. A., Adlam, V. J., Blaikie, F. H., Manas, A. R., Porteous, C. M., James, A. M., Ross, M. F., Logan, A., Cocheme, H. M., Trnka, J. et al. (2008) Mitochondria-targeted antioxidants in the treatment of disease. Ann. N. Y. Acad. Sci. 1147, 105-111
52. Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. and Murphy, M. P. (2010) The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a Phase II study of hepatitis C patients. Liver Int. 30, 1019-1026
53. Solesio, M. E., Prime, T. A., Logan, A., Murphy, M. P., Del Mar. Arroyo-Jimenez, M., Jordan, J. and Galindo, M. F. (2012) The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease., Biochim. Biophys. Acta 1832, 174-182
54. Kimura, Y., Selmi, C., Leung, P. S., Mao, T. K., Schauer, J., Watnik, M., Kuriyama, S., Nishioka, M., Ansari, A. A., Coppel, R. L. et al. (2005) Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. Hepatology 41, 55-63 (Pubitemid 40066383)
55. Lu, M. Y., Huang, J. F., Liao, Y. C., Bai, R. K., Trieu, R. B., Chuang, W. L., Yu, M. L., Juo, S. H. and Wong, L. J. (2012) Mitochondrial polymorphism 12361 AG is associated with nonalcoholic fatty liver disease. Transl. Res. 159, 58-59
56. Onishi, M., Sokuza, Y., Nishikawa, T., Mori, C., Uwataki, K., Honoki, K. and Tsujiuchi, T. (2007) Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. Biochem. Biophys. Res. Commun. 362, 183-187 (Pubitemid 47296309)
57. Zhang, R., Zhang, F., Wang, C., Wang, S., Shiao, Y. H. and Guo, Z. (2010) Identification of sequence polymorphism in the D-Loop region of mitochondrial DNA as a risk factor for hepatocellular carcinoma with distinct etiology. J. Exp. Clin. Cancer Res. 29, 130
58. Gomez-Duran, A., Pacheu-Grau, D., Lopez-Gallardo, E., Diez-Sanchez, C., Montoya, J., Lopez-Perez, M. J. and Ruiz-Pesini, E. (2010) Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups. Hum. Mol. Genet. 19, 3343-3353
59. Chuang, G. C., Yang, Z., Westbrook, D. G., Pompilius, M., Ballinger, C. A., White, C. R., Krzywanski, D. M., Postlethwait, E. M. and Ballinger, S. W. (2009) Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 297, L209-L216
60. Aitken, R. J., Baker, M. A. and Sawyer, D. (2003) Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic disease. Reprod. BioMed. Online 7, 65-70 (Pubitemid 36874408)
61. Ni Chonghaile, T., Sarosiek, K. A., Vo, T. T., Ryan, J. A., Tammareddi, A., Moore Vdel, G., Deng, J., Anderson, K. C., Richardson, P., Tai, Y. T. et al. (2011) Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 334, 1129-1133